Article
Cardiac & Cardiovascular Systems
Hyun-Soo Zhang, Seokyung An, Choonghyun Ahn, Sue K. Park, Boyoung Park
Summary: This study investigated the association of baseline obesity measures and their trajectories over time with incident CKD. Results showed that baseline obesity in terms of BMI, WC, and HC increased the odds of CKD incidence, while baseline WHR did not show such an association. Nonobese BMI, WC, or WHR trajectories, and constantly not large HC trajectory decreased the hazard of CKD incidence compared to constantly obese or became obese trajectories.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Wojciech Pluskiewicz, Piotr Adamczyk, Aleksandra Werner, Malgorzata Bach, Bogna Drozdzowska
Summary: A longitudinal, retrospective study found that hip bone density, height loss, and previous fractures were important variables predicting osteoporotic fractures in postmenopausal women.
Article
Health Care Sciences & Services
Feng-Ching Shen, Yi-Wen Chiu, Mei-Chuan Kuo, Ming-Yen Lin, Jia-Jung Lee, Shang-Jyh Hwang, Jer-Ming Chang, Chi-Chih Hung, Hung-Chun Chen
Summary: The study found the obesity paradox in patients with chronic kidney disease (CKD), where high BMI is associated with low all-cause mortality risk. Central obesity may have better prognostic value than BMI for all-cause mortality, and low WHR or low BMI and high WHR, rather than high BMI, are associated with all-cause mortality in advanced CKD.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Hong Cai, Yaping Zhan, Jiayue Lu, Minxia Zhu, Shang Liu, Jiuhong Mei, Pu Zhang, Ronghui Liu, Zhaohui Ni, Weiming Zhang, Gaojie Xu
Summary: The study found that body mass index, waist-to-hip ratio, and waist circumference are related to chronic kidney disease (CKD), with overweight and obesity potentially increasing the risk of CKD.
Article
Nutrition & Dietetics
Zonglei Zhou, Kunpeng Li, Xianzhi Li, Rongsheng Luan, Ruzhen Zhou
Summary: This study shows that BMI, waist circumference, and WHtR equally predict the development of hyperuricemia, and weight loss and waist circumference reduction are favorable in preventing hyperuricemia. Participants with weight loss of >= 4 kg or waist circumference loss of >= 6 cm had a lower risk of hyperuricemia, while weight gain increased the risk.
NUTRITION & METABOLISM
(2021)
Article
Respiratory System
Yan Wang, Lusi Mao, Xiaolei Zhang
Summary: The study aimed to explore the accuracies of waist-hip ratio (WHR) in conjunction with body mass index (BMI) in identifying the severity of obstructive sleep apnea (OSA). It was found that WHR is a moderate screening marker for moderate-to-severe OSA in nonobese male patients and an independent risk factor for OSA severity.
BMC PULMONARY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Fatemeh Moosaie, Seyede Marzie Fatemi Abhari, Niloofar Deravi, Arman Karimi Behnagh, Sadaf Esteghamati, Fatemeh Dehghani Firouzabadi, Soghra Rabizadeh, Manouchehr Nakhjavani, Alireza Esteghamati
Summary: This study followed up on 1,685 normotensive patients with type 2 diabetes and found that WHtR was a more accurate tool for predicting hypertension compared to WHR and BMI in these patients.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Dong Yoon Lee, Gyeong Im Yu, Yu-Mi Kim, Mi Kyung Kim, Min-Ho Shin, Mi-Young Lee
Summary: This study investigated the associations between waist circumference-related obesity metrics and estimated glomerular filtration rates. The results showed significant associations between most obesity metrics and estimated glomerular filtration rates, especially in women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Aleksandra Rymarz, Katarzyna Romejko, Anna Matyjek, Zbigniew Bartoszewicz, Stanislaw Niemczyk
Summary: This study explored the association between OPG levels and common complications of chronic kidney disease (CKD) such as anemia, protein energy wasting, inflammation, overhydration, hyperglycemia, and hypertension. The results suggest that OPG can be an independent marker of protein energy wasting, inflammation, and vascular metabolic disturbances in CKD patients.
Article
Endocrinology & Metabolism
Radka Taxova Braunerova, Marie Kunesova, Mirjam M. Heinen, Harry Rutter, Maria Hassapidou, Vesselka Duleva, Iveta Pudule, Ausra Petrauskiene, Agneta Sjoberg, Lauren Lissner, Igor Spiroski, Enrique Gutierrez-Gonzalez, Cecily C. Kelleher, Ingunn Holden Bergh, Tereza Metelcova, Jana Vignerova, Marek Brabec, Marta Buoncristiano, Julianne Williams, Philippa Simmonds, Hana Zamrazilova, Vojtech Hainer, Agneta Yngve, Ivo Rakovac, Joao Breda
Summary: This study evaluated waist circumference (WC) and waist-to-height ratio (WHtR) in 7-year-old children from 10 European countries, finding that children in Southern European countries had significantly higher BMI, WC, and WHtR compared to those in Eastern and Northern Europe.
Article
Public, Environmental & Occupational Health
Zahra Mosallanezhad, Mohammad Jalali, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi
Summary: This study aimed to explore the potential associations between dietary sodium, potassium, and sodium-to-potassium ratio with the risk of cardiovascular disease in Iranian adults. The results showed that higher sodium intake was associated with an increased risk of CVD, while higher potassium intake was associated with a reduced risk of CVD.
Article
Obstetrics & Gynecology
Mervi Jokelainen, Beata Stach-Lempinen, Kari Teramo, Arja Nenonen, Hannu Kautiainen, Miira M. Klemetti
Summary: This study examined the associations and interactions between maternal early-pregnancy waist circumference (WC), height, and pre-pregnancy body mass index (BMI) with plasma glucose concentrations. The results showed that a large waist circumference and short height are associated with higher glucose levels, and a waist-to-height ratio above 0.5 is correlated with both fasting and post-load glucose concentrations.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Pediatrics
Eujin Park, Hye Jin Lee, Hyun Jin Choi, Yo Han Ahn, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Jae Il Shin, Joo Hoon Lee, Young Seo Park, Il-Soo Ha, Min Hyun Cho, Hee Gyung Kang
Summary: The study found that children with CKD in Korea had a higher prevalence of short stature and underweight compared to the general population. Independent risk factors associated with short stature in these children included CKD stages 4 and 5, premature birth, underweight, low birth weight, and low household income. Among these factors, underweight is the only modifiable factor.
PEDIATRIC NEPHROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xuan Xi, Di Wu, Wenyi Wu, Yuanke Zhou, Qin Zhang, Yujie Wang, Hong Wang, Qin Liu
Summary: This study explores the influence of obesity indicators on the onset age of different pubertal characteristics and tempo among girls. The results show that overweight and obesity before pubertal onset can affect the age of onset and accelerate pubertal tempo. Furthermore, overweight and high waist circumference before menarche also impact the age of menarche.
FRONTIERS IN PUBLIC HEALTH
(2023)
Letter
Medicine, General & Internal
Katherine R. Tuttle, Cami R. Jones, Kenn B. Daratha, Alain K. Koyama, Susanne B. Nicholas, Radica Z. Alicic, O. Kenrik Duru, Joshua J. Neumiller, Keith C. Norris, Nilka Rios Burrows, Meda E. Pavkov
Summary: Despite a recent decline, the incidence of chronic kidney disease remains high in the United States among adults with diabetes. White adults with diabetes have a lower incidence compared to most other adults with diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chiaki Kamiya, Naoki Inui, Akio Hakamata, Sachiko Miyakawa, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Keiichi Odagiri, Hiroshi Watanabe
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Naoki Katayama, Keiichi Odagiri, Akio Hakamata, Chiaki Kamiya, Shinya Uchida, Shimako Tanaka, Naoki Inui, Noriyuki Namiki, Koichiro Tatsumi, Hiroshi Watanabe
Summary: This study investigated the impact of clopidogrel on the pharmacokinetics of selexipag and its active metabolite in 14 healthy Japanese volunteers. The results showed that co-administration of clopidogrel with selexipag did not affect selexipag's pharmacokinetics, but significantly increased the AUC(0-infinity) of ACT-333679. Furthermore, even when selexipag was administered 1 day after discontinuation of clopidogrel, there was still an increase in the AUC(0-infinity) of ACT-333679, indicating a persistent inhibitory effect of clopidogrel on CYP2C8.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Motoyasu Miura, Shinya Uchida, Shimako Tanaka, Chiaki Kamiya, Naoki Katayama, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Junichi Kawakami, Hiroshi Watanabe, Noriyuki Namiki
Summary: A cocktail approach was utilized to comprehensively evaluate CYP activity. Comparing the results from cocktail study and single study, a strong positive correlation of the AUC ratios was obtained, indicating that the cocktail study is an adequate method for evaluating DDIs quantitatively. The differences in AUC change ratios between single studies and cocktail study were acceptable for almost all combinations, demonstrating the reliability of the cocktail approach in assessing DDIs.
Article
Pharmacology & Pharmacy
Motoyasu Miura, Shimako Tanaka, Shinya Uchida, Chiaki Kamiya, Naoki Katayama, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Junichi Kawakami, Hiroshi Watanabe, Noriyuki Namiki
Summary: A cocktail study evaluates multiple CYP activities using a combination of substrates, and limited-point plasma concentration analysis can predict the area under the curve (AUC) of CYP substrates in a cocktail drug. The prediction accuracy is higher for inhibitors, aiding in the screening process.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Chiaki Kamiya, Keiichi Odagiri, Akio Hakamata, Ryugo Sakurada, Naoki Inui, Hiroshi Watanabe
Summary: This study found that high doses of omeprazole may suppress store-operated Ca2+ channels and the G protein-coupled receptor/phospholipase C/inositol 1,4,5-triphosphate pathway, leading to decreased phosphorylation of eNOS and impaired EDRF production. These results provide new insights into the impact of omeprazole on vascular biology.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Multidisciplinary Sciences
Noriyuki Enomoto, Seiichiro Suzuki, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Yutaro Nakamura, Keiichi Odagiri, Takamichi Ishikawa, Kensuke Kataoka, Yasuhiro Kondoh, Masato Maekawa, Naoki Inui, Hiroshi Watanabe, Takafumi Suda
Summary: The study evaluated the utility of serum angiopoietin (ANGP) as a diagnostic and prognostic biomarker in patients with pulmonary hypertension (PH), showing that serum ANGP-2 concentration was significantly higher in patients with PH and correlated with parameters related to PH. Higher ANGP-2 concentration was associated with worse survival in PH patients, making it a potential prognostic factor especially in patients with group 3 PH.
SCIENTIFIC REPORTS
(2021)
Correction
Multidisciplinary Sciences
Takeji Saitoh, Yoshiaki Takahashi, Hisae Minami, Yukako Nakashima, Shuhei Aramaki, Yuki Mihara, Takamasa Iwakura, Keiichi Odagiri, Yuichiro Maekawa, Atsuto Yoshino
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Michihiro Kaya, Kazuyo Nakamura, Kyohei Sugiyama, Ayumi Kinae, Hiromi Yamaguchi, Hirotoshi Ukita, Keiichi Odagiri, Chika Ujiie, Jun Kato, Fujito Kageyama, Mariko Nagura, Kumi Matsushita, Kaori Sugiue, Hiroki Ishida, Shinya Endo, Takaya Suzuki
Summary: In this retrospective multicentre study, the effectiveness and safety of ledipasvir/sofosbuvir, elbasvir/grazoprevir, and glecaprevir/pibrentasvir as first-line treatments for untreated hepatitis C virus genotype 1 patients were evaluated. The results showed that these direct-acting antivirals were effective and safe in real-world clinical practice.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Eiko Nagata, Yasuharu Kashiwagura, Eisaku Okada, Shimako Tanaka, Shinichiro Sano, Mitsuhiro Nishida, Satoshi Hayano, Satoru Iwashima, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Kazuo Umemura, Shinya Uchida
Summary: This study evaluated the efficacy and safety of topical propranolol in infants with infantile hemangioma. The results showed that topical propranolol may be an effective and safe treatment option, particularly for small and superficial hemangiomas in cosmetically problematic areas.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Keiichi Odagiri, Katsuya Yamauchi, Masahiro Toda, Ayako Uchida, Hiromi Tsubota, Kazuyoshi Zenba, Hiroaki Okawai, Hideo Eda, Seiichiro Mizuno, Hiroaki Yokota
Summary: Low power laser therapy is commonly used for neck and shoulder stiffness/pain. In this study, a newly developed self-care device incorporating light-emitting diodes (LEDs) was evaluated for its safety and effectiveness. The device was found to be safe and effectively alleviated subjective symptoms of neck and shoulder muscle stiffness and pain.
Article
Cardiac & Cardiovascular Systems
Yoshihisa Naruse, Makoto Sano, Nobutake Kurebayashi, Shuji Morikawa, Naoki Tsurumi, Tomoyuki Shiozawa, Shintaro Takano, Michio Ogano, Kei Kimura, Keisuke Miyajima, Ryo Sugiura, Ryuta Henmi, Masahiro Muto, Natsuko Hosoya, Hideyuki Hasebe, Akira Mizukami, Keisuke Iguchi, Akiko Atsumi, Keiichi Odagiri, Yumi Kiyama, Yuichiro Maekawa
Summary: This study aimed to compare the accuracy of the delivery catheter system and the stylet system for right ventricular lead placement. The results showed that the delivery catheter system had a higher success rate in placing the lead to the septum and resulted in a narrower paced QRS width than the stylet system. Therefore, the delivery catheter system is more effective for right ventricular lead placement.
Article
Chemistry, Medicinal
Sayuri Kawamoto, Shimako Tanaka, Motoyasu Miura, Yasuharu Kashiwagura, Chiaki Kamiya, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki, Shinya Uchida
Summary: Good adherence to medication is crucial for treating psychiatric disorders successfully. Tailor-made pharmaceutical formulations can offer individual patients a suitable dosage form to address poor adherence to industrially manufactured products. In this study, aripiprazole gummies with different flavors were prepared and their palatability was evaluated through gustatory sensation tests. The results showed that cocoa-flavored gummies containing aspartame, cocoa powder, and banana flavor, as well as grapefruit-flavored gummies, had the highest palatability scores. These tailor-made formulations could be acceptable for patients and serve as alternatives to enhance medication adherence.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Medicine, General & Internal
Yoshihisa Naruse, Keisuke Miyajima, Ryo Sugiura, Masahiro Muto, Michio Ogano, Nobutake Kurebayashi, Tomoyuki Shiozawa, Yumi Kiyama, Eiko Nagata, Keiichi Odagiri, Yuichiro Maekawa
Summary: This study aims to compare the accuracy of RV lead placement on the RV septum using a newly available delivery catheter system with traditional stylet system, to improve the risk of pacing-induced cardiomyopathy after pacemaker implantation.
Meeting Abstract
Clinical Neurology
Naoki Katayama, Keiichi Odagiri, Akio Hakamata, Naoki Inui, Katsuya Yamauchi, Hiroshi Watanabe
Article
Chemistry, Medicinal
Hidehito Takano, Shinya Uchida, Yasuharu Kashiwagura, Shimako Tanaka, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki
CHEMICAL & PHARMACEUTICAL BULLETIN
(2019)