Article
Cell Biology
Mi-Jeong Kim, Yoon Min, Soo-Kyung Jeong, Juhee Son, Ji Young Kim, Ji Su Lee, Duk-Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki-Young Lee
Summary: The study reveals that USP15 is significantly downregulated in lung cancer patients, and its knockout leads to increased migration, invasion, and autophagy induction in lung cancer cells. USP15 interacts with BECN1 and deubiquitinates it, thereby attenuating autophagy induction. Additionally, the expression of USP15 is associated with the upregulation of certain oncogenes and downregulation of tumor suppressor genes in lung cancer patients.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Linzi Sun, Razie Amraei, Nader Rahimi
Summary: NEDD4 ubiquitin E3 ligase binds to and mediates polyubiquitination of IGPR-1 leading to its lysosomal-dependent degradation. NEDD4 is a key regulator of IGPR-1 expression with implication in the therapeutic targeting of IGPR-1 in human cancers.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Oasis Perez, Masashi Kitazawa, Anshu Agrawal, Veedamali S. Subramanian
Summary: The study reveals the important role of Nedd4-1 and the proteasomal degradation pathway in regulating the functional expression of hSVCT2 in neuronal cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Xiaosong Wang, Xiaojun Yu, Haoran Xu, Kang Wei, Shanxi Wang, Yingguang Wang, Junfei Han
Summary: In this study, the researchers found that extracellular vesicles (EVs) transfer a long non-coding RNA (lncRNA) called HOTAIR, which regulates resistance to the chemotherapy drug temozolomide (TMZ) in glioblastoma (GBM). Through in vitro and in vivo experiments, it was demonstrated that HOTAIR promotes tumor growth, increases invasiveness, and enhances resistance to TMZ. In GBM cells, HOTAIR competitively binds to miR-526b-3p, weakening its ability to bind to EVA1 and consequently increasing EVA1 expression. Furthermore, HOTAIR carried by serum-EVs suppresses miR-526b-3p-mediated inhibition of EVA1, promoting tumor growth and TMZ resistance in vivo.
CELL DEATH & DISEASE
(2022)
Article
Biology
Aiqin Sun, Jun Zhu, Song Xia, Yanling Li, Tiantian Wu, Genbao Shao, Wannian Yang, Qiong Lin
Summary: The study revealed that NEDD4 interacts with MEKK5 through a conserved WW3 domain, but MEKK5 is not a ubiquitination substrate of NEDD4 and instead negatively regulates NEDD4-mediated ubiquitination. Overexpression of MEKK5 significantly reduces NEDD4-promoted lung cancer cell migration.
Article
Immunology
Min Chao, Nan Liu, Zhichuan Sun, Yongli Jiang, Tongtong Jiang, Meng Xv, Lintao Jia, Yanyang Tu, Liang Wang
Summary: Sox9, an upregulated transcription factor in clinical gliomas associated with poor prognosis, promotes migration and invasion of glioma cells and in vivo tumor development. It functions downstream of the TGF-beta pathway, where TGF-beta signaling prevents proteasomal degradation of Sox9 protein in glioma cells. These findings provide new insights into the interaction between TGF-beta signaling and oncogenic transcription factors, with implications for targeted therapy and prognostic assessment of gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Qirui Zhao, Ning Liu, Tongtong Xu, Keguan Song
Summary: This study investigates the role of a novel E3 ubiquitin ligase, RNF180, in the progression of osteosarcoma (OS). It was found that up-regulation of RNF180 inhibits proliferation and promotes apoptosis in OS cells, while down-regulation has the opposite effects. RNF180 also suppresses tumor growth and lung metastasis in a mouse model by regulating the ubiquitination of CBX4. The RNF180-CBX4 axis may serve as a potential therapeutic target for OS treatment.
Article
Multidisciplinary Sciences
Qiongying Zhang, Ruichun Bi, Xiaodong Bao, Xiaohui Xu, Daoquan Fang, Lei Jiang
Summary: This study reveals that MYT1L gene plays a role in promoting migration and invasion of glioma cells. Through activation of the Notch signaling pathway, MYT1L enhances cell migration and invasion, while inhibition of MYT1L or blocking the Notch pathway suppresses these processes. These findings suggest that MYT1L could be a potential target for glioma treatment.
Article
Cell Biology
Lifei Yu, Jin Huang
Summary: DNASE1L3 is downregulated in colorectal cancer and is associated with patient prognosis. It inhibits tumor cell proliferation and migration by upregulating CDKN1A and interacts with NEDD4, suppressing CDKN1A ubiquitination and degradation.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Oncology
Chunhong Wang, Haiyang Su, Rui Cheng, Hongming Ji
Summary: The study demonstrated that high expression of SPAG5 in glioma patients is associated with poor prognosis. Knockdown of SPAG5 can inhibit proliferation, migration, and invasion of glioma cells, promote apoptosis, and is associated with the expression of CDH2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yan Wang, Yu Zhang, Ben Sang, Xianlong Zhu, Rutong Yu, Xiuping Zhou
Summary: Hugl-1 promotes migration and invasion of malignant glioma cells by decreasing N-cadherin expression while inhibiting cell proliferation. It may serve a dual biological role in cellular processes, and could be applied in targeted and personalized treatment development.
Article
Cell Biology
Debo Yun, Jianshen Liang, Xuya Wang, Jikang Fan, Xisen Wang, Jiabo Li, Xiao Ren, Jie Liu, Xiude Ren, Hao Zhang, Guanjie Shang, Wenzhe Jin, Lei Chen, Tao Li, Chen Zhang, Shengping Yu, Xuejun Yang
Summary: This study investigated the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma and found significant relationships with age, WHO grade, IDH, and 1p/19q status. TCAF2 expression was markedly increased in glioblastoma compared to lower-grade glioma and promoted glioma cell migration and invasion through the activation of STAT3.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biology
Jin Zhang, Qianli Ma, Qiduo Yu, Fei Xiao, Zhenrong Zhang, Hongxiang Feng, Chaoyang Liang
Summary: PSMD3 is overexpressed in lung cancer tissues and cells, promoting cell proliferation, migration, and invasion, as well as stabilizing ILF3 protein expression and deubiquitination. The ILF3 inhibitor YM155 can suppress tumor growth in the presence of PSMD3, indicating that the PSMD3/ILF3 axis may be a novel strategy for diagnosis and treatment of lung cancer.
Article
Oncology
Xiangdong Xu, Yang Liu, Yan Li, Huajian Chen, Yuxuan Zhang, Jie Liu, Shaokang Deng, Yaofeng Zheng, Xinlin Sun, Jihui Wang, Taoliang Chen, Min Huang, Yiquan Ke
Summary: MiR-375 expression is downregulated in gliomas, and it suppresses glioma proliferation, migration, and invasion by inhibiting the CTGF-EGFR signaling pathway. MiR-375-containing exosomes were found in human blood samples from glioma patients, with levels correlating with disease progression. Exosomal miR-375 secretion impacts the activity of the CTGF-EGFR pathway, and once secreted, exosomal miR-375 is not taken back up by glioma cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Computer Science, Information Systems
Xiaogen Zhou, Zhiqiang Li, Yuyang Xue, Shun Chen, Meijuan Zheng, Cong Chen, Yue Yu, Xingqing Nie, Xingtao Lin, Luoyan Wang, Junlin Lan, Gang Chen, Min Du, Ensheng Xue, Tong Tong
Summary: In this paper, a cascaded unsupervised-based strategy (CUSS-Net) is proposed to improve the performance of the supervised CNN framework in white blood cell and skin lesion segmentation and classification. CUSS-Net consists of an unsupervised-based strategy (US) module, an enhanced segmentation network named E-SegNet, and a mask-guided classification network called MG-ClsNet. Experimental results show that CUSS-Net outperforms other state-of-the-art approaches.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Zhiqiang Li, Jinpeng Zhao, Lulu Liu, Zhe Li
Summary: A physical model test was conducted on an alpine tunnel in Qinghai Province using the Osaka Mountain tunnel. By analyzing the data and utilizing the Surfer software, the temperature variation trends and vector graph of the tunnel were obtained. The freezing front characteristics of the tunnel under airflow conditions were systematically analyzed, and the governing equations for the freezing front in the tunnel model were proposed. The results showed that the ventilation significantly influenced the temperature distribution of the tunnel, with greater wind speeds resulting in stronger effects. The freezing front distance was largest in the inverted arch area, and the freezing front expansion in the wall foot area was higher than in the vault area. The freezing front demonstrated a parabolic attenuation, gradually easing and disappearing with increased tunnel depth.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Zhiqiang Li, Jinpeng Zhao, Kunkun Hu, Youyun Li, Lulu Liu
Summary: This study systematically evaluates the adaptability of jet grouting pile composite foundation in shallow collapsible loess tunnel, using MIDAS finite element numerical simulation software. The control of foundation deformation during construction and settlement after construction is studied, and the differential deformation control is analyzed. The results show that the uplift displacement can be controlled by adjusting the pile length and replacement ratio, and the combination of long and short piles can reduce uneven settlement and plastic zone of the foundation. An uneven settlement of 9 mm can be used as an evaluation index for the reinforcement effect of the composite foundation in a shallow buried section of the loess tunnel.
APPLIED SCIENCES-BASEL
(2023)
Article
Geochemistry & Geophysics
Defu Zang, Yongli Ji, Yongsheng Chao, Zhiqiang Li
Summary: The principle of crosswell electromagnetic (EM) imaging is similar to that of induction logging. However, crosswell EM imaging can be used in two wells with a separation distance of up to 1000 m, while conventional induction logging can only measure the formation conductivity within a few meters around the well. Several signal processing methods for crosswell EM imaging systems are developed, including calibration, casing correction, and hybrid Jacobian matrix calculation. The calibration methods derive EM field formulas and establish relationships between the received signal and frequency, formation conductivity, and transceiver spacing.
INTERPRETATION-A JOURNAL OF SUBSURFACE CHARACTERIZATION
(2023)
Article
Thermodynamics
Xianfei Liu, Zirui Zhang, Caixia Zhu, Fang Wang, Doudou Zhao, Zhiqiang Li, Yuhang Liu, Hui Zhang, Hao Jiang
Summary: This experimental research shows that adding paraffin wax as an appropriate organic phase change material (PCM) has advantageous effects on controlling the temperature rise of a fast charging power module (100 mm x 50 mm x 20 mm). The study examines the impact of PCM physical parameters on thermal management performance and visualizes the PCM melting process to reveal the mechanism behind its improvement. The results demonstrate a temperature reduction of 46.4 degrees C with PCM coupling, and increasing air flow velocity decreases the temperature by 11.8 degrees C. Increasing PCM thermal conductivity from 0.2 W/(m center dot K) to 5 W/(m center dot K) in 1800 s lowers the extreme temperature from 60.1 degrees C to 51.9 degrees C. Filling PCM with a thickness of 4.5 mm outperforms other thicknesses in thermal management performance. These findings offer reliable technical solutions for improving the thermal management of charging piles and high-power quick charging piles.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Chemistry, Applied
Guizhen Yu, Qingyu Niu, Xiao Liu, Liang He, Jinxie Yu, Hang Han, Wenjing Wang, Ying Zhang, Zhiqiang Li, Qingqing Xiong
Summary: Hybrid anisotropic hydrogel is created by dispersing carbon quantum dots and ultrahigh magnetic nanoparticle-coated alumina (Fe/Al2O3) platelets in acrylamide aqueous solution with the assistance of a magnetic field, and then fixing the oriented structure through gelation. The aligned Fe/Al2O3 platelets lead to the formation of anisotropic structure, providing mechanical and fluorescent anisotropy to the hydrogels. White-light emission is achieved by adjusting the weight ratio of yellow-emitting ZnO QDs and blue-emitting N,S-CDs. This approach not only enriches the field of mechanical/fluorescent dual anisotropic soft materials, but also holds significant potential in organic light-emitting diodes, nonlinear optics, and field effect transistors.
Article
Energy & Fuels
Lin Li, Tiantian Liu, Zhiqiang Li, Xiangjun Chen, Lin Wang, Shuailong Feng
Summary: Spontaneous combustion of coal in coal mine goafs can lead to methane accumulation, increasing the risk of methane explosion disasters. This study investigates the impact of ventilation dilution on possible methane explosions during the spontaneous combustion of coal using a validated gas flow model. The research findings suggest that ventilation dilution can effectively dilute methane concentration and reduce the risk of methane explosions when coal combustion occurs on the air-inlet side, but it can increase the explosion risk if coal combustion takes place on the air-return side. This provides important insights for managing ventilation during spontaneous coal combustion disasters in coal mine goafs with methane.
Article
Environmental Sciences
Zongqiang Hu, Gang Chen, Chuntao Yan, Zhiqiang Li, Tao Wu, Li Li, Shengning Zhang
Summary: This study confirmed the role of autophagy in hepatic fibrosis and its effects on macrophage polarization and exosome secretion by establishing hepatic fibrosis model and co-culture model, providing evidence for treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xinyao Xia, Qiuhe Wei, Chunxia Xiao, Yiping Ye, Zhiqiang Li, Cecile Marivingt-Mounir, Jean-Francois Chollet, Wende Liu, Hanxiang Wu
Summary: A total of 408 gene members were identified from 5 maize inbred lines, and the NRT genes of maize were classified into NRT1/PTR (NPF), NRT2 and NRT3 subfamilies. Divergence of the duplication patterns of NRT genes were identified, providing a basis for classification and identification of maize varieties. Maize NRT transporters may have both positive and negative roles in the disease resistance response. This study will contribute to further understanding of the potential roles of NRT gene families in plant-pathogen interactions.
Article
Computer Science, Software Engineering
Zhiqiang Li, Hongyu Zhang, Xiao-Yuan Jing, Juanying Xie, Min Guo, Jie Ren
Summary: Cross-project defect prediction aims to identify defective software modules in a target project using historical data from other projects. However, existing methods often overlook the selection of appropriate source data and suffer from class imbalance issues. This paper proposes a non-parametric data selection and sampling based domain programming predictor (DSSDPP) which overcomes these limitations. DSSDPP learns a discriminative transfer classifier by leveraging the structures of source and target data, achieving better prediction results compared to competing methods in single-source and multi-source scenarios.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Zihao Yang, Minghui Yin, Yunxia You, Zhiqiang Li, Xin Liu, Weihua Zhang
Summary: This article presents a CNFET 10T SRAM cell based on Stanford Virtual Source model at the 5nm technology node. Through optimization design and simulation analysis, the optimum gate widths of transistors are selected to ensure the best performance in terms of stability, speed, and power consumption. The proposed 10T CNFET SRAM is compared with the optimized 6T CNFET SRAM, and it is found that the proposed 10T SRAM cell outperforms the 6T structure in terms of timing, power consumption, RSNM, read and write EDP.
IEICE ELECTRONICS EXPRESS
(2023)
Article
Chemistry, Physical
Xiaomin Yang, Qiaoyi Du, Li Qiao, Gesheng Xiao, Zhiqiang Li, Lin Yang
Summary: As a promising next-generation material for superconducting radiofrequency cavities, superconducting Nb3Sn has significant potential for both compact and large scale accelerator applications. However, the physical origin of the abnormal elastic behavior accompanying the superconducting transition in Nb3Sn crystals, especially at atomic and electronic scale, is still controversial. We proposed an analytical model through extended atomic and electronic modelling to depict the abnormal temperature-dependent elastic constants and transition resistivities of superconducting Nb3Sn. The extended ab initio studies indicate that the abnormal changes in the elastic properties and the transition resistivity response characteristics are intrinsically correlated, with the contribution arising from the d-band electrons determining the cross-scale abnormal elastic behavior.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Green & Sustainable Science & Technology
Xianfei Liu, Zirui Zhang, Hui Zhang, Fang Wang, Doudou Zhao, Zhiqiang Li, Caixia Zhu, Yuhang Liu, Hao Jiang
Summary: The benefits of adding phase change material (PCM) to the thermal control system of high-power fast charging power module are explored. The study investigates the effects of PCM's melting temperature, thermal conductivity, and filling thickness on the improvement of charging time, as well as visualizes the PCM melting rate. Results show that PCM significantly extends charging time, with the optimal melting temperature at 47.5 degrees C and a maximum charging time of 1540 s. PCM thickness and thermal conductivity also play crucial roles in extending charging time.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Geosciences, Multidisciplinary
Jigen Xia, Zhiqiang Li, Yongli Ji, Hengrong Zhang, Fangong Li, Junyi Li, Xingmeng Dong
Summary: In this study, the finite element method was used to analyze the micro-cylindrically focused logging tool in a three-dimensional non-uniform medium model. The logging response characteristics of the tool at different detection depths, mudcake thicknesses, flush zones, and mudcake resistivity contrasts were investigated. The least-squares method was used to obtain the flush zone resistivity, mudcake resistivity, and mudcake thickness, and the micropotential and microgradient curves were synthesized. A digital focusing method was proposed to improve the focusing accuracy and flexibility of the instrument, enhancing its performance.
FRONTIERS IN EARTH SCIENCE
(2023)
Article
Chemistry, Physical
Zhiqiang Li, Shuai Gu, Kemeng Liao, Hongzhi Wang, Lihong Yin, Yulin Cao, Ning Qin, Qingmeng Gan, Yingzhi Li, Zhenyu Wang, Shu Yin, Zhouguang Lu
Summary: This study proposes a renewable lithium dextran sulfate (LDS) binder that can dynamically bind to current collectors and metallic Li, and regulate Li-ion diffusion. The full cells with LDS coated Cu foil as anode exhibit excellent cycling stability and Coulombic efficiency.
MATERIALS TODAY ENERGY
(2023)
