A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response
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Title
A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response
Authors
Keywords
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Journal
PLoS One
Volume 9, Issue 6, Pages e98891
Publisher
Public Library of Science (PLoS)
Online
2014-06-06
DOI
10.1371/journal.pone.0098891
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- (2013) M. Yamada et al. GENES & DEVELOPMENT
- A New Target for an Old Drug: Identifying Mitoxantrone as a Nanomolar Inhibitor of PIM1 Kinase via Kinome-Wide Selectivity Modeling
- (2013) Xiaobo Wan et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) Ruichuan Yin et al. Scientific Reports
- MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells
- (2013) L R Barkley et al. Oncogenesis
- Drugging Topoisomerases: Lessons and Challenges
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- Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics
- (2012) Kamal Ahmed et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Inhibition of DNA Damage-induced Apoptosis through Cdc7-mediated Stabilization of Tob
- (2012) Toru Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
- (2011) S. E. Polo et al. GENES & DEVELOPMENT
- The CDK inhibitors in cancer research and therapy
- (2011) Jonas Cicenas et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
- (2011) A. Natoni et al. MOLECULAR CANCER THERAPEUTICS
- Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
- (2011) Theonie Anastassiadis et al. NATURE BIOTECHNOLOGY
- Mining for therapeutic gold
- (2011) Francis S. Collins NATURE REVIEWS DRUG DISCOVERY
- A High-Throughput, Cell-Based Screening Method for siRNA and Small Molecule Inhibitors of mTORC1 Signaling Using the In Cell Western Technique
- (2010) Gregory R. Hoffman et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
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- Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy
- (2010) A. Montagnoli et al. CLINICAL CANCER RESEARCH
- Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication
- (2010) Tovah A. Day et al. JOURNAL OF CELL BIOLOGY
- Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding
- (2010) Maria Menichincheri et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
- (2010) Yi-Jun Sheu et al. NATURE
- Cdc7 as a potential new target for cancer therapy
- (2009) S. Ito et al. DRUG NEWS & PERSPECTIVES
- Cdc7 kinase – A new target for drug development
- (2009) Ronan Swords et al. EUROPEAN JOURNAL OF CANCER
- Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry
- (2009) Li-Chiou Chuang et al. MOLECULAR CELL
- Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors
- (2008) Chunlin Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation
- (2008) M. D. Rainey et al. CANCER RESEARCH
- Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
- (2008) Ermes Vanotti et al. JOURNAL OF MEDICINAL CHEMISTRY
- First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery†
- (2008) Maria Menichincheri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone
- (2008) Daniel J. Smart et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
- (2008) Alessia Montagnoli et al. Nature Chemical Biology
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