Letter
Clinical Neurology
Huimin Chen, Yilong Wang
Summary: The study found that microbleeds in the cortex are closely related to veins, posing a challenge in distinguishing between vessels and microbleeds. A small number of individuals in the healthy control group may have had vascular structures misjudged as microbleeds in the brain.
Article
Multidisciplinary Sciences
Christopher N. Osuafor, Catarina Rua, Andrew D. Mackinnon, Marco Egle, Philip Benjamin, Daniel J. Tozer, Christopher T. Rodgers, Hugh S. Markus
Summary: Enhanced Time-of-Flight Magnetic Resonance Angiography at 7 T improves visualization of lenticulostriate arteries in patients with symptomatic lacunar stroke, suggesting it may enhance the detection of arterial pathology in cerebral small vessel disease.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Johanna Rotta, Valentina Perosa, Renat Yakupov, Hugo J. Kuijf, Frank Schreiber, Laura Dobisch, Jan Oltmer, Anne Assmann, Oliver Speck, Hans-Jochen Heinze, Julio Acosta-Cabronero, Emrah Duzel, Stefanie Schreiber
Summary: Cerebral microbleeds (MBs) are commonly found in patients with cerebral small vessel disease (CSVD), and a study found a link between MBs and the venous vasculature, potentially contributing to the development of CSVD and cerebral amyloid angiopathy (CAA). Further pathological studies are needed to confirm these findings.
Article
Chemistry, Analytical
Sangwoo Kim, Chulhyun Lee
Summary: This study applied MinVER technique to improve vessel-to-tissue contrast and shorten acquisition time on 7T TOF-MRA, achieving faster imaging speed and better contrast enhancement. The approach, unaffected by individual status and specific absorption ratio constraints, can serve as a valuable tool in observing microvascular changes and diagnosing various vascular diseases.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2021)
Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Multidisciplinary Sciences
Benedikt Hartmann, Max Mueller, Lisa Seyler, Tobias Bauerle, Tobias Wilferth, Nikolai Avdievitch, Loreen Ruhm, Anke Henning, Alexei Lesiv, Pavel Ivashkin, Michael Uder, Armin M. Nagel
Summary: Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo, offering great potential in analyzing uptake, perfusion, washout or metabolism. This study performed DMRS of deuterated 3-O-Methylglucose (OMG) and demonstrated the feasibility of using DMRS with deuterium labelled OMG. The data obtained may serve as a basis for future studies characterizing glucose transport using DMRS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhang Shi, Xueying Zhao, Shuo Zhu, Xiyin Miao, Yunfei Zhang, Shihong Han, Bei Wang, Boyu Zhang, Xiaodan Ye, Yongming Dai, Caizhong Chen, Shengxiang Rao, Jiang Lin, Mengsu Zeng, He Wang
Summary: This study evaluated the image quality and cerebrovascular visualization of 5-T 3D TOF MRA for visualizing intracranial small branch arteries. The results showed that 5-T MRA had significantly better visualization of distal arteries and small vessels compared to 3 T MRA. There was no significant difference in image quality and quantitative measurements between 5 T and 7 T.
Article
Clinical Neurology
Jose M. Ferro, Martin Bendszus, Olav Jansen, Jonathan M. Coutinho, Francesco Dentali, Adam Kobayashi, Diana Aguiar de Sousa, Lia L. Neto, Corinna Miede, Jorge Caria, Holger Huisman, Hans-Christoph Diener
Summary: This study found that the majority of patients with cerebral venous thrombosis had partial or complete recanalization of occluded sinuses and veins after being anticoagulated with either dabigatran or warfarin for six months.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Valentina Perosa, Johanna Rotta, Renat Yakupov, Hugo J. J. Kuijf, Frank Schreiber, Jan T. T. Oltmer, Hendrik Mattern, Hans-Jochen Heinze, Emrah Duezel, Stefanie Schreiber
Summary: This study explored the implications of using quantitative susceptibility mapping (QSM) at submillimeter resolution for detecting cerebral microbleeds (MBs) in patients with cerebral small vessel disease (CSVD). The results showed that QSM can improve the detection of MBs and revealed a higher prevalence of MBs in healthy elderly individuals than previously known.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Yifan Yuan, Yang Yu, Jun Chang, Ying-Hua Chu, Wenwen Yu, Yi-Cheng Hsu, Liebig Alexander Patrick, Mianxin Liu, Qi Yue
Summary: A combination of a convolutional neural network (CNN) and ultra-high field 7.0 Tesla (T) chemical exchange saturation transfer (CEST) imaging can be used to predict the isocitrate dehydrogenase (IDH) mutation status in glioma noninvasively, thereby guiding surgical strategies and individualized management.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neuroimaging
Emma A. Koemans, Marianne A. A. van Walderveen, Sabine Voigt, Ingeborg Rasing, Thijs W. van Harten, Hine J. A. van Os, Nelleke van der Weerd, Gisela M. Terwindt, Matthias J. P. van Osch, Susanne J. van Veluw, Whitney M. Freeze, Marieke J. H. Wermer
Summary: In this study, we observed frequent subarachnoid cerebrospinal fluid (CSF) hyperintensities at non-contrast 7-tesla (T) fluid-attenuated inversion recovery (FLAIR) MRI in participants with cerebral amyloid angiopathy (CAA), which were often associated with cortical superficial siderosis (cSS). These CSF hyperintensities were found to have an anatomical and temporal relationship with cSS. The occurrence and changes of these CSF hyperintensities were further investigated using 3T MRI.
NEUROIMAGE-CLINICAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thaddee Delebarre, Vincent Gras, Franck Mauconduit, Alexandre Vignaud, Nicolas Boulant, Luisa Ciobanu
Summary: The purpose of this study is to optimize the homogeneity of presaturation module in a CEST acquisition using pTx at 7T. An optimized pTx-CEST presaturation scheme is designed based on precomputed universal pulses, and the optimization is performed by minimizing the L2-norm between the effective B1,RMS+ and a given target under VOPs supervision. The proposed method is evaluated through simulations and experiments and shows superior performance compared to CP and other pTx approaches.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Peripheral Vascular Disease
Marieke van den Kerkhof, Merel M. van der Thiel, Alida A. Postma, Robert J. van Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Summary: This study found that patients with hypertension have higher pulsatility index (PI) and lower damping factor (DF) in small perforating arteries, which may be due to hypertension-induced arterial stiffening leading to increased blood flow pulsatility and decreased damping. These results highlight the impact of hypertension on cerebral blood vessel structure and function, and provide clues for further investigation into the relationship between hypertension and stroke and cerebral small vessel disease (cSVD).
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacco A. de Zwart, Peter van Gelderen, Jeff H. Duyn
Summary: The study investigated the practical resolution limits of perfusion-weighted fMRI in human visual stimulation experiments. Results showed that at high resolution, perfusion-weighted fMRI had lower sensitivity than BOLD, potentially compromising the detection of visual activation.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
S. Peretz, K. Pardo, J. Naftali, M. Findler, G. Raphaeli, R. Barnea, V Khasminsky, E. Auriel
Summary: This study finds that CTP-derived thalamostriate Delta TTP can serve as a reliable indicator for predicting striatocapsular infarction in patients post-M1 thrombectomy, suggesting the potential application of extracting venous outflow parameters from CTP.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Annika Herten, Dino Saban, Alejandro N. Santos, Bixia Chen, Marvin Darkwah Oppong, Laurel Rauschenbach, Ramazan Jabbarli, Karsten Wrede, Ulrike Bingel, Daniel Mueller, Dagny Holle-Lee, Boerge Schmidt, Yan Li, Ulrich Sure, Philipp Dammann
Summary: This study assessed the occurrence and significance of postoperative neuropathic pain in patients with surgically treated brainstem cavernous malformations. It was found that 8% of patients suffered from NP after surgery, impacting their health-related quality of life and life satisfaction.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Alejandro N. Santos, Laurel Rauschenbach, Marvin Darkwah Oppong, Oliver Gembruch, Dino Saban, Bixia Chen, Annika Herten, Boerge Schmidt, Yan Li, Neriman Oezkan, Ramazan Jabbarli, Karsten Wrede, Ulrich Sure, Philipp Dammann
Summary: This study found that cavernous malformations of the spinal cord have a higher risk of bleeding or rebleeding, and the neurological function significantly deteriorates after recurrent hemorrhage.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Clinical Neurology
Alejandro N. Santos, Laurel Rauschenbach, Dino Saban, Bixia Chen, Annika Herten, Thiemo Florin Dinger, Yan Li, Stephan Tippelt, Adela Della Marina, Christian Dohna-Schwake, Boerge Schmidt, Ramazan Jabbarli, Karsten H. Wrede, Ulrich Sure, Philipp Dammann
Summary: This study investigated the natural course of cerebral cavernous malformations (CCM) in pediatric patients, highlighting a higher risk of intracerebral hemorrhage (ICH) in children with brain stem CCM and familial history of CCM. Over a 5-year follow-up, untreated pediatric patients had a similar risk of (re)hemorrhage compared to adults, with an increased probability over time, especially in cases with ICH or brain stem localization.
Article
Clinical Neurology
Marcel Opitz, Georgios Alatzides, Sebastian Zensen, Denise Bos, Axel Wetter, Nika Guberina, Marvin Darkwah Oppong, Karsten H. Wrede, Tim Hagenacker, Yan Li, Isabel Wanke, Michael Forsting, Cornelius Deuschl
Summary: The study aimed to determine local diagnostic reference levels during endovascular diagnostics and therapy of carotid-cavernous fistulas. Different dose levels were observed between diagnostic angiography and embolization for CCF, with embolization having significantly higher doses.
CLINICAL NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Taku Sato, Toshinori Matsushige, Bixia Chen, Oliver Gembruch, Philipp Dammann, Ramazan Jabbarli, Michael Forsting, Andreas Junker, Stefan Maderwald, Harald H. Quick, Mark E. Ladd, Ulrich Sure, Karsten H. Wrede
Summary: This study investigates the relationship between thrombus signal intensity and aneurysm wall thickness in partially thrombosed intracranial aneurysms using 7T magnetic resonance imaging. The results show a correlation between the thrombus signal intensity ratio and aneurysm wall thickness, suggesting a link to wall instability.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Thiemo Florin Dinger, Maija Susanna Eerikaeinen, Anna Michel, Oliver Gembruch, Marvin Darkwah Oppong, Mehdi Chihi, Tobias Blau, Anne-Kathrin Uerschels, Daniela Pierscianek, Cornelius Deuschl, Ramazan Jabbarli, Ulrich Sure, Karsten Henning Wrede
Summary: Spinal epidural lipomatosis (SEL) is a rare condition characterized by hypertrophic growth of epidural fat. This study conducted a systematic literature review on patients with acute, severe SEL and found that surgery was the main treatment option, but nearly 50% of the patients had a poor prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Julia P. Lingl, Arthur Wunderlich, Steffen Goerke, Daniel Paech, Mark E. Ladd, Patrick Liebig, Andrej Pala, Soung Yung Kim, Michael Braun, Bernd L. Schmitz, Meinrad Beer, Johannes Rosskopf
Summary: This prospective study demonstrates the high diagnostic potential of APTw CEST imaging in a routine clinical setting for differentiating brain tumors.
Article
Biophysics
Johannes Breitling, Andreas Korzowski, Neele Kempa, Philip S. Boyd, Daniel Paech, Heinz-Peter Schlemmer, Mark E. Ladd, Peter Bachert, Steffen Goerke
Summary: In this study, a simple method for motion correction in CEST-MRI data is proposed. The method utilizes weighted averaging of motion parameters from conventional rigid image registration to identify and mitigate misaligned images. The proposed method outperforms other motion-correction algorithms in terms of accuracy and robustness.
NMR IN BIOMEDICINE
(2022)
Article
Clinical Neurology
Maryam Said, Svenja Odensass, Meltem Gumus, Jan Rodemerk, Mehdi Chihi, Laurel Rauschenbach, Thiemo Florin Dinger, Marvin Darkwah Oppong, Philipp Dammann, Karsten Henning Wrede, Ulrich Sure, Ramazan Jabbarli
Summary: This study analyzed the clinical value of different radiographic scores for predicting the prognosis of aneurysmal subarachnoid hemorrhage (aSAH). The Hijdra sum score was found to have the highest diagnostic accuracy and robust predictive value for early detection of risk of delayed cerebral ischemia (DCI), in-hospital mortality, and unfavorable outcome after aSAH. Moreover, the radiographic scores independently predicted the risk of different complications during aSAH, such as elevated intracranial pressure, cerebral vasospasm, and shunt dependency.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rafael Heiss, Marc-Andre Weber, Eva Balbach, Rainer Schmitt, Christoph Rehnitz, Azien Laqmani, Andreas Sternberg, Jutta J. Ellermann, Armin M. Nagel, Mark E. Ladd, Matthias Englbrecht, Andreas Arkudas, Raymund Horch, Ali Guermazi, Michael Uder, Frank W. Roemer
Summary: This study compared the subjective image quality of 3T and 7T ultrahigh-field-strength wrist MRI and found that 7T MRI had potential advantages in cartilage assessment, while 3T MRI was superior in evaluating the triangular fibrocartilage complex and wrist ligaments.
Article
Clinical Neurology
Steffen Rauscher, Alejandro N. Santos, Hanah Hadice Gull, Laurel Rauschenbach, Bixia Chen, Boerge Schmidt, Cornelius Deuschl, Arnau Benet, Ramazan Jabbarli, Karsten H. Wrede, Adrian M. Siegel, Michael Lawton, Ulrich Sure, Philipp Dammann
Summary: This study investigated the impact of modifiable vascular risk factors on the risk of bleeding in patients with a cavernous malformation (CM) of the central nervous system (CNS) over a 10-year period. The results showed that nicotine use and diabetes were associated with an increased risk of bleeding, although not statistically significant. Different cumulative 10-year risks of bleeding were observed based on the presence of modifiable vascular risk factors. Overall, the cumulative (10-year) hemorrhage risk was 30.3%.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Meltem Guemues, Maryam Said, Mehdi Chihi, Thiemo F. Dinger, Jan Rodemerk, Benedikt Frank, Marvin Darkwah Oppong, Philipp Dammann, Karsten H. Wrede, Michael Forsting, Ulrich Sure, Ramazan Jabbarli
Summary: This study analyzes the temporal distribution of aneurysmal subarachnoid hemorrhage (SAH) and explores the impact of socio-demographic and clinical characteristics on the timing of the rupture event. The results show two peaks in the circadian rhythm of SAH, with the strongest alterations observed for weekdays, age, sex, and ethnicity. The study also indicates that the rupture timing has no influence on the severity, complications, and outcome of SAH patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Maryam Said, Meltem Guemues, Jan Rodemerk, Mehdi Chihi, Laurel Rauschenbach, Thiemo F. F. Dinger, Marvin Darkwah Oppong, Yahya Ahmadipour, Philipp Dammann, Karsten H. H. Wrede, Ulrich Sure, Ramazan Jabbarli
Summary: This study evaluated the association between ventricular indices and the clinical course, occurrence of complications, and outcome of aneurysmal subarachnoid hemorrhage (SAH). The results showed that higher ventricular indices and older age were associated with higher WFNS and Fisher's scores and lower SEBES score at admission. Patients with larger ventricles had shorter duration of intracranial pressure increase and less frequent need for decompressive craniectomy. Ventricular indices were independently associated with inflammatory response parameters and all primary endpoints.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mark E. Ladd, Harald H. Quick, Oliver Speck, Michael Bock, Arnd Doerfler, Michael Forsting, Juergen Hennig, Bernd Ittermann, Harald E. Moeller, Armin M. Nagel, Thoralf Niendorf, Stefan Remy, Tobias Schaeffter, Klaus Scheffler, Heinz-Peter Schlemmer, Sebastian Schmitter, Laura Schreiber, N. Jon Shah, Tony Stoecker, Michael Uder, Arno Villringer, Nikolaus Weiskopf, Moritz Zaiss, Maxim Zaitsev
Summary: Multiple sites in Germany operate human MRI systems at 7 Tesla or 9.4 Tesla. The German Ultrahigh Field Imaging (GUFI) network was established in 2013 to facilitate research cooperation and make this technology available to a larger community of researchers and clinicians worldwide. This paper summarizes the history, current status, motivation, and challenges of pursuing MRI at higher magnetic field strengths, focusing on the perspective in Germany.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Witold X. X. Chmielewski, Sebastian Walbrodt, Laurel Rauschenbach, Mehdi Chihi, Oliver Gembruch, Marvin Darkwah Oppong, Sebastian Schroer, Karsten H. H. Wrede, Philipp Dammann, Ramazan Jabbarli, Ilonka Kreitschmann-Andermahr, Taku Sato, Nicole Unger, Stefan Mattheis, Ulrich Sure, Yahya Ahmadipour
Summary: A study on 81 patients who underwent adenomectomy found that those with previous nasal surgery may experience worsened sinus health, increased discomfort, visual impairment, and decreased psychological quality of life after the surgery. These patients should be fully informed about potential consequences before the operation.
MEDICINA-LITHUANIA
(2023)
