Article
Medicine, General & Internal
Felix Lehmann, Lorena M. Schenk, Inja Ilic, Christian Putensen, Alexis Hadjiathanasiou, Valeri Borger, Julian Zimmermann, Erdem Gueresir, Hartmut Vatter, Christian Bode, Matthias Schneider, Patrick Schuss
Summary: This study aimed to determine the impact of prolonged mechanical ventilation (PMV) on mortality in patients with deep-seated intracerebral hemorrhage (ICH) and identify associated risk factors. The results showed that ICH volume >30 mL and admission SOFA score > 5 were significant and independent predictors for the need of PMV in patients with deep-seated ICH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kara R. Melmed, Meng Cao, Siddhant Dogra, Ruina Zhang, Shadi Yaghi, Ariane Lewis, Rajan Jain, Seda Bilaloglu, Ji Chen, Barry M. Czeisler, Eytan Raz, Aaron Lord, Jeffrey S. Berger, Jennifer A. Frontera
Summary: This study assessed risk factors associated with intracerebral hemorrhage in COVID-19 patients, finding that anticoagulation use was linked to an increased risk of intracerebral hemorrhage and was associated with higher mortality. Further investigation is needed to understand the underlying mechanisms and develop prevention strategies in this population.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Medicine, General & Internal
Felix Lehmann, Matthias Schneider, Joshua D. Bernstock, Christian Bode, Valeri Borger, Stefan Felix Ehrentraut, Florian Gessler, Anna-Laura Potthoff, Christian Putensen, Lorena M. Schenk, Julian Zimmermann, Hartmut Vatter, Patrick Schuss, Alexis Hadjiathanasiou
Summary: This retrospective study examined the prevalence of treatment-limiting decisions (TLDs) and factors driving TLDs in patients with spontaneous intracerebral hemorrhage (ICH). The results showed that TLDs were reached in 42% of the patients, with severity of injury and expected outcomes being important factors.
MEDICINA-LITHUANIA
(2022)
Review
Medicine, General & Internal
Peter B. Sporns, Marios-Nikos Psychogios, Gregoire Boulouis, Andreas Charidimou, Qi Li, Enrico Fainardi, Dar Dowlatshahi, Joshua N. Goldstein, Andrea Morotti
Summary: Intracerebral hemorrhage (ICH) accounts for 10% to 20% of all strokes worldwide and is associated with high morbidity and mortality. Neuroimaging plays a crucial role in the rapid diagnosis of ICH, identification of ICH expansion, and assessment of early hematoma expansion risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Julio Cesar Garcia de Alencar, Claudia de Lucena Moreira, Alicia Dudy Muller, Cleuber Esteves Chaves, Marina Akemi Fukuhara, Elizabeth Aparecida da Silva, Maria de Fatima Silva Miyamoto, Vanusa Barbosa Pinto, Caue Gasparotto Bueno, Felippe Lazar Neto, Luz Marina Gomez Gomez, Maria Clara Saad Menezes, Julio Flavio Meirelles Marchini, Lucas Oliveira Marino, Rodrigo Antonio Brandao Neto, Heraldo Possolo Souza
Summary: The study found that high-dose NAC did not affect the progression of severe COVID-19 in patients. There were no significant differences observed between the group receiving NAC and the placebo group.
CLINICAL INFECTIOUS DISEASES
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tsz-Kit Chow, Ka-Lun Chiu, Chun-Ho Chan, Wai-Han Ma
Summary: This study described the changes in cerebral glucose metabolism after acute intracranial hemorrhage, which may be helpful for future research to optimize patient care.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hongyu Duan, Fan Yang, Bo Shao, Yu Zeng, Huihui Chen
Summary: This study explores the application of urapidil blood pressure regulation and mechanical ventilation combined with bone window craniotomy in the treatment of hypertensive basal ganglia intracerebral hemorrhage. The results demonstrate that this treatment method can reduce cerebral oxygen uptake rate, regulate middle cerebral artery blood flow parameters, and improve prognosis.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Clinical Neurology
Felix Hess, Christian Foerch, Fee Keil, Alexander Seiler, Sriramya Lapa
Summary: Dysphagia is a common symptom in patients with acute intracerebral hemorrhage, with about 63.6% of patients experiencing swallowing difficulties. Lesions in specific cortical and subcortical areas, such as the right insular cortex and central operculum, are associated with dysphagia development. Factors like intraventricular hemorrhage extension and midline shift do not appear to be related to dysphagia in these patients.
Article
Clinical Neurology
Laurent Puy, Antoine Rauch, Vincent Deramecourt, Charlotte Cordonnier, Vincent Berezowski
Summary: This study conducted a postmortem examination to investigate acute microvascular lesions (microbleeds and microinfarcts) in the perihematomal area of patients with spontaneous intracerebral hemorrhage (ICH). It was found that these lesions may contribute to secondary brain tissue damage.
Article
Clinical Neurology
Huaming Xiao, Lei Li, Feng Zhang, Lei Cheng, Yang Li, Wenlan Han, Huanting Li, Mingchao Fan
Summary: This study aimed to analyze the predictive value of preoperative systemic immune-inflammation index (SII) for prolonged mechanical ventilation (PMV) in patients with spontaneous basal ganglia intracerebral hemorrhage (ICH) who underwent surgical operations. The results showed that preoperative SII was a significant risk factor for PMV.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Vignan Yogendrakumar, Tim Ramsay, Bijoy K. Menon, Adnan Qureshi, Jeffrey L. Saver, Dar Dowlatshahi
Summary: This proof-of-concept study introduced an HE shift analysis model to enhance the evaluation of ICH therapies using data from the ATACH-2 trial. Results from analyzing 863 patients indicated that intensive blood pressure lowering treatment may reduce hematoma growth in high-risk patients, suggesting the potential benefits of the shift analysis model in assessing hemostatic agents for future studies.
Article
Clinical Neurology
Jawed Nawabi, Helge Kniep, Sarah Elsayed, Constanze Friedrich, Peter Sporns, Thilo Rusche, Maik Boehmer, Andrea Morotti, Frieder Schlunk, Lasse Duehrsen, Gabriel Broocks, Gerhard Schoen, Fanny Quandt, Goetz Thomalla, Jens Fiehler, Uta Hanning
Summary: The study demonstrated that machine learning algorithms based on image features have similar predictive capabilities for functional outcomes in patients with acute intracerebral hemorrhage as multidimensional clinical scoring systems. The integration of traditional scores and image features can significantly improve prediction accuracy.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Kristin Tveitan Larsen, Maiken Nordahl Selseth, Silje Holt Jahr, Vigdis Hillestad, Nojoud Koubaa, Else Charlotte Sandset, Ole Morten Ronning, Espen Saxhaug Kristoffersen
Summary: This study investigated the relationship between prehospital blood pressure (BP) and clinical and radiological outcomes in acute intracerebral hemorrhage patients. The results showed that elevated prehospital BP parameters were associated with in-hospital death and hematoma expansion. Changes in prehospital BP were not consistently associated with outcome. A possible U-shaped association between prehospital BP and in-hospital death needs further investigation.
Review
Cell & Tissue Engineering
Xiangyu Zhang, Suliman Khan, Ruixue Wei, Yan Zhang, Yang Liu, Voon Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by blood vessel rupture in the brain parenchyma, with a high mortality rate. Nanotechnology provides new prospects in ICH treatment by enhancing drug therapy and improving post-ICH outcomes such as neuroinflammation suppression, oxidative stress resistance, cell death reduction, and functional deficits improvement.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Clinical Neurology
Bastian Volbers, Angelika Mennecke, Nicola Kaestle, Hagen B. Huttner, Stefan Schwab, Manuel A. Schmidt, Tobias Engelhorn, Arnd Doerfler
Summary: This study explores objective imaging parameters during the acute phase of intracerebral hemorrhage (ICH) using quantitative corticospinal tract (CST) fiber reconstruction and finds that the number of ipsilesional CST fiber pathways is associated with favorable outcomes, while quantitative anisotropy (QA) in the ipsilesional posterior limb of the internal capsule shows a trend towards favorable outcomes. The total number of reconstructed fiber pathways is associated with favorable recovery, suggesting that quantitative tractography parameters assessed in the acute phase may be predictors of long-term outcomes and recovery.
TRANSLATIONAL STROKE RESEARCH
(2021)