Article
Biochemistry & Molecular Biology
Aida Javidan, Weihua Jiang, Lihua Yang, Ana Clara Frony, Venkateswaran Subramanian
Summary: The aim of this study is to investigate the effect of Celastrol on angiotensin II-induced abdominal aortic aneurysms (AAA) in hypercholesterolemic mice. The results showed that Celastrol supplementation significantly increased the dilation of abdominal aorta and incidence of AAA induced by AngII.
Article
Hematology
Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen
Summary: DOCK2 is identified as a novel regulator for AAA formation, playing a role in promoting vascular inflammation and elastin degradation by upregulating MCP-1 and MMP2 expression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng
Summary: This study investigates the role of GSDMD in vascular smooth muscle cell phenotypic alteration and abdominal aortic aneurysm (AAA) formation. Gsdmd is found to be upregulated in aortic VSMCs in Ang II-induced AAA. VSMC-specific Gsdmd deletion ameliorates AAA formation. Untargeted metabolomic analysis reveals a significant reduction of putrescine in GSDMD-deficient mice.
Article
Multidisciplinary Sciences
Chongyang Zhang, Hongmei Zhao, Yujun Cai, Jian Xiong, Amy Mohan, Danfei Lou, Hangchuan Shi, Yishuai Zhang, Xiaochun Long, Jing Wang, Chen Yan
Summary: Abdominal aortic aneurysm (AAA) is a common vascular pathology in elderly males characterized by aorta dilation, with cyclic nucleotide phosphodiesterase 1C (PDE1C) playing a critical role in its development. PDE1C elevation contributes to SMC senescence and AAA progression, potentially serving as a therapeutic target against aortic aneurysms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Chongyang Zhang, Amy Mohan, Hangchuan Shi, Chen Yan
Summary: This study investigated the effect of sildenafil on experimental abdominal aortic aneurysm (AAA). The results showed that sildenafil application aggravated aortic wall dilation and elastin degradation, potentially worsening the progression of AAA. The study also found that sildenafil dysregulated cGMP and contractile signaling in smooth muscle cells (SMCs) in AAA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Surgery
Jorn P. Meekel, Marina Dias-Neto, Natalija Bogunovic, Gloria Conceicao, Claudia Sousa-Mendes, Gawin R. Stoll, Adelino Leite-Moreira, Jennifer Huynh, Dimitra Micha, Etto C. Eringa, Ron Balm, Jan D. Blankensteijn, Kak K. Yeung
Summary: This study revealed that PVAT from AAA exhibits increased pro-inflammatory and matrix metallopeptidase gene expression, as well as decreased anti-inflammatory gene expression, suggesting its involvement in the pathophysiology of AAA. Furthermore, healthy SMC co-culture with PVAT from AAA patients showed increased expression of genes related to aneurysm formation, indicating potential roles of PVAT in inducing inflammation and providing new therapeutic targets in the treatment of AAA.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Shuo Wang, Xiaoxiang Tian, Dan Liu, Xiaolin Zhang, Chenghui Yan, Yaling Han
Summary: This study found that overexpression of TRPV5 could decrease the incidence and diameter of abdominal aortic aneurysm, inhibit collagen and elastin degradation, increase alpha-SMA, and reduce MMP2 expression. TRPV5 also played a role in regulating VSMC phenotype switch by downregulating KLF4 expression, suggesting it as a potential new strategy for treating AAA.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ping Gao, Pan Gao, Jinjing Zhao, Shengshuai Shan, Wei Luo, Orazio J. Slivano, Wei Zhang, Akiko Tabuchi, Scott A. LeMaire, Lars Maegdefessel, Ying H. Shen, Joseph M. Miano, Harold A. Singer, Xiaochun Long
Summary: The study demonstrated the critical role of MKL1 in AAA, showing that its deficiency can reduce the risk of AAA formation and aortic rupture, as well as decrease aging and pro-inflammatory effects in the vessel wall and VSMCs. This research revealed a molecular pathway of AAA formation involving MKL1/p38MAPK stimulation, suggesting that targeting the MKL1/p38MAPK pathway may be an effective treatment for AAA.
Review
Endocrinology & Metabolism
Tongtong Ye, Guangdong Zhang, Hangyu Liu, Junfeng Shi, Hongyan Qiu, Yongping Liu, Fang Han, Ningning Hou
Summary: PVAT plays a critical role in the development of AAAs and may serve as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Hematology
Huan Yang, Ting Zhou, Amelia Stranz, Elise DeRoo, Bo Liu
Summary: A study using single-cell RNA sequencing on mouse AAA tissues revealed 12 distinct populations of 8 cell types. The percentages of each population and gene expression were compared between sham and AAA tissue, showing that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Immunology
Zhen Yuan, Yi Lu, Jia Wei, Jiaqi Wu, Jin Yang, Zhejun Cai
Summary: Abdominal aortic aneurysms (AAAs) are local dilations of the infrarenal segment of aortas, with inflammation playing a central role in their development. In addition to inflammatory cells like T cells, macrophages, and neutrophils, special structures such as inflammasomes and neutrophil extracellular traps are investigated for their roles in aneurysm formation. Understanding the impacts and interactions of these inflammatory cells and structures is crucial for developing new screening and pharmacological interventions for AAA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Herrero-Cervera, Carla Espinos-Estevez, Susana Martin-Vano, Alida Taberner-Cortes, Maria Aguilar-Ballester, Angela Vinue, Laura Piqueras, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: The study suggests a protective role of LIGHT in preventing VSMC trans-differentiation and maintaining their contractile characteristics. Loss of LIGHT exacerbates AAA severity and affects the gene expression of VSMCs.
Article
Chemistry, Multidisciplinary
Jingyong Li, Ni Xia, Dan Li, Shuang Wen, Shirui Qian, Yuzhi Lu, Muyang Gu, Tingting Tang, Jiao Jiao, Bingjie Lv, Shaofang Nie, Desheng Hu, Yuhua Liao, Xiangping Yang, Guoping Shi, Xiang Cheng
Summary: In this study, a special group of Tregs that potentially inhibit the progression of abdominal aortic aneurysms (AAA) were identified and characterized. These Tregs are mainly recruited from peripheral circulation and secrete trefoil factor 1 (Tff1) to regulate smooth muscle cell (SMC) survival. The findings suggest a tissue-specific phenotype and function of aortic Tregs, providing a promising approach for AAA prevention.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ge Hu, Ning Ding, Zhiwei Wang, Zhengyu Jin
Summary: This study aimed to explore the relationship between body composition (BC) and postoperative abdominal aortic aneurysm (AAA) progression. The results showed that muscle imaging features are associated with volume change of postoperative aneurysms and can be used for early prediction, while the relationship between adipose tissue and AAA growth is unclear.
INSIGHTS INTO IMAGING
(2022)
Article
Hematology
Paul Loick, Goran Hamid Mohammad, Ismail Cassimjee, Anirudh Chandrashekar, Pierfrancesco Lapolla, Alison Carrington, Mayra Vera-Aviles, Ashok Handa, Regent Lee, Samira Lakhal-Littleton
Summary: In patients with abdominal aortic aneurysm (AAA), hepcidin is induced in smooth muscle cells (SMCs) of the aneurysm wall and inversely correlated with the expression of LNC2. The study suggests that hepcidin has a protective role in AAA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)