The Gemin Associates of Survival Motor Neuron Are Required for Motor Function in Drosophila

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy

(2013) A. Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal muscular atrophy: The role of SMN in axonal mRNA regulation

(2012) Claudia Fallini et al.   BRAIN RESEARCH

Behavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster

(2012) Christina Timmerman et al.   BRAIN RESEARCH

Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy

(2012) Eileen Workman et al.   BRAIN RESEARCH

An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function

(2012) Francesco Lotti et al.   CELL

SMN Is Required for Sensory-Motor Circuit Function in Drosophila

(2012) Wendy L. Imlach et al.   CELL

Drosophila Protein interaction Map (DPiM)

(2012) K.G. Guruharsha et al.   FLY

Gene Overexpression: Uses, Mechanisms, and Interpretation

(2012) G. Prelich   GENETICS

A Drosophila Model of Spinal Muscular Atrophy Uncouples snRNP Biogenesis Functions of Survival Motor Neuron from Locomotion and Viability Defects

(2012) Kavita Praveen et al.   Cell Reports

Spinal Muscular Atrophy

(2011) Stephen J. Kolb   ARCHIVES OF NEUROLOGY

Purification of the Human SMN–GEMIN2 Complex and Assessment of Its Stimulation of RAD51-Mediated DNA Recombination Reactions

(2011) Motoki Takaku et al.   BIOCHEMISTRY

Invertebrate models of spinal muscular atrophy: Insights into mechanisms and potential therapeutics

(2011) Stuart J. Grice et al.   BIOESSAYS

Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly

(2011) Rundong Zhang et al.   CELL

Gem formation upon constitutive Gemin3 overexpression inDrosophila

(2011) Ruben J. Cauchi   CELL BIOLOGY INTERNATIONAL

U bodies respond to nutrient stress in Drosophila

(2011) Mickey Buckingham et al.   EXPERIMENTAL CELL RESEARCH

The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons

(2011) C. Fallini et al.   JOURNAL OF NEUROSCIENCE

Imaging proteins inside cells with fluorescent tags

(2011) Georgeta Crivat et al.   TRENDS IN BIOTECHNOLOGY

Survival Motor Neuron Protein Regulates Stem Cell Division, Proliferation, and Differentiation in Drosophila

(2011) Stuart J. Grice et al.   PLoS Genetics

SMN and the Gemin proteins form sub-complexes that localise to both stationary and dynamic neurite granules

(2010) Adrian G. Todd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of SMN-neurite granules: Core Cajal body components are absent from SMN-cytoplasmic complexes

(2010) Adrian G. Todd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SMN and Gemins: ‘We are family’ … or are we?

(2010) Ruben J. Cauchi   BIOESSAYS

Helicase-inactivating mutations as a basis for dominant negative phenotypes

(2010) Yuliang Wu et al.   CELL CYCLE

Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies

(2010) Ruben J. Cauchi et al.   EXPERIMENTAL CELL RESEARCH

The role of RNA processing in the pathogenesis of motor neuron degeneration

(2010) Dirk Bäumer et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Gemin5 Delivers snRNA Precursors to the SMN Complex for snRNP Biogenesis

(2010) Jeongsik Yong et al.   MOLECULAR CELL

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

RNA metabolism and the pathogenesis of motor neuron diseases

(2010) Robin Lemmens et al.   TRENDS IN NEUROSCIENCES

The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body–P body pathway

(2009) Lin Lee et al.   DEVELOPMENTAL BIOLOGY

A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice

(2009) Eileen Workman et al.   HUMAN MOLECULAR GENETICS

RNA processing defects associated with diseases of the motor neuron

(2009) Stephen J. Kolb et al.   MUSCLE & NERVE

Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

(2009) Arthur H. M. Burghes et al.   NATURE REVIEWS NEUROSCIENCE

Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains

(2009) Chi-kong Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

(2009) Dirk Bäumer et al.   PLoS Genetics

SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing

(2008) Zhenxi Zhang et al.   CELL

SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain

(2008) Michael P. Walker et al.   HUMAN MOLECULAR GENETICS

Gemin3 Is an Essential Gene Required for Larval Motor Function and Pupation in Drosophila

(2008) Karl B. Shpargel et al.   MOLECULAR BIOLOGY OF THE CELL

A novel role for Gemin5 in mRNA translation

(2008) Almudena Pacheco et al.   NUCLEIC ACIDS RESEARCH

Modeling Spinal Muscular Atrophy in Drosophila

(2008) Howard Chia-Hao Chang et al.   PLoS One

Evolution of an RNP assembly system: A minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster

(2008) M. Kroiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Motor Function for the DEAD-Box RNA Helicase, Gemin3, in Drosophila

(2008) Ruben J. Cauchi et al.   PLoS Genetics

The SMN binding protein gemin2 is not involved in motor axon outgrowth

(2007) Michelle L. McWhorter et al.   Developmental Neurobiology