Article
Oncology
Fengmei Chen, Chen Xie, Kai Ren, Xiaomin Xu
Summary: This meta-analysis systematically evaluated the prognostic role of the Naples prognostic score (NPS) in patients with gastrointestinal (GI) cancers. Thirteen studies were included in the analysis. The results showed that a high NPS predicted poor overall survival, cancer-specific survival, and recurrence-free/disease-free survival in GI cancers. Subgroup analyses further confirmed the significant association between a high NPS and poor prognosis, regardless of NPS group, calculation method, and tumor type. Therefore, the NPS may serve as an effective prognostic indicator in patients with GI cancers.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Review
Oncology
Chellan Kumarasamy, Vaibhav Tiwary, Krishnan Sunil, Deepa Suresh, Sameep Shetty, Gothandam Kodiveri Muthukaliannan, Siddhartha Baxi, Rama Jayaraj
Summary: Inflammation plays a significant role in cancer development and progression, with PLR, NLR, and MLR being potential indicators of inflammation/prognostic markers. The study aimed to assess the prognostic efficacy of these markers in comparison to each other and investigate their potential in head and neck cancers. Results suggest that PLR, NLR, and MLR ratios are powerful prognostic markers in cancer that could guide treatment decisions, but further large-scale clinical studies are needed for clinical incorporation.
Review
Biotechnology & Applied Microbiology
Rongqiang Liu, Weihao Kong, Shiyang Zheng, Chenyu Yu, Yajie Yu, Yuling Xu, Linsen Ye, Yi Shao
Summary: Elevated expression of miR-24 in tumors is significantly associated with poor overall survival and may serve as a promising prognostic marker across different cancers. Further validation through additional investigations is warranted.
Article
Multidisciplinary Sciences
Meilong Wu, Shizhong Yang, Xiaobin Feng, Chengquan Li, Fei Yu, Jiahong Dong
Summary: Elevated postoperative neutrophil-lymphocyte ratio (postNLR) is associated with poor overall survival (OS) and disease-free survival (DFS) in patients with solid tumors. However, there is no correlation between high postNLR obtained within 7 days and poor DFS. Additional multicenter and prospective studies are needed to further explore the impact of the postNLR on the prognosis of solid tumors.
Review
Oncology
Rongqiang Liu, Kailiang Zhao, Kunpeng Wang, Lilong Zhang, Wangbin Ma, Zhengdong Qiu, Weixing Wang
Summary: Meta-analysis of nectin-4 expression revealed a significant association between high nectin-4 expression and poor overall survival (OS), but no relationship with disease-free survival/progression-free survival/relapse-free survival (DFS/PFS/RFS). Subgroup analysis showed that high nectin-4 expression was closely associated with adverse OS in esophageal cancer (EC) and gastric cancer (GC), as well as tumor diameter, stage, and invasion depth.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Yingji Fang, Tingting Zheng, Chengling Zhang
Summary: A high CRP/Alb ratio in patients with gynecological cancers is associated with poor overall survival and progression-/disease-free survival. Additionally, it predicts the risk of stages III-IV disease.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Q. Wang, S-R Zhu, X-P Huang, X-Q Liu, J-B Liu, G. Tian
Summary: Through a meta-analysis of multiple studies, it was found that SII is significantly associated with overall survival, progression-free survival, and cancer-specific survival in patients with urinary system cancers, suggesting that SII may serve as a prognostic indicator in USC patients to aid in prognosis evaluation and treatment strategy formulation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Buwen Zhang, Weiyun Yao
Summary: This meta-analysis demonstrates that an elevated pretreatment SII is significantly associated with worse overall survival and recurrence-free survival/progression-free survival in patients with biliary tract cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Chong-Yang Jia, Yan He, Shi-Nan Wu, Yan-Ting He, Ying Wang
Summary: This study aimed to identify the prognostic role of miR-144 in cancers. The results revealed that low miR-144 expression was significantly associated with favorable overall survival and had better predictive value in patients with urinary system cancer. Additionally, low miR-144 expression was associated with tumor diameter, tumor stage, and invasion depth.
Review
Oncology
Yanqing Li, Tianxiang Xu, Xin Wang, Xiangdong Jia, Meng Ren, Xiaoxia Wang
Summary: This meta-analysis investigated the impact of preoperative neutrophil-to-lymphocyte ratio (NLR) on the prognosis of colorectal liver metastasis (CRLM) patients. The pooled analysis of 18 studies showed that high NLR was associated with poor overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS) in CRLM patients. Therefore, NLR can be considered as an independent risk factor for adverse prognosis in CRLM patients.
CANCER CELL INTERNATIONAL
(2023)
Review
Oncology
Kian Heshmat-Ghahdarijani, Vida Sarmadi, Afshin Heidari, Alireza Falahati Marvasti, Sina Neshat, Sina Raeisi
Summary: This article evaluates the prognostic potential of the neutrophil-to-lymphocyte ratio (NLR) in cancer. By reviewing recent studies, the association between NLR and various malignancies is identified. These findings contribute to a better understanding of the role of NLR in cancer prognosis and provide guidance for future research directions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Zhangci Su, Leyao Xu, Xinning Dai, Mengyao Zhu, Xiaodan Chen, Yuanyuan Li, Jie Li, Ruihan Ge, Bin Cheng, Yun Wang
Summary: In this comprehensive meta-analysis, the high expression of METTL3 was found to be associated with poor prognosis, while the high expression of METTL14 was associated with better outcome in different types of cancers.
Review
Oncology
Mate Naszai, Alina Kurjan, Timothy S. Maughan
Summary: Inflammation is closely related to cancer, and NLR from routine blood testing serves as an easily accessible prognostic biomarker, aiding in assessing clinical outcomes in colorectal cancer patients. Combining results from numerous studies, high NLR was found to be associated with poor clinical outcomes, despite limitations in some studies, it should be routinely collected in clinical trials.
Review
Oncology
Hanlin Fu, Zhihui Fu, Meng Mao, Lulu Si, Jing Bai, Qian Wang, Ruixia Guo
Summary: This study evaluates the expression of PD-L1 and its prognostic significance in cervical cancer, endometrial cancer, and ovarian cancer. The results show that the prevalence of PD-L1 positivity is high in cervical cancer and moderately high in endometrial and ovarian cancer. Additionally, PD-L1 expression is associated with worse survival outcomes in cervical and endometrial cancer patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Oncology
Minhong Wu, Yan Zhou, Qingsheng Chen, Zhiling Yu, Hongyong Gu, Pengxiu Lin, Yanling Li, Cailing Liu
Summary: This study suggests that C-reactive protein to albumin ratio (CAR) has a potential prognostic role in patients with urinary cancers. High pretreated CAR is associated with inferior overall survival and progression-free survival. CAR can act as a predictor in renal cell carcinoma, bladder cancer, and prostate cancer subgroups. The results of this study are reliable and robust.
FRONTIERS IN ONCOLOGY
(2022)
Review
Infectious Diseases
Yongyue Wei, Liangmin Wei, Yihan Liu, Lihong Huang, Sipeng Shen, Ruyang Zhang, Jiajin Chen, Yang Zhao, Hongbing Shen, Feng Chen
Summary: This study estimated the median and dispersion of the SARS-CoV-2 incubation period more precisely. The incubation period for asymptomatic transmissions was significantly longer. Additionally, for every 10-year increase in age, there was an average 16% increment in the length of the median incubation period.
Article
Engineering, Multidisciplinary
Yongyue Wei, Jinxing Guan, Xiao Ning, Yuelin Li, Liangmin Wei, Sipeng Shen, Ruyang Zhang, Yang Zhao, Hongbing Shen, Feng Chen
Summary: This study evaluates the global situation of the COVID-19 pandemic from January 2020 to February 2021. The results show that nearly half of the countries and territories in the world have never controlled the epidemic. Among the countries and territories that had once contained the occurrence, nearly half failed to maintain their prevention and control, causing the COVID-19 pandemic to rebound. The study also identifies the countries with an increasing risk of COVID-19 transmission and highlights the association between non-pharmaceutical interventions and global transmission changes.
Article
Gastroenterology & Hepatology
Jinping Yang, Muhan Ni, Jingwei Jiang, Ximei Ren, Tingting Zhu, Shouli Cao, Shahzeb Hassan, Ying Lv, Xiaoqi Zhang, Yongyue Wei, Lei Wang, Guifang Xu
Summary: This study compared the outcomes of EFTR and EFTR-C for the treatment of small gastric GISTs. The results showed that EFTR-C had shorter operation times, better therapeutic outcomes, and faster postoperative recovery compared to EFTR.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Cardiac & Cardiovascular Systems
Yao Wang, Haojie Zhu, Xiaofeng Hou, Zhao Wang, Fengwei Zou, Zhiyong Qian, Yongyue Wei, Xiang Wang, Longyao Zhang, Xiaofei Li, Zhimin Liu, Siyuan Xue, Chaotong Qin, Jiaxin Zeng, Hui Li, Hongping Wu, Hong Ma, Kenneth A. Ellenbogen, Michael R. Gold, Xiaohan Fan, Jiangang Zou
Summary: Left bundle branch pacing (LBBP) shows greater improvement in left ventricular ejection fraction (LVEF) compared to biventricular pacing (BiVP) in heart failure patients with nonischemic cardiomyopathy and left bundle branch block (LBBB).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Oncology
Lan Zhang, Yong Wei, Yan He, Xiaping Wang, Zebo Huang, Libing Sun, Jie Chen, Qingyi Zhu, Xin Zhou
Summary: ANLN is upregulated in multiple cancers and associated with poor prognosis, as well as significantly correlated with tumor mutation burden, microsatellite instability, immune cell infiltration, and immune checkpoint genes. The study suggests that ANLN may serve as a prognostic biomarker for pan-cancer and provides new insights for cancer treatment.
Article
Immunology
Jiajin Chen, Xi Gao, Sipeng Shen, Jingyuan Xu, Zhe Sun, Ruilang Lin, Zhixiang Dai, Li Su, David C. Christiani, Feng Chen, Ruyang Zhang, Yongyue Wei
Summary: ObjectivePlatelet (PLT) is involved in immune and inflammatory responses, and its longitudinal trajectory patterns are associated with the prognosis of critically ill patients and the risk of thrombocytopenia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Yangqian Jiang, Yongyue Wei, Wenhui Guo, Jiangbo Du, Tao Jiang, Hongxia Ma, Guangfu Jin, Ting Chen, Rui Qin, Shiyao Tao, Qun Lu, Hong Lv, Xiumei Han, Kun Zhou, Bo Xu, Zhi Li, Mei Li, Yuan Lin, Yankai Xia, Zhibin Hu
Summary: Previous animal studies have shown that prenatal titanium exposure can lead to neurotoxicity in offspring, but there is a lack of human data. This study aimed to identify the associations between prenatal titanium exposure and child neurodevelopment. Participants were recruited during early pregnancy from 2014 to 2017, and urinary titanium concentrations were measured. Child neurodevelopment was assessed using the Chinese version of Gesell Developmental Schedules at the first year follow-up. The findings suggested that prenatal higher titanium exposure was associated with impaired language development, indicating that titanium may act as developmental neurotoxicants.
Article
Environmental Sciences
Liangmin Wei, Xin Chen, Hui Huang, Ruyang Zhang, Sipeng Shen, Weiwei Duan, Li Su, Hao Yu, Yongyue Wei, Feng Chen, David C. Christiani
Summary: Prenatal exposure to elements may be associated with birth weight via shortening of gestation. This study aimed to determine if prenatal exposure is associated with birth weight, and to explore the potential mediating role of gestational age in the association.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Jiajin Chen, Yunjie Song, Yi Li, Yongyue Wei, Sipeng Shen, Yang Zhao, Dongfang You, Li Su, Maria Moksnes Bjaanaes, Anna Karlsson, Maria Planck, Johan Staaf, Aslaug Helland, Manel Esteller, Hongbing Shen, David C. C. Christiani, Ruyang Zhang, Feng Chen
Summary: This study identified significant gene-gene interactions associated with non-small-cell lung cancer survival through a three-step analytic strategy. Two interactions were found at both the epigenetic and transcriptional levels, providing potential clues for precision treatment of NSCLC.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Bo Jiang, Junyuan Qi, Mingyuan Sun, Weiwei Zheng, Yongyue Wei, Jianxiang Wang, Fengkui Zhang
Summary: This study evaluated the pharmacokinetic profiles of flumatinib mesylate tablets at doses of 400 mg and 600 mg in patients with CML-CP. The results showed that flumatinib exposure increased in an approximately dose-proportional manner, with slow elimination and manageable adverse events. Further research is needed in a larger sample size study.
FRONTIERS IN ONCOLOGY
(2023)
Article
Infectious Diseases
Lishu Lou, Longyao Zhang, Jinxing Guan, Xiao Ning, Mengli Nie, Yongyue Wei, Feng Chen
Summary: In this study, a retrospective analysis of the Omicron epidemic in Shanghai was conducted to determine the timing and effectiveness of control measures. The findings indicate that precise control by grid management was not as effective as citywide static management. Implementing static management early significantly reduced daily new infections. The study underscores the importance of strict prevention and control measures for achieving dynamic zeroing and the need for preparation in changing strategies.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biology
Xiao Ning, Linlin Jia, Yongyue Wei, Xi-An Li, Feng Chen
Summary: This paper proposes a novel method, called Epi-DNNs, to model the complex dynamics of COVID-19 by integrating compartmental models and deep neural networks (DNNs). The method utilizes a neural network to express unknown parameters and solves ordinary differential equations (ODEs) using the Runge-Kutta method. By minimizing the discrepancy between predictions and observations, the best-fitted parameters for the compartmental model are identified. The experimental findings on real-world COVID-19 data demonstrate the effectiveness of Epi-DNNs in transmission modeling and the inferred parameters can be used for future predictions.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Sipeng Shen, Jiajin Chen, Hongru Li, Yongyue Wei, Yunke Jiang, Ruyang Zhang, Yang Zhao, Feng Chen
Summary: In this study, the influences of DNA methylation (DNAm) on non-coding RNAs (ncRNAs) were characterized, and significant associations between DNAm sites and various ncRNAs across multiple cancer types were identified. A subtype called ncmcluster was developed based on cancer-specific ncRNAs, which showed associations with tumor microenvironment, clinical outcome, and biological pathways. To comprehensively describe the ncQTM patterns, a database named Pancan-ncQTM was developed.
Article
Virology
Xiao Ning, Jinxing Guan, Xi-An Li, Yongyue Wei, Feng Chen
Summary: This study proposes an advanced artificial intelligence approach based on physics-informed neural networks (PINNs) to estimate time-varying parameters from given data for the compartmental model. The experimental findings on real-world reported data have demonstrated that our method robustly and accurately learns the dynamics and forecasts future states.
Article
Medicine, General & Internal
Zoucheng Pan, Ruyang Zhang, Sipeng Shen, Yunzhi Lin, Longyao Zhang, Xiang Wang, Qian Ye, Xuan Wang, Jiajin Chen, Yang Zhao, David C. Christiani, Yi Li, Feng Chen, Yongyue Wei
Summary: This study developed a reliable lung cancer risk prediction model called OWL using machine learning techniques and validated its performance on multiple datasets, demonstrating its superior performance in identifying individuals at high risk of lung cancer.
