Article
Oncology
Tiantian Cui, Hongjiao Zhang, Tao Yu, Yiru Chen, Chengxin Liu, Qian Zhao, Jian Zhu, Baosheng Li, Wei Huang
Summary: This study analyzed the recurrence patterns of thoracic esophageal squamous cell carcinoma (ESCC) after radical surgery and proposed a T-shaped CTV for postoperative radiotherapy to cover most regional lymph node recurrences. The most common type of recurrence was regional lymph node recurrence, with high rates in specific lymph node areas. The proposed CTV design was found to encompass the majority of lymph node recurrences, with rates outside the CTV being less than 15%.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yichun Wang, Dongmei Ye, Mei Kang, Liyang Zhu, Mingwei Yang, Jun Jiang, Wanli Xia, Ningning Kang, Xiangcun Chen, Jie Wang, Fan Wang
Summary: This study aimed to map the recurrent lymph nodes in the cervical and upper mediastinal regions and explore a reasonable CTVnd for postoperative radiotherapy in thoracic esophageal squamous cell carcinoma. The results indicated that the high-risk regions for recurrence were identified, providing guidance for the delineation of CTVnd in TESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dashan Ai, Yun Chen, Qi Liu, Jiaying Deng, Xiaofei Zhang, Junhua Zhang, Li Chu, Jingyi Shen, Longfei Ma, Yawei Zhang, Haiquan Chen, Longsheng Miao, Kuaile Zhao, Jiaqing Xiang
Summary: This study compared the efficacy and safety of postoperative radiotherapy with concurrent chemotherapy to postoperative radiotherapy alone for esophageal squamous cell carcinoma. The results showed that postoperative radiotherapy with concurrent chemotherapy was effective in controlling the tumor and prolonging overall survival, but it also had increased treatment-related toxicities.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Xiaofei Zhang, Dashan Ai, Juanqi Wang, Yun Chen, Qi Liu, Jiaying Deng, Huanjun Yang, Yongzhan Nie, Weiwei Chen, Weixin Zhao, Kuaile Zhao
Summary: The single-arm clinical trial showed that postoperative radiotherapy with 40 Gy is feasible and shows acceptable toxicity in patients with locally advanced thoracic esophageal squamous cell carcinoma, although the local recurrence rate is relatively high. The findings provide a basis for further exploration of high-dose radiation with extensive CTV combined with chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hayato Kaida, Takushi Yasuda, Osamu Shiraishi, Hiroaki Kato, Yutaka Kimura, Kohei Hanaoka, Minoru Yamada, Yuko Matsukubo, Masakatsu Tsurusaki, Kazuhiro Kitajima, Satoshi Hattori, Kazunari Ishii
Summary: This study investigated the usefulness of total metabolic tumor volume (TMTV) in predicting the postoperative recurrence of thoracic esophageal squamous cell carcinoma (ESCC). The results showed that TMTV is a significantly independent prognostic factor for relapse-free survival (RFS) in patients with resectable thoracic ESCC. It can be used to identify high-risk recurrence patients and guide patient management.
Article
Oncology
Qi Zhao, Jiaxing Zhu, Yandong Liu, Songbing Qin, Juying Zhou
Summary: The study evaluated the outcomes of postoperative radiotherapy in thoracic ESCC patients using a small T-shaped field, showing lower locoregional recurrence rates in the mediastinal lymph nodes compared to a tumor bed field. The overall survival was higher in the small T-shaped field group, suggesting it may be a feasible and efficacious approach for these patients.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Hui Li, Dayong Gu, Mingyu Du, Guoren Zhou, Zhi Zhang, Jinjun Ye
Summary: This study investigated the efficacy and safety of postoperative IMRT combined with chemotherapy for locally advanced thoracic esophageal squamous cell carcinoma patients. The results showed that this treatment approach had a high local control rate and a low probability of recurrence outside the irradiation field.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Hong-Mei Gao, Xue-Yuan Zhang, Wen-Bin Shen, Jin-Rui Xu, You-Mei Li, Shu-Guang Li, Shu-Chai Zhu
Summary: The location of the lesion, pN stage, vascular invasion, LND, and mediastinal lymph node metastasis were found to be independent factors influencing the development of abdominal lymph node metastasis in TESCC patients. A mathematical model constructed based on these factors accurately predicted abdominal lymph node metastasis, which can assist clinicians in determining the targets for postoperative radiotherapy.
FRONTIERS IN SURGERY
(2022)
Article
Computer Science, Artificial Intelligence
Dakai Jin, Dazhou Guo, Tsung-Ying Ho, Adam P. Harrison, Jing Xiao, Chen-Kan Tseng, Le Lu
Summary: Gross tumor volume (GTV) and clinical target volume (CTV) delineation are critical steps in cancer radiotherapy planning. Our customized methods provide a comprehensive solution for esophageal cancer radiotherapy, integrating RTCT and PET modalities for more accurate GTV segmentation, and formulating CTV segmentation as a deep contextual appearance-based problem to emulate oncologists' CTV delineation techniques. Extensive cross-validation on 148 esophageal cancer patients demonstrates significant improvements in performance over previous works.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Kyung Su Kim, Kwang-Ho Cheong, Kyubo Kim, Taeryool Koo, Hyeon Kang Koh, Ji Hyun Chang, Ah Ram Chang, Hae Jin Park
Summary: The study evaluated the inter-physician variability in target contouring for radiotherapy of ASCC. The results showed high agreement for pelvic CTV but lower agreement for inguinal CTV, indicating the need for further studies to establish clearer delineation guidelines.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Xing-Qiang Wu, Tian-Yue Zhang, Fan Yang, Xin-Yi Feng, Yu-Ling Feng, Ling-Li Wang, Tian-Wu Chen, Chun-Ping Li, Rui Li
Summary: This study investigated the association between radiotherapy and thoracic vertebral fractures in esophageal squamous cell carcinoma patients. It found that radiotherapy, as well as increased vertebral dose and RT fractions, were significant predictors of vertebral fractures in ESCC.
Article
Genetics & Heredity
Xin Xu, Zhiyong Sun, Ling Rong, Xiaohang Wang, Lei Xu, Jun Lu, Qing Ye, Lei Zhang, Yongrui Bai, Xiumei Ma
Summary: In this study, researchers investigated the associations between gene variants of alcohol metabolism and the prognosis of postoperative radiotherapy in esophageal squamous cell carcinoma (ESCC) patients. They found that the ADH1C rs1789924 polymorphism was associated with poor disease-free survival (DFS) and overall survival (OS) in patients undergoing adjuvant radiotherapy. However, the genotypes of ADH1B SNP rs1229984 and ALDH2 rs671 were not associated with differences in patient outcomes. The researchers concluded that ADH1C rs1789924 could be a prognostic genetic biomarker for ESCC patients receiving surgery and postoperative radiotherapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yongbin Cui, Yuteng Pan, Zhenjiang Li, Qiang Wu, Jingmin Zou, Dali Han, Yong Yin, Changsheng Ma
Summary: This study compares the differences in dosimetric and biological evaluations between photon and proton radiation therapy. The results show that proton radiation therapy is superior to photon radiation therapy in terms of the plan conformity index, homogeneity index, and gradient index. Proton radiation therapy improves tumor control probability and reduces the dose and volume of radiation received by the lungs, heart, and spinal cord compared to photon therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chi Zhang, Xiao-Lin Ge, Chen-Jun Huang, Shu Zhang, Xin-Chen Sun
Summary: This study retrospectively analyzed the clinical outcomes of 103 esophageal squamous cell carcinoma patients with lymph node recurrence treated with salvage RT or CRT, finding that fewer recurrent nodes may indicate better long-term survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Luxi Ye, Lijun Zhou, Shengping Wang, Lining Sun, Jiazhou Wang, Quan Liu, Xi Yang, Li Chu, Xiaofei Zhang, Weigang Hu, Jie Lin, Zhengfei Zhu
Summary: This study focused on generating a CT-based documentation of PALNs and proposing a CTV for high-risk abdominal failure in LTESCC patients after surgery. The proposed CTV covered a significant percentage of LNs and was deemed dosimetrically feasible, serving as a potential reference for adjuvant radiotherapy in LTESCC patients.