Article
Clinical Neurology
Lei Zhang, Xuan Liu, Tong Li, Bing Xu, Binfang Fu
Summary: The study found that fluoxetine may enhance cognitive ability in certain domains for patients with VCIND, and increase serum levels of BDNF and VEGF.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Clinical Neurology
Jemma Hazan, Michelle Wing, Kathy Y. Liu, Suzanne Reeves, Robert Howard
Summary: This study evaluated the clinical utility of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) in patients with cognitive impairment. The meta-analysis showed that the use of CSF biomarkers led to changes in diagnosis, increased diagnostic confidence, and influenced patient management. Further research is needed to explore the clinical utility of blood-based biomarkers.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Oncology
Yusuke Shinchi, Shiho Ishizuka, Yoshihiro Komohara, Eri Matsubara, Remi Mito, Cheng Pan, Daiki Yoshii, Kimihiro Yonemitsu, Yukio Fujiwara, Koei Ikeda, Koji Tamada, Takuro Sakagami, Makoto Suzuki
Summary: PD-1 and PD-L1 are target molecules for immunotherapy in non-small cell lung cancer. This study investigated the clinical significance of PD-L1 expression on macrophages in lung adenocarcinoma and found that high PD-L1 expression was correlated with EGFR mutation, lower cancer grade, and shorter overall survival. The mechanism of PD-L1 overexpression on macrophages was found to be induced by GM-CSF derived from cancer cells via STAT3 activation. Anti-GM-CSF therapy inhibited cancer development, but had no effect on PD-L1 expression on macrophages. PD-L1 overexpression on macrophages via the GM-CSF/STAT3 pathway was suggested to promote cancer progression in lung adenocarcinoma.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Kentaro Okamoto, Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Takamasa Ichijo, Takashi Yoneda, Mika Tsuiki, Norio Wada, Kenji Oki, Kouichi Tamura, Hiroki Kobayashi, Shoichiro Izawa, Akiyo Tanabe, Mitsuhide Naruse
Summary: AVS may not be necessary for all PA patients without apparent ATs. Female normokalemic PA patients without apparent ATs and low ARRs may skip AVS, while male hypokalemic PA patients with high ARRs should consider AVS due to the high rates of unilateral subtype.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Yueping Yang, Xuan Meng, Xuanrui Zhang, Ting Shu, Jiushan Wu, Zhuangmin Zhao, Junhao Li
Summary: This study proposes a partial discharge measurement method based on frequency-spectrum-based PD localization and apparent charge error correction. By modeling the winding RLC ladder network and utilizing FRA results and intelligent algorithms, the method reduces the error in apparent charge estimation. Experimental results show that the method reduces the error by 70% in real windings.
IEEE TRANSACTIONS ON POWER DELIVERY
(2022)
Article
Biochemistry & Molecular Biology
Marta Marquie, Fernando Garcia-Gutierrez, Adelina Orellana, Laura Montrreal, Itziar de Rojas, Pablo Garcia-Gonzalez, Raquel Puerta, Claudia Olive, Amanda Cano, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Vanesa Pytel, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Alba Perez-Cordon, Angela Sanabria, Nathalia Munoz, Nuria Lleonart, Nuria Aguilera, Ainhoa Garcia-Sanchez, Emilio Alarcon-Martin, Lluis Tarraga, Agustin Ruiz, Merce Boada, Sergi Valero
Summary: This study found that the association between Alzheimer's disease biomarkers and neuropsychiatric symptoms has a significant impact on the conversion to dementia in patients with mild cognitive impairment. A total of 500 individuals with MCI were followed-up yearly, and it was found that certain AT(N) profiles and the presence of depression and apathy were associated with a higher risk of conversion. The additive combination of AT(N) profile with depression exacerbates the risk of conversion, and a synergic effect of prodromal AD profile with depressive symptoms is evidenced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Kyra O'Brien, Rui Feng, Frederick Sieber, Edward R. Marcantonio, Ann Tierney, Jay Magaziner, Jeffrey L. Carson, Derek Dillane, Daniel Sessler, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S. Schwenk, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Jason Karlawish, Samir Mehta, Derek J. Donegan, Annamarie Horan, Susan S. Ellenberg, Mark D. Neuman
Summary: The effect of spinal versus general anesthesia on the risk of postoperative delirium or other outcomes for patients with or without cognitive impairment (including dementia) is unknown.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Sebastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P. Guiard
Summary: The study found that 5d-RFSS mice exhibited strong depressive characteristics in the FST, but the model has limitations in replicating the broad spectrum of depressive symptoms observed in other chronic models. However, it showed a significant impact on the hypothalamic-pituitary-adrenal axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tae-Yeon Kim, Yong-Yeon Song, Il-Jung, Yong-Jin Na, Young-Hoon Lee, Jung-Yeul Kim, Min-Woo Lee
Summary: The study aimed to investigate the effects of prolonged type 2 diabetes (T2DM) on the retinal microvasculature of patients without clinical diabetic retinopathy (DR). The results showed that T2DM patients without DR had decreased vessel densities in both the superficial and deep capillary plexus. The impairment in the deep capillary plexus was more severe in patients with T2DM for more than 10 years. Best corrected visual acuity, hypertension, and duration of diabetes were significant factors associated with the deep vascular density.
Article
Biochemistry & Molecular Biology
Dorota Suszczyk, Wiktoria Skiba, Witold Zardzewialy, Anna Pawlowska, Karolina Wlodarczyk, Grzegorz Polak, Rafal Tarkowski, Iwona Wertel
Summary: This study found that the PD-L1/PD-L2 pathway plays an important role in EMS. In the peritoneal fluid of EMS patients, there is an increased proportion of mDCs and pDCs expressing PD-L1 or PD-L2, as well as a higher concentration of soluble PD-L1 and PD-L2. This suggests that the peritoneal cavity environment and the PD-1/PD-L1/PD-L2 axis may play a crucial role in regulating immune response and the development and/or progression of EMS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Ana Rita Silva, Patricia Regueira, Ana Luisa Cardoso, Ines Baldeiras, Isabel Santana, Joaquim Cerejeira
Summary: Dementia is a known risk factor for delirium and acute systemic infections, leading to cognitive decline in older patients. The study found that presence of delirium in individuals with prior dementia during hospitalization predicted cognitive decline at 1 year following admission. The findings suggest a pathophysiological interaction between neurodegenerative changes, acute infection, and delirium.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Pavlos Vlachogiannis, Lars Hillered, Per Enblad, Elisabeth Ronne-Engstrom
Summary: This study aims to investigate the role of chemokines, a relatively unexplored family of proteins, in the inflammatory pathophysiology of subarachnoid hemorrhage (SAH). Through analyzing the levels of 92 inflammation-related proteins in the cerebrospinal fluid of 29 SAH patients, the study found that higher levels of multiple chemokines at the late stage of SAH were associated with worse clinical outcome. The study also discovered correlations between certain chemokines and WFNS score, Fisher score, occurrence of DCI/DIND, and clinical outcome based on Glasgow score.
Article
Psychiatry
Lijun Liu, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Jing Wang, Hongjun Tian, Kerang Zhang, Jing Wei, Chuanyue Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Nan Zhang, Yu Huang, Tianmei Si, Xin Yu
Summary: The study aimed to explore the impact of SSRIs on cognitive function in depressed patients and identify factors associated with cognitive remission and nonremission. Results showed that most patients experienced improvements in cognitive function after treatment, but only a minority achieved cognitive remission.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yuichi Tatsuno, Yoshinari Morimoto, Megumi Hayashi, Takatoshi Iida
Summary: Although both elderly patients with severe dementia and those without cognitive impairment showed a decrease in BIS values after midazolam sedation, the dementia-positive group had a significant 9% decrease in the nTHI, reflecting cerebral blood flow. However, midazolam sedation did not significantly differentiate the nTHI between the dementia-positive and dementia-negative groups. The measured values in the dementia-negative group did not differ from baseline, while sedation with midazolam in the dementia-positive group resulted in a 9% decrease in cerebral blood flow.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Pietro Mattioli, Beatrice Orso, Claudio Liguori, Francesco Fama, Laura Giorgetti, Andrea Donniaquio, Federico Massa, Andrea Giberti, David V. Allez Garcia, Sanne K. Meles, Klaus L. Leenders, Fabio Placidi, Matteo Spanetta, Agostino Chiaravalloti, Riccardo Camedda, Orazio Schillaci, Francesca Izzi, Nicola B. Mercuri, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili, Dario Arnaldi
Summary: A brain glucose metabolism pattern related to phenoconversion in iRBD patients was derived and validated using spatial covariance analysis. This pattern can efficiently discriminate converters from nonconverters and has the potential to be a biomarker for phenoconversion in iRBD patients.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Chiara Del Bianco, Martina Ulivi, Claudio Liguori, Antonio Pisani, Nicola Biagio Mercuri, Fabio Placidi, Francesca Izzi
Summary: Non-sleep symptoms such as depression, anxiety, and overweight are common in narcoleptic patients. This study aimed to evaluate the psychological and emotional aspects of narcolepsy patients and their correlation with clinical data and sleep parameters. The results showed that narcolepsy type 1 (NT1) patients had higher levels of depressive mood and emotion dysregulation compared to controls, while alexithymic symptoms were more prominent in NT1 than narcolepsy type 2 (NT2) patients. Hypnagogic hallucinations, emotion dysregulation, and alexithymia were found to be correlated. These findings support the hypothesis of mutual interaction between these areas in narcolepsy.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Article
Clinical Neurology
Ada Ledonne, Mariangela Massaro Cenere, Emanuela Paldino, Vincenza D'Angelo, Sebastian Luca D'Addario, Nicolas Casadei, Annalisa Nobili, Nicola Berretta, Francesca R. Fusco, Rossella Ventura, Giuseppe Sancesario, Ezia Guatteo, Nicola Biagio Mercuri
Summary: Prolonged overexpression of alpha-synuclein has detrimental effects on the structural and functional properties of substantia nigra pars compacta dopamine neurons, including compromised soma and dendritic arborization, increased firing activity, and altered ion channel function.
MOVEMENT DISORDERS
(2023)
Article
Health Care Sciences & Services
Matteo Carpi, Mariangela Pierantozzi, Stefano Cofano, Mariana Fernandes, Rocco Cerroni, Francesca De Cillis, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori
Summary: This observational study investigates the presence of non-motor symptoms (NMS) and non-motor fluctuations (NMF) in Parkinson's disease (PD) patients using the Non-Motor Fluctuation Assessment questionnaire (NoMoFa). The study finds that NMF are frequently reported by mild-to-moderate PD patients and are associated with an increased number of NMS. The study emphasizes the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Marco Conti, Francesca Morciano, Enida Bufi, Anna D'Angelo, Camilla Panico, Valerio Di Paola, Elisabetta Gori, Gianluca Russo, Giovanni Cimino, Simone Palma, Paolo Belli, Riccardo Manfredi
Summary: The effectiveness of neoadjuvant treatment has expanded its indications from locally advanced to early-stage breast cancers, aiming to increase conservative treatments and improve long term outcomes. Diagnostic techniques play an important role in tumoral staging, treatment response prediction, and surgical planning. This review examines the strengths of imaging modalities, particularly magnetic resonance imaging, and discusses the evolution of surgical approaches in breast cancer patients treated with neoadjuvant chemotherapy.
Article
Oncology
Rossella Rella, Marco Conti, Enida Bufi, Charlotte Marguerite Lucille Trombadori, Alba Di Leone, Daniela Terribile, Riccardo Masetti, Luca Zagaria, Antonino Mule, Francesca Morciano, Gianluca Franceschini, Paolo Belli
Summary: This study aimed to evaluate the accuracy of the ROLL technique in nodal staging after neoadjuvant chemotherapy in breast cancer patients with biopsy-proven metastatic lymph nodes. The results showed that the ROLL procedure was accurate in axillary nodal staging after neoadjuvant chemotherapy.
Review
Oncology
Valerio Di Paola, Giorgio Mazzotta, Marco Conti, Simone Palma, Federico Orsini, Laura Mola, Francesca Ferrara, Valentina Longo, Enida Bufi, Anna D'Angelo, Camilla Panico, Paola Clauser, Paolo Belli, Riccardo Manfredi
Summary: Targeted axillary dissection (TAD) is an axillary staging technique that involves removing confirmed metastatic lymph nodes in addition to sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT). It has lower false-negative rates and avoids the complications of traditional axillary lymph node dissection. Therefore, marking positive axillary lymph nodes before NACT is crucial. Various localization methods such as clip placement, carbon-suspension liquids, localization wires, radioactive tracer-based localizers, magnetic seeds, radar reflectors, and radiofrequency identification devices are available. This paper aims to explain the management of axillary lymph nodes based on guidelines and discuss the features, advantages, and disadvantages of axillary lymph node markers.
Review
Cell Biology
Alida Spalloni, Susanna de Stefano, Juliette Gimenez, Viviana Greco, Nicola B. Mercuri, Valerio Chiurchiu, Patrizia Longone
Summary: Since its discovery in the brain, hydrogen sulfide (H2S) has been recognized as a gas transmitter in the Central Nervous System (CNS), and studies have focused on its neuromodulatory and protectant functions. H2S has been found to have multiple roles in the peripheral and central systems, acting as a double-faced compound that can be both protective and toxic depending on its concentration. This review discusses the bell-shaped nature of H2S as an angiogenic factor, its release by glial cells and non-neuronal cells, and its role in a neurodegenerative disease, Amyotrophic Lateral Sclerosis.
Review
Biochemistry & Molecular Biology
Martina Montanari, Paola Imbriani, Paola Bonsi, Giuseppina Martella, Antonella Peppe
Summary: The enteric nervous system (ENS), composed of neurons and glial cells, regulates the motor and secretory functions of the gastrointestinal tract. Dysfunction of the connections between the brain and the GI tract is implicated in Parkinson's disease (PD). Alterations in the ENS, including α-synuclein aggregation, occur early in the disease and spread to the central nervous system. This review highlights the role of the ENS in PD pathogenesis and its potential as a target for new therapeutic approaches.
Review
Imaging Science & Photographic Technology
Marco Conti, Francesca Morciano, Claudia Rossati, Elisabetta Gori, Paolo Belli, Francesca Fornasa, Giovanna Romanucci, Rossella Rella
Summary: Angiosarcoma of the breast is a rare form of breast cancer that can occur as a primary or secondary malignancy, often in patients with a history of radiation therapy. The increased use of breast-conserving surgery and radiation therapy has led to a higher incidence of secondary angiosarcomas. This paper reviews the radiological features of breast angiosarcomas to help radiologists diagnose and manage this rare tumor.
JOURNAL OF IMAGING
(2023)
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Nutrition & Dietetics
Manuela Di Lauro, Cristina Guerriero, Kevin Cornali, Maria Albanese, Micaela Costacurta, Nicola Biagio Mercuri, Nicola Di Daniele, Annalisa Noce
Summary: Migraine, one of the most common causes of disability in adults, has been associated with gut dysbiosis, as the intestine is capable of modulating central nervous system activities. In addition to conventional pharmacological treatments, modifying nutrition and lifestyle to positively influence gut microbiota composition may serve as a beneficial adjunct therapy for various migraine subtypes.
Article
Medicine, General & Internal
Mariacarolina Vacca, Matteo Spanetta, Andrea Ballesio, Mariana Fernandes, Fabio Placidi, Francesca Izzi, Caterina Lombardo, Nicola Biagio Mercuri, Giuseppina Lagana, Claudio Liguori
Summary: This study found that impulsivity mediated the relationship between excessive daytime sleepiness (EDS) and depression in patients with obstructive sleep apnea syndrome (OSAS). The results provide a new perspective on the link between sleepiness and depression, and have important implications for clinical treatment and intervention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Antonio Franco, Alba Di Leone, Marco Conti, Alessandra Fabi, Luisa Carbognin, Andreina Daniela Terribile, Paolo Belli, Armando Orlandi, Martin Alejandro Sanchez, Francesca Moschella, Elena Jane Mason, Giovanni Cimino, Alessandra De Filippis, Fabio Marazzi, Ida Paris, Giuseppe Visconti, Liliana Barone Adesi, Lorenzo Scardina, Sabatino D'Archi, Marzia Salgarello, Diana Giannarelli, Riccardo Masetti, Gianluca Franceschini, Kenneth P. H. Pritzker
Summary: This study developed a post-Neoadjuvant Score System (pNESSy) to choose the appropriate surgery and improve oncological and aesthetic outcomes. The system uses clinical and radiological features to predict the optimal surgery method post-neoadjuvant chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Oriella Gnarra, Carmen Calvello, Tommaso Schirinzi, Francesca Beozzo, Claudia De Masi, Matteo Spanetta, Mariana Fernandes, Piergiorgio Grillo, Rocco Cerroni, Mariangela Pierantozzi, Claudio L. A. Bassetti, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori
Summary: This study aimed to evaluate the sleep architecture and head position in Parkinson's disease patients and correlate them with motor and non-motor symptoms. The results demonstrated the importance of maintaining the lateral head position during sleep stages essential for glymphatic system function and brain health.
JOURNAL OF PERSONALIZED MEDICINE
(2023)