Article
Cardiac & Cardiovascular Systems
Anne Gulbech Ording, Peter Bronnum Nielsen, Flemming Skjoth, Thure Filskov Overvad, Simon Noble, Timothy L. Lash, Samuel Zachery Goldhaber, Thomas Decker Christensen, Torben Bjerregaard Larsen, Mette Sogaard
Summary: This study describes the risk of recurrent venous thromboembolism in patients with active cancer and highlights the variations in recurrence risks based on cancer type and patient characteristics.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Hematology
Steve Raoul Noumegni, Vincent Mansourati, Cecile Tromeur, Raphael Le Mao, Clement Hoffmann, Emmanuelle Le Moigne, Bahaa Nasr, Jean-Christophe Gentric, Marie Guegan, Elise Poulhazan, Luc Bressollette, Karine Lacut, Francis Couturaud, Romain Didier
Summary: This study found that risk factors for CVDT after VTE in patients include some traditional cardiovascular risk factors as well as other risk factors related to characteristics of VTE and patients' comorbidities. Specific factors such as age, cancer-associated VTE, unprovoked VTE, tobacco use history, hypertension, chronic heart failure, etc., were associated with the risk of CVDT.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
I. K. Greiber, A. P. Mikkelsen, M. A. Karlsen, L. Storgaard, J. H. Viuff, L. Mellemkjaer, C. S. Hjortshoj, O. Lidegaard
Summary: Pregnant women with cancer have a significantly higher risk of developing VTE compared to those without cancer. This suggests the need for increased vigilance and potential thromboprophylaxis in pregnant women with cancer.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Health Care Sciences & Services
Jung-Hyun Park, Yoonkyung Chang, Jin-Woo Kim, Tae-Jin Song
Summary: This study investigated the association between oral health status, oral hygiene behavior, and venous thromboembolism (VTE). The study found that periodontitis and an increased number of missing teeth were associated with an increased risk of VTE, while tooth brushing frequency ≥3 times/day and dental scaling were associated with a decreased risk of VTE.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Jacob Tonnesen, Jannik Pallisgaard, Peter Vibe Rasmussen, Martin H. Ruwald, Morten Lamberts, Nina Nouhravesh, Jarl Strange, Gunnar Hilmar Gislason, Morten Lock Hansen
Summary: This study aimed to investigate the characteristics of patients with incident gastrointestinal cancers and their associated 1-year risk and timing of venous thromboembolic events and the 1-year mortality. It found that most VTE events happened close to onset of the GI cancer diagnosis, and the thrombogenicity differed by type of GI cancer.
Article
Nutrition & Dietetics
Shuai Yuan, Jie Chen, Tian Fu, Xue Li, Maria Bruzelius, Agneta Akesson, Susanna C. Larsson
Summary: This study aimed to investigate the association between ultra-processed food (UPF) intake and the risk of venous thromboembolism (VTE). After adjusting for covariates, higher UPF intake was moderately associated with an increased risk of VTE compared to the lowest intake quintile.
CLINICAL NUTRITION
(2023)
Article
Hematology
Steve Raoul Noumegni, Romain Didier, Vincent Mansourati, Cecile Tromeur, Emmanuelle Le Moigne, Clement Hoffmann, Bahaa Nasr, Jean-Christophe Gentric, Marie Guegan, Elise Poulhazan, Karine Lacut, Luc Bressollette, Raphael Le Mao, Francis Couturaud
Summary: The risk factors for arterial thrombotic events (ATE) after unprovoked venous thromboembolism (VTE) and cancer-associated VTE remain unclear. This study identified several classic cardiovascular risk factors and the influence of anticoagulant treatment on the risk of ATE after these VTE types.
THROMBOSIS RESEARCH
(2022)
Article
Endocrinology & Metabolism
Alon Peled, Itay Nitzan, Jacob Megreli, Estela Derazne, Dorit Tzur, Orit Pinhas-Hamiel, Arnon Afek, Gilad Twig
Summary: This study found an association between adolescent BMI and myopia severity, showing a J-shaped pattern. The results indicate that both low and high BMI are associated with mild-to-moderate and severe myopia, with a stronger association in men compared to women.
Article
Surgery
Qi Wei, Zheng-Qiang Wei, Chang-Qing Jing, Yong-Xiang Li, Dong-Bing Zhou, Mou-Bin Lin, Xian-Li He, Fan Li, Qian Liu, Jian-Yong Zheng, Gui-Ying Wang, Shi-Liang Tu, Zhen-Jun Wang, Ang Li, Gang Xiao, Jing Zhuang, Lian Bai, He Huang, Yong Li, Wu Song, Zhong-Lin Liang, Zhan-Long Shen, Fan-Long Liu, Yong Dai, Xiao-Jun Zhou, Ming Dong, Hui Wang, Jian Qiu, Lei Zhou, Xin-Xiang Li, Zi-Qiang Wang, Hong Zhang, Quan Wang, Ming-Hui Pang, Hong-Bo Wei, Zhi-Qian Hu, Yi-Dan Yan, Yan Che, Zhi-Chun Gu, Hong-Wei Yao, Zhong-Tao Zhang, CRC VTE Investigators
Summary: This study investigated the incidence and prevention of VTE in Chinese patients after CRC surgery and identified risk factors for developing VTE. A new scoring system was proposed for clinical decision-making and care planning. It provides important guidance for VTE prevention in patients after CRC surgery.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Paul A. Kyrle, Lisbeth Eischer, Hana Sinkovec, Paul Gressenberger, Thomas Gary, Marianne Brodmann, Georg Heinze, Sabine Eichinger
Summary: This study evaluated the performance of the VPM in patients with unprovoked VTE, showing a 1-year recurrence rate of 5.2%. Recalibration improved the identification of patients at low recurrence risk and stratified them into distinct low-risk categories.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Milad Nazarzadeh, Zeinab Bidel, Hamid Mohseni, Dexter Canoy, Ana-Catarina Pinho-Gomes, Abdelaali Hassaine, Abbas Dehghan, David-Alexandre Tregouet, Nicholas L. Smith, Kazem Rahimi
Summary: This study found that lower systolic blood pressure was associated with an increased risk of venous thromboembolism (VTE). Two Mendelian randomization analyses further confirmed this association. It is important to cautiously control blood pressure reduction to avoid potential harm in individuals with a predisposition for VTE.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Shangping Zhao, Hong Chen, Xiaoying Shi, Qiling Tan, Bo Gu
Summary: This study investigated the incidence and risk factors of venous thromboembolism (VTE) within 6 months after kidney transplantation, finding that central vena catheterization and severe pulmonary disease were the risk factors for VTE in kidney transplantation recipients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Hematology
Shuai Yuan, Olga E. Titova, Ke Zhang, Wanglong Gou, Tessa Schillemans, Pradeep Natarajan, Jie Chen, Xue Li, Agneta akesson, Maria Bruzelius, Derek Klarin, Scott M. Damrauer, Susanna C. Larsson
Summary: We conducted cohort and Mendelian randomisation analyses to explore the associations between circulating proteins and risk of venous thromboembolism (VTE), with the aim of providing evidence for disease prevention and drug development. The cohort analysis identified 21 proteins significantly associated with VTE risk, while the machine-learning model highlighted the importance of body mass index and von Willebrand factor (vWF) in predicting VTE risk. The Mendelian randomisation analysis revealed causal associations between genetically predicted levels of vWF, SERPINE1, EPHB4, TYRO3, TNFRSF11A, and BOC and VTE risk.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Critical Care Medicine
Ruben J. Eck, Lisa Hulshof, Renske Wiersema, Chris H. L. Thio, Bart Hiemstra, Niels C. Gritters van den Oever, Reinold O. B. Gans, Iwan C. C. van der Horst, Karina Meijer, Frederik Keus
Summary: This study aimed to describe the prevalence, incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients receiving thrombosis prophylaxis. The development of PE-LDVT but not NLDVT was associated with increased mortality. Prognostic factors for developing PE-LDVT or NLDVT despite prophylaxis can be identified at ICU admission.
Article
Transplantation
Kanna Shinkawa, Satomi Yoshida, Tomotsugu Seki, Motoko Yanagita, Koji Kawakami
Summary: The study found that in patients with nephrotic syndrome, female sex, BMI >= 30, acute kidney injury (AKI), sepsis, lupus nephritis, and intravenous corticosteroid use were significantly associated with a higher risk of developing VTE.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Obstetrics & Gynecology
Thomas Bergholt, Finn E. Skjeldestad, Aura Pyykonen, Steen C. Rasmussen, Anna-Maija Tapper, Ragnheidur Bjarnadottir, Alexander Smarason, Birna B. Masdottir, Kari Klungsoyr, Susanne Albrechtsen, Karin Kallen, Mika Gissler, Ellen C. L. Lokkegaard
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Genetics & Heredity
Klaus Rieneck, Frederik Banch Clausen, Thomas Bergholt, Lone Nikoline Norgaard, Morten Hanefeld Dziegiel
Summary: A new method for predicting fetal blood type using NGS technology was developed, with results from 55 consecutive RHCE prenatal analyses showing no discordant results. It was confirmed that the method is reliable and accurate, making it a valuable tool for use in clinical settings.
PRENATAL DIAGNOSIS
(2021)
Review
Hematology
Morten Hanefeld Dziegiel, Grethe Risum Krog, Anne Todsen Hansen, Marianne Olsen, Birgitte Lausen, Lone Nikoline Norgaard, Thomas Bergholt, Klaus Rieneck, Frederik Banch Clausen
Summary: The laboratory monitoring of mother, fetus, and newborn in hemolytic disease of fetus and newborn at Copenhagen University Hospital in Denmark involves screening and testing measures for pregnant women, including Rh typing and antibody screening, with preventive measures such as Rh immunoglobulin for RhD-negative pregnant women.
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2021)
Article
Obstetrics & Gynecology
Mia Noergaard, Per Bo Jensen, Ditte Resendal Gotfredsen, Thomas Bergholt, Jon Traerup Andersen, Line Mathiesen
Summary: The study aimed to estimate maternal-to-fetal transfer clearance of ciprofloxacin and fetal exposure to the drug. Results showed that ciprofloxacin crosses the placenta at a slow, constant rate, indicating moderate fetal exposure, with potential accumulation in the placenta prolonging fetal exposure duration. Further studies are needed to assess fetal safety.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Hematology
Klaus Rieneck, Frederik Banch Clausen, Thomas Bergholt, Lone Nikoline Norgaard, Morten Hanefeld Dziegiel
Summary: This article presents a non-invasive method for predicting fetal K status. By analyzing DNA sequences from maternal plasma, the K status of the fetus can be accurately predicted. This method facilitates early intervention in pregnancies at risk of hemolytic disease of the fetus caused by maternal anti-K IgG antibodies. The research results show that the predicted results are consistent with postnatal serological results.
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Stinne Hogh, Line Thellesen, Thomas Bergholt, Ane Lilleore Rom, Marianne Johansen, Jette Led Sorensen
Summary: The study found that some obstetric events occur extremely rarely, making it difficult to acquire and maintain the clinical skills needed to manage them through clinical practice alone. By assessing the frequency of healthcare professionals attending obstetric emergencies, the study highlights the need for supplementary educational initiatives and interventions to learn and maintain clinical skills.
Review
Obstetrics & Gynecology
Olivia Engholt Mortensen, Sarah Emilie Christensen, Ellen Lokkegaard
Summary: This study reviewed the literature on the use of LASER for genitourinary syndrome of menopause, vulvovaginal atrophy, urinary incontinence, and lichen sclerosus, and discussed the controversies surrounding its efficacy and safety. The review found that the effect of vaginal and vulvar LASER decreases with higher study quality, and emphasized the need for further high-quality evidence to support the use of LASER as a treatment for these conditions.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Betina Ristorp Andersen, Ida Ammitzboll, Jesper Hinrich, Sune Lehmann, Charlotte Vibeke Ringsted, Ellen Christine Leth Lokkegaard, Martin G. Tolsgaard
Summary: This study used machine learning to identify the most important predictors of the arrival-to-delivery interval during emergency caesarean sections (ECS). The results showed that team member qualifications and experience were the most important predictors, followed by ECS indication and maternal objective predictors.
Article
Multidisciplinary Sciences
Klaus Rieneck, Karen Koefoed Rasmussen, Erwin M. Schoof, Frederik Banch Clausen, Henrietta Holze, Thomas Bergholt, Marianne Horby Jorgensen, Vibeke Brix Christensen, Runar Almaas, Peter Luttge Jordal, Marie Locard-Paulet, Kasper Runager, Leif Kofoed Nielsen, Balthasar Clemens Schlotmann, Joachim Lutken Weischenfeldt, Lars Juhl Jensen, Morten Hanefeld Dziegiel
Summary: The prevailing concept suggests that gestational alloimmune liver disease (GALD) is caused by maternal antibodies targeting an unknown antigen on the fetal liver. This study used three different experimental approaches to identify the liver target antigen of maternal antibodies from women with GALD-diagnosed babies, but did not find the GALD target antigen. The results also did not support the hypothesis that the GALD antigen is an alloantigen.
Article
Obstetrics & Gynecology
Jesper Friis Petersen, Lennart Jan Friis-Hansen, Thue Bryndorf, Andreas Kryger Jensen, Anders Nyboe Andersen, Ellen Lokkegaard
Summary: This study aimed to develop a dynamic model using baseline demographic data and collected blood samples and transvaginal sonographies to predict the outcome of pregnancy during the first trimester. The study found that over 1/5 of the women had a higher risk of miscarriage, and detecting fetal heart rate before 8 weeks' gestation had a 90% chance of subsequent delivery. Factors such as maternal age, crown-rump length (CRL), bleeding, and serum biomarkers like hCG, progesterone, and estradiol impacted the risk of miscarriage.
REPRODUCTIVE SCIENCES
(2023)
Article
Hematology
Rie Adser Virkus, Anders P. Mikkelsen, Ojvind Lidegaard, Christian Torp-Pedersen, Thomas Bergholt, Kenneth J. Rothman, Ellen Lokkegaard
Summary: The risk of venous thromboembolism is slightly higher in pregnancies bearing a male fetus compared to those bearing a female fetus.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Nutrition & Dietetics
Line B. Lovschal, Stinne Hogh, Thomas Bergholt, Kate Maslin, Jill Shawe, Hanne K. Hegaard, Mie G. de Wolff
Summary: This study aimed to analyze the iron supplementation rate during the last 3 weeks of the first trimester according to Danish recommendations and identify potential sociodemographic, reproductive, and health-related pre-pregnancy predictors. The study found that approximately half of the pregnant women followed the recommended dose of iron supplementation, and factors such as being 40 years or older, having a lower educational level, and following a vegetarian or vegan diet were predictors for iron supplementation during the first trimester. Interventions targeting women of reproductive age and emphasizing iron supplementation during pre-pregnancy and interpregnancy counseling are necessary.
JOURNAL OF NUTRITIONAL SCIENCE
(2022)
Article
Pediatrics
Grethe R. Krog, Mette L. Donneborg, Bo M. Hansen, Henriette Lorenzen, Frederik B. Clausen, Kristian V. Jensen, Anette Kjaerbye-Thygesen, Per Albertsen, Finn Ebbesen, Thomas Bergholt, Mette K. Smed, Morten H. Dziegiel
Summary: The research found a significant association between maternal anti-A/B IgG titer and hyperbilirubinemia in ABO-incompatible newborns. Maternal anti-A/B titer in the first trimester and at birth can predict hemolytic disease in the newborn. Increased production of IgG anti-A/B throughout pregnancy is associated with the development of hyperbilirubinemia in ABO-incompatible newborns.
PEDIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Ida Marie Wohlk-Hansen, Thomas Bergholt, Kim Ekelund
DANISH MEDICAL JOURNAL
(2020)
Article
Hematology
Klaus Rieneck, Christoffer Egeberg Hother, Frederik Banch Clausen, Marianne Antonius Jakobsen, Thomas Bergholt, Ellinor Hellmuth, Lene Gronbeck, Morten Hanefeld Dziegiel
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2020)