Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein

γ-Secretase Catalyzes Sequential Cleavages of the AβPP Transmembrane Domain

(2017) Xuemin Xu   JOURNAL OF ALZHEIMERS DISEASE

Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids

(2017) Annamalai Prakasam et al.   JOURNAL OF ALZHEIMERS DISEASE

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

(2014) Vinod Udayar et al.   Cell Reports

Major Carboxyl Terminal Fragments Generated by γ-Secretase Processing of the Alzheimer Amyloid Precursor Are 50 and 51 Amino Acids Long

(2013) Inga Pinnix et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Toward the structure of presenilin/γ-secretase and presenilin homologs

(2013) Michael S. Wolfe   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data

(2013) Camilla Niva et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012

(2013) Martin Pettersson et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes

(2013) Javier Pacheco-Quinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-  Peptide

(2013) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease

(2013) Željko M. Svedružić et al.   PLoS One

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice

(2012) Ruben Vidal et al.   FASEB JOURNAL

Locus-specific mutation databases for neurodegenerative brain diseases

(2012) Marc Cruts et al.   HUMAN MUTATION

Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1

(2012) K. R. Walker et al.   JOURNAL OF NEUROSCIENCE

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

(2012) Jeremy H. Herskowitz et al.   MOLECULAR BIOLOGY OF THE CELL

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1

(2012) Li Zhu et al.   PLoS One

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

(2012) Gael Barthet et al.   PROGRESS IN NEUROBIOLOGY

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

(2011) Gael Barthet et al.   FASEB JOURNAL

Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis

(2011) Jason A. Bailey et al.   GENE

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

(2011) Bryan Maloney et al.   GENE

Targets for AD treatment: conflicting messages from γ-secretase inhibitors

(2011) Kumar Sambamurti et al.   JOURNAL OF NEUROCHEMISTRY

Twenty years of Alzheimer’s disease-causing mutations

(2011) Alison Goate et al.   JOURNAL OF NEUROCHEMISTRY

PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway

(2011) Jun Cai et al.   PLoS One

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Can Be Inferred from the Interruption of the Semagacestat Trial for Treatment of Alzheimer's Disease?

(2010) Jeffrey Cummings   BIOLOGICAL PSYCHIATRY

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

(2010) Michael A. Brodney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives

(2010) Nikolaos K. Robakis   NEUROBIOLOGY OF AGING

Are Aβ and Its Derivatives Causative Agents or Innocent Bystanders in AD?

(2010) Nikolaos K. Robakis   Neurodegenerative Diseases

ADDLs and the signaling web that leads to Alzheimer’s disease

(2010) Grant A. Krafft et al.   NEUROPHARMACOLOGY

The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel

(2010) Kohji MORI et al.   Psychogeriatrics

 -Secretase and Human Disease

(2010) R. J. Kelleher et al.   SCIENCE

Pigment Epithelium-derived Factor Maintains Retinal Pigment Epithelium Function by Inhibiting Vascular Endothelial Growth Factor-R2 Signaling through γ-Secretase

(2009) Zsolt Ablonczy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression

(2008) Catherine R. Burton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ

(2007) Yan Zhou et al.   FASEB JOURNAL

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

(2003) H. F. Dovey et al.   JOURNAL OF NEUROCHEMISTRY