Article
Nutrition & Dietetics
Jinru Pan, Xiao Xu, Zi Wang, Tiantian Ma, Jie Dong
Summary: This study found that dietary potassium intake was not independently associated with all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients. Initially, unadjusted analyses showed that patients with lower dietary potassium intake had higher mortality rates. However, after adjusting for demographic and laboratory data, this association weakened and even disappeared.
Article
Urology & Nephrology
Miho Murashima, Naohiko Fujii, Shunsuke Goto, Takeshi Hasegawa, Masanori Abe, Norio Hanafusa, Masafumi Fukagawa, Takayuki Hamano
Summary: This study aimed to evaluate the associations between calcium, phosphate, and intact parathyroid hormone (iPTH) levels and outcomes in peritoneal dialysis (PD) patients. The results showed that higher levels of calcium and phosphate were associated with higher mortality, while lower levels of calcium and phosphate were associated with faster decline in urine output and lower incidence of transition to hemodialysis.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Seoyon Koh, Seung-Jung Kim, Shina Lee
Summary: This study investigated the effects of chronic fluid overload on the microcirculation and macrocirculation in peritoneal dialysis patients. The results showed a significant association between central pulse pressure and microvascular endothelial function, indicating a connection between macrocirculation and microcirculation. However, there is a lack of conclusive evidence regarding fluid overload as a mediator between these circulatory systems.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Hongyu Li, Yating Wang, Yiping Xu, Kefei Wu, Xiaohui Lu, Yagui Qiu, Xiao Yang, Qinghua Liu, Haiping Mao
Summary: This study found that lower serum chloride levels were associated with increased all-cause and cardiovascular disease mortality in continuous ambulatory peritoneal dialysis (CAPD) patients, especially in patients over the age of 50 or with a history of diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Yaling Zhang, Lulu Jing, Xiao Xu, Tiantian Ma, Jie Dong
Summary: This study aimed to investigate the association between dietary fatty acid intake and all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients. The results showed that time-averaged intake of polyunsaturated fatty acids (PUFA) was associated with a lower risk of all-cause mortality, while a higher ratio of monounsaturated fatty acids (MUFA) to PUFA and a higher ratio of omega-6 to omega-3 fatty acids were associated with an increased risk of all-cause mortality.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Marko Baralic, Dragana Robajac, Ana Penezic, Voin Brkovic, Nikola Gligorijevic, Ana Bontic, Jelena Pavlovic, Jelena Nikolic, Goran Miljus, Zorana Dobrijevic, Milos Sunderic, Lucia Pazitna, Jaroslav Katrlik, Olgica Nedic, Mirjana Lausevic
Summary: In previous publications, it was found that mannosylation of fibrinogen and fucosylation can predict cardiovascular complications and peritoneal membrane dysfunction in PD patients. In this study, after a 30-month follow-up period during the COVID-19 pandemic, it was demonstrated that calcitriol therapy and diabetes mellitus were potential predictors of mortality in PD patients, with diabetes mellitus being the strongest predictor. Calcitriol therapy significantly reduced mortality in these patients. This study also suggests that aberrant fibrinogen glycosylation may contribute to thrombogenic events observed in PD patients during the pandemic.
Article
Urology & Nephrology
Yiping Xu, Zhong Zhong, Yi Li, Zhijian Li, Yi Zhou, Zhibin Li, Haiping Mao
Summary: The study investigated the effects of baseline fasting plasma glucose (FPG) and its interaction with lipid profiles on all-cause and cardiovascular disease (CVD) cause-specific mortality in peritoneal dialysis (PD) patients. The results showed a significant interaction between baseline FPG and low-density lipoprotein cholesterol (LDL-C) on all-cause mortality, with higher FPG levels (>= 7.0 mmol/L) significantly associated with an increased risk of all-cause mortality for PD patients with LDL-C >= 3.37 mmol/L.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Xiaoran Feng, Xiaojiang Zhan, Yueqiang Wen, FenFen Peng, Xiaoyang Wang, Niansong Wang, Xianfeng Wu, Junnan Wu
Summary: This study examined the relationship between hyperlipidemia and mortality in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The results showed that patients with hyperlipidemia at the beginning of CAPD had a higher risk of long-term mortality, and this association may be mediated by hypertension. Therefore, long-term lipid-lowering treatment should be used in patients with hyperlipidemia.
Article
Urology & Nephrology
Fang-Yu Wang, Zhuan Cui, Chun-yan Su, Tao Wang, Wen Tang
Summary: This study found that anorexia was the most common predialysis symptom in PD patients, followed by insomnia, fatigue, syndromes of heart failure, and nausea. Nausea was the only symptom significantly associated with both short-term and long-term mortality on PD, while anorexia was significantly associated with overall mortality in the long-term. The findings suggest that evaluation and management of symptoms such as nausea and anorexia before dialysis may improve patient outcomes on PD.
Article
Cell Biology
Guansen Huang, Yi Wang, Yingfeng Shi, Xiaoyan Ma, Min Tao, Xiujuan Zang, Yinghui Qi, Cheng Qiao, Lin Du, Lili Sheng, Shougang Zhuang, Na Liu
Summary: The study found that baseline high peritoneal solute transport rate (PSTR) is a significant risk factor for technique failure in peritoneal dialysis (PD) patients, while baseline hyperuricemia was an independent predictor of mortality. In vitro experiments revealed that hyperuricemia induces epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells, which could contribute to poor outcomes in PD patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Hyung Seok Lee, Hye-Mi Noh, Jung Nam An, Young Rim Song, Sung Gyun Kim, Jwa-Kyung Kim
Summary: Obesity is common in PD patients, leading to high serum ferritin levels. Increased adiposity is associated with higher ferritin levels and mortality in PD patients.
Article
Cardiac & Cardiovascular Systems
Dan Luo, Zhong Zhong, Yagui Qiu, Yating Wang, Hongyu Li, Jianxiong Lin, Wei Chen, Xiao Yang, Haiping Mao
Summary: The study showed that iron deficiency or high iron status was associated with mortality in peritoneal dialysis patients, with high iron status patients having a significantly increased risk of all-cause and cardiovascular mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Marko Baralic, Ivan Spasojevic, Goran Miljus, Milos Sunderic, Dragana Robajac, Zorana Dobrijevic, Nikola Gligorijevic, Olgica Nedic, Ana Penezic
Summary: This study aims to investigate the changes in the antioxidative capacity of HSA and Cu(II) binding affinity in peritoneal dialysis patients. The findings suggest that ESRD patients have modified HSA molecules with reduced antioxidant capacity and impaired Cu(II) binding capacity, which exacerbates oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Hematology
Xiyu Song, Yang Zha, Jing Liu, Peng He, Lijie He
Summary: This review summarizes the association of common and novel liver function parameters with clinical outcomes in peritoneal dialysis (PD) patients by integrating the latest research, contributing to a better understanding of potential risk factors and helping to develop strategies for preventing disease progression.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Urology & Nephrology
Miho Murashima, Takayuki Hamano, Masanori Abe, Ikuto Masakane
Summary: This study found that the combination therapy of PD and once-weekly hemodialysis is associated with lower infection-related mortality but not with a lower incidence of EPS in the short term. Patients on combination therapy had a decreasing D/P Cr ratio over time, while those on PD alone had an increasing ratio.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)