Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein

(2013) Laurence Morellato-Castillo et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 ENV gp120 structural determinants for peptide triazole dual receptor site antagonism

(2013) Ferit Tuzer et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

(2013) Priyamvada Acharya et al.   STRUCTURE

Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

(2012) Judith M. LaLonde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1

(2012) Francesca Curreli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

(2012) Y. D. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

(2010) Judith M. LaLonde et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds

(2010) K. Yoshimura et al.   JOURNAL OF VIROLOGY

Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

(2009) Hillel Haim et al.   PLoS Pathogens

CD4 mimetic miniproteins: potent anti-HIV compounds with promising activity as microbicides

(2008) Y. Van Herrewege et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

(2008) François Stricher et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

(2008) Navid Madani et al.   STRUCTURE