Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xiaolin Wang, Zhou Guo, Jiamin Lin, Kai Sun, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Xiong Zhang, Fengjing Guo, Youxiu Wei
Summary: The aim of this study was to investigate the inhibitory effect of indirubin on arthritis and its cellular-level processes. The results showed that indirubin can reduce chondrocyte inflammation and improve cartilage degradation. It also inhibited the abnormal activation of NF-Kappa B and MAPK signaling pathways. These findings suggest the potential of indirubin as an anti-arthritis drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Guangxia Yang, Kai Wang, Hua Song, Rujie Zhu, Shuai Ding, Hui Yang, Jian Sun, Xin Wen, Lingyun Sun
Summary: This study investigated the effect of celastrol on osteoarthritis (OA) and identified the mechanisms involved. The results showed that celastrol delayed cartilage damage, reduced osteophyte formation and bone resorption in an OA rat model. In vitro experiments also demonstrated that celastrol suppressed the production of inflammatory factors and inhibited matrix degradation. Furthermore, celastrol inhibited the TLR2/NF-kappa B signaling pathway. These findings suggest that celastrol could be a potential therapy for OA by targeting this signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Zhu Xu, Zhong-hai Shen, Bin Wu, Sui-liang Gong, Bin Chen
Summary: Nepetin can inhibit IL-1 beta-induced inflammation, reduce ECM catabolism, enhance ECM anabolism, and have protective and therapeutic effects on a mouse OA model.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Orthopedics
Weiyi Xia, Jian Xiao, ChengLin Tong, Jiajie Lu, Yurong Tu, Sunlong Li, Libing Ni, Yifeng Shi, Peng Luo, Xiaolei Zhang, Xiangyang Wang
Summary: The effects of Orientin on murine chondrocytes treated with IL-1 beta were evaluated in vitro, and the healing effect of Orientin was assessed in a standard OA model in mice. Results showed that Orientin suppressed pro-inflammatory mediators and cartilage degradation, and downregulated activation of NF-kappa B by activating Nrf2/HO-1 axis and SIRT6 signaling pathway, suggesting its potential as a treatment for OA.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Plant Sciences
Huan Yu, Sai Yao, Chengchong Zhou, Fangda Fu, Huan Luo, Weibin Du, Hongting Jin, Peijian Tong, Di Chen, Chengliang Wu, Hongfeng Ruan
Summary: The study demonstrated that morroniside can attenuate the progression of osteoarthritis in mice by promoting cartilage matrix synthesis, inhibiting chondrocyte pyroptosis, reducing osteophyte formation, and subchondral sclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Yiping Mu, Yang Zhang, Jie Wu, Qi Li
Summary: NLRC5 is a critical mediator of inflammatory response and its overexpression in chondrocytes suppressed IL-1β-induced inflammation. Knockdown of NLRC5 had the opposite effect. NLRC5 attenuated IL-1β-induced inflammatory injury through regulating the NF-κB signaling pathway in chondrocytes.
Article
Biochemistry & Molecular Biology
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen
Summary: The study demonstrates that PRP can protect chondrocytes from doxorubicin-induced damage, inhibiting apoptosis and inflammation, and improving cartilage destruction. This research provides a new theoretical basis for the clinical treatment of osteoarthritis caused by doxorubicin.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yi Cheng, Feng Li, Wen-Sheng Zhang, Guo-You Zou, Yi-Xin Shen
Summary: The study reveals that silencing BLNK can delay the progression of OA and IL-1 beta-induced chondrocyte injury by regulating the NF Kappa B pathway.
Article
Biochemistry & Molecular Biology
Yinzhong Chen, Wei Guo, Weizhao Lu, Xiucheng Guo, Weilu Gao, Zongsheng Yin
Summary: This study found that SNIP1 plays an inhibitory role in the progression of osteoarthritis, alleviating inflammation by inhibiting the activation of NF-kappa B. This discovery may provide new insights into the treatment of osteoarthritis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Medicine, Research & Experimental
Huan Yang, Zhengting Wang, Lihuan Wang, Yijie Li, Jiadong Guo, Xiao Yang, Jie Zhao, Kewei Rong, Pu Zhang, Bin Ye, Kai Zhang, Hui Ma
Summary: Osteoarthritis is a chronic degenerative disease that greatly affects the quality of life among the elderly. Scutellarin, derived from Erigeron breviscapus, has shown anti-inflammatory effects, making it a potential treatment for osteoarthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Shuaibing Hou, Xiaomin Wang, Tengxiao Guo, Yanjie Lan, Shengnan Yuan, Shuang Yang, Fei Zhao, Aizhong Fang, Na Liu, Wanzhu Yang, Yajing Chu, Erlie Jiang, Tao Cheng, Xiaojian Sun, Weiping Yuan
Summary: This study reveals that PHF6 plays a significant role in myeloid leukemia by inhibiting NF-κB signaling pathway to suppress cell proliferation and induce apoptosis. The authors also discovered that PHF6 acts as a tumor suppressor gene in lymphocytic leukemia but as an oncogene in myeloid leukemia.
Article
Pharmacology & Pharmacy
Guiliang Zhai, Wenfei Liang, Yongjun Xu
Summary: This study found that the concentration of lysophosphatidic acid (LPA) in patients with lumbar spinal stenosis (LSS) was significantly higher than in the control group, and the level of LPA was positively correlated with the severity of LSS. LPA induced nerve injury and apoptosis in Rat Neurons-spinal cord (RN-SC) cells through the Akt mediated NF-kappa B p65 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yung-Chien Hsu, Pey-Jium Chang, Chun-Wu Tung, Ya-Hsueh Shih, Wen-Chiu Ni, Yi-Chen Li, Takuhiro Uto, Yukihiro Shoyama, Cheng Ho, Chun-Liang Lin
Article
Otorhinolaryngology
Ching-Lung Wu, Ming-Sha Tsai, Ta-Jen Lee, Yun-Ting Wang, Chia-Yen Liu, Yao-Hs Yang, Yao-Te Tsai, Cheng-Min Hsu, Ching-Yuan Wu, Pey-Jium Chang, Geng-He Chang
Summary: In patients with T2DM, the incidence of PTA is relatively high and increases with the severity of T2DM. It is important to pay special attention to preventing PTA in T2DM patients within 1 to 5 years after diagnosis.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lee-Wen Chen, Shie-Shan Wang, Chien-Hui Hung, Ya-Hui Hung, Chun-Liang Lin, Pey-Jium Chang
Summary: The unfolded protein response (UPR) is crucial for alleviating endoplasmic reticulum (ER) stress and many viruses manipulate the UPR signaling network. In the lytic cycle of Epstein-Barr virus (EBV), the expression of central UPR regulator GRP78 is up-regulated, and knockdown of GRP78 reduces virus particle production. BMLF1 is identified as a key regulator contributing to the activation of the grp78 gene promoter and can trigger the activation of the UPR senor ATF6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Yung-Chien Hsu, Pey-Jium Chang, Shih-Jiun Lin, Chia-Ching Liaw, Ya-Hsueh Shih, Lee-Wen Chen, Chun-Liang Lin
Summary: The study demonstrates that curcumin can attenuate diabetic renal fibrosis by modulating the miR-29a/CB1R signaling axis. Curcumin treatment counteracted high glucose-induced changes in genetic expressions, reduced collagen IV deposition in renal tissues, and blocked diabetes-induced dysregulation of miR-29a and CB1R in renal glomeruli.
Article
Biochemistry & Molecular Biology
Kuo-Ti Peng, Jiun-Liang Chen, Liang-Tseng Kuo, Pei-An Yu, Wei-Hsiu Hsu, Chiang-Wen Lee, Pey-Jium Chang, Tsung-Yu Huang
Summary: The study found that GMI, a fungal immunomodulatory peptide isolated from Ganoderma microsporum, suppresses MDSC expansion and promotes the proliferation of cytotoxic T cells by increasing the expression of IL-6 and TNF-alpha and reducing ROS expression. This suggests that GMI may be potentially useful for treating Staphylococcus aureus-induced PJIs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Geng-He Chang, Yu-Shih Lin, Ke-Hsin Hsu, Yu-Ching Cheng, Pei-Rung Yang, Ming-Shao Tsai, Yao-Te Tsai, Cheng-Ming Hsu, Pey-Jium Chang, Chung-Sheng Shi, Yao-Hsu Yang, Ching-Yuan Wu
Summary: The study demonstrates that licorice nasal irrigation is an effective treatment for allergic rhinitis, with superior results compared to corticosteroid nasal irrigation and saline nasal irrigation. This natural and safe therapy not only shows significant improvements in symptoms but also provides better procedural comfort during treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Geng-He Chang, Ang Lu, Yao-Hsu Yang, Chia-Yen Liu, Pey-Jium Chang, Chuan-Pin Lee, Yao-Te Tsai, Cheng-Ming Hsu, Ching-Yuan Wu, Wei-Tai Shih, Ming-Shao Tsai
Summary: ESRD patients have a significantly higher incidence of PTA compared to non-ESRD individuals, but ESRD itself does not necessarily predict a poor prognosis of PTA. Despite no significant differences in PTA-related hospital stay length, deep-neck infection complication, or mortality between ESRD patients and controls, ESRD remains an independent risk factor for PTA.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Microbiology
Ju-Bei Yen, Lee-Wen Chen, Ling-Huei Wei, Chien-Hui Hung, Shie-Shan Wang, Chun-Liang Lin, Pey-Jium Chang
Summary: This study reveals that the human norovirus NTPase protein interacts with lipid droplets in cells, promoting apoptosis through LD targeting motifs (LTM-1 and LTM-2) in its N-terminal domain. Additionally, the N-terminal region of NTPase contains multiple functional motifs and regions that play a role in cellular processes.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Li-Yu Chen, Lee-Wen Chen, Chien-Hui Hung, Chun-Liang Lin, Shie-Shan Wang, Pey-Jium Chang
Summary: This study reveals that Sp3 protein is proteolytically cleaved during the viral lytic cycle of KSHV, and identifies 12 caspase cleavage sites in Sp3. Despite the cleavage, the resulting C-terminal fragments of Sp3 retain the ability to synergistically activate specific gene promoters with ORF50.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Chih-Wei Luan, Chia-Yen Liu, Yao-Hsu Yang, Ming-Shao Tsai, Yao-Te Tsai, Cheng-Ming Hsu, Ching-Yuan Wu, Pey-Jium Chang, Geng-He Chang
Summary: Deep neck infection is a deadly condition, especially for patients with diabetes. Treatment involves surgical drainage and antibiotics, with Klebsiella pneumoniae and Viridans Streptococci being common pathogens. Patients with diabetes have higher mortality risks when infection markers are elevated.
Article
Microbiology
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng
Summary: This study investigated the genotypic and phenotypic characteristics of MRSA clones isolated from PJI patients in a hospital in Taiwan. The findings showed that ST239 MRSA isolates were highly resistant to multiple antibiotics, had a high biofilm formation ability, and infected patients typically exhibited fever and inflammation. Additionally, knee infections were mainly attributed to ST59 MRSA, and there was an increasing trend of infections caused by ST8 and other MRSA genotypes in PJI patients.
Article
Biochemistry & Molecular Biology
Chia- Lin, Shie-Shan Wang, Chien-Hui Hung, Pey-Jium Chang, Lee-Wen Chen
Summary: The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded ORF50 protein negatively regulates MDM2 expression through repressing Sp1- and p53-mediated transactivation. This reciprocal negative regulation between ORF50 and MDM2 provides insights into the regulatory mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yung-Chien Hsu, Cheng-Chih Chang, Ching-Chuan Hsieh, Yu-Ting Huang, Ya-Hsueh Shih, Hsiu-Ching Chang, Pey-Jium Chang, Chun-Liang Lin
Summary: Chronic kidney disease (CKD) is a serious public health problem, and the Wnt antagonist Dickkopf-1 (DKK1) plays an important role in CKD progression. Patients with advanced CKD have higher levels of serum DKK1, and this is associated with faster progression to end-stage renal disease (ESRD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Chien-Hui Hung, Ju-Bei Yen, Pey-Jium Chang, Lee-Wen Chen, Tsung-Yu Huang, Wan-Ju Tsai, Yu-Chin Tsai
Summary: Human noroviruses (HuNVs) are the main cause of gastroenteritis worldwide, and NS1.2 plays a critical role in HuNV pathogenesis, although its exact function is still unclear. Unlike GI NS1.2, GII NS1.2 of HuNVs is localized in the endoplasmic reticulum (ER) and lipid droplets (LDs), accompanied by distorted ER morphology and enlarged LDs. Non-autophagic recruitment of LC3 to the NS1.2-localized membrane, as well as protein-protein interactions, are crucial for the formation of viral replication complexes.
Article
Microbiology
Lee-Wen Chen, Shie-Shan Wang, Li-Yu Chen, Hsiao-Yun Huang, Si-min He, Chien-Hui Hung, Chun-Liang Lin, Pey-Jium Chang
Summary: This study reveals the protein-protein interaction network of KSHV-encoded core replication proteins and suggests a critical role of Hsp90 in assisting the construction of the viral core replication machinery. Additionally, the study identifies several discrete, stable subcomplexes in the cell nucleus.
MICROBIOLOGY SPECTRUM
(2023)