Targeting Innate Receptors with MIS416 Reshapes Th Responses and Suppresses CNS Disease in a Mouse Model of Multiple Sclerosis

Loss of IFN-  Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

(2014) J. J. Sabatino et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-Induced Expression of Matrix Metalloproteinases in Human Monocytes Is Suppressed by IFN-  via Superinduction of ATF-3 and Suppression of AP-1

(2014) H. H. Ho et al.   JOURNAL OF IMMUNOLOGY

Evaluating the role of Toll-like receptors in diseases of the central nervous system

(2011) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

(2011) Patrick J. Shaw et al.   IMMUNITY

LPS-induced CD11b+Gr1intF4/80+ regulatory myeloid cells suppress allergen-induced airway inflammation

(2011) Meenakshi Arora et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role for MyD88, TLR2 and TLR9 but Not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis

(2011) S. Miranda-Hernandez et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ Orchestrates the Number and Function of Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2011) Nele Berghmans et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Variation in NOD2 Augments Th2- and Th17 Responses to Myelin Basic Protein in Multiple Sclerosis

(2011) Chris Juul Hedegaard et al.   PLoS One

Interferon-β inhibits toll-like receptor 9 processing in multiple sclerosis

(2010) Konstantin E. Balashov et al.   ANNALS OF NEUROLOGY

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

(2010) J. A. C. VOORTHUIS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity

(2010) Clare Y Slaney et al.   IMMUNOLOGY AND CELL BIOLOGY

The TLR7 agonist, imiquimod, increases IFN-β production and reduces the severity of experimental autoimmune encephalomyelitis

(2010) Kate O'Brien et al.   JOURNAL OF NEUROIMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity

(2010) Rebecca C. Girvan et al.   VACCINE

The role of innate immune responses in autoimmune disease development

(2009) Hanspeter Waldner   AUTOIMMUNITY REVIEWS

Myeloid-derived suppressor cell activation by combined LPS and IFN-γ treatment impairs DC development

(2009) Verena Greifenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

NOD2 Ligation Subverts IFN-  Production by Liver Plasmacytoid Dendritic Cells and Inhibits Their T Cell Allostimulatory Activity via B7-H1 Up-Regulation

(2009) A. Castellaneta et al.   JOURNAL OF IMMUNOLOGY

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosis

(2009) Juergen Haas et al.   JOURNAL OF NEUROIMMUNOLOGY

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

(2009) Tomoko Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

(2008) Monica Marta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type II-activated macrophages suppress the development of experimental autoimmune encephalomyelitis

(2008) Joanna B Tierney et al.   IMMUNOLOGY AND CELL BIOLOGY

A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis

(2008) Howard L. Weiner   JOURNAL OF NEUROLOGY