Article
Obstetrics & Gynecology
Claudia Massarotti, Sara Stigliani, Arianna Ramone, Francesca Bovis, Fausta Sozzi, Valentino Remorgida, Angelo Cagnacci, Paola Anserini, Paola Scaruffi
Summary: Suboptimal prolonged ovarian stimulation can induce the occurrence of smooth endoplasmic reticulum aggregates (SERa) in oocytes, thereby reducing their reproductive potential. The transfer of embryos from cycles with SERa+ oocytes showed lower clinical success, emphasizing the importance of proper timing and stimulation protocols to maximize oocyte quality and quantity.
HUMAN REPRODUCTION
(2021)
Article
Cell Biology
Sofia Makieva, Celine Staehli, Min Xie, Ana Velasco Gil, Maike Katja Sachs, Brigitte Leeners
Summary: This study aimed to determine the association between the time interval from insemination to vitrification and pregnancy rate. The findings suggest that the latest timing of vitrification is significantly associated with a higher pregnancy rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhaoyang Shen, Xiaoyan Luo, Jianming Xu, Yuqing Jiang, Wenhui Chen, Qingling Yang, Yingpu Sun
Summary: This study investigated the effects of progesterone elevation on triggering day on the clinical pregnancy rate (CPR) of IVF/ICSI cycles in patients with different BMI. The results showed that women with higher BMI had lower progesterone levels on triggering day and a decreased CPR. Additionally, progesterone elevation on hCG day was associated with decreased CPRs regardless of women's BMI level.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Fang Gu, Simin Ruan, Chenxiang Luo, Ying Huang, Lu Luo, Yanwen Xu, Canquan Zhou
Summary: The study found that middle-aged women (35-40 years old) can benefit from repeat IVF treatments with a high success rate, while patients over 40 years old have a sharp decline in success rate.
Article
Endocrinology & Metabolism
Shintaro Kamijo, Toshio Hamatani, Hiroyuki Sasaki, Hiroki Suzuki, Akane Abe, Osamu Inoue, Maki Iwai, Seiji Ogawa, Kei Odawara, Kanako Tanaka, Mutsumi Mikashima, Masami Suzuki, Kenji Miyado, Ryo Matoba, Yasushi Odawara, Mamoru Tanaka
Summary: By analyzing miRNAs in embryo culture medium, we generated a predictive model for embryo implantation success and identified a non-invasive evaluation method. The abundance levels of certain miRNAs in the culture medium were found to be associated with the quality of blastocysts and implantation success.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhuoyao Mai, Manlin Liu, Ping Pan, Lin Li, Jia Huang, Xiaoli Chen, Dongzi Yang
Summary: This study found that women with PCOS aged 35 years and older had a higher cumulative live birth rate over two years of IVF/ICSI cycles compared with age- and BMI-matched controls. Factors such as the number of transferable embryos and antral follicle counts were significant predictors of cumulative live birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Hui-Na Zhang, Ying-Fen Ying, Hai-Tao Xi, Xiao-Sheng Lu, Jun-Zhao Zhao, Yi-Lu Chen
Summary: The study found comparable clinical pregnancy rates (53.37% vs 59.97%) and live birth rates (43.25% vs 50.89%) between the D4 and D5 groups, with no significant differences. Transferring compacted embryos or early blastocysts can result in high clinical pregnancy rates and live birth rates, making morula ET a potential alternative option for clinicians in addition to cleavage and blastocyst ET.
MEDICAL SCIENCE MONITOR
(2021)
Article
Obstetrics & Gynecology
Chiara Dallagiovanna, Valeria Stella Vanni, Edgardo Somigliana, Andrea Busnelli, Enrico Papaleo, Roberta Villanacci, Massimo Candiani, Marco Reschini
Summary: In this study, the risk factors for monozygotic twinning in pregnancies achieved by IVF were investigated through a retrospective case-control study. It was found that only assisted hatching remained significantly associated with monozygotic twinning after performing multivariate logistic analysis. Blastomere separation during the passage through the artificial hole or interference with the signaling pathway within the embryo could be potential mechanisms involved in this association.
REPRODUCTIVE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Xingyu Sun, Fei Yao, Chengliang Yin, Muzi Meng, Yunzhu Lan, Ming Yang, Chenyu Sun, Ling Liu
Summary: The aim of this study was to determine whether the progesterone to number of mature oocytes index (PMOI) can predict pregnancy outcome in fresh IVF/ICSI cycles. The results showed that PMOI levels were significantly correlated with the probability of pregnancy outcome and could independently predict the occurrence of pregnancy. The optimal serum PMOI cutoff value for pregnancy outcome was found to be 0.063 ug/L.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Liyan Wang, Yanbiao Jiang, Haofei Shen, Xiaoling Ma, Mingxia Gao, Panpan Jin, Rui Zhang, Lihui Zhao, Xuehong Zhang
Summary: The serum beta-hCG level after 14 days of embryo transfer has a strong independent predictive value for the occurrence of early pregnancy loss in fresh IVF/ICSI cycles.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amira Podolak, Joanna Liss, Jolanta Kiewisz, Sebastian Pukszta, Celina Cybulska, Michal Rychlowski, Aron Lukaszuk, Grzegorz Jakiel, Krzysztof Lukaszuk
Summary: This study investigated the correlation between mitochondrial DNA content in embryos and their developmental potential. The findings showed that aneuploid embryos had a higher mitochondrial DNA content compared to euploid embryos.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiang Wang, Shun Xiong, Yang Gao, Fei Xia, Biao Wei, Jiayi Zou, Guoning Huang, Wei Han
Summary: This study aimed to assess whether Intracytoplasmic sperm injection (ICSI) can improve the quality of embryos in patients with poor-quality embryos in the previous In-vitro fertilization (IVF) cycle. The results showed that the ICSI group had significantly higher rates of high-quality embryos and clinical pregnancy compared to the IVF group, while there were no significant differences in miscarriage rate and implantation rate.
Article
Obstetrics & Gynecology
Kevin Loewke, Justina Hyunjii Cho, Camelia D. Brumar, Paxton Maeder-York, Oleksii Barash, Jonas E. Malmsten, Nikica Zaninovic, Denny Sakkas, Kathleen A. Miller, Michael Levy, Matthew David VerMilyea
Summary: This study evaluated an artificial intelligence (AI) model for ranking blastocyst-stage embryos and found that it outperformed manual morphology grading in predicting clinical pregnancy. The study also identified limitations related to image quality, bias, and granularity of scores that may impact clinical use.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Liyan Wang, Lin Wang, Xia Yang, Panpan Jin, Rui Zhang, Yanbiao Jiang, Xuehong Zhang
Summary: This study aimed to evaluate the risk factors for early pregnancy loss (EPL) in fresh in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. The results showed that lower antral follicle count (AFC), E2/P ratio, and serum human chorionic gonadotropin (hCG) levels were associated with a higher risk of EPL in fresh IVF/ICSI cycles.
Article
Obstetrics & Gynecology
C. Harrison, S. Gameiro, J. Boivin
Summary: The majority of patients value the opportunity to plan for multiple cycles of IVF/ICSI treatment, acknowledging both challenges and benefits. There is inconsistency between patients' willingness to undergo multiple cycles and the current cycle-by-cycle treatment planning approach.
HUMAN REPRODUCTION
(2021)