Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase

(2013) Johan Winquist et al.   ANTIVIRAL RESEARCH

New horizons in hepatitis C antiviral therapy with direct-acting antivirals

(2013) Alessio Aghemo et al.   HEPATOLOGY

Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase

(2013) Brittny C. Davis et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

(2012) Izuru Ando et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

(2012) M. Fenaux et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential scanning calorimetry as a tool for protein folding and stability

(2012) Christopher M. Johnson   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

(2012) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

(2012) R. T. Mosley et al.   JOURNAL OF VIROLOGY

Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

(2012) N. Scrima et al.   JOURNAL OF VIROLOGY

Differential Scanning Fluorometry Signatures as Indicators of Enzyme Inhibitor Mode of Action: Case Study of Glutathione S-Transferase

(2012) Wendy A. Lea et al.   PLoS One

Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir

(2011) Guanghui Yi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Objective Assessment of Conformational Variability in Complexes of Hepatitis C Virus Polymerase with Non-Nucleoside Inhibitors

(2011) Célia Caillet-Saguy et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of Activity and Inhibition of the Hepatitis C Virus RNA-dependent RNA Polymerase

(2010) Stefan Reich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of De Novo-Initiated RNA Synthesis in Hepatitis C Virus RNA-Dependent RNA Polymerase by Intermolecular Interactions

(2010) S. Chinnaswamy et al.   JOURNAL OF VIROLOGY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

(2009) Frank Ruebsam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5,5′- and 6,6′-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

(2009) David A. Ellis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

(2009) Julie Qi Hang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

(2009) Hui Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

(2008) Frank Ruebsam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

(2008) Dmitry F. Zamyatkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

(2008) Sreedhar Chinnaswamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY