Review
Medicine, General & Internal
Laszlo Modis, Zsofia Aradi, Ildiko Fanny Horvath, Janos Bencze, Tamas Papp, Miklos Emri, Ervin Berenyi, Antal Bugan, Antonia Szanto
Summary: Central nervous system (CNS) involvement is common in primary Sjogren's syndrome (pSS), with neurological symptoms often preceding sicca symptoms. Magnetic resonance imaging (MRI) reveals white matter hyperintensities (WMH) around the ventricles and subcortically, as well as cortical atrophy and ventricular dilatation. However, the link between these MRI lesions and clinical manifestations is not well established, and further studies are needed to elucidate the correlations.
Review
Chemistry, Medicinal
Lorena R. Lizarraga-Valderrama
Summary: Essential oils have a wide range of biological activities and can produce anxiolytic, antidepressant, sedative, and anticonvulsant effects on the nervous system. Animal models have shown involvement of multiple neurotransmitter systems leading to measurable physiological effects in the brain, and clinical trials have demonstrated their influence on physiological parameters and psychological effects. More research is needed to validate their influence on the human central nervous system and their potential as drugs for mental illnesses.
PHYTOTHERAPY RESEARCH
(2021)
Review
Virology
Jia-Mei Liu, Bai-Hong Tan, Shuang Wu, Yue Gui, Jia-Le Suo, Yan-Chao Li
Summary: This review provides strong evidence for SARS-CoV-2 infection of the central nervous system, shedding light on the neurological mechanism underlying the lethality of the infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Cell Biology
Jacek Baj, Alicja Forma, Wojciech Flieger, Izabela Morawska, Adam Michalski, Grzegorz Buszewicz, Elzbieta Sitarz, Piero Portincasa, Gabriella Garruti, Michal Flieger, Grzegorz Teresinski
Summary: H. pylori, known for causing gastrointestinal impairments, is increasingly being studied for its potential involvement in extragastric diseases like neurological disorders. Impairments in the gut-brain axis and altered gut microbiota due to H. pylori colonization are believed to be primarily responsible for neurological issues induced by H. pylori infection. Most studies so far have focused on the relationship between H. pylori and neurological disorders.
Article
Immunology
Ruxue Yin, Mengzhu Zhao, Dong Xu, Qian Wang, Mengtao Li, Wen Zhang, Fengchun Zhang, Xiaofeng Zeng, Yuping Huo, Yong Hou
Summary: Cardiac involvement in RP is associated with age, CNS involvement, NLR, and disease duration, and it is mutually exclusive with airway involvement. Regular cardiac examinations are necessary for RP patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Leonard Ngarka, Joseph Nelson Siewe Fodjo, Esraa Aly, Willias Masocha, Alfred K. Njamnshi
Summary: Neurological disorders related to neuroinfections are highly prevalent in Sub-Saharan Africa (SSA), with epilepsy, dementia, motor neuron diseases, headache disorders, sleep disorders, and peripheral neuropathy being major health concerns. These disorders are often associated with HIV infection, as well as other infections such as toxoplasmosis and malaria. The pathogenesis involves the direct role of the virus, antiretroviral treatments, and immune system dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eduardo Villa, Alejandra Torres, Patricia Orellana, Jose de Grazia, Maria Elena Villanueva, Carlos Guevara
Summary: Neurological manifestations can occur in a significant proportion of patients with primary Sjogren's Syndrome, with a small percentage experiencing central nervous system involvement. We present a case of a patient with Neuro-Sjogren's syndrome who initially presented with limb weakness and visual loss, and later developed sicca symptoms. The patient was diagnosed through a saliva gland biopsy and successfully treated with a combination of steroids, cyclophosphamide, and rituximab.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Rheumatology
Wei Fan, Jennefer Par-Young, Kaiyan Li, Yi Zhang, Pingping Xiao, Li Hua, Lin Leng, Xuyan Chen, Richard Bucala
Summary: This retrospective study aimed to describe the clinical profiles and high-risk indicators of primary Sjogren's syndrome (pSS) patients with central nervous system (CNS) involvement (pSS-CNS). The study found that the prevalence of CNS involvement in pSS patients was 10.2%, with neurological manifestations as the initial symptom in 31.3% of the cases. Hemiparesis, paraparesis, dysphonia, blurred vision, and dysfunctional proprioception were common manifestations in pSS-CNS patients. Cerebral infarction, demyelination, myelitis, and angiostenosis were commonly found on imaging in these patients. Lung involvement, positive anti-SSA antibody test, and reduced C3 levels were identified as potential risk factors for CNS involvement in pSS. High-dose glucocorticoids and immunosuppressive therapy were effective in improving the condition in 60% of pSS-CNS patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Guihua Fan, Fan Dai, Shiju Chen, Yuechi Sun, Hongyan Qian, Guomei Yang, Yuan Liu, Guixiu Shi
Summary: Neurological involvement is common in patients with primary Sjogren's syndrome (pSS) and needs careful evaluation. Patients with pSS with high anti-SSA titers and low anti-SSB presence may have a relatively high risk of developing neurological involvement. Future studies should focus on identifying biomarkers for early diagnosis of neurological involvement in patients with pSS.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Review
Physiology
Jing Yan, Xiaole Tang, Zhi-qiang Zhou, Jie Zhang, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: SIRTs are a class of NAD+-dependent deacylases that regulate cell functions. CNS decline leads to impaired cognitive and social abilities, so understanding potential targets to promote CNS homeostasis is crucial.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Rheumatology
Mengzhu Zhao, Di Wu, Min Shen
Summary: A total of 187 patients with adult-onset Still's disease (AOSD) were studied, revealing a 7.5% prevalence of neurological involvement. Common symptoms included fever, rash, liver dysfunction, arthralgia/arthritis, and lymphadenopathy. Treatment strategies mainly consisted of high-dose corticosteroids and immunosuppressive agents, with a 100% clinical remission rate.
Article
Clinical Neurology
Ricardo Taipa, Luisa Sousa, Miguel Pinto, Ines Reis, Aurora Rodrigues, Pedro Oliveira, Manuel Melo-Pires, Teresa Coelho
Summary: This study explores the sequence and severity of CNS TTR deposition in patients with ATTRv. The results suggest that CNS pathological involvement occurs early in the disease course, particularly in V30M ATTRv, and follows a distinct sequence. Early and severe involvement is observed in the brainstem and spinal cord, while parenchymal deposition outside the brain is rare.
ACTA NEUROPATHOLOGICA
(2023)
Review
Immunology
Simone Appenzeller, Samuel de Oliveira Andrade, Mariana Freschi Bombini, Samara Rosa Sepresse, Fabiano Reis, Marcondes C. Franca Jr
Summary: This article reviews the epidemiology, clinical and immunological characterization, diagnosis, and treatment of neurologic events in primary Sjogren's Syndrome (pSS). It highlights the lack of diagnostic criteria and clinical trials to support treatment, and emphasizes the need for well-designed clinical trials to improve therapeutic options.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Review
Clinical Neurology
Lingling Xu, Yao Yao
Summary: This review discusses the anatomical location and molecular markers of fibroblast-like cells in the CNS, their functions in CNS development and neurological disorders, and current challenges and future directions in the field of research on CNS fibroblast-like cells.
Review
Medicine, General & Internal
Elena Cecilia Rosca, Raluca Tudor, Amalia Cornea, Mihaela Simu
Summary: The study reviewed the evidence of CNS involvement in trichinellosis and identified specific clinical features that can predict the risk of death in patients, providing important insights for early detection and intervention.
Article
Clinical Neurology
Gianluca Coppola, Antonio Di Renzo, Barbara Petolicchio, Emanuele Tinelli, Cherubino Di Lorenzo, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Vincenzo Parisi, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli
JOURNAL OF NEUROLOGY
(2020)
Article
Clinical Neurology
Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli
JOURNAL OF HEADACHE AND PAIN
(2020)
Article
Clinical Neurology
Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli, Gianluca Coppola
JOURNAL OF HEADACHE AND PAIN
(2020)
Article
Clinical Neurology
Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Vincenzo Parisi, Mariano Serrao, Camillo Porcaro, Marco Fiorelli, Francesca Caramia, Jean Schoenen, Vittorio Di Piero, Francesco Pierelli
Summary: The study found differences in resting-state functional connectivity in patients with different types of aura-related migraines, with these differences related to the microstructure of the thalamus. MA+ patients showed lower microstructural metrics correlated with DMN connectivity strength. While MA patients did not differ significantly from HCs in microstructural metrics, they lacked the same correlation with DAS connectivity as seen in HCs.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Multidisciplinary Sciences
Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Stefano Seri, Cherubino Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli, Gianluca Coppola
Summary: The study showed that during the interictal period of migraine, patients exhibit altered hypothalamic microstructure and connectivity at cortical level. Additionally, abnormalities in fractal dimensions of specific brain networks were found to be associated with the severity of migraine, suggesting abnormal efficiency demands in sensory, emotional, and cognitive information integration.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Alessandra Morano, Emanuele Cerulli Irelli, Enrico Michele Salamone, Biagio Orlando, Martina Fanella, Emanuele Tinelli, Gabriele Ruffolo, Luigi Zuliani, Jinane Fattouch, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura
Summary: This study compares patients with autoimmune encephalitis (AE) and late-onset epilepsy of unknown origin (LOEUO) and finds that high-frequency focal seizures with autonomic manifestations may be indicative of AE in the elderly. It highlights the importance of using 24-h ambulatory electroencephalography (AEEG) to recognize AE and reduce diagnostic delay.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Vincenzo Parisi, Cherubino Di Lorenzo, Francesca Caramia, Marco Fiorelli, Giada Giuliani, Ettore Cioffi, Stefano Seri, Vittorio Di Piero, Francesco Pierelli, Giorgio Di Lorenzo, Gianluca Coppola
Summary: This study analyzed the role of the hypothalamus and the limbic system in the onset of a migraine attack. The findings revealed significant changes in diffusivity metrics within the hypothalamus of patients compared to healthy controls, particularly in posterior regions. The severity of the migraine attack was positively correlated with the hypothalamic axial diffusivity and the complexity of the salience network involved in pain processing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chiara Abagnale, Antonio Di Renzo, Gabriele Sebastianelli, Francesco Casillo, Emanuele Tinelli, Giada Giuliani, Maria Giulia Tullo, Mariano Serrao, Vincenzo Parisi, Marco Fiorelli, Francesca Caramia, Jean Schoenen, Vittorio Di Piero, Gianluca Coppola
Summary: This study compared white matter fiber bundles and gray matter cortical thickness between healthy controls, patients with pure visual auras, and patients with complex neurological auras. The results show that both types of aura are associated with cortical thinning in multiple brain areas. Furthermore, the clinical heterogeneity of the aura is reflected by opposite thickness changes in high-level visual-information-processing, sensorimotor, and language areas.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Meeting Abstract
Clinical Neurology
Maria Eugenia Caligiuri, Emanuele Tinelli, Francesco Cicone, Giuseppe Lucio Cascini, Cesare Oliveti, Stefania Colafati, Alessia Carboni, Sabrina Maffi, Simone Migliore, Eugenia Scaricamazza, Aldo Quattrone, Umberto Sabatini, Ferdinando Squitieri
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Meeting Abstract
Clinical Neurology
Emanuele Tinelli, Maria Eugenia Caligiuri, Francesco Cicone, Giuseppe Lucio Cascini, Cesare Oliveti, Giovanna Stefania Colafati, Antonio Napolitano, Sabrina Maffi, Simone Migliore, Eugenia Scaricamazza, Aldo Quattrone, Ferdinando Squitieri, Umberto Sabatini
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Massimo Marianetti, Silvia Pinna, Angelo Venuti, Gianfranco Liguri
Summary: This study evaluated the potential benefits of olive polyphenols and bioavailable glutathione for patients with mild Alzheimer's disease. The results showed that all measured neurocognitive parameters stabilized or improved after 6 months of treatment.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Article
Clinical Neurology
Valentina Calistri, Patrizia Mancini, Eytan Raz, Maria Nicastri, Emanuele Tinelli, Francesca Yoshie Russo, Marco Fiorelli, Elio De Seta, Daniele Carpentieri, Marco De Vincentiis, Francesca Caramia
Summary: In patients with acute Bell's palsy, fMRI revealed greater activation in the frontal and insular areas on the side of facial paresis. There was an inverse correlation between activation in the paretic hemisphere and the degree of paresis at baseline in BP patients. Additionally, activation was associated with clinical outcomes, including complete recovery and improvement in paresis.
JOURNAL OF NEUROIMAGING
(2021)
Article
Medicine, General & Internal
Emanuele Tinelli, Nicoletta Locuratolo, Alberto Pierallini, Massimo Rossi, Francesco Fattapposta
CASE REPORTS IN MEDICINE
(2020)
Meeting Abstract
Clinical Neurology
Gianluca Coppola, Antonio Di Renzo, Barbara Petolicchio, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli
Meeting Abstract
Clinical Neurology
Gianluca Coppola, Antonio Di Renzo, Barbara Petolicchio, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli