Article
Cell Biology
Anfei Liu, Yunting Li, Sitong Lu, Chunqing Cai, Fei Zou, Xiaojing Meng
Summary: Lung metastasis is a major cause of breast cancer-related death. Tumor microenvironment and secreted factors, such as STC1, play important roles in promoting the metastasis. STC1 enhances cancer cell invasiveness, promotes angiogenesis and lung fibroblast activation in the metastatic microenvironment. Mechanistically, STC1 mediates its effects through the upregulation of S100A4 via EGFR and ERK signaling. Knockdown of S100A4 diminishes STC1-induced lung metastasis. Additionally, JNK signaling pathway activates STC1 expression in breast cancer cells with lung-tropism.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Yen-Yun Wang, Anupama Vadhan, Ping-Ho Chen, Yen-Lung Lee, Chih-Yeh Chao, Kuang-Hung Cheng, Yu-Chiuan Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan
Summary: The study investigated the role of CD44 in lung cancer metastasis through clinical, in vitro, and in vivo studies, revealing that CD44 promotes migration and invasion abilities of lung cancer cells. Understanding and targeting CD44 may offer potential therapeutic strategies to decrease lung cancer metastasis.
Article
Oncology
Afeez Adekunle Ishola, Chian-Shiu Chien, Yi-Ping Yang, Yueh Chien, Aliaksandr A. Yarmishyn, Ping-Hsing Tsai, Jerry Chieh-Yu Chen, Po-Kuei Hsu, Yung-Hung Luo, Yuh-Min Chen, Kung-Hou Liang, Yuan-Tzu Lan, Teh-Ia Huo, Hsin- Ma, Ming-Teh Chen, Mong-Lien Wang, Shih-Hwa Chiou
Summary: Lung cancers, particularly non-small cell lung cancers, have a poor prognosis. A circular noncoding RNA called C190 has been identified as a negative prognostic biomarker for lung cancer, and this study explores its mechanistic function and potential as a therapeutic target for NSCLC.
Article
Biochemistry & Molecular Biology
Ran Wang, Wei Huang, Kaimei Cai, Shihan Xiao, Wuming Zhang, Xianqin Hu, Jianping Guo, Linfeng Mao, Weijie Yuan, Yi Xu, Zihua Chen, Zhikang Chen, Chen Lai
Summary: Flotillin-1 (FLOT1) promotes gastric cancer progression and metastasis through interaction with BCAR1 via ERK signaling. FLOT1 regulates BCAR1 phosphorylation and translocation, and BCAR1 knockdown blocks FLOT1-induced gastric cancer cell proliferation, migration, and invasion. Moreover, the expression of FLOT1 and BCAR1 is closely related to poor prognosis in gastric cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yaqiong Yang, Yu Sun, Rong Hu, Jia Yan, Ziheng Wang, Wenlong Li, Hong Jiang
Summary: This study investigated the regulatory mechanism of epidermal growth factor receptor (EGFR) on microglial activation induced by morphine in BV-2 cells. The results showed that morphine treatment increased CD11b expression, EGFR phosphorylation, ERK1/2 activation, cell migration, and production of proinflammatory cytokines, which were inhibited by blocking the EGFR signaling pathway with AG1478. These findings suggest that the EGFR/ERK signaling pathway could be a novel pharmacological strategy to attenuate morphine tolerance by suppressing microglial activation.
Article
Oncology
Li-Xia Peng, Ming-Dian Wang, Ping Xie, Jun-Ping Yang, Rui Sun, Li-Sheng Zheng, Yan Mei, Dong-Fang Meng, Xing-Si Peng, Yan-Hong Lang, Yuan-Yuan Qiang, Chang-Zhi Li, Liang Xu, Zhi-Jie Liu, Ling-Ling Guo, De-Huan Xie, Di-Tian Shu, Si-Ting Lin, Fei-Fei Luo, Bi-Jun Huang, Chao-Nan Qian
Summary: Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal epithelium and is known for its high metastatic rate. The study found elevated expression of LACTB in tumor tissues of NPC, which correlated with poorer patient survival. The role of LACTB in promoting NPC metastasis is dependent on the activation of ERBB3/EGFR-ERK signaling pathway.
Article
Medicine, Research & Experimental
Karla Rubio, Addi J. Romero-Olmedo, Pouya Sarvari, Guruprasadh Swaminathan, Vikas P. Ranvir, Diana G. Rogel-Ayala, Julio Cordero, Stefan Guenther, Aditi Mehta, Birgit Bassaly, Peter Braubach, Malgorzata Wygrecka, Stefan Gattenloehner, Achim Tresch, Thomas Braun, Gergana Dobreva, Miguel N. Rivera, Indrabahadur Singh, Johannes Graumann, Guillermo Barreto
Summary: A study revealed that non-canonical ITGB2 signaling activates EGFR and RAS/MAPK/ERK signaling in small cell lung cancer (SCLC), providing a potential target for therapy independent of EGFR mutations.
Article
Cell Biology
Li-Li Wang, Jie Luo, Zhang-Hai He, Ye-Qing Liu, Hai-Gang Li, Dan Xie, Mu-Yan Cai
Summary: The overexpression of nuclear STEAP3 is associated with tumor differentiation and poor prognosis in HCC, and it promotes HCC cell proliferation by regulating EGFR and intracellular signaling pathways.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Mayu Sun, Zheshun Jiang, Pengfei Gu, Bao Guo, Jingquan Li, Shujun Cheng, Qian Ba, Hui Wang
Summary: Cadmium exposure can promote the metastasis of colorectal cancer (CRC) by enhancing the invasiveness and mobility of cancer cells through the non-canonical activation of EGFR signaling pathway. This study reveals the unique signaling dynamics of EGFR induced by Cd exposure, which preferentially enhances the metastatic capacity of CRC cells rather than promoting their growth.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Oncology
Jian Sun, Lin Chen, Ming Dong
Summary: The study revealed that miR-338-5p controls epithelial-mesenchymal transition and metastasis of pancreatic cancer cells by targeting the EGFR/ERK pathway, and its expression in clinical analysis is negatively associated with lymph node metastasis and AJCC staging.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shuo Cai, Zhiwei Sun, Ping-Hui Sun, Xiangyu Gao, Ke Ji, Xiuyun Tian, Jiafu Ji, Chunyi Hao, Faris Soliman, Chang Liu, Bilal Al-Sarireh, Paul Griffiths, Stephen Hiscox, Wen G. Jiang, Lin Ye
Summary: The study revealed that reduced expression of Kidins220 was associated with tumorigenesis, metastasis, and overall survival in pancreatic cancer. Knockdown of Kidins220 promoted proliferation, colony formation, and tumorigenic capacity of pancreatic cancer cells, and regulated cell migration through the EGFR/AKT/ERK signaling pathway. Kidins220 also influenced cell invasion via MMP1 in pancreatic cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Runping Fang, Xin Chen, Sicong Zhang, Hui Shi, Youqiong Ye, Hailing Shi, Zhongyu Zou, Peng Li, Qing Guo, Li Ma, Chuan He, Suyun Huang
Summary: In this study, it was revealed that YTHDF2 overexpression is associated with poor prognosis in glioma patients due to EGFR-induced protein stabilization, leading to reduced cholesterol homeostasis and promoting GBM tumorigenesis through an RNA m6A methylation dependent mechanism.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhenfei Bi, Lu Li, Jingyun Yang, Xue Li, Fei Mo, Tianqi Lu, Yanlin Song, Zesheng Cheng, Qianmei Fu, Hong Lei, Xuemei He, Yuquan Wei, Xiawei Wei
Summary: Research reveals that long-term exposure to graphene and carbon black may lead to lung cancer metastasis and progression, raising concerns about their potential toxicity. Pulmonary exposure to graphene or carbon black induces cell necrosis and the release of DAMPs, promoting tumor formation and metastasis.
Article
Cell Biology
Shuyan Han, Zhihua Tian, Huifang Tian, Haibo Han, Jun Zhao, Yanna Jiao, Chunli Wang, Huifeng Hao, Shan Wang, Jialei Fu, Dong Xue, Hong Sun, Pingping Li
Summary: This study examined the role of hepatoma-derived growth factor (HDGF) in gefitinib resistance in non-small cell lung cancer (NSCLC) and identified the underlying mechanisms. The results showed that HDGF overexpression aggravated the malignant phenotype of NSCLC cells, while HDGF knockdown reversed these effects. The overexpression of HDGF also led to gefitinib resistance, while knockdown enhanced gefitinib sensitivity. Higher levels of HDGF in plasma or tumor tissue were associated with gefitinib resistance. HDGF activated the Akt and ERK signaling pathways, independent of EGFR phosphorylation, contributing to gefitinib resistance.
CELL DEATH DISCOVERY
(2023)
Article
Plant Sciences
Jen-Chih Tseng, Bi-Juan Wang, Ya-Pei Wang, Ying-Yu Kuo, Jen -Kun Chen, Tzyh-Chyuan Hour, Li-Kuo Kuo, Po-Jen Hsiao, Chien-Chih Yeh, Cheng-Li Kao, Li-Jane Shih, Chih-Pin Chuu
Summary: The study revealed that CAPE can simultaneously suppress EGFR and Akt signaling in PCa cells, leading to inhibition of cell migration and tumor growth. This highlights the potential of CAPE as a therapeutic agent for advanced PCa.
Article
Oncology
Wei Zhao, Dan Lu, Liang Liu, Juan Cai, Yu Zhou, Ying Yang, Yu Zhang, Jun Zhang
Article
Oncology
Qing-Wen Xu, Wei Zhao, Yue Wang, Maureen A. Sartor, Dong-Mei Han, Jixin Deng, Rakesh Ponnala, Jiang-Ying Yang, Qing-Yun Zhang, Guo-Qing Liao, Yi-Mei Qu, Lu Li, Fang-Fang Liu, Hong-Mei Zhao, Yan-Hui Yin, Wei-Feng Chen, Yu Zhang, Xiao-Song Wang
Article
Oncology
Dan Lv, Wei Zhao, Dong Dong, Xiao-Ping Qian, Yu Zhang, Xiao-Jun Tian, Jun Zhang
EUROPEAN JOURNAL OF CANCER
(2011)
Article
Endocrinology & Metabolism
Wei Zhao, Jingjing Tong, Jie Liu, Jin Liu, Jinghua Li, Yongtong Cao
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Wei Zhao, Jing-Jing Tong, Yong-Tong Cao, Jing-Hua Li
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Biochemistry & Molecular Biology
Jia Song, Tongtong Liu, Yue Yin, Wei Zhao, Zhiqiang Lin, Yuxin Yin, Dan Lu, Fuping You
Summary: This study identifies OTDU1 as a crucial regulator in iron transportation in cancer, promoting the immune response against tumors. OTUD1 depletion limits tumor-reactive T-cell accumulation and exacerbates cancer progression. The data highlights the significance of OTUD1-IREB2-TFRC signaling axis in host antitumor immunity.
Article
Endocrinology & Metabolism
Wei Zhao, Jingjing Tong, Jinghua Li, Yongtong Cao
Summary: The study in Japanese patients found that the body roundness index was positively linearly associated with an elevated risk of incident type 2 diabetes, especially in women. In men, the relationship was J-shaped. BRI proved to be an effective predictor of type 2 diabetes, with higher discriminatory power compared to BMI and WC in both sexes.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medical Laboratory Technology
Wei Zhao, Lei Duan, Long Fang, Jinghua Li, Shirui Li, Lina Wang, Jingying Zhang, Wan Zhang, Yongtong Cao
Summary: This study reported a case of a patient with gradually increased CA19-9 concentrations over 4 years, but without any clinical manifestations. Through multiple system detection and other tests, it was found that the increase in CA19-9 concentration in the patient's blood sample was due to the presence of heterophilic antibodies. It is recommended to evaluate heterophilic antibodies in cases of elevated CA19-9 levels without associated clinical manifestations to prevent false positive results.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Jia Song, Wei Zhao, Xin Zhang, Wenyu Tian, Xuyang Zhao, Liang Ma, Yongtong Cao, Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu
Summary: A study has identified frameshift germline mutations of RIG-I in colon cancer patients, which may be associated with increased susceptibility to colon cancer. The study provides insights into the action of mutant RIG-I and proposes a potential strategy for the treatment of colon cancer.
NATURE COMMUNICATIONS
(2022)
Article
Medical Laboratory Technology
Wei Zhao, Gang Feng, Jun Wan, Xing Wang, Jiping Feng, Wanwan Zhang, Yalan Yu, Rui Pu, Yong Du, Yongtong Cao
Summary: This study aimed to investigate differences in B-type natriuretic peptide (BNP) concentration and stability in different collection tubes, and to assess BNP accuracy. The results showed that BNP concentrations in EDTA/glass tubes were 31.4% higher than those in heparin/glass tubes, and 3.04% lower than those in EDTA/PET tubes. BNP stability significantly decreased in the heparin/glass tube, while it remained stable in EDTA/glass and EDTA/PET tubes at room temperature for 4 hours. The recovery rates of BNP in heparin/glass, EDTA/glass, and EDTA/PET tubes were 77.46%, 86.04%, and 88.23%, respectively. In conclusion, plasma in EDTA/glass and EDTA/PET tubes is suitable for BNP measurement on the Mindray CL-6000i.
ANNALS OF CLINICAL BIOCHEMISTRY
(2023)
