EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers

Altered Subcellular Distribution of c-Abl in Alzheimer's Disease

(2017) Zheng Jing et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Changes in Hippocampal Eph Receptors Precede the Onset of Memory Decline in Mouse Models of Alzheimer's Disease

(2017) Ana María Simón et al.   JOURNAL OF ALZHEIMERS DISEASE

Acute Delivery of EphA4-Fc Improves Functional Recovery after Contusive Spinal Cord Injury in Rats

(2013) Mark Damien Spanevello et al.   JOURNAL OF NEUROTRAUMA

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

EphA4 Receptor Tyrosine Kinase Is a Modulator of Onset and Disease Severity of Experimental Autoimmune Encephalomyelitis (EAE)

(2013) Kathryn M. Munro et al.   PLoS One

Amyloid plaque formation precedes dendritic spine loss

(2012) Tobias Bittner et al.   ACTA NEUROPATHOLOGICA

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

(2012) Ilaria Lamberto et al.   BIOCHEMICAL JOURNAL

Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain

(2012) Aarti N. Patel et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5

(2012) Yi-Rong Peng et al.   NEUROPHARMACOLOGY

Inhibition of EphA4 signaling after ischemia–reperfusion reduces apoptosis of CA1 pyramidal neurons

(2012) Jianguo Li et al.   NEUROSCIENCE LETTERS

Eph receptors at synapses: Implications in neurodegenerative diseases

(2011) Yu Chen et al.   CELLULAR SIGNALLING

C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology

(2011) L. D. Estrada et al.   Current Alzheimer Research

c-Abl in Neurodegenerative Disease

(2011) Sarah D. Schlatterer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Eph Receptors Are Involved in the Activity-Dependent Synaptic Wiring in the Mouse Cerebellar Cortex

(2011) Roberta Cesa et al.   PLoS One

EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice

(2011) Yona Goldshmit et al.   PLoS One

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

(2010) Waldo Cerpa et al.   Molecular Neurodegeneration

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

(2010) Amy K Y Fu et al.   NATURE NEUROSCIENCE

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

(2010) Li Shen et al.   NEUROIMAGE

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts

(2009) W. D. Bradley et al.   JOURNAL OF CELL SCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

(2009) Alessandro Filosa et al.   NATURE NEUROSCIENCE

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

(2009) Gonzalo I. Cancino et al.   NEUROBIOLOGY OF AGING

Transcriptome Analysis of Synaptoneurosomes Identifies Neuroplasticity Genes Overexpressed in Incipient Alzheimer's Disease

(2009) Celia Williams et al.   PLoS One

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

(2009) M. A. Carmona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits

(2008) Gonzalo I. Cancino et al.   BRAIN

Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease

(2008) Alejandra R. Alvarez et al.   FASEB JOURNAL

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

(2008) Roberta Noberini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons

(2008) Michael A Beazely et al.   Molecular Brain