Article
Multidisciplinary Sciences
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Summary: This study reveals the role of a clock-output molecule in reducing arousal circuit excitability during the active phase, suggesting a multifaceted role for the circadian clock in regulating arousal.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Elysandra M. Solis, Levi B. Good, Rafael Granja Vazquez, Sourav Patnaik, Ana G. Hernandez-Reynoso, Qian Ma, Gustavo Angulo, Aksharkumar Dobariya, Stuart F. Cogan, Joseph J. Pancrazio, Juan M. Pascual, Vikram Jakkamsetti
Summary: Glut1 deficiency (G1D) results in brain disease and seizures. Mouse studies indicate that the loss of inhibitory neurons in the thalamus and cortex underlies these seizures. Changes in bath glucose concentration affect the frequency of brain oscillations. This research provides insights into the mechanisms and effects of interventions in epileptogenic circuits associated with G1D.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Oleksandr Sorochynskyi, Jakob H. Macke, Stephane Deny, Olivier Marre, Ulisse Ferrari
Summary: A major goal in neuroscience is to understand how populations of neurons process sensory stimuli, but current experimental techniques are limited in recording entire relevant neuronal populations. A new method has been proposed to infer the activity of an entire population of neurons of the same type from sequential recordings, using copula distributions and maximum entropy modeling. This method shows promising results in predicting collective behavior and synchronous activity within neuron populations.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrew E. Warfield, Pooja Gupta, Madison M. Ruhmann, Quiana L. Jeffs, Genevieve C. Guidone, Hannah W. Rhymes, McKenzi I. Thompson, William D. Todd
Summary: Alzheimer's disease is associated with disruptions in circadian rhythms, and a study on AD model mice reveals phase delays in circadian rhythms and increased aggression, which are related to Tau pathology in the brainstem.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Christopher Lee, Jonathan Frew, Nicholas L. Weilinger, Stefan Wendt, Wenji Cai, Stefano Sorrentino, Xiujuan Wu, Brian A. MacVicar, Stephanie M. Willerth, Haakon B. Nygaard
Summary: Frontotemporal dementia (FTD) is a group of neurodegenerative disorders characterized by pathology in the frontal and temporal lobes. Mutations in the progranulin (PGRN) gene, GRN, are responsible for 20% of familial FTD cases. The involvement of astrocytes in FTD-GRN remains unclear, but this study provides evidence of non-cell autonomous effects of GRN mutant astrocytes on neurons. The delayed development of neuronal activity and changes in synaptic markers suggest a potential role of astrocytes in the early pathophysiology of FTD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, Research & Experimental
E. E. Genrikhs, M. R. Kapkaeva, E. Stelmashook, N. K. Isaev, L. G. Khaspekov
Summary: Streptozotocin exhibited dose-dependent cytotoxic effects on hippocampal neurons, most prominently in immature neurons, but resistance was observed in more mature neurons. Neurons showed functional immaturity and weak bioelectric activity initially, progressing to a high level of differentiation and network burst activity over time.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Mathematics, Applied
Tugba Palabas, Andre Longtin, Dibakar Ghosh, Muhammet Uzuntarla
Summary: Recent evidence suggests that astrocytes play critical roles in regulating the proper functioning of the nervous system. This study investigates the effect of astrocytes on the spontaneous firing activity of neurons and identifies their role in inducing different firing modes and controlling irregular and bursty spiking activities.
Article
Cell Biology
Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M. Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Rachel A. Ross, Yan Hao, Xu Huang, Jin-Jing Jia, Qianyi Yang, Hao Zheng, Johan van Nispen, Jun Chen, Hui Li, Jiayi Zhang, Yun-Qing Li, Zhou-Feng Chen
Summary: This study reveals that visual itch information is transmitted from the retina to GRP neurons through ipRGCs and GRPR neurons in the SCN mediate contagious itch behavior. The PVT is involved in relaying itch information. These findings suggest the existence of a previously unknown visual pathway that encodes salient environmental cues and enables animals to imitate behaviors of conspecifics to cope with adverse conditions.
Article
Neurosciences
Jean C. Rodriguez Diaz, Paul M. Jenkins, Dominique L. Pritchett, Kevin S. Jones
Summary: Gamma-band oscillations (GBOs), generated by fast-spiking interneurons (FSIs), play a critical role in cognitive functions. Abnormalities in GBOs are frequently observed in schizophrenia and bipolar disorder, but the underlying mechanisms are poorly understood. In this study, a novel approach using perforated microelectrode arrays (pMEAs) was developed to study GBOs in ex vivo hippocampal slices from mature animals, enhancing our understanding of network dysfunction in psychiatric disorders.
Article
Neurosciences
Tsvetomira Atanasova, Tiina Savonlehto, Tiina-Kaisa Kukko-Lukjanov, Zoia Kharybina, Wei-Chih Chang, Sari E. Lauri, Tomi Taira
Summary: Kainate receptors play an important role in the development and pathological synchronization of the hippocampal neural network. GluK1 KARs regulate functional connectivity between excitatory neurons, possibly through morphological changes in the glutamatergic circuit that affect the synchronization of neuronal populations.
Article
Endocrinology & Metabolism
Zahra S. Thirouin, Claire Gizowski, Anzala Murtaz, Charles W. Bourque
Summary: The suprachiasmatic nucleus (SCN) of the hypothalamus functions as the main circadian clock in mammals. VP and VIP neuropeptides play a significant role in defining different clusters within the SCN and mediating the SCN's output. Previous research has shown that SCN VP neurons display activity-dependent VP release and higher firing rates during the light phase.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Yvan M. Vachez, Jessica R. Tooley, Kavitha Abiraman, Bridget Matikainen-Ankney, Eric Casey, Tom Earnest, Leana M. Ramos, Hanna Silberberg, Elizabeth Godynyuk, Olivia Uddin, Lauren Marconi, Claire E. Le Pichon, Meaghan C. Creed
Summary: The nucleus accumbens shell (NAcSh) and the ventral pallidum (VP) are important for reward processing, with a subpopulation of VP neurons, the ventral arkypallidal (vArky) neurons, inhibiting NAcSh neurons and promoting reward consumption in a value-dependent manner.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Michael H. Berry, Michael Moldavan, Tavita Garrett, Marc Meadows, Olga Cravetchi, Elizabeth White, Joseph Leffler, Henrique von Gersdorff, Kevin M. Wright, Charles N. Allen, Benjamin Sivyer
Summary: Visual input from ipRGCs to the hypothalamus influences various functions, including circadian entrainment, body temperature, and sleep. However, little is known about the ipRGCs that project to the supraoptic nucleus (SON). This study identifies a subtype of ipRGCs in the dorsal retina that selectively projects to the SON and challenges the idea of overlapping dendrites for optimizing photon capture.
NATURE COMMUNICATIONS
(2023)
Article
Physics, Multidisciplinary
Chenggui Yao, Fei Xu, Jianwei Shuai, Xiang Li
Summary: The environmental temperature plays a critical role in the propagation of firing rate in neural networks, with synchronization of firing rate being optimized at an appropriate temperature.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2022)
Article
Multidisciplinary Sciences
Mikkel Elle Lepperod, Ane Charlotte Christensen, Kristian Kinden Lensjo, Alessio Paolo Buccino, Jai Yu, Marianne Fyhn, Torkel Hafting
Summary: The study shows that optogenetic activation of specific cells surrounding grid cells in the medial entorhinal cortex can influence their spatial activity patterns but not their velocity coding. Phase precession of grid cells is abolished, but speed information is still transmitted through rate coding of individual neurons.
Article
Cell Biology
Olga Kopach, Anastasiia Maistrenko, Iryna Lushnikova, Pavel Belan, Galina Skibo, Nana Voitenko
Article
Neurosciences
D. P. Shevchuk, K. S. Agashkov, P. V. Bilan, N. V. Voitenko
Article
Neurosciences
Volodymyr Krotov, Anastasia Tokhtamysh, Olga Kopach, Andrew Dromaretsky, Yevhenii Sheremet, Pavel Belan, Nana Voitenko
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Volodymyr Cherkas, Sergei Grebenyuk, Denys Osypenko, Alexandr V. Dovgan, Eugene O. Grushevskyi, Matthew Yedutenko, Yevhenii Sheremet, Andrew Dromaretsky, Arseniy Bozhenko, Kirill Agashkov, Nikolai I. Kononenko, Pavel Belan
Article
Anesthesiology
Volodymyr Krotov, Anastasia Tokhtamysh, Boris V. Safronov, Pavel Belan, Nana Voitenko
Article
Neurosciences
D. S. Osypenko, A. V. Dovgan, N. I. Kononenko, A. V. Dromaretsky, M. Matvieienko, O. A. Rybachuk, J. Zhang, S. M. Korogod, V. Venkataraman, P. Belan
NEUROBIOLOGY OF DISEASE
(2019)
Article
Multidisciplinary Sciences
K. Agashkov, V Krotov, M. Krasniakova, D. Shevchuk, Y. Andrianov, Y. Zabenko, B. Safronov, N. Voitenko, P. Belan
SCIENTIFIC REPORTS
(2019)
Article
Anesthesiology
Volodymyr Krotov, Kirill Agashkov, Marharyta Krasniakova, Boris Safronov, Pavel Belan, Nana Voitenko
Summary: This study reveals the input sources and regulation mechanisms of spinal lamina X neurons, demonstrating that primary afferent fibers are regulated by both spinal and supraspinal control through at least 5 distinct pathways.
Article
Neurosciences
Dmytro E. Duzhyy, Nana V. Voitenko, Pavel V. Belan
Summary: The study revealed that under peripheral inflammation conditions, the functional expression of acid-sensing ion channels and T-type Ca2+ channels in neurons increased, leading to enhanced neuronal excitability, which may contribute to chronic inflammatory pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Takahiro Tadokoro, Mariana Bravo-Hernandez, Kirill Agashkov, Yoshiomi Kobayashi, Oleksandr Platoshyn, Michael Navarro, Silvia Marsala, Atsushi Miyanohara, Tetsuya Yoshizumi, Michiko Shigyo, Volodymyr Krotov, Stefan Juhas, Jana Juhasova, Duong Nguyen, Helena Kupcova Skalnikova, Jan Motlik, Hana Studenovska, Vladimir Proks, Rajiv Reddy, Shawn P. Driscoll, Thomas D. Glenn, Taratorn Kemthong, Suchinda Malaivijitnond, Zoltan Tomori, Ivo Vanicky, Manabu Kakinohana, Samuel L. Pfaff, Joseph Ciacci, Pavel Belan, Martin Marsala
Summary: Changing the excitatory neurotransmitter phenotype of secondary spinal cord neurons to inhibitory can successfully treat neuropathic pain without causing detectable side effects.
Article
Biochemistry & Molecular Biology
Olga Kopach, Yulia Dobropolska, Pavel Belan, Nana Voitenko
Summary: The dorsal horn (DH) neurons of the spinal cord play a critical role in processing nociceptive input in the central nervous system. The hyperexcitability of DH neurons has been linked to Ca2+-permeable AMPA receptors (AMPARs) and contributes to nociceptive hypersensitivity. Inflammatory pain conditions result in changes in action potential (AP) parameters in DH neurons, and selective inhibition of Ca2+-permeable AMPARs can alleviate nociceptive hypersensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Volodymyr Krotov, Kirill Agashkov, Sergii Romanenko, Oleh Halaidych, Yaroslav Andrianov, Boris V. V. Safronov, Pavel Belan, Nana Voitenko
Summary: Although our understanding of how afferent-driven presynaptic inhibition shapes peripheral input to nociceptive neurons is limited, this study examined this effect on primary afferent input to spinal neurons in two nociceptive-processing regions. The results showed that attenuation of presynaptic inhibition resulted in the appearance of new mono- and polysynaptic excitatory postsynaptic current components. These mechanisms are important for shaping primary afferent input to neurons in the spinal nociceptive-processing network.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Ye Sheremet, B. Olifirov, A. Okhrimenko, V Cherkas, O. Bagatskaya, P. Belan
Review
Neurosciences
P. V. Belan, Y. M. Usachev, D. E. Duzhyy, S. Y. Ivanova, A. N. Tarasenko, N. V. Voitenko
Meeting Abstract
Physiology
M. Yedutenko, V. P. Cherkas, A. V. Dovgan, N. I. Kononenko, T. M. Tsugorka, P. V. Belan