Article
Plant Sciences
Dewei Yang, Shengping Li, Yueping Xiao, Ling Lu, Zichao Zheng, Dingzhong Tang, Haitao Cui
Summary: The study highlights the importance of rapid, high-amplitude transcriptional reprogramming in rice defense against blast fungus, with ribosome- and protein translation-related genes being significantly enriched among differentially expressed genes at 12 hpi in both susceptible and resistant cultivars. A core set of genes involved in response to both biotic and abiotic stress was identified, including metallothionein genes positively regulating rice resistance and a peroxidase gene negatively regulating it. This study provides novel insights into transcriptional reprogramming and serves as a valuable resource for functional studies on rice immune signaling components in resistance to blast disease.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Alejandra Martinez-D'Alto, Xia Yan, Tyler C. Detomasi, Richard I. Sayler, William C. Thomas, Nicholas J. Talbot, Michael A. Marletta
Summary: Blast disease caused by the fungus Magnaporthe oryzae leads to significant crop loss in cereal plants. The study shows that the expression of the putative polysaccharide monooxygenase MoPMO9A is increased during infection. MoPMO9A exhibits activity on cereal-derived mixed β-D-glucans and its domain architecture is different from other characterized AA9 PMOs. The results suggest that MoPMO9A plays a role in MBG degradation during plant infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Vasco Branco, Luis Carvalho, Cassia Barboza, Eduarda Mendes, Afonso Cavaco, Cristina Carvalho
Summary: This study found that pregnant women highly exposed to mercury through fish consumption had sub-optimal selenium status, resulting in reduced plasma selenoprotein activity. However, low selenium levels did not affect the activity of thioredoxin reductase. On the other hand, the decrease in thioredoxin activity with an increase in mercury may be a good indicator for preventing fetal susceptibility.
Review
Agriculture, Multidisciplinary
Hai-feng Zhang, Tofazzal Islam, Wen-de Liu
Summary: This article introduces and summarizes the classification, geographical distribution, host range, disease symptoms, biology and ecology, economic impact, and integrated pest management (IPM) program of rice and wheat blast diseases.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Agronomy
Jin-Feng Chen, Zhi-Xue Zhao, Yan Li, Ting-Ting Li, Yong Zhu, Xue-Mei Yang, Shi-Xin Zhou, He Wang, Ji-Qun Zhao, Mei Pu, Hui Feng, Jing Fan, Ji-Wei Zhang, Yan-Yan Huang, Wen-Ming Wang
Summary: The study found that rice microRNA159a plays a positive role in rice resistance to rice blast disease by regulating target genes to modulate the immune response. Proper expression of Osa-miR159a is crucial for coordinating rice blast resistance with grain development.
Article
Environmental Sciences
Debarati Chanda, William Dudefoi, Joshua Anadu, Matteo Minghetti
Summary: The study found that AgNO3 or cit-AgNP can inhibit the activity of selenoenzymes without inducing oxidative stress in RTgutGC cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Jessie Fernandez, Victor Lopez, Lisa Kinch, Mariel A. Pfeifer, Hillery Gray, Nalleli Garcia, Nick Grishin, Chang-Hyun Khang, Kim Orth
Summary: The study identified two metalloproteinase enzymes, MoMca1 and MoMca2, in M. oryzae, which play significant roles in fungal growth and development, potentially regulating stress responses. The absence of these enzymes resulted in delays in fungal morphogenesis and insights into the mechanisms of M. oryzae pathogenicity.
Article
Ecology
Kuleshwar Prasad Sahu, Aundy Kumar, Asharani Patel, Mukesh Kumar, S. Gopalakrishnan, G. Prakash, R. Rathour, Robin Gogoi
Summary: Dark brown necrotic lesions caused by Magnaporthe oryzae on rice foliage provide a contrasting microhabitat for leaf-colonizing microbiome, with 17 bacterial species identified in these lesions showing biocontrol potential against the pathogen. Over 50% of the bacterial isolates were able to suppress the growth of M. oryzae, with certain strains triggering the expression of defense genes in rice, indicating their potential as biocontrol agents for managing rice blast disease.
Article
Biochemistry & Molecular Biology
Arjan de Groot, Laurence Blanchard, Nicolas Rouhier, Pascal Rey
Summary: Deinococcus species have remarkable tolerance to oxidative damage in extreme environmental conditions. Thiol reductases (TRs) play important roles in metabolism regulation and stress responses. The study reveals that Deinococcus possesses multiple enzyme systems that protect proteins and maintain redox status. Recent research further confirms the importance of TRs in Deinococcus' tolerance to oxidative treatments.
Article
Genetics & Heredity
Mostafa Rahnama, Baohua Wang, Jane Dostart, Olga Novikova, Daniel Yackzan, Andrew Yackzan, Haley Bruss, Maray Baker, Haven Jacob, Xiaofei Zhang, April Lamb, Alex Stewart, Melanie Heist, Joey Hoover, Patrick Calie, Li Chen, Jinze Liu, Mark L. L. Farman
Summary: Telomeres play a crucial role in solving the end-replication problem, protecting chromosomes, and shaping genome architecture in the blast fungus Pyricularia. Telomere instability in some strains is caused by novel retrotransposons, leading to frequent break-induced rearrangements, while even telomeres lacking insertions exhibit poor preservation and frequent polymorphism. Chromosomal responses to failed telomere maintenance suggest that compromised telomere function may be driving the polymorphism in Pyricularia, including potential adaptive advantages from Adaptive Telomere Failure.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Omer F. Bay, Kelly S. Hayes, Jean-Marc Schwartz, Richard K. Grencis, Ian S. Roberts
Summary: Genome-scale metabolic model of Trichuris muris reveals the essential role of Thioredoxin Reductase (TrxR) enzyme for its survival, as well as the mechanism of glutathione reduction by TrxR enzyme. The model also predicts several essential amino acids that cannot be synthesized by T. muris.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Patricia P. Adriani, Fernanda C. R. de Paiva, Gabriel S. de Oliveira, Amanda C. Leite, Adriana S. Sanches, Adriana Rios Lopes, Marcio V. B. Dias, Felipe S. Chambergo
Summary: The study characterized the functional and structural features of a glutathione peroxidase (GPx) identified in Trichoderma reesei, demonstrating that TrGPx is a thioredoxin peroxidase with better hydrolysis activity towards H2O2 than t-BOOH. Additionally, TrGPx showed optimal pH range and half-life at 80 degrees Celsius.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Debaprasad Koner, Niharika Nag, Parismita Kalita, Aditya K. Padhi, Timir Tripathi, Nirmalendu Saha
Summary: The presence of thioredoxin glutathione reductase (TGR) in the facultative air-breathing catfish, Clarias magur, was identified for the first time. The TGR enzyme showed both TrxR and GR activities, contributing to the maintenance of redox homeostasis and antioxidant defense under oxidative stress induced by environmental stressors. Phylogenetic analysis revealed its relationship to fish TrxRs and distant relation to platyhelminth parasites TGRs. The characterization of C. magur TGR provides insights into its unique adaptation to environmental challenges.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Pengyun Huang, Huijuan Cao, Yan Li, Siyi Zhu, Jing Wang, Qing Wang, Xiaohong Liu, Fu-Cheng Lin, Jianping Lu
Summary: This study reveals the functional diversity and complexity of melanin in different strains of Magnaporthe oryzae. Melanin promotes spore production in the rice blast pathogen, but its effect is related to the background melanin content of the wild-type strains. Transcription factors like Cnf1 have opposite effects on conidiophore differentiation in different strains. Pig1 regulates melanin synthesis in hyphae but not in conidiophores, spores, or appressoria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Azahara Casatejada, Leonor Puerto-Galan, Juan M. Perez-Ruiz, Francisco J. Cejudo
Summary: Oxidizing signals mediated by thiol-dependent peroxidase activity play a crucial role in chloroplast redox balance, with both 2-Cys peroxiredoxins (PRXs) and glutathione peroxidases (GPXs) being involved. However, the specific contribution of GPXs in this process is not well understood. This study generated mutant plants devoid of GPXs to investigate their functional relationship with the NADPH-dependent thioredoxin reductase C (NTRC)-2-Cys PRXs redox system. The results indicate that GPXs contribute to chloroplast redox homeostasis independently of NTRC.
Article
Biochemistry & Molecular Biology
Nicole J. De Nisco, Mohammed Kanchwala, Peng Li, Jessie Fernandez, Chao Xing, Kim Orth
Article
Biochemistry & Molecular Biology
Nicole J. De Nisco, Mohammed Kanchwala, Peng Li, Jessie Fernandez, Chao Xing, Kim Orth
Review
Biochemistry & Molecular Biology
Jessie Fernandez, Kim Orth
TRENDS IN MICROBIOLOGY
(2018)
Review
Plant Sciences
Jessie Fernandez, Margarita Marroquin-Guzman, Richard A. Wilson
ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 52
(2014)
Article
Microbiology
Thomas Calder, Marcela de Souza Santos, Victoria Attah, John Klimko, Jessie Fernandez, Dor Salomon, Anne-Marie Krachler, Kim Orth
FEMS MICROBIOLOGY LETTERS
(2014)
Article
Biochemistry & Molecular Biology
Jessie Fernandez, Margarita Marroquin-Guzman, Renu Nandakumar, Sara Shijo, Kathryn M. Cornwell, Gang Li, Richard A. Wilson
MOLECULAR MICROBIOLOGY
(2014)
Article
Multidisciplinary Sciences
Thomas Calder, Lisa N. Kinch, Jessie Fernandez, Dor Salomon, Nick V. Grishin, Kim Orth
Review
Plant Sciences
Jessie Fernandez, Richard A. Wilson
Article
Biochemistry & Molecular Biology
Victor A. Lopez, Brenden C. Park, Dominika Nowak, Anju Sreelatha, Patrycja Zembek, Jessie Fernandez, Kelly A. Servage, Marcin Gradowski, Jacek Hennig, Diana R. Tomchick, Krzysztof Pawlowski, Magdalena Krzymowska, Vincent S. Tagliabracci
Article
Microbiology
Richard A. Wilson, Jessie Fernandez, Raquel O. Rocha, Margarita Marroquin-Guzman, Janet D. Wright
Article
Biochemistry & Molecular Biology
Wei Peng, Amanda K. Casey, Jessie Fernandez, Emily M. Carpinone, Kelly A. Servage, Zhe Chen, Yang Li, Diana R. Tomchick, Vincent J. Starai, Kim Orth
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Article
Microbiology
Jessie Fernandez, Victor Lopez, Lisa Kinch, Mariel A. Pfeifer, Hillery Gray, Nalleli Garcia, Nick Grishin, Chang-Hyun Khang, Kim Orth
Summary: The study identified two metalloproteinase enzymes, MoMca1 and MoMca2, in M. oryzae, which play significant roles in fungal growth and development, potentially regulating stress responses. The absence of these enzymes resulted in delays in fungal morphogenesis and insights into the mechanisms of M. oryzae pathogenicity.
Review
Biochemistry & Molecular Biology
Nalleli Garcia, Rachel E. E. Kalicharan, Lisa Kinch, Jessie Fernandez
Summary: This review discusses the recent advances in understanding the diverse functionality of metacaspases in plants and fungi, focusing on their roles in plant development, immunity, stress responses, fungal development, and virulence. It highlights the importance of bridging the gap between metacaspase roles in immunity and pathogenicity to control plant pathogens and increase crop production. The exploitation and manipulation of metacaspases in plants or fungi offer new potential avenues for developing mitigation strategies against plant pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Jessie Fernandez
Summary: Magnaporthe oryzae is a fungus that causes rice blast disease, which is economically devastating and difficult to control. It can also infect other crops such as wheat and millet. Despite previous findings, the fungus remains a major threat to global food security.