Article
Immunology
Maud D'Aveni, Anne-Beatrice Notarantonio, Viviane A. Agbogan, Allan Bertrand, Guillemette Fouquet, Pauline Gastineau, Meriem Garfa-Traore, Marcelo De Carvalho, Olivier Hermine, Marie-Therese Rubio, Flora Zavala
Summary: Allo-HSCT often uses G-CSF to mobilize PBSCs, which can enhance the immunosuppressant effect of Tregs on alloreactive T cells, reducing the lethality of GVHD in mice and potentially in humans. This suggests G-CSF-mobilized MPPs could be a valuable cellular therapy to expand donor Tregs and prevent GVHD in allo-HSCT for leukemia treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Weiwei Wang, Yali Ye, Yuwei Du, Zhengqing Xu, Ke Yuan, Yizhou Wang, Seyram Yao Adzraku, Yue Li, Kailin Xu, Jianlin Qiao, Wen Ju, Lingyu Zeng
Summary: This study investigated the role of endothelial progenitor cells (EPC) in repairing endothelial injury in graft-versus-host disease (GVHD). The results showed that infusion of EPC reduced T cell infiltration and pathological endothelial activation, improving endothelial damage in GVHD. EPC infusion combined with bone marrow transplantation could potentially be a promising strategy for the prevention and treatment of acute GVHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Lingyi Yang, Jia Cheng, Fei Li, Ruiqi Qian, Xiuqin Zhang, Song Jin, Xuefeng He, Ting Xu, Xiaohui Hu, Xiao Ma, Jia Chen, Yehan Zhu, Feng Chen
Summary: This study evaluated the predictive value of pre-transplant pulmonary function tests (PFT) for chronic graft-versus-host disease (cGVHD) after hematopoietic stem cell transplantation (HSCT). The results showed that higher levels of FEV1/FVC and PEF/pred were associated with a lower incidence of cGVHD and decreased non-relapse mortality.
BMC PULMONARY MEDICINE
(2022)
Review
Immunology
Xiaoxiao Xu, Xiaoqin Li, Yanmin Zhao, He Huang
Summary: Histone deacetylase inhibitors are the focus of extensive research for their potential in treating immune-mediated diseases like GVHD while preserving beneficial effects on GVL. These drugs may become novel therapies by modifying gene expression and immune cell function to prevent or treat GVHD and other immune conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ning Wu, Ruoyang Liu, Shuang Liang, Haitao Gao, Lan-Ping Xu, Xiao-Hui Zhang, Jiangying Liu, Xiao-Jun Huang
Summary: In the development of aGVHD, gamma delta T cells were found to indirectly regulate the migration of CD4 T cells to target tissues, rather than directly triggering alloreactive responses. This study suggests a potential role for gamma delta T cells in recruiting alloreactive CD4 T cells through the expression of CXCR4, providing new insights into the mechanism of aGVHD and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han, Sizhou Feng
Summary: This study shows that both graft MAIT cells and peripheral blood MAIT cells are closely related to the development of aGVHD post allogeneic HCT. The interferon-alpha response pathway may be a critical regulatory mechanism for the involvement of MAIT cells in aGVHD development.
CANCER CELL INTERNATIONAL
(2022)
Letter
Oncology
Binjie Liu, Jingwen Cai, Wenjie Li, Gui Liu, Jun Chen
Summary: Graft-versus-host disease (GVHD) is a common and serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), with approximately 45% to 83% of patients developing GVHD in the oral cavity. However, there is currently no medical record of oral submucous fibrosis (OSF) induced by GVHD after allo-HSCT, which should be brought to the attention of dentists.
Article
Oncology
Simonetta Saldi, Christian Paolo Luca Fulcheri, Claudio Zucchetti, Amr Mohamed Hamed Abdelhamid, Alessandra Carotti, Antonio Pierini, Loredana Ruggeri, Sara Tricarico, Marino Chiodi, Gianluca Ingrosso, Vittorio Bini, Andrea Velardi, Massimo Fabrizio Martelli, Susanta Kumar Hui, Cynthia Aristei
Summary: This study investigated the impact of radiotherapy on the incidence of acute GvHD in transplant recipients and found no clear evidence that current dosages were linked to the development of aGvHD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Janina Linnik, Mohammedyaseen Syedbasha, Hans-Michael Kaltenbach, Dominik Vogt, Yvonne Hollenstein, Lukas Kaufmann, Nathan Cantoni, Sabine Ruosch-Girsberger, Antonia M. S. Mueller, Urs Schanz, Thomas Pabst, Georg Stuessi, Maja Weisser, Joerg Halter, Joerg Stelling, Adrian Egli
Summary: Patients after hematopoietic stem cell transplantation exhibit heterogeneous antibody responses to seasonal influenza vaccination, with factors such as type of immunosuppressive treatment, absolute lymphocyte count, and donor relationship playing a role. While HSCT patients required 2 vaccine doses for adequate responses, they can elicit potent antibody responses over time. However, factors like an unrelated donor, low lymphocyte counts, and certain treatments can lower the odds of responding to vaccination.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ryotaro Yoshida, Hidenori Yamana, Michihiro Hayashi, Emi Yasuda, Yuro Shibayama, Yoshinobu Hirose, Nobuhiko Tanigawa, Kazuhisa Uchiyama, Takahiro Kubota
Summary: GVHD involves a response of the graft to allogeneic hosts, including macrophage-induced GVHD and CTL-mediated GVL effect. T cell activation of the graft after BM transplantation skips GVHD.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2021)
Article
Immunology
Elisabeth Meedt, Andreas Hiergeist, Andre Gessner, Katja Dettmer, Gerhard Liebisch, Sakhila Ghimire, Hendrik Poeck, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Ernst Holler, Daniela Weber
Summary: The decrease of butyrogenic commensals after allogeneic stem cell transplantation is associated with increased severity of graft-vs-host disease and increased transplantation-related mortality.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Oncology
Ana Claudia Scaraficci, Patricia Maria Fernandes, Fabio Abreu Alves, Jayr Schmidt Filho, Graziella Chagas Jaguar
Summary: The study revealed that the mean time for oral GVHD to develop after AHCT was 229 days, with pain and xerostomia being the main symptoms, and ulcers being the most common oral manifestation. Patients who received myeloablative conditioning regimen had a higher survival rate.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Jin Lee, Yerang Shin, Youjin Kim, Hyeon-Su Im, Hyeyeong Kim, Su Jin Koh, Young Joo Min, Jae-Cheol Jo, Yunsuk Choi
Summary: This study investigated the serum protein profiles of patients who had undergone hematopoietic cell transplantation (HCT) to identify predictive biomarkers of severe acute graft versus host disease (GVHD). The results showed that higher levels of sVCAM-1 at baseline and on day + 14 could be significant predictive biomarkers of severe aGVHD.
Article
Immunology
Shepherd H. Schurman, Terrance P. O'Hanlon, John A. McGrath, Artiom Gruzdev, Arsun Bektas, Hong Xu, Stavros Garantziotis, Darryl C. Zeldin, Frederick W. Miller
JOURNAL OF AUTOIMMUNITY
(2020)
Editorial Material
Critical Care Medicine
David N. O'Dwyer, Stavros Garantziotis
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Surgery
Samantha E. Halpern, Alec McConnell, Sarah B. Peskoe, Vignesh Raman, Oliver K. Jawitz, Ashley Y. Choi, Megan L. Neely, Scott M. Palmer, Matthew G. Hartwig
Summary: The study found that nonideal but acceptable lung donors are underutilized, and differences in practices among organ procurement organizations (OPOs) also contribute to this trend. Risk aversion varies among different OPOs and impacts donor pursuit, consent attainment, lung recovery, and transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Editorial Material
Surgery
Megan L. Neely, Scott M. Palmer, Laurie D. Snyder
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Editorial Material
Biochemistry & Molecular Biology
Stavros Garantziotis
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Surgery
Haley P. Hostetler, Megan L. Neely, Elizabeth Lydon, Lara A. Danziger-Isakov, Jamie L. Todd, Scott M. Palmer
Summary: The study found that a considerable number of lung transplant candidates had undetectable virus-specific antibody titers, especially for varicella zoster virus and measles. Younger age groups had lower immunity rates. These results highlight the importance of screening for immunity to vaccine-preventable infections in this population and the need for revaccination in selected patients before transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Pharmacology & Pharmacy
Stavros Garantziotis
Summary: The extracellular matrix plays a vital role in maintaining homeostasis and disease development. Recent research has shown the therapeutic potential of targeting hyaluronan, a key component of the extracellular matrix, in treating inflammatory and immune diseases. This review summarizes the current state of the art and explores the challenges and opportunities in developing matrix biologics as a new class of therapeutic agents.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Cynthia L. Green, Brian C. Gulack, Shaf Keshavjee, Lianne G. Singer, Kenneth McCurry, Marie M. Budev, Tammy L. Reece, Anne O. Lidor, Scott M. Palmer, R. Duane Davis
Summary: A multicenter retrospective study found limited benefits of fundoplication for preventing bronchiolitis obliterans syndrome and improving survival compared to reflux disease without surgery after lung transplantation. However, the study had limitations in terms of sample size, follow-up duration, and potential selection bias, highlighting the need for a randomized, prospective study.
ANNALS OF THORACIC SURGERY
(2023)
Article
Virology
Lorenzo Zaffiri, Joshua E. Messinger, Erika J. Bush, Janet S. Staats, Prekshaben Patel, Scott M. Palmer, Kent J. Weinhold, Laurie D. Snyder, Micah A. Luftig
Summary: Reactivation of Epstein-Barr virus (EBV) is often seen in lung transplant recipients (LTRs), but the cellular immune responses to EBV in adult LTRs have not been fully described. In this study, we found significant changes in CD4/CD8 ratio, EBV-specific CD8(+)CD69(+) T cell responses, and NK cell phenotypic changes in adult LTRs with EBV-associated diseases. These findings provide valuable insights into the immune responses to EBV in adult LTRs and may contribute to improved management of EBV-related complications.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Meeting Abstract
Critical Care Medicine
Y. Sakamachi, A. Solis, C. G. Johnson, S. Hussain, D. N. O'Dwyer, S. Mehta, C. Trempus, S. Y. Thomas, P. Karmaus, D. A. Schwartz, N. Kaminski, Y. Zhang, I. V. Yang, P. L. Molyneaux, D. Kass, K. F. Gibson, S. Garantziotis
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
V. Stober, N. Martin, M. Cronce, S. Chen, Y. Sakamachi, S. Gabel, G. Mueller, R. Petrovich, T. Stanley, S. Rowe, S. Garantziotis
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
C. Trempus, B. Papas, X. Xu, C. Bortner, E. Scappini, A. T. Perl, S. Garantziotis
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Hong Li, J. Alyce Bradbury, Matthew L. Edin, Joan P. Graves, Artiom Gruzdev, Jennifer Cheng, Samantha L. Hoopes, Laura M. DeGraff, Michael B. Fessler, Stavros Garantziotis, Shepherd H. Schurman, Darryl C. Zeldin
Summary: EETs have been shown to reduce macrophage activation and phagocytosis of Streptococcus pneumoniae by downregulating TLR2 and PGLYRP1 expression. Ephx2(-/-) mice had impaired lung bacterial clearance and reduced phagocytosis by macrophages.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Respiratory System
Flavia Galdi, Claudio Pedone, Christopher A. McGee, Margaret George, Annette B. Rice, Shah S. Hussain, Kadambari Vijaykumar, Evan R. Boitet, Guillermo J. Tearney, John A. McGrath, Audrey R. Brown, Steven M. Rowe, Raffaele A. Incalzi, Stavros Garantziotis
Summary: Inhaled HMW-HA can shorten the duration of respiratory failure and the need for non-invasive ventilation in patients with AECOPD, with beneficial effects on mucociliary clearance and inflammation.
RESPIRATORY RESEARCH
(2021)