Article
Immunology
Tingzheng Zhan, Yuhong Wu, Xueling Deng, Qing Li, Yu Chen, Jiahui Lv, Jilong Wang, Shitao Li, Zhanshuai Wu, Dengyu Liu, Zeli Tang
Summary: This study revealed that the most severe symptoms in mice infected with C. sinensis occurred at 5 weeks post-infection. Moreover, multi-omics analysis uncovered predominant molecular events related to fibrosis changes in the liver. This study not only enhances our understanding of clonorchiasis progression but also provides valuable insights into the molecular-level interaction mechanism between C. sinensis and its host liver.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalia Semenova, Elena Kamenets, Eleonora Annenkova, Andrey Marakhonov, Elena Gusarova, Nina Demina, Daria Guseva, Inga Anisimova, Anna Degtyareva, Natalia Taran, Tatiana Strokova, Ekaterina Zakharova
Summary: Alagille syndrome (ALGS) is a condition characterized by cholestasis and bile duct paucity caused by gene mutations. It affects multiple systems and presents with variable clinical features. Genetic testing is essential for accurate diagnosis and differentiation from other types of cholestasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Saisai Tian, Li Yan, Lu Fu, Zhen Zhang, Jinbo Zhang, Guofeng Meng, Weidong Zhang
Summary: This study found that elevated levels of plasmacytoid dendritic cells (pDC) were associated with prolonged survival outcomes in breast cancer patients, with lower mutation burden and intratumoral heterogeneity observed in the high pDC abundance group. Patients with high pDC abundance showed a more sensitive immune response and better chemotherapy outcomes, suggesting potential benefits from combination therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Sayed Haidar Abbas Raza, Chengcheng Liang, Wang Guohua, Sameer D. Pant, Zuhair M. Mohammedsaleh, Abdullah F. Shater, Mashael Alhumaidi Alotaibi, Rajwali Khan, Nicola Schreurs, Gong Cheng, Chugang Mei, Linsen Zan
Summary: In this study, differentially expressed genes specific to multiple muscle tissues in mice were identified using bioinformatics techniques, providing potential candidate genes for studying the regulatory mechanisms of muscle development. The genes were found to be associated with myofibril, cytoskeletal protein binding, and metabolic pathways, offering important insights for further research on muscle development.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Tim Althoff, Hamed Nilforoshan, Jenna Hua, Jure Leskovec
Summary: An unhealthy diet is a major risk factor for chronic diseases. Limited access to healthy food options may contribute to unhealthy diets. A nationwide observational study utilizing smartphones found that better access to grocery stores, lower access to fast food, higher income, and higher education are independently associated with healthier eating habits.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ruizhen Zhao, Wei Cheng, Juan Shen, Weiming Liang, Zhao Zhang, Yifei Sheng, Tailiang Chai, Xueting Chen, Yin Zhang, Xiang Huang, Huanjie Yang, Chunqing Song, Li Pang, Cuoji Nan, Yangrui Zhang, Rouxi Chen, Junpu Mei, Hong Wei, Xiaodong Fang
Summary: The gut-liver axis is a bidirectional communication pathway between the intestine and the liver that affects liver function. This study used single-cell and spatial transcriptomic analysis to investigate the effects of microorganisms on the liver. The results showed alterations in immune cells, changes in gene expression, and metabolic differences in germ-free mice compared to specific-pathogen-free mice.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Qishun Zhou, Jakob Kerbl-Knapp, Fangrong Zhang, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hoerl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl
Summary: Energy metabolism is closely related to aging and longevity, and metabolomics studies have provided insights into the changes in metabolite composition during aging. However, little is known about the metabolic changes in tissues responsible for food intake and lipid storage.
Article
Immunology
Xuetao Mao, Xuan Peng, Qiong Pan, Xingping Zhao, Zheng Yu, Dabao Xu
Summary: This research found that dysbiosis of gut microbiota may be a risk factor for uterine fibroids. The study showed that patients with uterine fibroids had lower alpha-diversity and altered microbial composition. The microbial interactions and networks in uterine fibroids were also less connected and more clustered compared to healthy controls. This study provides new insights into the relationship between the host-gut microbiota interaction and the pathogenesis of uterine fibroids.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Zehua Dong, Mengli Xu, Xu Sun, Xiaosheng Wang
Summary: There is an inverse relationship between Alzheimer's disease (AD) and cancer, with increased AD risk associated with reduced cancer risk. VLDL is identified as a key mediator of this relationship. The upregulation of the PVRIG gene is a risk factor for AD but a protective factor for cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Polymer Science
Feng-Yang Wu, Jin Yin, Shao-Chen Chen, Xue-Qin Gao, Li Zhou, Ying Lu, Jun Lei, Gan-Ji Zhong, Zhong-Ming Li
Summary: Revealing the relationship between processing-structure-property using machine learning is a promising solution to shorten the development cycle of polymer materials. The quantitative data of processing field, polymorphic structure, and mechanical properties are successfully obtained, providing a dataset for machine learning application. Regression models are established using four machine learning algorithms to predict the contents of polymorphic structure and mechanical properties of isotactic polypropylene injection molding, showing satisfactory performance (R2max = 0.95).
Article
Biology
Jelmer W. Poelstra, B. Karina Montero, Jan Luedemann, Ziheng Yang, S. Jacques Rakotondranary, Paul Hohenlohe, Nadine Stetter, Joerg U. Ganzhorn, Anne D. Yoder
Summary: Microsatellites are commonly used in evolutionary genetic studies, but their high mutation rate leads to uncertainty in deeper evolutionary comparisons. In this study, RADseq data was used to re-examine hybridization patterns in two mouse lemur species in Madagascar, and it was found that previously inferred hybrids were false positives, providing new insights into the reproductive isolation of these species.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lise Desquilles, Luis Cano, Gevorg Ghukasyan, Nicolas Mouchet, Clemence Landreau, Anne Corlu, Bruno Clement, Bruno Turlin, Romain Desert, Orlando Musso
Summary: The study analyzed the expression and localization of ACE2 and TMPRSS2 in human liver cancers and non-tumor livers. The results showed that ACE2 and TMPRSS2 were mainly located at the biliary pole of tumor hepatocytes in liver cancers. In normal liver samples, ACE2 was distributed in hepatocyte's bile canaliculi, biliary epithelium, sinusoidal, and capillary endothelial cells. Additionally, tumors carrying mutated beta-catenin showed upregulated ACE2 expression, consistent with the predicted response sites in the ACE2 promoter. These findings reveal a potential link between liver cancer, liver diseases, and SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Jie Zou, Wen Zhang, Xiaoming Chen, Wenxing Su, Daojiang Yu
Summary: Diabetic foot ulcer and peripheral artery disease are common diseases that are closely related. Shared signaling pathways and genes have been identified and may serve as potential drug targets for intervention in both diseases.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
John Rooney, Leah C. Wehmas, Natalia Ryan, Brian N. Chorley, Susan D. Hester, Elaina M. Kenyon, Judith E. Schmid, Barbara Jane George, Michael F. Hughes, Yusupha M. Sey, Alan H. Tennant, Jane Ellen Simmons, Charles E. Wood, J. Christopher Corton
Summary: Short-term biomarkers of toxicity play an increasingly important role in screening new chemicals, one study found that organophosphate chemicals may have different impacts on liver toxicity and liver cancer induction mechanisms.
Article
Gastroenterology & Hepatology
Douglas N. Vanderwerken, Nicholas L. Wood, Dorry L. Segev, Sommer E. Gentry
Summary: This study estimated the survival probabilities without liver transplant for candidates with different MELD scores and IA status using real data. The research found an improvement in 90-day survival rates over the past decade and demonstrated the effectiveness of MELD in prioritizing candidates. It also showed that IA candidates have higher short-term survival rates compared to MELD 40 candidates but lower than MELD 39 candidates.
Article
Genetics & Heredity
A. R. Prickett, M. Ishida, S. Boehm, J. M. Frost, W. Puszyk, S. Abu-Amero, P. Stanier, R. Schulz, G. E. Moore, R. J. Oakey
Article
Genetics & Heredity
Nick Dand, Reiner Schulz, Michael E. Weale, Laura Southgate, Rebecca J. Oakey, Michael A. Simpson, Thomas Schlitt
Article
Microbiology
Luis Apolonia, Reiner Schulz, Tomaz Curk, Paula Rocha, Chad M. Swanson, Torsten Schaller, Jernej Ule, Michael H. Malim
Article
Immunology
Olga Sobolev, Elisa Binda, Sean O'Farrell, Anna Lorenc, Joel Pradines, Yongqing Huang, Jay Duffner, Reiner Schulz, John Cason, Maria Zambon, Michael H. Malim, Mark Peakman, Andrew Cope, Ishan Capila, Ganesh V. Kaundinya, Adrian C. Hayday
Article
Biochemistry & Molecular Biology
Adam R. Prickett, Nikolaos Barkas, Ruth B. McCole, Siobhan Hughes, Samuele M. Amante, Reiner Schulz, Rebecca J. Oakey
Article
Biochemistry & Molecular Biology
Charlotte Proudhon, Rachel Duffie, Sophie Ajjan, Michael Cowley, Julian Iranzo, Guillermo Carbajosa, Heba Saadeh, Michelle L. Holland, Rebecca J. Oakey, Vardhman K. Rakyan, Reiner Schulz, Deborah Bourc'his
Article
Multidisciplinary Sciences
Caroline Goujon, Olivier Moncorge, Helene Bauby, Tomas Doyle, Christopher C. Ward, Torsten Schaller, Stephane Hue, Wendy S. Barclay, Reiner Schulz, Michael H. Malim
Article
Genetics & Heredity
Heba Saadeh, Reiner Schulz
EPIGENETICS & CHROMATIN
(2014)
Article
Multidisciplinary Sciences
Heba Badraiq, Aleksandra Cvoro, Antonio Galleu, Marisa Simon, Cristian Miere, Carl Hobbs, Reiner Schulz, Richard Siow, Francesco Dazzi, Dusko Ilic
SCIENTIFIC REPORTS
(2017)
Article
Virology
Mattia Ficarelli, Irati Antzin-Anduetza, Rupert Hugh-White, Andrew E. Firth, Helin Sertkaya, Harry Wilson, Stuart J. D. Neil, Reiner Schulz, Chad M. Swanson
JOURNAL OF VIROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Samuele M. Amante, Bertille Montibus, Michael Cowley, Nikolaos Barkas, Jessica Setiadi, Heba Saadeh, Joanna Giemza, Stephania Contreras-Castillo, Karin Fleischanderl, Reiner Schulz, Rebecca J. Oakey
NUCLEIC ACIDS RESEARCH
(2020)
Article
Microbiology
Helene Bauby, Christopher C. Ward, Rupert Hugh-White, Chad M. Swanson, Reiner Schulz, Caroline Goujon, Michael H. Malim
Summary: The interaction between HIV-1 and CD4(+) T cells have been studied through transcriptomics analysis, unveiling global changes in gene expression. The viral accessory protein Vpr plays a crucial role in these gene expression changes, highlighting its significance in infection and pathogenesis. This finding sheds new light on the interplay between HIV-1 and its host at the cellular level.
Article
Cell Biology
Adam R. Prickett, Bertille Montibus, Nikolaos Barkas, Samuele M. Amante, Mauricio M. Franco, Michael Cowley, William Puszyk, Matthew F. Shannon, Melita D. Irving, Marta Madon-Simon, Andrew Ward, Reiner Schulz, H. Scott Baldwin, Rebecca J. Oakey
Summary: Dopa decarboxylase (DDC) synthesizes serotonin in the developing mouse heart and is encoded by Ddc_exon1a, a tissue-specific paternally expressed imprinted gene. Ddc_exon1a shares an imprinting control region (ICR) with the maternally expressed Grb10 gene, but they are not co-expressed in heart or brain, suggesting a mechanistic link through their shared ICR rather than Grb10 gene expression. Evidence from a Ddc_exon1a gene knockout mouse model shows its role in mediating myocardial growth, and there is a paternal expression bias with polymorphic imprinting patterns observed in individual human hearts at DDC_EXON1a.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Biotechnology & Applied Microbiology
Benjamin Lehne, Alexander W. Drong, Marie Loh, Weihua Zhang, William R. Scott, Sian-Tsung Tan, Uzma Afzal, Reiner Schulz, James Scott, Marjo-Ritta Jarvelin, Paul Elliott, Mark I. McCarthy, Jaspal S. Kooner, John C. Chambers