Review
Immunology
Sonalika Kar, Abhinav Sinha
Summary: The neglected but highly prevalent Plasmodium vivax in South-east Asia and South America poses a great challenge for long-term in-vitro culturing and functional assays, hindering the development of new drugs and vaccines. The leading vaccine candidate antigen PvDBP, despite completing clinical trial Phase 1 successfully, faces challenges such as its highly polymorphic nature and strain-specific immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari, Kwadwo A. Koram
Summary: Recent studies have shown that Plasmodium vivax can infect red blood cells in Duffy-negative individuals, contrary to previous beliefs. This study in Ghana found no cases of P. vivax infection and a high prevalence of the FYES allele among the subjects tested, which may contribute to the lack of P. vivax infections. These results shed light on the susceptibility of hosts to P. vivax infections in Ghana.
Review
Immunology
Erica M. Pasini, Clemens H. M. Kocken
Summary: This article reviews the modeling of relapsing parasites Plasmodium vivax and Plasmodium ovale in non-human primates, highlighting the contribution of these models to our current understanding of the factors that govern parasite-host interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Eugenia Lo, Gianluca Russo, Kareen Pestana, Daniel Kepple, Beka Raya Abagero, Ghyslaine Bruna Djeunang Dongho, Karthigayan Gunalan, Louis H. Miller, Muzamil Mahdi Abdel Hamid, Delenasaw Yewhalaw, Giacomo Maria Paganotti
Summary: Plasmodium vivax malaria was previously thought to be rare in Africans lacking the Duffy blood group antigen, but recent studies show that it can infect Duffy-negative individuals. The prevalence and genetic features of P. vivax vary across African regions, with higher infection rates and lower parasite densities in Duffy-negative populations. Sharing similar DBP haplotypes, Duffy-negative and Duffy-positive populations do not show monophyletic patterns, indicating the need for standardized diagnostic approaches and resources for vivax malaria in Africa.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Daniel Kepple, Alfred Hubbard, Musab M. Ali, Beka R. Abargero, Karen Lopez, Kareen Pestana, Daniel A. Janies, Guiyun Yan, Muzamil Mahdi Hamid, Delenasaw Yewhalaw, Eugenia Lo
Summary: Plasmodium vivax malaria, once thought to be rare in Africa, is increasingly reported in the continent, challenging previous beliefs. This study in Ethiopia and Sudan shows that P. vivax can be transmitted between individuals with and without the Duffy antigen, providing new insights into the spread of this disease in sub-Saharan Africa. No significant genetic differentiation was found between P. vivax from Duffy-negative and -positive individuals, indicating potential between-host transmission.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Ghyslaine Bruna Djeunang Dongho, Karthigayan Gunalan, Mariangela L'Episcopia, Giacomo Maria Paganotti, Michela Menegon, Rose Efeutmecheh Sangong, Bouting Mayaka Georges, Joseph Fondop, Carlo Severini, Martin Sanou Sobze, Louis H. Miller, Gianluca Russo
Summary: Unusually high numbers of P. vivax infections were found in Duffy-negative Africans in Dschang, Cameroon, compared with other areas in Cameroon. This raises questions about the reasons behind this difference and the factors contributing to P. vivax infections in Duffy-negative individuals.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Immunology
Jie Bai, Fei Liu, Fan Yang, Yan Zhao, Xitong Jia, Sataporn Thongpoon, Wanlapa Roobsoog, Jetsumon Sattabongkot, Li Zheng, Zeshi Cui, Wenqi Zheng, Liwang Cui, Yaming Cao
Summary: The potential of Pv22 as a transmission-blocking vaccine (TBV) candidate was evaluated by expressing it in transgenic Plasmodium berghei parasites. The study showed that Pv22 has weaker TB activity, suggesting it may not be a promising TBV candidate for Plasmodium vivax.
Article
Multidisciplinary Sciences
Polrat Wilairatana, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Giovanni De Jesus Milanez, Manas Kotepui
Summary: This study used a meta-analysis approach to investigate the prevalence and risk of Plasmodium vivax infection among Duffy-negative individuals. The results showed that P. vivax infection could occur among Duffy-negative individuals, but the prevalence was relatively low.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Jessica R. S. Alves, Fernanda F. de Araujo, Camilla V. Pires, Andrea Teixeira-Carvalho, Barbara A. S. Lima, Leticia M. Torres, Francis B. Ntumngia, John H. Adams, Flora S. Kano, Luzia H. Carvalho
Summary: The study confirmed that the multiplex DBPII reactive antibody detection method facilitates identification of DBPII BIAb carriers and is considered accurate for identifying BIAb responders. Results showed that DBPII-BIAb activity was associated with the breadth of anti-DBPII antibodies rather than the magnitude.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Colleen M. Leonard, Hussein Mohammed, Mekonnen Tadesse, Jessica N. McCaffery, Doug Nace, Eric S. Halsey, Samuel Girma, Ashenafi Assefa, Jimee Hwang, Eric Rogier
Summary: This study investigated whether mixed infections were missed by microscopy in a therapeutic efficacy study in Ethiopia. The results showed that even with multiple trained readers, microscopy can miss P. falciparum/P. vivax mixed infections.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Infectious Diseases
Abnet Abebe, Didier Menard, Sisay Dugassa, Ashenafi Assefa, Jonathan J. Juliano, Eugenia Lo, Lemu Golassa
Summary: Both microscopy and RDT showed moderate agreement with PCR in the detection and identification of P. vivax (mono) and P. vivax/P. falciparum (mixed) infections. Therefore, to achieve malaria elimination goals, strengthening routine malaria diagnostic methods by implementing diagnostic tools with a good performance in detecting and accurately identifying malaria species in clinical settings is recommended.
Article
Infectious Diseases
Daniel Hosea Haiyambo, Larysa Aleksenko, Davies Mumbengegwi, Ronnie Bock, Petrina Uusiku, Benoit Malleret, Laurent Renia, Isaac Kweku Quaye
Summary: Through the study, it was found that P. vivax infections in Namibia occurred in individuals who were Duffy negative and carried a specific genetic mutation. Further investigations are needed to understand the role of additional mutations in P. vivax infections.
BMC INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Anand Odedra, Kari Mudie, Glen Kennedy, Rebecca E. Watts, Emilie Rossignol, Hayley Mitchell, Jeremy Gower, Maria Rebelo, Zuleima Pava, Rebecca Pawliw, Stephen Woolley, David G. Lalloo, Greg Robinson, Sean Lynch, Katharine A. Collins, Fiona Amante, James McCarthy
Summary: The study assessed the safety and effectiveness of using apheresis for extracting and concentrating P. vivax parasites, finding that apheresis can concentrate asexual parasites and gametocytes, but the concentration level is modest and may not be ideal for harvesting P. vivax.
Article
Biology
Joao L. Silva-Filho, Joao C. K. Dos-Santos, Carla Judice, Dario Beraldi, Kannan Venugopal, Diogenes Lima, Helder Nakaya, Erich De Paula, Stefanie C. P. Lopes, Marcus V. G. Lacerda, Matthias Marti, Fabio T. M. Costa
Summary: In patients with vivax malaria, there is a correlation between peripheral and total parasite biomass and host response, with high heterogeneity in clinical features, parasite burden, and host signatures. Patients can be categorized into Vivax(low) and Vivax(high) clusters based on differences in total parasite biomass, rather than peripheral parasitaemia, showing distinct alterations in various parameters related to host homeostasis.
Article
Immunology
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhelio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Summary: This study reveals that monocytes in patients with malaria produce high levels of inflammatory cytokines and also have a regulatory role through specific receptors, suggesting a dual role of monocytes in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)