Article
Clinical Neurology
Francesca Pizzo, Nicolas Roehri, Bernard Giusiano, Stanislas Lagarde, Romain Carron, Didier Scavarda, Aileen McGonigal, Cristina Filipescu, Isabelle Lambert, Francesca Bonini, Agnes Trebuchon, Christian-George Benar, Fabrice Bartolomei
Summary: In this study, it was found that thalamic involvement during seizures is common in different seizure types, with a significant effect of thalamic epileptogenicity on postsurgical outcome. Moreover, basal ganglia may also show high values of epileptogenicity, although to a lesser degree than the thalamus.
Article
Neurosciences
Heiko J. Luhmann
Summary: This review article provides an overview of the molecular, cellular, and network mechanisms underlying focal seizures in neocortical networks with developmental malformations. Neocortical malformations are a large variety of structural abnormalities associated with epilepsy and other neurological and psychiatric disorders. Animal models and state-of-the-art techniques have contributed to our understanding of neocortical hyperexcitability in developmental disorders. Additionally, molecular biological and electro-physiological techniques have provided insights into the subcellular, cellular, and network mechanisms of focal seizures.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Xiaodi Zhang, Eric A. Maltbie, Shella D. Keilholz
Summary: Recent resting-state fMRI studies have shown that brain activity exhibits temporal variations in functional connectivity using various methods. However, the results from these methods are just a simplification of the continuous process of brain activity.
Article
Engineering, Biomedical
Francesca Miraglia, Fabrizio Vecchio, Francesca Alu, Alessandro Orticoni, Elda Judica, Maria Cotelli, Paolo Maria Rossini
Summary: The study aimed to investigate the brain rhythms characteristics in resting state condition before a visuo-motor task in healthy adults. The results showed a negative correlation between brain activity and reaction times to the task, suggesting a potential tool for exploring brain state characterization for task performance.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
William C. Palmer, Brenna A. Cholerton, Cyrus P. Zabetian, Thomas J. Montine, Thomas J. Grabowski, Swati Rane
Summary: The study found significant differences in cerebello-cortical functional connectivity between PD patients and normal controls, particularly in the somatomotor network. Cognitive function was found to be associated with connectivity of the cerebellar SMN and dorsal attention network. Altered cerebellar connectivity with frontoparietal and default mode networks was also correlated with the severity of motor function in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Rockelle S. Guthrie, Davide Ciliberti, Emily A. Mankin, Gina R. Poe
Summary: A study found that the neocortex and hippocampus in the human brain may exhibit asynchronous state transitions during sleep, which questions the assessment of the functions and drivers of sleep states throughout the brain from a whole-brain perspective.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Joao P. O. F. T. Guimaraes, E. Sprooten, C. F. Beckmann, B. Franke, J. Bralten
Summary: This study used genomic structural equation modeling to analyze the genetic effects on brain resting state networks (RSNs) and identified the SNPs and genes driving the pleiotropy of RSNs. The results suggest that multivariate modeling is a powerful approach to investigate the biological mechanisms of brain function.
HUMAN BRAIN MAPPING
(2022)
Article
Behavioral Sciences
Zaira Romeo, Dante Mantini, Eugenia Durgoni, Laura Passarini, Francesca Meneghello, Marco Zorzi
Summary: Localized brain damage can lead to specific cognitive deficits, while stroke lesions can also alter the functional connectivity of intrinsic brain networks, impacting behavior. By analyzing the relationship between EEG patterns and cognitive performance, researchers identified specific EEG frequency bands associated with distinct cognitive impairments.
Article
Neurosciences
Jean Paul Medina, Anna Nigri, Mario Stanziano, Ludovico D'Incerti, Davide Sattin, Stefania Ferraro, Davide Rossi Sebastiano, Chiara Pinardi, Giorgio Marotta, Matilde Leonardi, Maria Grazia Bruzzone, Cristina Rosazza
Summary: Resting-state fMRI was used to investigate the association between lower-order networks and clinical assessment in patients with Disorders of Consciousness (DoC). The results showed that patients in vegetative state had fewer networks and decreased activity in each network compared to minimally conscious state patients. Visual networks were correlated with clinical status, and the combination of rs-fMRI and structural MRI data improved classification results. The findings suggest that lower-order rs-fMRI networks can be used to support visual function assessments in DoC.
Article
Neurosciences
Ileana L. Hanganu-Opatz, Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco Garcia, Jessica A. Cardin, Bradley Voytek, Alysson R. Muotri
Summary: This review summarizes recent research on the development of the mammalian neocortex, from genetic determination in neural stem cells to the dynamic role of specific neuronal populations in the earliest circuits of the neocortex, and how they contribute to emergent function and cognition. The perspective across species is imperative when investigating the dysfunction of early neocortical circuits in neurodevelopmental disorders, in order to identify targets for therapeutic intervention.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Benjamin Edmonds, Makoto Miyakoshi, Luigi Gianmaria Remore, Samuel Ahn, H. Westley Phillips, Atsuro Daida, Noriko Salamon, Ausaf Bari, Raman Sankar, Joyce H. Matsumoto, Aria Fallah, Hiroki Nariai
Summary: This study aimed to characterize the ictal EEG changes in the CM and AN of the thalamus using SEEG recordings in pediatric-onset neocortical drug-resistant epilepsy patients. Visual and quantitative analysis showed consistent detection of ictal EEG changes in both CM and AN, with low-voltage fast activity being the most common pattern. The results suggest the feasibility of using a closed-loop system in the thalamus for detecting and modulating seizure activity in neocortical epilepsy.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Ji-Won Hur, Taekwan Kim, Kang Ik K. Cho, Jun Soo Kwon
Summary: Exploring disruptions in intrinsic resting-state networks in schizophrenia-spectrum disorders provides insight into disease-specific pathophysiology. This study investigated abnormalities in RSNs in schizotypal personality disorder (SPD) and found impaired large-scale intrinsic brain networks in individuals with SPD, correlating with cognitive-perceptual deficits and social functioning impairments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Perry W. E. Spratt, Ryan P. D. Alexander, Roy Ben-Shalom, Atehsa Sahagun, Henry Kyoung, Caroline M. Keeshen, Stephan J. Sanders, Kevin J. Bender
Summary: The loss of Na(V)1.2 channels in pyramidal neurons leads to intrinsically hyperexcitable neurons, firing high-frequency bursts of action potentials despite reductions in AP size and speed. This cell-intrinsic mechanism may explain why loss-of-function variants in SCN2A gene paradoxically promote seizure.
Article
Neurosciences
Perez -Ramirez Maria-Belen, Parada Isabel, Prince David
Summary: Status epilepticus (SE) is a life-threatening emergency that can lead to the development or worsening of epilepsy. The study found that neocortical focal status epilepticus (FSE) can induce structural and functional changes in the thalamus, which may contribute to hyperexcitability in thalamocortical circuit. These changes include cell loss in the ventrobasal nucleus (VB) and increased excitatory synapses in intra-thalamic and cortico-thalamic networks.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Alexandre Girard, Claudia Moreau, Jacques L. Michaud, Berge Minassian, Patrick Cossette, Simon L. Girard
Summary: Despite the use of large cohorts, the discovery of new variants in epilepsy studies has stagnated in recent years, leaving most of the heritability unexplained. Rare non-coding variants, which can significantly impact gene expression, have been overlooked in epilepsy research. This study demonstrates the association between rare non-coding deleterious variants and epilepsy, particularly in Genetic Generalized Epilepsy (GGE).
Article
Engineering, Biomedical
David T. Bundy, Mrinal Pahwa, Nicholas Szrama, Eric C. Leuthardt
JOURNAL OF NEURAL ENGINEERING
(2016)
Review
Neurosciences
Maxwell D. Murphy, David J. Guggenmos, David T. Bundy, Randolph J. Nudo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2016)
Article
Neurosciences
Ammar H. Hawasli, Ravi Chacko, Nicholas P. Szrama, David T. Bundy, Mrinal Pahwa, Chester K. Yarbrough, Brian J. Dlouhy, David D. Limbrick, Dennis L. Barbour, Matthew D. Smyth, Eric C. Leuthardt
FRONTIERS IN HUMAN NEUROSCIENCE
(2017)
Article
Clinical Neurology
David T. Bundy, Lauren Souders, Kelly Baranyai, Laura Leonard, Gerwin Schalk, Robert Coker, Daniel W. Moran, Thy Huskey, Eric C. Leuthardt
Article
Multidisciplinary Sciences
Mrinal Pahwa, Matthew Kusner, Carl D. Hacker, David T. Bundy, Kilian Q. Weinberger, Eric C. Leuthardt
Article
Multidisciplinary Sciences
S. Kathleen Bandt, Jarod L. Roland, Mrinal Pahwa, Carl D. Hacker, David T. Bundy, Jonathan D. Breshears, Mohit Sharma, Joshua S. Shimony, Eric C. Leuthardt
Article
Multidisciplinary Sciences
Zachary V. Freudenburg, Charles M. Gaona, Mohit Sharma, David T. Bundy, Jonathan D. Breshears, Robert B. Pless, Eric C. Leuthardt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Neurosciences
David T. Bundy, Nicholas Szrama, Mrinal Pahwa, Eric C. Leuthardt
JOURNAL OF NEUROSCIENCE
(2018)
Article
Engineering, Biomedical
Maxwell Murphy, Stefano Buccelli, Yannick Bornat, David Bundy, Randolph Nudo, David Guggenmos, Michela Chiappalone
JOURNAL OF NEURAL ENGINEERING
(2019)
Review
Neurosciences
David T. Bundy, Eric C. Leuthardt
TRENDS IN NEUROSCIENCES
(2019)
Article
Multidisciplinary Sciences
David T. Bundy, David J. Guggenmos, Maxwell D. Murphy, Randolph J. Nudo
Article
Biochemical Research Methods
Scott Barbay, Hongyu Zhang, Shawn B. Frost, Jeremy C. Peterson, David J. Guggenmos, Heather M. Hudson, David T. Bundy, Stacey L. DeJong, Randolph J. Nudo
Summary: This study utilized a controlled cortical impact device to induce a focal contusion in the hand area of the primary motor cortex in three New World monkeys and assessed changes in reach and grasp function over 3 months post-injury. Results showed significant reductions in grey matter and corona radiata in the hand representation area, with impaired motor function affecting mainly the contralateral hand, and skilled hand activity being impaired over the three-month period.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Biochemical Research Methods
David T. Bundy, Scott Barbay, Heather M. Hudson, Shawn B. Frost, Randolph J. Nudo, David J. Guggenmos
Summary: This study used intracortical microstimulation (ICMS) and multi-unit action potential recordings to assess mesoscale effective connectivity within sensorimotor cortex. The results showed that ICMS-evoked responses correlated with known anatomical connections and remained stable over time. This technique provides a viable way to longitudinally assess effective connectivity and compare it with changes in behavioral function.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Clinical Neurology
Stefano Milighetti, Silvia Sterzi, Felipe Fregni, Colleen A. Hanlon, Page Hayley, Maxwell D. Murphy, David T. Bundy, Randolph J. Nudo, David J. Guggenmos