Article
Engineering, Biomedical
Wei Sun, Yingxuan Chen, Liang Wang, Ze Wang, Shuwei Liu, Mengzhu Zhang, Yi Liu, Quanshun Li, Hao Zhang
Summary: The gastrointestinal tract, with the largest mucosal surface area in the body, is prone to inflammatory damage from external stimuli. Antioxidant therapy is a potential strategy for treating intestinal inflammatory diseases. The preparation of quercetin supramolecular nanoribbons (SNRs) as oral medicines can effectively prevent and treat these diseases, providing excellent antioxidant activity in the harsh environment of the gastrointestinal tract.
Article
Biochemistry & Molecular Biology
Giulio Verna, Marina Liso, Elisabetta Cavalcanti, Giusy Bianco, Veronica Di Sarno, Angelo Santino, Pietro Campiglia, Marcello Chieppa
Summary: Dendritic cells can be divided into myeloid dendritic cells and plasmacytoid dendritic cells, which play important roles in regulating immune responses. Inflammatory bowel diseases are characterized by leaky intestinal barrier and translocation of bacterial lipopolysaccharide. It was found that quercetin can modulate dendritic cell responses through a specific molecular pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Mariana Juste Contin Gomes, Nikolai Kolba, Nikita Agarwal, Dean Kim, Adi Eshel, Omry Koren, Elad Tako
Summary: This study evaluated the effects of resveratrol and pterostilbene on the gut microbiome and brush border membrane. It showed beneficial morphological changes, improved mineral metabolism, and potential enhancement in gut health. The results suggest a significant bacterial-host interaction that contributes to intestinal functionality and physiological status.
Article
Multidisciplinary Sciences
Paulina M. Opyd, Adam Jurgonski
Summary: In this study, it was found that milk thistle seeds have the potential to reduce liver fat content and improve lipid disorders in obese rats, with the unsaturated fatty acids in the seeds playing a role to some extent.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Ying Xie, Xin Zhan, Jiyuan Tu, Kang Xu, Xiongjie Sun, Chunlian Liu, Chang Ke, Guosheng Cao, Zhongshi Zhou, Yanju Liu
Summary: This study confirmed the therapeutic effect of Atractylodes lanceolata oil (AO) in a rat model of IBS-D, showing that AO inhibits the SCF/c-kit pathway to reduce inflammation and protects against intestinal barrier damage via the MLCK/MLC2 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Chuanqi Wang, Haoyang Sun, Xu Jiang, Xin Guan, Feng Gao, Baoming Shi
Summary: Research shows that oxidized oil in the diet can have toxic effects on the growth and development of animals and humans. However, the mechanism of how different degrees of oxidation affect two generations is still unclear. This study used a rat model to investigate the effects of oxidized soybean oil during pregnancy and lactation on placental RNA methylation and DNA methylation in offspring jejunum. The results demonstrate that maternal intake of oxidized oil can negatively affect placental health and intestinal development of the offspring.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhiqiang Li, Kai Wang, Xiaoxia Ji, Huanhuan Wang, Yuanshu Zhang
Summary: The study revealed that ACE2 plays a crucial role in regulating inflammatory response by degrading Ang II to resist LPS-induced inflammation. The anti-inflammatory effect of ACE2 is achieved through regulating the NF-kappa B and MAPK pathways.
Article
Nutrition & Dietetics
Akiko Nakamoto, Miho Goto, Hina Hasegawa, Chieri Anzaki, Mariko Nakamot, Emi Shuto, Tohru Sakai
Summary: Sudachi oil can suppress immune function both in vitro and in vivo, including cell proliferation and antigen presentation, leading to the inhibition of antigen-specific T cell induction.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2022)
Article
Cell Biology
Liangfeng Wang, Fang Wang, Xiaofei Zhang, Qingyao Chen, Jie Xu, Huiting Li, FengQin Li, Ming Yang
Summary: The study found that ZhiShi and BaiZhu volatile oils can alleviate slow transit constipation by promoting intestinal peristalsis, increasing fecal water content, and regulating intestinal microbiota and fecal metabolites.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Marina Liso, Annamaria Sila, Giulio Verna, Aurelia Scarano, Rossella Donghia, Fabio Castellana, Elisabetta Cavalcanti, Pasqua Letizia Pesole, Eduardo Maria Sommella, Antonio Lippolis, Raffaele Armentano, Anna Maria Giudetti, Daniele Vergara, Pietro Campiglia, Rodolfo Sardone, Margherita Curlo, Mauro Mastronardi, Katia Petroni, Chiara Tonelli, Angelo Santino, Marcello Chieppa
Summary: Antioxidants can be used as adjuvants to improve the effectiveness of pharmacological therapies, especially for chronic inflammatory syndromes. A study found that taking an antioxidant-enriched purple corn supplement can improve the response to medication in patients with inflammatory bowel diseases, although the effect may vary between Crohn's disease and ulcerative colitis.
Article
Nutrition & Dietetics
Mirco Vacca, Benedetta Raspini, Francesco Maria Calabrese, Debora Porri, Rachele De Giuseppe, Marcello Chieppa, Marina Liso, Rosa Maria Cerbo, Elisa Civardi, Francesca Garofoli, Hellas Cena, Maria De Angelis
Summary: This study aimed to characterize the gastrointestinal microbiota in infants during early childhood and determine how different factors during pregnancy, delivery, and postnatal period influenced its composition. The results showed that milk-feeding and weaning played a significant role in shaping the microbiota.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Byung-Gyu Kim, Sung Hee Choi, John J. Letterio, Jie-Young Song, Alex Y. Huang
Summary: The study demonstrates that overexpression of VEGF in plasmacytoma inhibits tumor growth and enhances T-cell-mediated antitumor immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Angelica Giuliani, Giulia Matacchione, Deborah Ramini, Mirko Di Rosa, Anna Rita Bonfigli, Jacopo Sabbatinelli, Vladia Monsurro, Rina Recchioni, Fiorella Marcheselli, Francesca Marchegiani, Francesco Piacenza, Maurizio Cardelli, Roberta Galeazzi, Giovanni Pomponio, Alessia Ferrarini, Armando Gabrielli, Silvia Svegliati Baroni, Marco Moretti, Riccardo Sarzani, Piero Giordano, Antonio Cherubini, Andrea Corsonello, Roberto Antonicelli, Antonio Domenico Procopio, Manuela Ferracin, Massimiliano Bonafe, Fabrizia Lattanzio, Fabiola Olivieri
Summary: This study aimed to identify circulating miRNAs associated with the risk of in-hospital mortality in COVID-19 patients. Serum samples of 12 COVID-19 patients were analyzed and the findings were validated in a separate cohort. The study identified significantly elevated levels of miR-320b and miR-483-5p in deceased patients compared to survivors.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Cell Biology
Adelfia Tala, Flora Guerra, Silvia Caterina Resta, Matteo Calcagnile, Amilcare Barca, Salvatore Maurizio Tredici, Maria Dolores De Donno, Mirco Vacca, Marina Liso, Marcello Chieppa, Maria De Angelis, Tiziano Verri, Maria Giuseppina Bozzetti, Cecilia Bucci, Pietro Alifano
Summary: This study demonstrates that the intestinal environment of mice with a missense mutation in the MUC2 mucin gene selects a specific intestinal microbial community characterized by pro-inflammatory, genotoxic, and metabolic features, suggesting its direct involvement in the pathogenesis of chronic intestinal inflammation.
Article
Biochemistry & Molecular Biology
Rachele De Giuseppe, Federica Loperfido, Rosa Maria Cerbo, Maria Cristina Monti, Elisa Civardi, Francesca Garofoli, Micol Angelini, Beatrice Maccarini, Eduardo Sommella, Pietro Campiglia, Laura Bertuzzo, Marcello Chieppa, Stefano Ghirardello, Hellas Cena
Summary: Childhood obesity is a strong predictor of adult obesity, with significant health and economic consequences. Early adiposity rebound (EAR) occurring at around 2 years old may be related to early changes in the gut microbiome due to maternal/lifestyle changes and environmental exposures. The LIMIT study aims to identify the interplay between infant gut microbiome, infant/maternal lifestyle, and environmental factors, in order to find modifiable factors for effective and personalized prevention of childhood obesity.
Article
Biochemistry & Molecular Biology
Giulio Verna, Marina Liso, Elisabetta Cavalcanti, Raffaele Armentano, Alessandro Miraglia, Vladia Monsurro, Marcello Chieppa, Stefania De Santis
Summary: Colorectal cancer is a prime example of the link between inflammation and cancer. Targeting inflammatory mediators has shown to decrease the overall risk of colorectal cancer, although its chemopreventive potential remains debated. The role of tumor necrosis factor (TNF) in the development and progression of colorectal cancer is complex, with TNF having a dual effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Kristen A. A. VanHeyst, Sung Hee Choi, Daniel T. T. Kingsley, Alex Y. Y. Huang
Summary: Vascular Cell Adhesion Molecule-1 (VCAM-1) is a membrane protein with critical physiological functions in cellular immune response. It can be cleaved into a soluble form (sVCAM-1) and elevated concentrations of sVCAM-1 have been found in the peripheral blood of cancer patients. The VCAM-1/VLA-4 signaling plays a vital role in tumor metastasis and therapy resistance.
Article
Chemistry, Multidisciplinary
Simona Bettini, Michela Ottolini, Donato Valli, Rosanna Pagano, Chiara Ingrosso, Maarten Roeffaers, Johan Hofkens, Ludovico Valli, Gabriele Giancane
Summary: Inorganic chiral nanoparticles, particularly gold chiral nanostructures, are receiving increasing attention for their unique optical properties and potential biological applications. This study successfully synthesized gold nanostructures with opposite circular dichroism signals depending on the amino acid enantiomer used during synthesis. The gold nanostructures were further decorated with penicillamine, and it was shown that both penicillamine enantiomers can be successfully bonded with both the enantiomers of the gold nanostructures without affecting their chirality. This research provides important insights into the control of chirality and surface properties in chiral nano-systems.
Review
Biochemistry & Molecular Biology
Aurelia Scarano, Barbara Laddomada, Federica Blando, Stefania De Santis, Giulio Verna, Marcello Chieppa, Angelo Santino
Summary: This article examines the effects of dietary polyphenols on human health, focusing on their antioxidant properties and chelating abilities. It explores the importance of polyphenols and their iron-binding abilities in inflammatory/immunomodulatory responses, with specific attention to macrophages and dendritic cells, as well as their impact on gut microbiota. The article also highlights the need for further investigation into the polyphenol-iron metabolism-inflammatory responses axis and the polyphenol-iron availability-gut microbiota relationship to prevent or counteract pathological conditions.
Article
Oncology
Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons, Mei Zhang
Summary: This study found that the carbohydrate ligand BG34-200 can bind to activated CD11b, resulting in significant effects on tumor-associated inflammatory monocytes (TAIMs) in three solid tumor backgrounds (osteosarcoma, advanced melanoma, and PDAC). This binding triggers structural biological changes in TAIMs, inducing F-actin cytoskeletal rearrangement, effective phagocytosis, and ICAM-1 clustering. These changes lead to the differentiation of TAIMs into monocyte-derived dendritic cells, enhancing T-cell activation in the tumor microenvironment and potentially improving immunotherapy for solid cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Mohammad Alshebremi, Suzanne L. Tomchuck, Jay T. Myers, Daniel T. Kingsley, Saada Eid, Muta Abiff, Melissa Bonner, Shahrazad T. Saab, Sung Hee Choi, Alex Yee-Chen Huang
Summary: The tumor cell-intrinsic STING pathway plays a crucial role in the effectiveness of cryoablation, and the expression of STING-related signaling components may serve as a potential therapy response biomarker.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Endocrinology & Metabolism
Dario Domenico Lofrumento, Alessandro Miraglia, Velia La Pesa, Antonella Sonia Treglia, Marcello Chieppa, Francesco De Nuccio, Giuseppe Nicolardi, Claudia Miele, Francesco Beguinot, Corrado Garbi, Bruno Di Jeso
Summary: In type 2 Diabetes, beta-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction. The study found that increased flux of glucose in the hexosamine biosynthetic pathway affects beta-cell-beta-cell homotypic interactions.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)