Article
Plant Sciences
Xuanqing Chen, Tingting Xu, Xiangyu Lv, Jingwei Zhang, Shijia Liu
Summary: The study found that Rh2 exhibits potential application value in the treatment of ulcerative colitis (UC), and its mechanism is related to the downregulation of STAT3/miR-214 levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Guan-Nan He, Na-Ren Bao, Shuang Wang, Man Xi, Tian-Hao Zhang, Feng-Shou Chen
Summary: Ketamine was found to suppress liver cancer cell proliferation and induce ferroptosis, potentially through regulating the lncPVT1/miR-214-3p/GPX4 axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Xianqing Li, Shunlin Ouyang
Summary: This study found that lncAMPC is overexpressed in nasopharyngeal carcinoma (NPC) and can promote cell proliferation by upregulating miR-214 and indirectly downregulating PTEN.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Neurosciences
Yan Shi, Tian Tian, Er-Li Cai, Can Yang, Xin Yang
Summary: The study demonstrates the involvement of the miR-124/DAPK1 pathway in ischemic neuronal death. Upregulation of miR-124 levels significantly improves stroke damage, highlighting the therapeutic potential of targeting this pathway for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Zhenzhen Sang, Shimin Dong, Pu Zhang, Yunxia Wei
Summary: The study demonstrated that miR-214 alleviated AKI in septic mice by inhibiting kidney autophagy levels. miR-214 further inhibited autophagy by silencing PTEN expression in the kidney tissues of septic mice. These results suggest that miR-214 ameliorated CLP-induced AKI by reducing oxidative stress and inhibiting autophagy through the regulation of the PTEN/AKT/mTOR pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Liang Cao, Haifeng Jiang, Jing Yang, Jun Mao, Guofeng Wei, Xiangyun Meng, Hongmei Zang
Summary: Our study demonstrates that tocilizumab suppresses RA-FLS inflammation by regulating the MIR31HG-miR-214-PTEN-AKT pathway, affecting cell proliferation, migration, and the production of inflammatory molecules and matrix metalloproteinases (MMPs), presenting new insights on RA pathogenesis and potential targets for RA therapy.
Article
Biochemistry & Molecular Biology
Yan Li, Ming Xia, Liang Peng, Haiyang Liu, Guochun Chen, Chang Wang, Du Yuan, Yu Liu, Hong Liu
Summary: The study revealed that miR-214-3p accelerates mesangial cell proliferation in IgAN by directly targeting PTEN to modulate JNK/c-Jun signaling, suggesting that it may represent a novel therapeutic target for IgAN.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Reem Sabry, Makenna Williams, Nicholas Werry, Jonathan LaMarre, Laura A. Favetta
Summary: This study investigates the regulation of miR-21 in bovine granulosa cells and its potential mechanisms. The research shows that miR-21 has anti-apoptotic effects and explains its impact on specific apoptotic targets. Additionally, the study confirms the influence of BPA on miR-21 expression and explores the temporal effects of BPA on miR-21 regulation. Furthermore, the research reveals that BPA induces upregulation of miR-21 expression by modulating upstream regulators. Overall, this study enhances our understanding of the function of miR-21 in granulosa cells and the mechanisms underlying BPA-induced reproductive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Naijun Yuan, Xiaojuan Li, Kairui Tang, Hua Gan, Xiaoli Da, Wenzhi Hao, Lijuan Deng, Junqing Huang, Qingyu Ma, Mansi Wu, Jiaxu Chen
Summary: This study found that Xiaoyaosan (XYS) can reduce neuronal apoptosis and stress-related behaviors by inhibiting the expression of miR-200a/b-3p induced by chronic unpredictable mild stress (CUMS), and regulating the miR-200a/b-3p/NR3C1 signaling pathway in the prefrontal cortex (PFC).
Article
Biochemistry & Molecular Biology
Maria Asuncion Barreda-Manso, Altea Soto, Teresa Munoz-Galdeano, David Reigada, Manuel Nieto-Diaz, Rodrigo M. Maza
Summary: During neuronal maturation, the expression of miR-138-5p and its target caspase3 play a crucial role in modulating apoptosis and promoting neuronal survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Junkui Xu, Yanjiang Pei, Jun Lu, Xiaojun Liang, Yi Li, Junhu Wang, Yingang Zhang
Summary: The study revealed that SNHG7 was downregulated in OA while miR-214-5p was upregulated. SNHG7 enhanced cell viability and suppressed apoptosis and inflammation, whereas upregulation of miR-214-5p had opposite effects on chondrocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xia Lv, Xiang-Yan Zhang, Qian Zhang, Ying-Jie Nie, Guang-Heng Luo, Xia Fan, Song Yang, Qing-Hua Zhao, Jian-Quan Li
Summary: The study reveals that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
LABORATORY INVESTIGATION
(2021)
Article
Environmental Sciences
Huifang Zhang, Xiaoya Cai, Changxin Xiang, Yingchao Han, Qiao Niu
Summary: Aluminum exposure can lead to neurotoxic injuries, including structural and functional damage to neurons and eventually neuronal death. miR-29a plays a crucial role in Al-induced neuronal damage by regulating the PTEN-GSK3 beta signaling pathway. Up-regulation of miR-29a can reverse the negative effects of Al on neuronal electrical activity and neurite outgrowth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pathology
Feng Huang, Yuan Xiang, Ting Li, You Huang, Jun Wang, Hui-Min Zhang, Han-Han Li, Zhou-Tong Dai, Jia-Peng Li, Hui Li, Jun Zhou, Xing-Hua Liao
Summary: Metformin has been found to inhibit proliferation and induce apoptosis in gastric cancer cells by modulating the AMPK signaling pathway. Additionally, it synergistically promotes cancer cell apoptosis with miR-365 through the miR-365-PTEN-AMPK axis. This study reveals a novel signaling pathway in gastric cancer regulation and highlights the potential therapeutic application of metformin in the future.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Medicine, Research & Experimental
Fei Peng, Maohua Wang, Huihuang Yang, Xiaoli Yang, Menghong Long
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Neurosciences
Lu Wang, Menghong Long, Maohua Wang, Shuangchun Peng, Guangxiang Chen, Jun Zhou, Cehua Ou
Article
Cardiac & Cardiovascular Systems
Jiali Wu, Xiangdong Liu, Maohua Wang, Xiaobin Wang, De Luo, Song Su
INTERNATIONAL HEART JOURNAL
(2020)
Article
Surgery
Mao-Hua Wang, Dong-Sheng Zhang, Wei Zhou, Shun-Ping Tian, Tian-Qi Zhou, Wei Sui, Zhuan Zhang
Summary: The study demonstrated that peak inspiratory pressure (PIP)-guided intracuff pressure (ICP) modulation during the use of LMA Supreme TM can effectively seal the airway at lower cuff volume and pressure, and result in fewer postoperative pharyngolaryngeal complications in patients undergoing laparoscopic cholecystectomy.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Review
Neurosciences
Yu Tang, Maohua Wang, Ting Zheng, Yan Xiao, Song Wang, Fugang Han, Guangxiang Chen
Summary: Neuroimaging studies have shown that postherpetic neuralgia (PHN) is closely associated with structural and functional abnormalities in the brain, particularly affecting regions like the thalamus and insula within the pain matrix. Disruption of multiple networks, including the default-mode network and limbic system, may contribute to the neurophysiological mechanisms underlying PHN.
Article
Surgery
Jianguo Feng, Wei Pan, Xiaoli Yang, Feiyu Long, Jun Zhou, Yi Liao, Maohua Wang
Summary: RBM3 acts as a double-edged sword in acute lung injury (ALI) by alleviating cell apoptosis through NF-KB signaling pathway modulation, while also increasing cell permeability, leading to pulmonary edema.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Neurosciences
Yu Tang, Changhe Ren, Maohua Wang, Guidong Dai, Yan Xiao, Song Wang, Fugang Han, Guangxiang Chen
Summary: Neuroimaging studies have shown abnormalities in brain structure and function in patients with postherpetic neuralgia (PHN) and herpes zoster (HZ). This study found significant differences in gray matter volume and functional connectivity in the transition from HZ to PHN, particularly in the right putamen. These changes are closely associated with chronic pain and may provide new insights into the pathophysiology of PHN.
Review
Cardiac & Cardiovascular Systems
Hu Zhenyu, Yuan Qiaoli, Chen Guangxiang, Wang Maohua
Summary: This study evaluated the effect of urinary trypsin inhibitor (UTI) on patients undergoing cardiopulmonary bypass. The results showed that continuous or moderate use of UTI can shorten the length of stay in the intensive care unit (ICU LOS) and mechanical ventilation duration (MVD). However, the impact on hospital length of stay, renal failure incidence (RFI), and all-cause mortality rate was inconclusive.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Immunology
Xiao Liu, Bo Yang, Ya-Fang Tan, Jian-Guo Feng, Jing Jia, Cheng-Jie Yang, Ye Chen, Mao-Hua Wang, Jun Zhou
Summary: This study investigated the role of the AMPK-Sirt1-autophagy pathway in intestinal injury and found that propofol can reduce intestinal injury and improve the prognosis by activating this pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Lan Feng, Yuhao Wang, Daojun Zeng, Maohua Wang, Xiaoxia Duan
Summary: To evaluate the effect of overall peripheral inflammatory levels on cognitive function, this study reviewed and summarized observational studies on the relationship between biomarkers of peripheral inflammation (CRP, IL-6, and TNF-alpha) and cognitive decline. The results showed that individuals with high levels of peripheral inflammation had a 14% higher risk of subsequent cognitive decline. This study further demonstrates the link between systemic inflammation and cognitive status.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Cell Biology
Feiyu Long, Liren Hu, Yingxu Chen, Xiaoxia Duan, Keliang Xie, Jianguo Feng, Maohua Wang
Summary: This study found that RBM3 was overexpressed in sepsis patients and LPS-induced mice, and its deficiency aggravates sepsis-associated acute lung injury through the NF-kappa B/NLRP3 pathway.
INFLAMMATION RESEARCH
(2023)
Review
Clinical Neurology
Li Wang, Zhi Feng, Ting Zheng, Guidong Dai, Maohua Wang, Li Zhou, Yurong Zheng, Guangxiang Chen
Summary: Previous studies have shown that an imbalance in the kynurenine (KYN) pathway is an important mechanism of depression. However, the evidence regarding the association between the KYN pathway and brain abnormalities in depression has been inconsistent. This review systematically reviewed 22 neuroimaging studies and found that an imbalance in the KYN pathway is associated with structural and functional abnormalities in various brain regions of patients with major depressive disorder (MDD).
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Oncology
Yang Li, Maohua Wang, Siyuan Yang, Licheng Kuang, Xinling Tao, Jilan Yang, Wentao Zhao, Ji Zhang
Summary: Previous studies have shown that intratumoral heterogeneity (ITH) is associated with poor clinical outcomes in breast cancer patients. Individuals with low ITH scores have longer overall survival and enhanced immune responses.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Pediatrics
Xiaoli Yang, Zhenyu Hu, Fei Peng, Guangxiang Chen, Yu Zhou, Qiange Yang, Xiaoling Yang, Maohua Wang
FRONTIERS IN PEDIATRICS
(2020)
Article
Multidisciplinary Sciences
Fei Peng, Tao Peng, Qiange Yang, Meihan Liu, Guangxiang Chen, Maohua Wang
SCIENTIFIC REPORTS
(2020)