Osteopontin Deletion Prevents the Development of Obesity and Hepatic Steatosis via Impaired Adipose Tissue Matrix Remodeling and Reduced Inflammation and Fibrosis in Adipose Tissue and Liver in Mice

Fibrosis and Adipose Tissue Dysfunction

(2013) Kai Sun et al.   Cell Metabolism

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis

(2013) Oriol Morales-Ibanez et al.   HEPATOLOGY

CD44 Plays a Critical Role in Regulating Diet-Induced Adipose Inflammation, Hepatic Steatosis, and Insulin Resistance

(2013) Hong Soon Kang et al.   PLoS One

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

(2013) M. Aouadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Peripheral signalling involved in energy homeostasis control

(2012) Andoni Lancha et al.   NUTRITION RESEARCH REVIEWS

Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance

(2012) Sara Becerril et al.   PHYSIOLOGICAL GENOMICS

Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

(2012) Neira Sáinz et al.   PLoS One

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes

(2012) K. Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice

(2011) F. W. Kiefer et al.   DIABETOLOGIA

Osteopontin Is an Activator of Human Adipose Tissue Macrophages and Directly Affects Adipocyte Function

(2011) Maximilian Zeyda et al.   ENDOCRINOLOGY

Matrix metalloproteinases in metabolic syndrome

(2011) E. Hopps et al.   European Journal of Internal Medicine

Osteopontin in macrophage function

(2011) Susan R. Rittling   EXPERT REVIEWS IN MOLECULAR MEDICINE

Insulin- and Leptin-Mediated Control of Aquaglyceroporins in Human Adipocytes and Hepatocytes Is Mediated via the PI3K/Akt/mTOR Signaling Cascade

(2011) Amaia Rodríguez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation

(2011) Erawan Borkham-Kamphorst et al.   LIVER INTERNATIONAL

A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells

(2010) Hao Liu et al.   CANCER LETTERS

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

(2010) C. Duval et al.   DIABETES

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

(2010) I. K.M. Law et al.   DIABETES

Neutralization of Osteopontin Inhibits Obesity-Induced Inflammation and Insulin Resistance

(2010) F. W. Kiefer et al.   DIABETES

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Regulation of matrix metalloproteinase activity in health and disease

(2010) Elin Hadler-Olsen et al.   FEBS Journal

Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis

(2010) Lisa Lo et al.   JOURNAL OF HEPATOLOGY

Body-Mass Index and Mortality among 1.46 Million White Adults

(2010) Amy Berrington de Gonzalez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteopontin Is Required for the Early Onset of High Fat Diet-Induced Insulin Resistance in Mice

(2010) Justin Chapman et al.   PLoS One

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion

(2010) Dimitra Bourboulia et al.   SEMINARS IN CANCER BIOLOGY

Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes

(2009) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

(2009) V. Catalán et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

(2009) Neira Sáinz et al.   PLoS One

BAT: a new target for human obesity?

(2009) Gema Frühbeck et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity

(2008) A. Bertola et al.   DIABETES

Relationship between plasma osteopontin and oxidative stress in patients with coronary artery disease

(2008) P Georgiadou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

The Bone-Adipose Axis in Obesity and Weight Loss

(2008) J. Gómez-Ambrosi et al.   OBESITY SURGERY

Osteopontin Expression in Human and Murine Obesity: Extensive Local Up-Regulation in Adipose Tissue but Minimal Systemic Alterations

(2007) Florian W. Kiefer et al.   ENDOCRINOLOGY