Article
Geriatrics & Gerontology
Zhengqi Chen, Julia Cordero, Adel M. Alqarni, Cathy Slack, Martin P. Zeidler, Ilaria Bellantuono
Summary: Increased longevity has not been accompanied by extended health span. Zoledronate, a drug used to prevent osteoporosis, has been found to extend lifespan, improve physical activity, and reduce the occurrence of intestinal disease and permeability. It enhances resistance to oxidative stress and reduces DNA damage accumulation. Zoledronate also interacts with molecules associated with increased longevity. Therefore, repurposing Zoledronate holds great promise for improving health span.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yi Xiao, Huiling Zhang, Yi Sheng, Fang Liu, Jiajun Gao, Guosheng Liu, Sanhua Li, Nian Jiang, Changya Yu, Yun Liu
Summary: Inhibition of mTOR has been suggested as a strategy to promote lifespan and delay age-related diseases in various organisms. Usnic Acid extended healthy lifespan by acting on mTOR and delaying neurodegenerative diseases through a mTOR-dependent manner.
Article
Biochemistry & Molecular Biology
Liu Yang, Qi Ye, Xuguang Zhang, Ke Li, Xiaoshan Liang, Meng Wang, Linran Shi, Suhui Luo, Qiang Zhang, Xumei Zhang
Summary: The study demonstrates that PQQ can significantly extend the lifespan of C. elegans, potentially mediated via the IIS pathway and autophagy. PQQ also improves locomotion, reduces fat accumulation, and decreases ROS levels in the worms.
Article
Cell Biology
Rebecca L. McIntyre, Marte Molenaars, Bauke V. Schomakers, Arwen W. Gao, Rashmi Kamble, Aldo Jongejan, Michel van Weeghel, Andre B. P. van Kuilenburg, Richard Possemato, Riekelt H. Houtkooper, Georges E. Janssens
Summary: The human population is aging, and there is a growing need for interventions to slow down age-related diseases. The repurposing of clinically used compounds, such as the anti-retroviral nucleoside reverse transcriptase inhibitor zidovudine, shows promising results in extending lifespan and health span in C. elegans. This effect is achieved through the modification of pyrimidine metabolism and proteostasis-related transcripts, as well as the activation of transcription factor 4 (ATF-4) and reduction of translation.
Article
Multidisciplinary Sciences
Robyn Branicky, Ying Wang, Arman Khaki, Ju-Ling Liu, Maximilian Kramer-Drauberg, Siegfried Hekimi
Summary: Elevation of mitochondrial superoxide generation increases the lifespan of Caenorhabditis elegans by enhancing a RAS-dependent ROS signaling pathway (RDRS) that controls gene expression, animal composition, and physiology. RDRS stimulation mimics changes in gene expression observed at the end of postembryonic development. Negative feedback from superoxide dismutase 1 (SOD-1)-dependent conversion of superoxide to hydrogen peroxide regulates RDRS by acting on a redox-sensitive cysteine of RAS.
Article
Medicine, Research & Experimental
Eduardo Cepeda Canedo, Stephanie Totten, Ryuhjin Ahn, Paul Savage, Deanna MacNeil, Jesse Hudson, Chantal Autexier, Genevieve Deblois, Morag Park, Michael Witcher, Josie Ursini-Siegel
Summary: TNBC lacks effective targeted therapies, and PARP inhibitors are being tested as a potential treatment option. Studies suggest that increasing ROS levels can enhance sensitivity to PARP inhibitors, and the p66ShcA protein has been found to potentiate the synergy between PARP inhibitors and doxorubicin in TNBCs.
Article
Biology
Eun Jae Yang, Ji Hwan Park, Hyun-Ji Cho, Jeong-A Hwang, Seung-Hwa Woo, Chi Hyun Park, Sung Young Kim, Joon Tae Park, Sang Chul Park, Daehee Hwang, Young-Sam Lee
Summary: Inhibition of ATM and ROCK kinases synergistically increases the proliferation of human diploid fibroblasts undergoing replicative senescence, promoting cell cycle progression through activation of transcription factors E2F1 and FOXM1.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Masaaki Yokoyama, Mariko Sasaki, Takehiko Kobayashi
Summary: Genome instability plays a crucial role in the aging process of many organisms. The rDNA cluster, a highly unstable region in the genome, affects the replicative lifespan of budding yeast. By studying yeast mutants with more stable rDNA and extended lifespans, we found that the absence of a transcription elongation factor called Spt4 leads to increased rDNA stability, decreased non-coding RNA transcripts from the E-pro promoter in rDNA, and extended replicative lifespan in a SIR2-dependent manner. Furthermore, Spt4-dependent lifespan restriction is abolished when non-coding RNA transcription is absent at the E-pro locus. The amount of Spt4 increases and its function becomes more important as cells age. These findings highlight Spt4 as a promising aging factor that accelerates cellular senescence through rDNA instability driven by non-coding RNA transcription.
Article
Cell Biology
Hyun Ju Lee, Hafiza Alirzayeva, Seda Koyuncu, Amirabbas Rueber, Alireza Noormohammadi, David Vilchez
Summary: Moderate cold temperature extends lifespan by eliminating protein aggregation through PSME3-activated proteasomes. This mechanism is effective in both C. elegans and human cells, and it can ameliorate age-related deficits in protein degradation and reduce neurodegeneration.
Article
Biochemical Research Methods
Barbara Schnitzer, Linnea Osterberg, Iro Skopa, Marija Cvijovic
Summary: Protein damage accumulation is a major driver of replicative ageing, and is closely linked to reactive oxygen and nitrogen species. Cells can adapt their metabolism to slow down damage accumulation, but older or damaged cells have less flexibility in allocating enzymes across the metabolic network, leading to further metabolic adaptations.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Christopher D. Wiley, Judith Campisi
Summary: Cellular senescence involves a permanent proliferative arrest and the release of biologically active molecules known as SASP. Studies show that senescence and SASP are sensitive to metabolic states, potentially driving phenotypes associated with metabolic dysfunction. Effective interventions may disrupt the feedback loop in which cellular senescence promotes metabolic diseases.
Article
Biochemistry & Molecular Biology
Yuichi Takashi, Shun Sawatsubashi, Itsuro Endo, Yukiyo Ohnishi, Masahiro Abe, Munehide Matsuhisa, Daiji Kawanami, Toshio Matsumoto, Seiji Fukumoto
Summary: The study demonstrates the significance of FGFR1 signaling in regulating FGF23 production and serum phosphate level in vivo. Knockout of Fgfr1 leads to increased hyperphosphatemia, body weight loss, and shorter lifespan in mice, highlighting the role of FGFR1 in phosphate metabolism and normal lifespan.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Cell Biology
Yu Liu, Yu-Yang Lu, Lv Huang, Lin Shi, Zhuo-Ya Zheng, Jian-Ning Chen, Yuan Qu, Hai-Ting Xiao, Huai-Rong Luo, Gui-Sheng Wu
Summary: The phenolic compounds found in Gastrodia elata, such as gastrodin and para-hydroxybenzyl alcohol (HBA), have antioxidative and anti-inflammatory effects. In models of Caenorhabditis elegans, HBA can delay the progression of neurodegenerative diseases, extend lifespan, and improve physiological functions. Mechanistic studies have shown that HBA activates multiple cellular protective pathways, enhancing stress resistance and protecting against aging and aging-related diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)