Article
Cardiac & Cardiovascular Systems
Diane Fatkin, Hugh Calkins, Perry Elliott, Cynthia A. James, Stacey Peters, Jason C. Kovacic
Summary: Inherited cardiomyopathies are common myocardial disorders with significant morbidity and mortality. Clinical management focuses on treating heart failure and arrhythmias, with precision medicine offering new possibilities tailored to genetic variations, although phenotypic variability suggests involvement of other factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Jiayu Feng, Lin Liang, Yuyi Chen, Pengchao Tian, Xuemei Zhao, Boping Huang, Yihang Wu, Jing Wang, Jingyuan Guan, Liyan Huang, Xinqing Li, Yuhui Zhang, Jian Zhang
Summary: This study aimed to investigate the predictive value of Big endothelin-1(ET-1) for LVRR and prognosis in patients with DCM. The study found that Big ET-1 was independently associated with LVRR and had prognostic implications, which might help to improve the risk stratification of patients with DCM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ting-Chun Huang, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shin-Huei Liu, Wen-Han Cheng, Ping-Yen Liu, Shih-Ann Chen
Summary: Renal denervation (RDN) has been found to suppress the renin-angiotensin-aldosterone system and reduce inflammatory cytokines, leading to the prevention of cardiac remodeling. However, limited studies have investigated the effect of RDN on ventricular electrophysiology. This study used optical mapping to evaluate the impact of RDN on ventricular structural and electrical remodeling in a tachycardia-induced cardiomyopathy rabbit model. The results showed that RDN reversed the reduction of conduction velocity and prolongation of action potential duration, which are significant hallmarks of heart failure.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Rubina Perestrelo, Ana Catarina Silva, Jorge Oliver-De La Cruz, Fabiana Martino, Vladimir Horvath, Guido Caluori, Ondrej Polansky, Vladimir Vinarsky, Giulia Azzato, Giuseppe de Marco, Vita Zampachova, Petr Skladal, Stefania Pagliari, Alberto Rainer, Perpetua Pinto-do-O, Alessio Caravella, Kamila Koci, Diana S. Nascimento, Giancarlo Forte
Summary: The study reveals that the remodeling of cardiac extracellular matrix (ECM) during heart failure (HF) leads to cardiac fibroblast activation and focal adhesion protein expression through hyperactivated YAP signaling, impacting cell homing.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Raffaele Marfella, Nunzia D'Onofrio, Gelsomina Mansueto, Vincenzo Grimaldi, Maria Consiglia Trotta, Celestino Sardu, Ferdinando Carlo Sasso, Lucia Scisciola, Cristiano Amarelli, Salvatore Esposito, Michele D'Amico, Paolo Golino, Marisa De Feo, Giuseppe Signoriello, Pasquale Paolisso, Emanuele Gallinoro, Marc Vanderheyden, Ciro Maiello, Maria Luisa Balestrieri, Emanuele Barbato, Claudio Napoli, Giuseppe Paolisso
Summary: The study found that high glycated-hemoglobin (HbA1c) levels in type-2 diabetic (T2DM) patients with reduced ejection fraction were associated with an increased risk of adverse cardiovascular outcomes. The diabetic environment affects the levels of glycosylated ACE2 (GlycACE2) in cardiomyocytes, which weakens the anti-remodeling effects of renin-angiotensin system (RAS) inhibitors. Poor glycemic control increases the expression of GlycACE2, while achieving tight glycemic control restores the cardioprotective effects of RAS inhibition.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Immunology
Jaqueline de Jesus Pereira, Renata Nishiyama Ikegami, Joyce Tiyeko Kawakami, Sherrira Menezes Garavelo, Marcia Martins Reis, Suely Aparecida Pinheiro Palomino, Sandrigo Mangini, Camila Rodrigues Moreno, Samar Freschi de Barros, Aline Rodrigues Souza, Maria de Lourdes Higuchi
Summary: The study found that myocardial inflammation and microbial communities in IDCM explanted hearts may be associated with post-transplant rejection, with different infectious agents potentially contributing to rejection outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Maria Luisa Barcena, Greta Tonini, Natalie Haritonow, Pavelas Breiter, Hendrik Milting, Istvan Baczko, Ursula Mueller-Werdan, Yury Ladilov, Vera Regitz-Zagrosek
Summary: This study aims to investigate the effects of sex and age on mitochondrial homeostasis, inflammation, and cellular senescence. The results show that AMPK expression and phosphorylation are significantly increased in male cardiac tissue from patients with inflammatory dilated cardiomyopathy (DCMI), while Sirt1 expression remains unchanged in all groups. In older female patients, the expression of mitochondrial genes is significantly reduced. Additionally, inflammatory markers NF-κB and TLR4 are downregulated in older male DCMI patients, but IL-18 expression is increased in older female patients, accompanied by accelerated senescence in older DCMI hearts.
Review
Cell Biology
Yiyu Zhang, Guoqing Huang, Zhaohu Yuan, Yonggang Zhang, Rong Chang
Summary: DCM is a progressive heart disease that can lead to heart failure, and research on circRNAs and hiPSC technology plays important roles in DCM study. Gene mutations can cause complex cardiac disorders, and genome editing methods can help rescue these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev
Summary: Many anticancer therapies cause cardiovascular complications, especially doxorubicin which leads to cardiomyopathy. This study shows that endothelial cells accumulate more doxorubicin than other cardiac cell types and that the TGF-beta/Smad3 pathway plays a critical role in cardiac damage caused by doxorubicin.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Cell Biology
Christine Mages, Heike Gampp, Pascal Syren, Ann-Kathrin Rahm, Florian Andre, Norbert Frey, Patrick Lugenbiel, Dierk Thomas
Summary: This review highlights the pathomechanisms underlying arrhythmogenicity in patients with heart failure, such as myocardial fibrosis and ion channel remodeling. It emphasizes the association of dysregulated ion channel expression with cardiomyopathy and arrhythmia development, and discusses potential therapeutic options.
Article
Cardiac & Cardiovascular Systems
Chantal J. M. van Opbergen, Navratan Bagwan, Svetlana R. Maurya, Joon-Chul Kim, Abigail N. Smith, Daniel J. Blackwell, Jeffrey N. Johnston, Bjorn C. Knollmann, Marina Cerrone, Alicia Lundby, Mario Delmar
Summary: This study reveals the relationship between exercise, catecholaminergic stimulation, Ca-i(2+) homeostasis, and arrhythmogenesis in PKP2-deficient hearts. Training disrupts Ca-i(2+) homeostasis in PKP2cKO hearts, leading to proarrhythmogenic changes facilitated by intracellular beta-adrenergic receptors and hyperphosphorylation of phospholamban. The findings suggest potential treatments for arrhythmogenic right ventricular cardiomyopathy and highlight the importance of PKP2 and phospholamban in arrhythmogenesis.
Article
Cardiac & Cardiovascular Systems
Vincenzo Nuzzi, Anne Raafs, Paolo Manca, Michiel T. H. M. Henkens, Caterina Gregorio, Andrea Boscutti, Job Verdonschot, Mark Hazebroek, Christian Knackstedt, Marco Merlo, Davide Stolfo, Gianfranco Sinagra, Stephane R. B. Heymans
Summary: This study aimed to evaluate the prognostic implications of left atrial volume index (LAVI) reduction and found that a decrease in LAVI was associated with a reduced risk of mortality, heart transplantation, and heart failure hospitalization. The findings suggest that LAVI reduction may be an important parameter in risk stratification for patients with dilated cardiomyopathy.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cell Biology
Mohammed Arif, Perwez Alam, Rafeeq P. H. Ahmed, Raghav Pandey, Hafeez M. Faridi, Sakthivel Sadayappan
Summary: The study found that upregulated angiogenesis mediated by miR-210 is not sufficient to rescue the DCM phenotype in mice, despite significant increases in blood vessel density and upregulation of proangiogenic molecules observed in the hearts of TMx210 and 210-TG mice.
Article
Cardiac & Cardiovascular Systems
Yuanwei Xu, Weihao Li, Ke Wan, Yaodan Liang, Xincheng Jiang, Jie Wang, David Mui, Yangjie Li, Siqi Tang, Jiajun Guo, Xinli Guo, Xiumin Liu, Jiayu Sun, Qing Zhang, Yuchi Han, Yucheng Chen
Summary: The study revealed that the absence of late gadolinium enhancement, lower T2, and extracellular volume values at baseline are significant predictors of LVRR in patients with idiopathic DCM. Furthermore, after guideline-directed medical therapy, patients with LVRR showed significant decreases in myocardial T1, matrix, and cell volume.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Sadia Ashraf, Heinrich Taegtmeyer, Romain Harmancey
Summary: Transcription factors, specifically NR4A2, play a crucial role in cardiovascular adaptation to stress. Upregulation of NR4A2 in cardiac myocytes is induced by beta-adrenergic stimulation. This study found that overexpression of NR4A2 in mice led to cardiomyocyte hypertrophy, left ventricular dilation, heart failure, and death. The activation of NR4A2 also caused a shift in metabolism, disassembly of sarcomeric structures, and reactivation of cell cycle progression in adult cardiac myocytes.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Katsuki Okada, Atsuhiko T. Naito, Tomoaki Higo, Akito Nakagawa, Masato Shibamoto, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Tomokazu Sumida, Seitaro Nomura, Masamichi Ito, Toshihiro Yamaguchi, Toru Oka, Hiroshi Akazawa, Jong-Kook Lee, Sachio Morimoto, Yasushi Sakata, Ichiro Shiojima, Issei Komuro
CIRCULATION-HEART FAILURE
(2015)
Article
Pharmacology & Pharmacy
Naoya Kubokura, Fumi Takahashi-Yanaga, Masaki Arioka, Tatsuya Yoshihara, Kazunobu Igawa, Katsuhiko Tomooka, Sachio Morimoto, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Takayuki Matsumoto, Takanari Kitazono, Toshiyuki Sasaguri
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2015)
Meeting Abstract
Biophysics
Michiko Tashiro, Hana Inoue, Shinobu Tai, Masato Konishi
BIOPHYSICAL JOURNAL
(2016)
Article
Developmental Biology
Kiyomasa Nishii, Akiko Seki, Madoka Kumai, Sachio Morimoto, Takeshi Miwa, Nobuhisa Hagiwara, Yosaburo Shibata, Yasushi Kobayashi
MECHANISMS OF DEVELOPMENT
(2016)
Article
Cardiac & Cardiovascular Systems
Takuro Arimura, Antoine Muchir, Masayoshi Kuwahara, Sachio Morimoto, Taisuke Ishikawa, Cheng-Kun Du, Dong-Yun Zhan, Shu Nakao, Noboru Machida, Ryo Tanaka, Yoshihisa Yamane, Takeharu Hayashi, Akinori Kimura
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kengo Hayamizu, Sachio Morimoto, Miki Nonaka, Sumio Hoka, Toshiyuki Sasaguri
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2018)
Article
Biochemistry & Molecular Biology
Shinichi Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Masakazu Fukuda, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Sachio Morimoto, Masafumi Yano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Physiology
Michiko Tashiro, Hana Inoue, Masato Konishi
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Takamaru Ishizu, Shuichiro Higo, Yuki Masumura, Yasuaki Kohama, Mikio Shiba, Tomoaki Higo, Masato Shibamoto, Akito Nakagawa, Sachio Morimoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
SCIENTIFIC REPORTS
(2017)
Article
Physiology
Michiko Tashiro, Masato Konishi, Ryo Kobayashi, Hana Inoue, Utako Yokoyama
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2020)
Article
Physiology
Hana Inoue, Takashi Murayama, Takuya Kobayashi, Masato Konishi, Utako Yokoyama
Summary: The zinc-binding motif is essential for intracellular Mg2+-dependent regulation of TRPM7 channel activity and cysteines in the zinc-binding motif play a vital role in the oxidative stress response of TRPM7.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Dermatology
Chika Suzuki, Takako Komiya, Hana Inoue, Takayuki Yoshimoto, Hajime Matsumura
Summary: The study shows that adding collagen to transplanted adipose tissue can significantly improve the engraftment rate, increase neovascularization and adipocyte numbers, and induce M2 macrophages involved in wound healing.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Physiology
Hana Inoue, Masato Inazu, Masato Konishi, Utako Yokoyama
PHYSIOLOGICAL REPORTS
(2019)
Article
Neurosciences
Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T. Pearson
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2017)
Meeting Abstract
Biophysics
Michiko Tashiro, Hana Inoue, Masato Konishi
BIOPHYSICAL JOURNAL
(2017)