Article
Oncology
Yi Shen, Yi Shao, Xiaoli Ruan, Lingyan Zhu, Zhaoping Zang, Tong Wei, Rena Nakyeyune, Wenqiang Wei, Fen Liu
Summary: This study found that the rs1804506 polymorphism located in miR-17-92 cluster binding sites is associated with the susceptibility of ESCC, especially in older individuals, females, or non-smokers. The rs1804506 T allele reduces the binding of miR-19a-3p and TGFBR3, suggesting its potential role in ESCC development.
Article
Medicine, General & Internal
Yuting Shi, Lihua Zhang, Yang Bao, Pengfei Wu, Xiaoli Zhang
Summary: This study revealed an association between TNIP1 polymorphisms and increased risk of HCC in a Northwest Chinese Han population, particularly the G allele of rs7708392. Additionally, the GC haplotype was also significantly correlated with higher occurrence of HCC. Further research is warranted to explore these associations.
Article
Biochemistry & Molecular Biology
Hanyi Zhang, Siyao Deng, Jiayu Zhang, Guiquan Zhu, Jie Zhou, Wenjing Ye, Qingwei Wang, Yi Wang, Bingwen Zou, Peng Zhang, Shichuan Zhang, Jinyi Lang, Shun Lu
Summary: Genetic variants in genes involved in the LMP1 signaling pathway, particularly the NFKBIA promoter SNP rs2233409, may be moderately associated with the risk of nasopharyngeal carcinoma (NPC). Further studies with larger sample sizes and functional analysis are needed to confirm these findings.
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jusi Wang, Tingyu Chen, Weifeng Tang, Mingqiang Kang, Shuchen Chen
Summary: The study found that the rs2227282 (C > G) and rs2243283 (C > G) loci in the IL4 gene play protective roles in the development of ESCC, reducing the risk for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Dongwei Gong, Shizong Li, Zhiwei Yu, Kaiqiong Wang, Xin Qiao, Changxiong Wu
Summary: This study found an association between specific single nucleotide polymorphisms of the PNPLA3 gene and susceptibility to hepatocellular carcinoma (HCC), particularly the G allele and GG genotype of rs2896019 being significantly correlated with increased HCC susceptibility. Furthermore, all four SNPs were found to be related to increased HCC susceptibility in individuals over the age of 55.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Paula Roberta Aguiar Pastrez, Ana Margarida Barbosa, Vania Sammartino Mariano, Rhafaela Lima Causin, Antonio Gil Castro, Egidio Torrado, Adhemar Longatto-Filho
Summary: Esophageal squamous cell carcinoma (ESCC) is a rapidly progressing cancer with high mortality rates. In this study, we investigated the levels of inflammatory cytokines in ESCC patients and healthy individuals. We found increased levels of IL-1 beta, IL-6, IL-8, and IL-10 in ESCC patients. Among these cytokines, IL-8 was identified as an independent prognostic factor for ESCC. Additionally, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a higher overall survival rate. Our findings suggest IL-8 as a potential biomarker for ESCC.
Article
Oncology
Jinxiao Liang, Yinjie Wang, Lei Cai, Jinshi Liu, Junrong Yan, Xin Chen, Xiaoying Wu, Qixun Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and deadly malignant tumor, with smoking, drinking, and poor eating habits being contributing factors. This study used whole-exome sequencing to analyze genetic variations in ESCC tumors and normal mucosa, finding significant differences in mutation frequencies and copy number variations. The study also revealed different evolution modes of primary tumors in bifocal ESCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pediatrics
Jianrong Shi, Lin He, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Ran Tao
Summary: This study investigated the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of atopic dermatitis (AD) in Chinese children. The results showed that IL-4 rs2243283 G allele, CG genotype, and CG+GG genotype were significantly decreased in AD patients, while IL-18 rs7106524 A allele, AA genotype, and AG+AA genotype were significantly increased in severe AD patients.
FRONTIERS IN PEDIATRICS
(2023)
Article
Oncology
Dongqing Gao, Peipei Lu, Nan Zhang, Li Zhao, Jinhui Liu, Jia Yang, Jingmin Liu, Deli Zhao, Jialin Wang
Summary: This study examined the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese and aimed to provide more support for ESCC screenings. The results showed that the higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening and follow-up management should be strengthened for males and the elderly population.
Article
Multidisciplinary Sciences
Jiaying Li, Hongjiao Wu, Hui Gao, Ruihuan Kou, Yuning Xie, Zhi Zhang, Xuemei Zhang
Summary: The study revealed an association between TLR4 genetic polymorphisms and esophageal cancer risk, with the rs1927914 GG genotype carriers having a lower risk. This variant affects promoter activity and is particularly relevant in elderly individuals and non-smokers.
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Minyan Yuan, Xueqing Zheng, Jiaojiao Jing, Yang Li, Nianke Liu, Yaling Song
Summary: This study evaluated the association between SYN2, PPARG, RAF1, TIMP4, and IQSEC1 polymorphisms in 3p25 and oral squamous cell carcinoma (OSCC) in the Chinese Han population. IQSEC1-rs2686742 was found to be correlated with the onset of OSCC, and several SNPs in IQSEC1 and PPARG genes were significantly associated with clinical characteristics of OSCC. IQSEC1-rs2600322 was shown to have an important role in the survival of OSCC patients, and various SNPs influenced survival outcomes. Functional annotation revealed changes in transcript levels of IQSEC1 and PPARG genes in OSCC tissues.
