Article
Immunology
Yaritza Inostroza-Nieves, Alicia Rivera, Jose R. Romero
Summary: A study found that Major Histocompatibility Complex (MHC) molecules play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules after exposure to cytokines. SCD is characterized by vascular endothelial cell activation, oxidative stress, sickle cell adhesion, and excess levels of endothelin-1 (ET-1). The study suggests that ET-1 is a novel regulator of MHC class II molecules and ET-1 receptor blockade may be a promising therapeutic approach for regulating immune and vascular responses in SCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yoriko Ibuki, Yutaka Takahashi, Keisuke Tamari, Kazumasa Minami, Yuji Seo, Fumiaki Isohashi, Masahiko Koizumi, Kazuhiko Ogawa
Summary: The study demonstrates that the combination therapy of local hyperthermia with CTLA-4 blockade not only enhances the antitumor response in heated tumors but also in unheated distant tumors, leading to a prolonged overall survival.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Ecology
Piotr Minias, Ke He, Peter O. Dunn
Summary: The study found highly consistent levels of selection and polymorphism between both peptide-binding domains (alpha(1) and alpha(2)) of the avian MHC class I, suggesting similar characteristics in antigen recognition and selective pressure for the two domains.
BMC ECOLOGY AND EVOLUTION
(2021)
Article
Cell Biology
Florence Mompart, Alain Kamgoue, Yvette Lahbib-Mansais, David Robelin, Agnes Bonnet, Claire Rogel-Gaillard, Silvia Kocanova, Martine Yerle-Bouissou
Summary: The research found that the MHC has different 3D organization in humans and pigs. LPS/IFN gamma activation induces chromatin decompaction, but it is not the same area affected in the two species. The position of the centromere inside the swine MHC could influence chromatin reorganization during the activation process.
BMC MOLECULAR AND CELL BIOLOGY
(2021)
Article
Ecology
David J. Ayre, Natalie Rosser
Summary: The research found that despite extensive populations of surf barnacles on both sides of the Southeast Australian Biogeographic Barrier (SEABB) being separated for millennia, recent dispersal across the barrier suggests that lineage differentiation could be eroded with crossbarrier migration. Population differentiation within eastern and western regions is low (F-ST < 0.021), but there is a strong regional separation of lineages (F-RT = 0.23), with evidence of significant regional diversifying selection observed in some surveyed loci.
MARINE ECOLOGY PROGRESS SERIES
(2021)
Article
Biochemistry & Molecular Biology
Yingying Zhao, Liangchen Zhu
Summary: This study found that Ganoderma lucidum spore powder has a protective effect against DSS-induced colitis by alleviating symptoms and improving gut barrier function.
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
(2023)
Article
Toxicology
David W. Roberts
Summary: The text discusses the importance of information on skin sensitization testing in the murine local lymph node assay (LLNA) and the quantification of potency by the EC3 value. It also addresses the difficulties in interpreting LLNA results and the concept of the overload effect, which can potentially lead to misinterpretation of results. Additionally, the text presents a mechanistic rationale for explaining the overload effect and the production of danger signals even in the absence of irritant sensitizers.
CURRENT RESEARCH IN TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Helen Parker, Stuart M. Ellison, Rebecca J. Holley, Claire O'Leary, Aiyin Liao, Jalal Asadi, Emily Glover, Arunabha Ghosh, Simon Jones, Fiona L. Wilkinson, David Brough, Emmanuel Pinteaux, Herve Boutin, Brian W. Bigger
EMBO MOLECULAR MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Francesca Bartoli-Leonard, Fiona L. Wilkinson, Andrew Schiro, Ferdinand Serracino Inglott, M. Yvonne Alexander, Ria Weston
Summary: This study found that in diabetic calcified arteries, SIRT1 levels are reduced and DNA damage marker expression is increased. Vascular smooth muscle cells isolated from diabetic patients show elevated DNA damage and senescence. In vitro, hyperglycaemic conditions induced DNA damage and enhanced senescence in vascular smooth muscle cells.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Yvonne Alexander, Elena Osto, Arno Schmidt-Trucksass, Michael Shechter, Danijela Trifunovic, Dirk J. Duncker, Victor Aboyans, Magnus Back, Lina Badimon, Francesco Cosentino, Marco De Carlo, Maria Dorobantu, David G. Harrison, Tomasz J. Guzik, Imo Hoefer, Paul D. Morris, Giuseppe D. Norata, Rosa Suades, Stefano Taddei, Gemma Vilahur, Johannes Waltenberger, Christian Weber, Fiona Wilkinson, Marie-Luce Bochaton-Piallat, Paul C. Evans
Summary: Endothelial cells play a crucial role in cardiovascular health, and dysfunction can be caused by cardiovascular risk factors but restored once stimuli are removed. There are various methods to measure endothelial function, with each having its pros and cons. It is recommended to adopt a consensus methodology like flow-mediated dilatation and establish reference values for different populations. Future studies should explore the integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers.
CARDIOVASCULAR RESEARCH
(2021)
Article
Multidisciplinary Sciences
Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vila Gonzalez, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti
NATURE COMMUNICATIONS
(2020)
Correction
Multidisciplinary Sciences
Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vila Gonzalez, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti
NATURE COMMUNICATIONS
(2020)
Review
Surgery
J. J. Pilkington, T. W. Davies, O. Schaff, M. Y. Alexander, J. Pritchett, F. L. Wilkinson, A. J. Sheen
Summary: This systematic review considered potential systemic factors as biomarkers of hernia formation, focusing on markers of extracellular matrix remodelling and collagen turnover. Results showed some specific markers were increased or decreased in hernia patients. Despite a lack of high-quality evidence, biomarker-based diagnostic studies hold promise to improve management of hernia pathogeneses.
AMERICAN JOURNAL OF SURGERY
(2021)
Editorial Material
Cell Biology
Ayman M. Mahmoud, Fiona L. Wilkinson, Mansur A. Sandhu, Adam P. Lightfoot
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Kuin Tian Pang, Mean Ghim, Chenghao Liu, Hui Min Tay, Chee Wai Fhu, Rui Ning Chia, Beiying Qiu, Padmini Sarathchandra, Adrian H. Chester, Magdi H. Yacoub, Fiona L. Wilkinson, Ria Weston, Christina M. Warboys, Han Wei Hou, Peter D. Weinberg, Xiaomeng Wang
Summary: Elevated levels of Leucine-Rich Alpha-2-Glycoprotein1 (LRG1) are found in patients with inflammatory, autoimmune, and cardiovascular diseases. LRG1 is highly expressed in stenotic arteries' endothelial cells and its expression in this context is shear-dependent and TNF-alpha-inducible. Mechanistically, LRG1 inhibits TNF-alpha-induced activation of NF-kappa B signaling by promoting shedding of TNFR1 and subsequent ADAM10 activation, thereby affecting monocyte adhesion and transendothelial migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Cell Biology
Ayman M. Mahmoud, Fiona L. Wilkinson, Adam P. Lightfoot, Julia M. Dos Santos, Mansur A. Sandhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Cai Astley, Chahinez Houacine, Azziza Zaabalawi, Fiona Wilkinson, Adam P. Lightfoot, Yvonne Alexander, Debra Whitehead, Kamalinder K. Singh, May Azzawi
Summary: The study demonstrates that nanostructured lipid carriers (NLCs) loaded with resveratrol (RV) have the potential to restore vascular dilator function and improve potency for antihypertensive treatment strategies. This effective delivery modality shows promising implications for sustained drug release and improved bioavailability of vasoprotective compounds.
Article
Biochemistry & Molecular Biology
Daniel M. Gill, Ana Paula R. Povinelli, Gabriel Zazeri, Sabrina A. Shamir, Ayman M. Mahmoud, Fiona L. Wilkinson, M. Yvonne Alexander, Marinonio L. Cornelio, Alan M. Jones
Summary: This study optimized the synthesis of 17 small molecule glycomimetics, clarified the absolute stereochemical configurations of C1-4, and investigated the role and importance of sulfation on the modulation of endothelial dysfunction. In vitro studies demonstrated the modulatory effects of sulfated glycomimetics on endothelial dysfunction through their interaction with HGF.
RSC MEDICINAL CHEMISTRY
(2021)
Meeting Abstract
Biotechnology & Applied Microbiology
Stuart M. Ellison, Helen Parker, Rebecca Holley, Claire O'Leary, Aiyin Liao, Jalal Asadi, Emily Glover, Arunabha Ghosh, Simon Jones, Fiona L. Wilkinson, David Brough, Emmanuel Pinteaux, Herve Boutin, Brian Bigger
Meeting Abstract
Biochemistry & Molecular Biology
N. Edwards, A. W. Langford-Smith, S. Tandel, B. Parker, I. Bruce, J. A. Reynolds, M. Y. Alexander, E. McCarthy, F. L. Wilkinson
Meeting Abstract
Cardiac & Cardiovascular Systems
N. Edwards, A. W. W. Langford-Smith, M. Floren, A. Hasan, R. Weston, S. T. Rashid, A. Boulton, F. Bowling, W. Tan, F. L. Wilkinson, M. Y. Alexander
CARDIOVASCULAR DRUGS AND THERAPY
(2019)
Meeting Abstract
Physiology
Yvonne Alexander, Alexander W. Langford-Smith, Ahmad Hassan, Nicola Edwards, Fiona L. Wilkinson
JOURNAL OF VASCULAR RESEARCH
(2019)