Article
Endocrinology & Metabolism
Muhammad Rahmad Royan, Khadeeja Siddique, Rasoul Nourizadeh-Lillabadi, Finn-Arne Weltzien, Christiaan Henkel, Romain Fontaine
Summary: Using single cell transcriptomics, two distinct prolactin-expressing cell types were discovered in Japanese medaka. Small satellite lactotrope cell clusters were also found in the medaka pituitary, which develop early during development and increase in cell number throughout life. These satellite clusters are not directly related to the stem cell-like lactotropes.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Kavita Ranjeeta Lall, Kegan Romelle Jones, Gary Wayne Garcia
Summary: This literature review focuses on reproductive technologies used in female neo-tropical hystricomorphic rodents. These technologies are crucial for efficient reproduction as these species are hunted and valued for their meat. Similar characteristics and unique features of different rodent species are highlighted, and reproductive technologies such as colpocytology, ultrasonography, and hormonal analysis have been utilized. However, there is still a lack of comprehensive information in this field despite some attempts at estrous induction and synchronization.
Article
Agriculture, Dairy & Animal Science
A. -m. Deacon, R. Blouin, C. Thibault, P. Lacasse
Summary: This study investigated the effect of incomplete milking on mammary gland activity and responsiveness to prolactin. The results showed that incomplete milking reduced milk yield, decreased mammary epithelial cell activity and number, and impaired the response to blood prolactin.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Marianna Zanatelli, Simone Jacovaci Colleta, Luiz Henrique Alves Guerra, Fernanda Cristina Alcantara Santos, Rejane Maira Goes, Patricia Simone Leite Vilamaior, Sebastiao Roberto Taboga
Summary: The study reveals that prolactin has a strong influence on prostate morphology, acting in synergy with androgens in males and mainly with estrogens in females to sustain prostate cell activity. It also demonstrates that prolactin can assist in recovering from atrophic effects caused by castration.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Oncology
Laia Cuesta-Casanovas, Jennifer Delgado-Martinez, Josep M. Cornet-Masana, Jose M. Carbo, Antonia Banus-Mulet, Francesca Guijarro, Jordi Esteve, Ruth M. Risueno
Summary: The upregulation of prolactin receptor (PRLR) in acute myeloid leukemia (AML) patients is associated with resistance to the anti-cancer drug cytarabine. The findings suggest that PRLR could be a therapeutic target for AML, and the development of specific PRLR inhibitors could be a potential treatment strategy.
CANCER CELL INTERNATIONAL
(2023)
Article
Toxicology
Yongzhen Liu, Xiang He, Yuli Wang, Houzu Zhou, Yuan Zhang, Jianyun Ma, Zhaochu Wang, Fangfang Yang, Henglei Lu, Yifu Yang, Zhongping Deng, Xinming Qi, Likun Gong, Jin Ren
Summary: This study found that Aristolochic acid I (AAI) impairs Spermatogonial Stem Cells (SSCs) during the early stages of spermatogenesis, leading to testicular impairment. This damage to SSCs may be caused by apoptosis and autophagy, highlighting the potential risks of botanical products containing trace amounts of AAI.
TOXICOLOGY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Eleni C. R. Hackwell, Sharon R. Ladyman, Rosemary S. E. Brown, David R. Grattan
Summary: Lactation in mice is associated with infertility, which is mainly mediated by lactational anestrus characterized by reduced LH secretion and lack of ovulation. Prolactin plays a key role in mediating anestrus during early lactation, even in the absence of suckling stimulus. Pharmacological suppression of prolactin can reduce the period of lactational infertility.
Article
Endocrinology & Metabolism
Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo
Summary: This study found that supplementation with androgens affects the characteristics of KNDy neurons, increasing kisspeptin and NKB levels and decreasing DynA levels. These changes may lead to dysfunction of the hypothalamic-pituitary-gonadal axis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Moe Watanabe, Caroline M. Kopruszinski, Aubin Moutal, Daigo Ikegami, Rajesh Khanna, Yanxia Chen, Sarah Ross, Kimberly Mackenzie, Jennifer Stratton, David W. Dodick, Edita Navratilova, Frank Porreca
Summary: This study reveals the mechanism of stress-induced migraine by activating KOR in the hypothalamus, increasing circulating prolactin, and sensitizing prolactin receptors in the trigeminal nerve. This sexually dimorphic mechanism helps explain the higher prevalence of migraine in females.
Article
Biochemistry & Molecular Biology
Nolwenn Adam, Sakina Mhaouty-Kodja
Summary: Phthalates have been shown to have reproductive toxic effects in male rodents, and can also impact the female rodent brain. Research indicates that exposure to phthalates may affect behaviors in female rodents, highlighting the need for further investigation to assess the potential risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Joelle Lopez, Rosemary C. Bagot
Summary: Women are twice as likely to experience depression than men, but previous studies have predominantly focused on male rodents. As interest in sex differences grows, new chronic stress models are being applied to female rodents, though not all have been systematically validated.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Anagha M. Kaluve, Jenny T. Le, Bronwyn M. Graham
Summary: Recent meta-analyses have shown that female rodents do not have greater variability than males across various traits. Despite anxiety disorders being more prevalent in women, male-only samples are still widely used in preclinical studies. This study found no evidence for increased variability in females compared to males. Staged females showed lower variability compared to unstaged females.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Endocrinology & Metabolism
Josephine F. Trott, Anke Schennink, Katherine C. Horigan, Danielle G. Lemay, Julia R. Cohen, Thomas R. Famula, Julie A. Dragon, Russell C. Hovey
Summary: This study found that ovarian steroids and pituitary-derived prolactin play important regulatory roles in the growth and differentiation of the mammary gland in pigs. Estrogen affects mitosis and gene expression, while prolactin is associated with fatty acid metabolism and inflammatory response. The findings provide insights into the connection between the hormone-regulated genome and phenome of the mammary gland, and shed light on the synergistic actions of estrogen and prolactin during mammary gland development.
Article
Multidisciplinary Sciences
Tuomas Eerola, Jonna K. Vuoskoski, Hannu Kautiainen, Henna-Riikka Peltola, Vesa Putkinen, Katharina Schafer
Summary: In the high empathy group, levels of PRL and OT were significantly lower with music compared to no music. Individuals with high empathy reported an increase in positive mood and higher levels of being moved by the music compared to the low empathy group.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nair C. F. Castro, Izabelle S. Silva, Sabrina C. Cartagenes, Luanna M. P. Fernandes, Paula C. Ribera, Mayara A. Barros, Rui D. Prediger, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: This study evaluated the long-lasting neurobehavioral and nociceptive consequences in adult rats and mice exposed to morphine during pregnancy and lactation periods. The results showed that both male and female rats exhibited anxiety- and depressive-like behaviors, while mice displayed alterations in nociceptive responses. These findings suggest that intrauterine and lactation exposure to morphine can have long-lasting effects on psychological and pain responses in adulthood.
Article
Neurosciences
Carolina Thorn Perez, Jimena Ferraris, Josina Anna van Lunteren, Arash Hellysaz, Maria Jesus Iglesias, Christian Broberger
JOURNAL OF NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Santiago Jordi Orrillo, Nataly de Dios, Antonela Sofia Asad, Fernanda De Fino, Mercedes Imsen, Ana Clara Romero, Sandra Zarate, Jimena Ferraris, Daniel Pisera
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Candler Paige, Priscilla A. Barba-Escobedo, Jennifer Mecklenburg, Mayur Patil, Vincent Goffin, David R. Grattan, Gregory Dussor, Armen N. Akopian, Theodore J. Price
JOURNAL OF NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Virginie Grouthier, Zeina Chakhtoura, Isabelle Tejedor, Yasmina Badachi, Vincent Goffin, Philippe Touraine
ENDOCRINE CONNECTIONS
(2020)
Article
Clinical Neurology
Amanda Avona, Bianca N. Mason, Carolina Burgos-Vega, Anahit H. Hovhannisyan, Sergei N. Belugin, Jennifer Mecklenburg, Vincent Goffin, Naureen Wajahat, Theodore J. Price, Armen N. Akopian, Gregory Dussor
Summary: This study found an interaction between prolactin and CGRP in the meninges of rodents, leading to female-specific migraine behaviors, potentially explaining the higher prevalence of migraines in women.
ANNALS OF NEUROLOGY
(2021)
Article
Developmental Biology
Carolina Marvaldi, Daniel Martin, Julia G. Conte, Maria Florencia Gottardo, Matias L. Pidre, Mercedes Imsen, Martin Irizarri, Sharron L. Manuel, Francesca E. Duncan, Victor Romanowski, Adriana Seilicovich, Gabriela Jaita
Summary: Humanin (HN) is a short peptide involved in various biological processes such as apoptosis, cell survival, inflammatory response, and stress response. The study found that HN plays a cytoprotective role in granulosa cells in antral follicles and may be involved in folliculogenesis regulation in the ovary. Additionally, HN also acts as a cytoprotective factor in KGN cells, suggesting its potential role in granulosa tumor cell behavior.
Article
Multidisciplinary Sciences
Nicolas Barry Delongchamps, Alexandre Schull, Julien Anract, Jean-Paul Abecassis, Marc Zerbib, Mathilde Sibony, Lea Jilet, Hendy Abdoul, Vincent Goffin, Michael Peyromaure
Summary: This study evaluated the feasibility, safety, and precision of OBT-fusion targeted FMA in patients with low to intermediate risk prostate cancer. The results showed that this method achieved good ablation outcomes in the majority of patients, with no significant deterioration in urinary and sexual function post-operatively.
Article
Biochemistry & Molecular Biology
Anju Dwivedi, Chiranjeevi Padala, Anita Kumari, Saratchandra Singh Khumukcham, Vasudevarao Penugurti, Sinjini Ghosh, Aprotim Mazumder, Vincent Goffin, Bramanandam Manavathi
Summary: This study identified HPIP as a critical regulator of PRL signaling in lactogenic differentiation of mammary epithelial cells, involving multiple pathways such as PI3K/AKT and miR-148a, which control the differentiation process.
Review
Urology & Nephrology
Manon Baures, Charles Dariane, Elisavet Tika, Emilia Puig Lombardi, Nicolas Barry Delongchamps, Cedric Blanpain, Jacques-Emmanuel Guidotti, Vincent Goffin
Summary: This review paper summarizes various approaches used to characterize luminal progenitor cells in the prostate and discusses their functional properties and potential role in prostate pathology. The authors also describe different methods and identifiers used to classify these cells.
NATURE REVIEWS UROLOGY
(2022)
Article
Immunology
Jennifer Mecklenburg, Andi Wangzhou, Anahit H. Hovhannisyan, Priscilla Barba-Escobedo, Sergey A. Shein, Yi Zou, Korri Weldon, Zhao Lai, Vincent Goffin, Gregory Dussor, Alexei Tumanov, Theodore J. Price, Armen N. Akopian
Summary: This study developed pain models with sex-dependent resolution trajectories and identified factors associated with the resolution of pain in males and females. The results showed that different treatment protocols with prolactin (PRL) can lead to distinct pain development and resolution patterns, with acute PRL-evoked pain fully resolved within one day and prolonged high dose PRL treatment causing mechanical hypersensitivity that resolves within 5-7 days. Furthermore, pro-inflammatory responses in the hindpaws, particularly with macrophages/monocytes, were observed during pain resolution in both sexes.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Oncology
Charles Dariane, Sylvie Clairefond, Benjamin Peant, Laudine Communal, Zhe Thian, Veronique Ouellet, Dominique Trudel, Nazim Benzerdjeb, Feryel Azzi, Arnaud Mejean, Marc-Olivier Timsit, Manon Baures, Jacques-Emmanuel Guidotti, Vincent Goffin, Pierre I. Karakiewicz, Anne-Marie Mes-Masson, Fred Saad
Summary: Keratin-7 overexpression is associated with poor prognosis in several cancers, and its high expression in benign glands surrounding localized prostate tumors is correlated with shorter bone metastasis-free survival and increased risk of cancer-specific mortality. In prostate cancer patients, high Keratin-7 expression is significantly associated with hypertrophic basal cell phenotype.
Article
Oncology
Manon Baures, Emilia Puig Lombardi, Delphine Di Martino, Wail Zeitouni, Emeline Pacreau, Leila Dos Santos, Charles Dariane, Florence Boutillon, Jacques-Emmanuel Guidotti, Vincent Goffin
Summary: The study identified LSCmed cells as matching human prostate Club/Hillock cells, regulated by EGFR/ERBB4, IGF-1 and MET pathways, and exhibiting drug resistance. These cells are considered a relevant preclinical model for investigating the cellular and molecular mechanisms driving CRPC.
Article
Oncology
Maite Verreault, Irma Segoviano Vilchis, Shai Rosenberg, Nolwenn Lemaire, Charlotte Schmitt, Jeremy Guehennec, Louis Royer-Perron, Jean-Leon Thomas, TuKiet T. Lam, Florent Dingli, Damarys Loew, Francois Ducray, Sophie Paris, Catherine Carpentier, Yannick Marie, Florence Laigle-Donadey, Audrey Rousseau, Natascha Pigat, Florence Boutillon, Franck Bielle, Karima Mokhtari, Stuart J. Frank, Aurelien de Reynies, Khe Hoang-Xuan, Marc Sanson, Vincent Goffin, Ahmed Idbaih
Summary: This study identifies a distinct molecular subset of GBMs that is characterized by GHR signaling instead of EGFR overexpression. GHR signaling promotes tumorigenesis and regulates cell proliferation and migration, providing a new direction for improving the prognosis of GBM patients.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Meeting Abstract
Oncology
Laura Cheradame, Ida Chiara Guerrera, Julie Gaston, Alain Schmitt, Vincent Jung, Marion Pouillard, Nina Radosevic-Robin, Mauro Modesti, Jean-Gabriel Judde, Vincent Goffin, Stefano Cairo
Meeting Abstract
Oncology
Laura Cheradame, Chiara Guerrera, Jean-Gabriel Judde, Vincent Goffin, Stefano Cairo