Article
Engineering, Biomedical
Xiaobin Chen, Hancheng Wang, Jiayue Shi, Zhiyong Chen, Yaoben Wang, Siyi Gu, Ye Fu, Jiale Huang, Jiandong Ding, Lin Yu
Summary: Proposed a novel injectable magnetic and ferroptotic hydrogel to overcome the obstacles in the clinical application of magnetic hyperthermia therapy (MHT) and enhance its antitumor efficacy.
Article
Pharmacology & Pharmacy
Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: Despite the clinical benefits of chemotherapeutics, drug resistance remains a major challenge in breast cancer treatment. Nanomedicines, such as porous silicon nanoparticles (pSiNPs), offer a targeted and effective approach by delivering multiple therapeutics and minimizing drug resistance. In this study, breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs) were engineered. The combination of hyperthermia and chemotherapy using targeted pSiNPs showed higher cell-killing efficacy compared to monotherapy and a nontargeted system with combined therapeutics. These findings highlight the potential of targeted pSiNPs as a versatile platform for personalized medicine.
Article
Chemistry, Multidisciplinary
Hao Fu, Lizhu Chen, Wenming Fang, Ping Hu, Jianlin Shi
Summary: Immunotherapy has great potential in solid tumor therapy, but current outcomes are unsatisfactory. This study proposes a novel strategy using a magnetic nanocatlytic medicine to stimulate innate and adaptive immunity while enhancing immune cell infiltration, leading to improved immunotherapy for solid tumors.
Article
Materials Science, Biomaterials
Xutao Guo, Shuxian Wang, Shubin Wang, Jun Wang, Feng Jiang, Yuhan Liu, Catherine J. Storey, Wolfgang Theis, Zhouguang Lu, Kai Li, Leigh T. Canham, Zhenghe Xu
Summary: In this study, a simple green method of magnesiothermic co-reduction was used to synthesize mesoporous, magnetic, and biodegradable iron silicide nanoparticles (FeSi NPs) for photothermal therapy (PTT). The synthesized FeSi NPs exhibited excellent optical absorption with a photothermal conversion efficiency of 76.2% and a weight extinction coefficient of 13.3 L g(-1) cm(-1) at 1064 nm (NIR-II), surpassing other Si-based and Fe-based photothermal agents. Cell viability assay and in vivo experiments on mice demonstrated the effectiveness of FeSi NPs in killing cancer cells and suppressing tumor growth. The biodegradability of FeSi NPs was also observed in simulated body fluids.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Plant Sciences
Arruje Hameed, Tahir Farooq, Amjad Hameed, Munir Ahmad Sheikh
Summary: The study revealed that using sodium silicate as a seed priming agent can help wheat plants acclimate to mild water-deficit stress, enhancing stress tolerance and increasing yield and biomass.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Minghua Li, Xiaolong Gao, Chao Lin, Aijun Shen, Jing Luo, Qiongqiong Ji, Jiaqi Wu, Peijun Wang
Summary: The development of macrophage cell membrane-camouflaged nanocarriers with intelligent cascade response capabilities has shown promise in improving drug release accuracy and effectively inhibiting tumor growth.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
N. Nizam-Uddin, Wazie M. Abdulkawi, Ibrahim Elshafiey, Abdel-Fattah A. Sheta
Summary: This study aims to establish a simplified experimental setup for investigating temperature rise in a microwave hyperthermia treatment system. The proposed system uses numerical simulations to study energy propagation in tissue layers at various excitation frequencies, and a novel applicator element is designed for efficient radiation in the medium. The research confirms the feasibility of the adopted testbed for hyperthermia applications and suggests the efficacy of the system in treating breast tumors.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Neurosciences
Lyles R. Clark, Sanghee Yun, Nana K. Acquah, Priya L. Kumar, Hannah E. Metheny, Rikley C. C. Paixao, Akivas S. Cohen, Amelia J. Eisch
Summary: This study discusses the impact of mild traumatic brain injuries (mTBIs) on the process of adult hippocampal DG neurogenesis. The results show that mTBI induces transient increases in neurogenesis in the ipsilateral hippocampal region, but not in the contralateral hemisphere. These findings are important for understanding the functional implications of TBI-induced neurogenesis and potential neuron replacement or repair after TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Computer Science, Artificial Intelligence
M. Nagabushanam, G. S. Nandeesh, Venkateshappa, R. Vijayarajeswari
Summary: This study proposes a machine learning technique for detecting and localizing brain tumors using MRI images. The method involves preprocessing the images to improve contrast, applying a transformation method to construct feature vectors, and using a neuro-fuzzy inference system for classification. The second phase involves localization of tumor regions using morphological operations. The results show high accuracy and sensitivity in tumor detection.
JOURNAL OF AMBIENT INTELLIGENCE AND HUMANIZED COMPUTING
(2022)
Article
Ophthalmology
Guoting Qin, Hasna Baidouri, Adrian Glasser, VijayKrishna Raghunathan, Carol Morris, Inna Maltseva, Alison M. McDermott
Article
Genetics & Heredity
Jun Li, Junhua Mai, Louis Hinkle, Daniel Lin, Jingxin Zhang, Xiaoling Liu, Maricela R. Ramirez, Youli Zu, Ganesh L. Lokesh, David E. Volk, Haifa Shen
Article
Nanoscience & Nanotechnology
Zhiling Zhu, Yanxin Chen, Siheng Li, Hong Lin, Guoting Qin, Chengzhi Cai
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biotechnology & Applied Microbiology
Miguel Ferreira, Ilaria Francesca Rizzuti, Anna Lisa Palange, Maria Grazia Barbato, Valentina Di Francesco, Martina Di Francesco, Paolo Decuzzi
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Paolo Decuzzi, Dan Peer, Daniele Di Mascolo, Anna Lisa Palange, Purnima Naresh Manghnani, S. Moein Moghimi, Z. Shadi Farhangrazi, Kenneth A. Howard, Daniel Rosenblum, Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu, Zhen Gu, Netanel Korin, Didier Letourneur, Cedric Chauvierre, Roy van der Meel, Fabian Kiessling, Twan Lammers
Summary: Initiated by the National Cancer Institute in 2004, the Alliance for Nanotechnology in Cancer has spurred global efforts to advance cancer diagnosis, treatment, and prevention through nanoscience and nanotechnology. Scientists from diverse backgrounds have collaborated to develop novel nanosystems for clinical applications, marking significant progress in the field over the past 15 years.
Article
Multidisciplinary Sciences
Mei Song, Oladapo O. Yeku, Sarwish Rafiq, Terence Purdon, Xue Dong, Lijing Zhu, Tuo Zhang, Huan Wang, Ziqi Yu, Junhua Mai, Haifa Shen, Briana Nixon, Ming Li, Renier J. Brentjens, Xiaojing Ma
NATURE COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Daniele Di Mascolo, Anna Lisa Palange, Rosita Primavera, Francesca Macchi, Tiziano Catelani, Federica Piccardi, Raffaele Spano, Miguel Ferreira, Roberto Marotta, Andrea Armirotti, Alberto L. Gallotti, Rossella Galli, Christy Wilson, Gerald A. Grant, Paolo Decuzzi
Summary: Surgical resection is the primary treatment for glioblastoma multiforme, but the infiltrating nature of the tumor, heterogeneity, and blood-brain barrier hinder drug delivery, leading to recurrence and poor prognosis. A mechanically flexible mesh has been engineered to release nanomedicines and small molecules for tumor therapy, offering a potential solution to these challenges.
NATURE NANOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yan Ting Liu, Shreya Goel, Megumi Kai, Jose Alberto Moran Guerrero, Thao Nguyen, Junhua Mai, Haifa Shen, Arturas Ziemys, Kenji Yokoi
Summary: Our study showed that tumors derived from different seed and soil sources exhibited varying responses to immunotherapy, with differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation. This highlights the importance of understanding organ-specific heterogeneity in the delivery and response to immunotherapy in polyclonal tumors.
Article
Chemistry, Physical
Maria Grazia Barbato, Rui C. Pereira, Hilaria Mollica, AnnaLisa Palange, Miguel Ferreira, Paolo Decuzzi
Summary: The selective permeation of molecules and nanomedicines across the diseased vasculature can be effectively analyzed using a double-channel microfluidic device. Permeation enhancers were found to promote the perivascular accumulation of particles smaller than 200 nm, while having no effect on larger particles in the proposed on-chip microvasculature. Additionally, the microfluidic device offers insights into the role of particle deformability in vascular dynamics.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Xiaoling Liu, Junhua Mai, Chaoyang Meng, Aldona J. Spiegel, Wei Wei, Haifa Shen
Summary: The concurrent administration of abdominal flap reconstruction and vaccine inoculation in a murine model of HER2-positive breast cancer effectively stimulated a systemic immune response, increased activation of dendritic cells, promoted the generation of IFN-gamma-expressing T cells, and extended median survival by 9 days compared to the control group.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Ophthalmology
Cecilia Chao, Lauren Lattery, Guoting Qin, Manasi Kamat, Kari Basso, Carol Lakkis, Mohamad Hasan, Kathryn Richdale
Summary: This study found differences in tear proteomics between young adults and children wearing different types of vision correction (soft contact lenses, orthokeratology, or spectacles). Young adults had higher overall protein levels in tears compared to children, and there were specific proteins unique to each group. The type of vision correction also affected tear protein levels.
CURRENT EYE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Guoting Qin, Pengzhi Zhang, Mingxia Sun, Wenjiang Fu, Chengzhi Cai
Summary: This study generated spectral assay libraries for various compartments of rabbit eyes, providing a freely available resource for proteomic studies in the field of vision.
Article
Biochemical Research Methods
Guoting Qin, Cecilia Chao, Lauren J. Lattery, Hong Lin, Wenjiang Fu, Kathryn Richdale, Chengzhi Cai
Summary: Contact lens-related ocular surface complications are more common in teenagers and young adults. This study investigated the changes in tear proteome of young patients wearing glasses, orthokeratology lenses, and soft contact lenses. The results showed that tear proteomes were altered by orthokeratology and soft contact wear and age. These findings highlight the need for further research on the ocular surface responses to contact lens wear in teenagers and young adults separately.
JOURNAL OF PROTEOMICS
(2023)
Article
Pharmacology & Pharmacy
Zhe Chen, Chaoyang Meng, Junhua Mai, Yongbin Liu, Hangwen Li, Haifa Shen
Summary: This study demonstrates that a lipid-formulated RNA vaccine composed of a protamine/mRNA core and a lipid shell is highly effective in promoting cytotoxic CD8 T cell responses and mediating anti-tumor immunity. Both the mRNA core and lipid shell are necessary for stimulating the expression of type I interferons and inflammatory cytokines in dendritic cells. The expression of interferon relies exclusively on STING, and the antitumor activity of the mRNA vaccine is compromised in mice with a defective Sting gene. Thus, the mRNA vaccine induces STING-dependent antitumor immunity.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Stephan Tetenborg, Viktoria Liss, Leonhard Breitsprecher, Ksenia Timonina, Anna Kotova, Alejandra Jesus Acevedo Harnecker, Chunxu Yuan, Eyad Shihabeddin, Fatemeh Ariakia, Guoting Qin, Chengzhi Cai, Karin Dedek, Georg Zoidl, Michael Hensel, John O'Brien
Summary: The present study characterizes the role of the PDZ-binding motif in the transport of Cx36 in HEK293T cells. The intact PDZ-binding motif is crucial for the proper ER export of Cx36, and its removal leads to ER retention and the formation of vesicles containing connexin aggregates. These findings suggest that the PDZ-binding motif coordinates the transport of Cx36 and is essential for the assembly of gap junctions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)