Review
Cardiac & Cardiovascular Systems
Kahtan Fadah, Gokul Gopi, Ajay Lingireddy, Vanessa Blumer, Tracy Dewald, Robert J. Mentz
Summary: Synthetic steroids have a negative impact on the heart, leading to cardiomyopathy and heart failure. While some treatments exist, further research is needed to understand the long-term effects and potential therapies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sabah Hammoud, Bart J. F. van den Bemt, Ayman Jaber, Mazen Kurdi
Summary: This study demonstrates that long-term cardiac structural and functional impairments persist during off-cycle periods of anabolic androgenic steroid (AAS) overuse. Even after considerable AAS abstain, AAS-users show impaired global longitudinal strain (GLS) and decreased diastolic function compared to non-users. This highlights the importance of assessing GLS to predict hypertrophy and heart failure events, rather than relying solely on left ventricular ejection fraction (LVEF).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cell Biology
Olivia Moraes Ruberti, Andressa Silva Sousa, Lais Rosa Viana, Moises Felipe Pereira Gomes, Alessandra Medeiros, Maria Cristina Cintra Gomes Marcondes, Luciano de Figueiredo Borges, Carlos Cesar Crestani, Cristiano Mostarda, Telma Fatima da Cunha Moraes, Rafael Renatino Canevarolo, Maria Andreia Delbin, Bruno Rodrigues
Summary: The study evaluated the impact of aerobic training on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes in ovariectomized rats with myocardial infarction. Aerobic training improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis revealed distinct metabolic profiles among different groups, with aerobic training group showing prevention of certain metabolic responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Ana Petrovic, Sonja Vukadin, Renata Sikora, Kristina Bojanic, Robert Smolic, Davor Plavec, George Y. Wu, Martina Smolic
Summary: Anabolic androgenic steroids have therapeutic benefits but are commonly misused and have detrimental effects on various organs, particularly the liver. This article reviews the latest knowledge on the adverse effects of anabolic androgenic steroids on the liver and their mechanisms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Sport Sciences
Shalender Bhasin, Disa L. Hatfield, Jay R. Hoffman, William J. Kraemer, Michele Labotz, Stuart M. Phillips, Nicholas A. Ratamess
Summary: This consensus statement acknowledges the lawful and ethical therapeutic use of anabolic-androgenic steroids (AAS) but condemns the illicit use of AAS for enhancing performance and appearance, especially among competitive athletes. It updates the science behind how AAS work metabolically/biochemically, discusses potential side effects, prevalence of use among athletes, and AAS use in clinical scenarios.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Sport Sciences
Tea Saetereng Fyksen, Paul Vanberg, Knut Gjesdal, Thomas G. von Lueder, Reidar Bjornerheim, Kjetil Steine, Dan Atar, Sigrun Halvorsen
Summary: This study compared the cardiovascular phenotypes of strength-trained men with long-term use of AAS and athletes without AAS use. The results showed that AAS users had higher hematocrit and hemoglobin levels, lower HDL cholesterol levels, slightly lower maximal exercise capacity, thicker intraventricular septum and left ventricular posterior wall, and lower LV ejection fraction compared to non-users. Furthermore, 17% of AAS users showed evidence of coronary artery disease. These findings indicate a divergent cardiovascular profile associated with increased cardiovascular risk among AAS users.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Jon J. Rasmussen, Caroline Kistorp
Summary: Abuse of anabolic-androgenic steroids (AAS) is associated with reduced fibrin clot lysis, likely due to increased plasma concentrations of fibrinogen, FXIII, and plasmin inhibitor, rather than alterations in fibrin structure. This suggests a potential link between AAS abuse and increased thrombotic disease risk.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Review
Physiology
Hugo Falqueto, Marcelo Rodrigues dos Santos, Leandro H. Manfredi
Summary: Sarcopenia is a health concern characterized by reduced physical function and muscle mass. Exercise training can help improve these conditions, but it may not be effective for many elderly individuals. Thus, the use of anabolic-androgenic steroids may be a viable strategy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Yaseelan Palarasah, Jon Jarlov Rasmussen, Caroline Kistorp
Summary: Current AAS abuse reduces the kallikrein-generating capacity of CAS by increasing the concentration of C1inh and reducing the concentration of prekallikrein. These changes may contribute to the anti-inflammatory effect of testosterone.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Endocrinology & Metabolism
Agne Andriuskeviciute, Giulia Cossu, Adelina Ameti, Georgios Papadakis, Roy Thomas Daniel, Vincent Dunet, Mahmoud Messerer
Summary: This case report describes a 40-year-old male patient who developed pituitary apoplexy shortly after using anabolic androgenic steroids for bodybuilding. The patient presented with sudden onset headache and left partial third cranial nerve palsy, confirmed by MRI findings. Endocrine work-up revealed high testosterone levels due to exogenous testosterone use without medical prescription. The association between pituitary apoplexy and anabolic androgenic steroids should be considered as a potential risk factor.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Marie Lindvik Jorstad, Morgan Scarth, Svenn Torgersen, Harrison Graham Pope, Astrid Bjornebekk
Summary: This study found that personality disorders and clinical psychiatric syndromes are common among users of anabolic-androgenic steroids. The study identified four distinct psychopathology subgroups among AAS users, highlighting the importance of considering individual psychiatric profiles when providing treatment to this population.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Astrid Bjornebekk, Tobias Kaufmann, Lisa E. Hauger, Sandra Klonteig, Ingunn R. Hullstein, Lars T. Westlye
Summary: High-dose long-term use of anabolic-androgenic steroids (AASs) may accentuate brain aging, particularly related to dependency and exaggerated use patterns. Accelerated brain aging was primarily associated with dependence and longer history of AAS use.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Multidisciplinary Sciences
Bryan S. Nelson, Tom Hildebrandt, Pascal Wallisch
Summary: This study found that bodybuilders who have used anabolic-androgenic steroids (AAS) are more likely to exhibit risk-taking behaviors, anger problems, and physical problems, as well as have a higher likelihood of psychopathic traits. This research provides important insights into the risks associated with AAS use.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
H. S. Melsom, C. M. Heiestad, E. Eftestol, M. K. Torp, K. Gundersen, A. K. Bjornebekk, P. M. Thorsby, K. O. Stenslokken, J. Hisdal
Summary: Long-term use of anabolic-androgenic steroids (AAS) can lead to unfavorable changes in vascular function and morphology, increasing the risk of cardiovascular complications.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Morgan Scarth, Marie Lindvik Jorstad, Amund Reierstad, Sandra Klonteig, Svenn Torgersen, Ingunn R. Hullstein, Astrid Bjornebekk
Summary: Females who use anabolic-androgenic steroids (AAS) generally experience increased levels of psychopathology compared to weight-lifting controls (WLC). These include externalizing personality disorders, such as borderline, antisocial, and sadistic, as well as depressive, negativistic, and masochistic personality disorders. The study also found that all clinical syndromes were elevated among AAS users, with 56% of them meeting the clinical criteria for six or more disorders. These findings highlight the importance of recognizing and addressing the challenges in providing care for this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Oncology
Wagner A. Poles, Erika E. Nishi, Mariana B. de Oliveira, Angela I. P. Eugenio, Tathiana A. de Andrade, Antonio Hugo F. M. Campos, Ruy R. de Campos, Jose Vassallo, Antonio C. Alves, Cristovam Scapulatempo Neto, Roberto Antonio Pinto Paes, Gilles Landman, Maria Claudia N. Zerbini, Gisele W. B. Colleoni
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2019)
Article
Peripheral Vascular Disease
Erika E. Nishi, Nathalia R. Lopes, Guiomar N. Gomes, Juliana C. Perry, Alex Y. S. Sato, Maria G. Naffah-Mazzacoratti, Cassia T. Bergamaschi, Ruy R. Campos
HYPERTENSION RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Camila T. Picollo, Alexandra A. dos Santos, Ednei L. Antonio, Jairo M. A. Silva, Danilo Bocalini, Andrey Jorge Serra, Silvia S. M. Ihara, Paulo J. F. Tucci
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Peripheral Vascular Disease
Amanda C. Veiga, Maycon I. O. Milanez, Giovanna R. Ferreira, Nathalia R. Lopes, Camila P. Santos, Katia De Angelis, Michelle L. Garcia, Lila M. Oyama, Guiomar N. Gomes, Fernando N. Nogueira, Polliane M. Carvalho, Ruy R. Campos, Cassia T. Bergamaschi, Erika E. Nishi
JOURNAL OF HYPERTENSION
(2020)
Article
Pharmacology & Pharmacy
Maycon I. O. Milanez, Gustavo R. Martins, Erika E. Nishi, Cassia T. Bergamaschi, Ruy R. Campos
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Physiology
Nathalia R. Lopes, Maycon I. O. Milanez, Beatriz S. Martins, Amanda C. Veiga, Giovanna R. Ferreira, Guiomar N. Gomes, Adriana C. Girardi, Polliane M. Carvalho, Fernando N. Nogueira, Ruy R. Campos, Cassia T. Bergamaschi, Erika E. Nishi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Maycon I. O. Milanez, Adilson M. Silva, Juliana C. Perry, Jean Faber, Erika E. Nishi, Cassia T. Bergamaschi, Ruy R. Campos
PHARMACOLOGICAL REPORTS
(2020)
Article
Neurosciences
Maycon I. O. Milanez, Erika E. Nishi, Antonio A. Rocha, Cassia T. Bergamaschi, Ruy R. Campos
NEUROSCIENCE LETTERS
(2020)
Article
Biology
M. I. O. Milanez, A. M. A. Liberatore, E. E. Nishi, C. T. Bergamaschi, R. R. Campos, I. H. J. Koh
Summary: Sepsis can cause long-term disability, including immune dysfunction, neuropsychological disorders, persistent inflammation, catabolism, and immunosuppression. This experimental study in rats revealed that sepsis can lead to long-term alterations in renal and splanchnic sympathetic nerve activity, as well as baroreflex sensitivity. These findings suggest that impairment of sympathetic vasomotor response may contribute to the high risk of post-sepsis morbidity in survivors.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maycon I. O. Milanez, Erika E. Nishi, Rodrigo Mendes, Antonio A. Rocha, Cassia T. Bergamaschi, Ruy R. Campos
Summary: This study investigated the role of spinal angiotensin II type 1 receptor (AT1) receptors in sympathoexcitatory responses in renovascular hypertension using the Goldblatt rat model. The results indicate that acute sympathoexcitation induced by activation of the rostral ventrolateral medulla (RVLM) is dependent on spinal AT1 receptors in Goldblatt rats but not in control rats. The study highlights the need for further research to determine the involvement of central cardiovascular nuclei in spinal angiotensinergic actions and the source of angiotensin II in this model.
Article
Biochemistry & Molecular Biology
Roberto B. Pontes, Erika E. Nishi, Renato O. Crajoinas, Maycon I. O. Milanez, Adriana C. C. Girardi, Ruy R. Campos, Cassia T. Bergamaschi
Summary: This study examined the effects of an acute increase in blood pressure and renal sympathetic nerve activity on sodium and water excretion and NHE3 activity. It was found that renal nerve stimulation independently decreased sodium and water excretion. However, when blood pressure was acutely increased during the stimulation, diuresis, natriuresis, and NHE3 activity inhibition were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Maycon I. O. Milanez, Antonio M. Cabral, Jose G. P. Pires, Cassia T. Bergamaschi, Ruy R. Campos, Henrique A. Futuro Neto, Nyam F. Silva
Article
Physiology
Vanessa Araujo Varela, Elizabeth B. Oliveira-Sales, Edgar Maquigussa, Fernanda T. Borges, Pedro P. Gattai, Antonio da S. Novaes, Caroline G. Shimoura, Ruy R. Campos, Mirian A. Boim
KIDNEY & BLOOD PRESSURE RESEARCH
(2019)
Article
Physiology
Lysien Zambrano, Roberto B. Pontes, Michelle L. Garcia, Erika E. Nishi, Fernando N. Nogueira, Elisa M. S. Higa, Juliana G. Cespedes, Cassia T. Bergamaschi, Ruy R. Campos
PHYSIOLOGICAL REPORTS
(2019)
Meeting Abstract
Pediatrics
Ivan Rodriguez Nunez, Ruy Campos, Fernando Romero Mejia
PEDIATRIC RESEARCH
(2019)