Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells

Lycopene Enhances Docetaxel's Effect in Castration-Resistant Prostate Cancer Associated with Insulin-like Growth Factor I Receptor Levels

(2015) Yaxiong Tang et al.   NEOPLASIA

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

bis-Dehydroxy-Curcumin Triggers Mitochondrial-Associated Cell Death in Human Colon Cancer Cells through ER-Stress Induced Autophagy

(2013) Valentina Basile et al.   PLoS One

Cancer Cells Resistant to Therapy Promote Cell Surface Relocalization of GRP78 Which Complexes with PI3K and Enhances PI(3,4,5)P3 Production

(2013) Yi Zhang et al.   PLoS One

The Mammalian Tribbles Homolog TRIB3, Glucose Homeostasis, and Cardiovascular Diseases

(2012) Sabrina Prudente et al.   ENDOCRINE REVIEWS

Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir

(2012) Joong Sup Shim et al.   JNCI-Journal of the National Cancer Institute

Functional p53 determines docetaxel sensitivity in prostate cancer cells

(2012) Chengfei Liu et al.   PROSTATE

Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer

(2011) H. Yin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models

(2011) Thomas C. Chen et al.   CANCER LETTERS

Long-Term Androgen Ablation and Docetaxel Up-Regulate Phosphorylated Akt in Castration Resistant Prostate Cancer

(2011) Takeo Kosaka et al.   JOURNAL OF UROLOGY

The changing therapeutic landscape of castration-resistant prostate cancer

(2011) Timothy A. Yap et al.   Nature Reviews Clinical Oncology

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

(2011) Hong Wa Yung et al.   PLoS One

New and emerging agents for the treatment of castration-resistant prostate cancer

(2011) Celestia S. Higano et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Docetaxel-based combination therapy for castration-resistant prostate cancer

(2010) M. D. Galsky et al.   ANNALS OF ONCOLOGY

Chemotherapeutic sensitization by endoplasmic reticulum stress: Increasing the efficacy of taxane against prostate cancer

(2010) Yue Wu et al.   CANCER BIOLOGY & THERAPY

Concurrent blockade of the NF-κB and Akt pathways potently sensitizes cancer cells to chemotherapeutic-induced cytotoxicity

(2010) Hai-Ning He et al.   CANCER LETTERS

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells

(2010) José Edgar Nicoletti-Carvalho et al.   JOURNAL OF ENDOCRINOLOGY

GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer

(2010) Shaun S Tan et al.   JOURNAL OF PATHOLOGY

The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization

(2010) Ansgar Brüning et al.   Molecular Cancer

Rh2 or its aglycone aPPD in combination with docetaxel for treatment of prostate cancer

(2010) Alain G. Musende et al.   PROSTATE

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells

(2009) L. Wang et al.   MOLECULAR PHARMACOLOGY

Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma

(2008) Nizar M. Mhaidat et al.   APOPTOSIS

DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway

(2008) Song-Shei Lin et al.   CANCER LETTERS

Curcumin and cancer: An “old-age” disease with an “age-old” solution

(2008) Preetha Anand et al.   CANCER LETTERS

TRIB3 is implicated in glucotoxicity- and oestrogen receptor-stress-induced β-cell apoptosis

(2008) Bo Qian et al.   JOURNAL OF ENDOCRINOLOGY

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

(2008) Hae Kyung Lee et al.   NEURO-ONCOLOGY

Intracellular death platform steps-in: Targeting prostate tumors via endoplasmic reticulum (ER) apoptosis

(2008) Steven R. Schwarze et al.   PROSTATE

Repositioning HIV protease inhibitors as cancer therapeutics

(2008) Wendy B Bernstein et al.   Current Opinion in HIV and AIDS

Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper

(2008) Mette Munk Jensen et al.   BMC MEDICAL IMAGING