Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

(2013) Elissaveta Petrova et al.   Nature Chemical Biology

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

An Emerging Role of Sonic Hedgehog Shedding as a Modulator of Heparan Sulfate Interactions

(2012) Stefanie Ohlig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hedgehog processing pathway is required for NSCLC growth and survival

(2012) J Rodriguez-Blanco et al.   ONCOGENE

Bioorthogonal chemical tagging of protein cholesterylation in living cells

(2011) William P. Heal et al.   CHEMICAL COMMUNICATIONS

Sonic Hedgehog Shedding Results in Functional Activation of the Solubilized Protein

(2011) Stefanie Ohlig et al.   DEVELOPMENTAL CELL

Two Distinct Sites in Sonic Hedgehog Combine for Heparan Sulfate Interactions and Cell Signaling Functions

(2011) Shu-Chun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of peroxisome proliferator-activated receptor γ activity suppresses pancreatic cancer cell motility

(2010) Atsushi Nakajima et al.   CANCER SCIENCE

Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog

(2010) John A. Buglino et al.   PLoS One

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyltransferases for secreted signalling proteins (Review)

(2009) Shu-Chun Chang et al.   MOLECULAR MEMBRANE BIOLOGY

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity

(2008) Shohreh F. Farzan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Acyl-CoA:Lysophospholipid Acyltransferases

(2008) Hideo Shindou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

N-Myristoyl transferase-mediated protein labelling in vivo

(2008) William P. Heal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides

(2008) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA