Article
Health Care Sciences & Services
Paivi E. Korhonen, Sem Kiiski, Hannu Kautiainen, Seppo Ojanen, Risto Tertti
Summary: This study investigated the long-term clinical consequences of different eGFR levels calculated by the CKD-EPI equation in apparently healthy cardiovascular risk subjects. It found that subjects with eGFR >= 105 ml/min/1.73 m(2) had an increased risk for all-cause mortality, incident peripheral artery disease, and atrial fibrillation/flutter compared to those with eGFR in the range of 90-104 ml/min. These patients also had a higher mortality rate compared to the general population in Finland. Therefore, close monitoring and timely interventions are necessary for patients with eGFR >= 105 ml/min/1.73 m(2).
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Hye-Yeon Kim, Sun-Seog Kweon, Young-Hoon Lee, So-Yeon Ryu, Hae-Sung Nam, Min-Ho Shin, Kyeong-Soo Park, Seong-Woo Choi
Summary: The study found independent associations between estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR) with all-cause and cardiovascular mortality in Korean adults aged >= 50 years. When comparing eGFR performance, eGFR(cys) showed superior predictive accuracy for all-cause mortality compared to eGFR(MDRD) and eGFR(CKD-EPI).
Article
Urology & Nephrology
Tyrone G. Harrison, Shannon M. Ruzycki, Matthew T. James, Paul E. Ronksley, Kelly B. Zarnke, Marcello Tonelli, Braden J. Manns, Deirdre McCaughey, Prism Schneider, Elijah Dixon, Rebecca L. Hartley, Victoria S. Owen, Zhihai Ma, Brenda R. Hemmelgarn
Summary: People with reduced kidney function have a significantly higher incidence of major surgery compared to those with normal kidney function, with age and sex modifying this risk. Men under 65 years old receiving maintenance dialysis experienced the highest rates of major surgery.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Medicine, General & Internal
Chi D. Chu, Fang Xia, Yuxian Du, Rakesh Singh, Delphine S. Tuot, Julio A. Lamprea-Montealegre, Ralph Gualtieri, Nick Liao, Sheldon X. Kong, Todd Williamson, Michael G. Shlipak, Michelle M. Estrella
Summary: This study found that approximately two-thirds of patients with hypertension or diabetes were undetected for albuminuria, leading to an increased risk of chronic kidney disease (CKD) progression and cardiovascular morbidity. Therefore, improving the accuracy and utilization of albuminuria testing can help reduce the risk of CKD progression and cardiovascular complications.
Article
Cardiac & Cardiovascular Systems
Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh
Summary: This study aimed to investigate the association between eGFR slope and CVD among individuals with and without diabetes. The results showed that a steeper decline in eGFR slope was significantly associated with a higher risk of CVD events in individuals with diabetes, but not in individuals without diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medicine, General & Internal
Jianhao Huang, Weiwei Li, Suosu Wei, Xing Zhou, Yuechou Nong, Jingxia Sun, Zhenwei Zhai, Wensheng Lu
Summary: This study found that decreased eGFR is a risk factor for all-cause mortality and MACE in individuals with DFO. Male with decreased eGFR had a higher risk of all-cause mortality and MACE, but female did not.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, General & Internal
Leonardo De Luca, Francesca Cappadona, Pier Luigi Temporelli, Lucio Gonzini, Antonietta Ledda, Arturo Raisaro, Francesca Viazzi, Domenico Gabrielli, Furio Colivicchi, Michele Massimo Gulizia, Roberto Pontremoli
Summary: In patients with stable coronary artery disease (CAD), a reduction in estimated glomerular filtration rate (eGFR) is associated with an increased risk of all-cause mortality. Chronic kidney disease may limit treatment optimization.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Wei Liu, Xue-Lian Ma, Hong-Qiu Gu, Hao Li, Zi-Xiao Li, Yong-Jun Wang
Summary: This study investigated the association between hyperhomocysteinemia and in-hospital mortality following ischemic stroke, transient ischemic attack, or intracerebral hemorrhage. The results showed that hyperhomocysteinemia was associated with in-hospital mortality, but this association disappeared after controlling for renal function.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Anesthesiology
Fang Gong, Quan Zhou, Chunmei Gui, Shaohua Huang
Summary: This retrospective cohort analysis explored the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in acute pancreatitis (AP) patients admitted to intensive care units. The study found that eGFR was negatively correlated with 28-day mortality, with a 15% decrease in mortality for every 10 ml/min/1.73 m(2) increase in eGFR. When eGFR < 57 ml/min/1.73 m(2), there was a negative correlation between eGFR and 28-day mortality. Additionally, eGFR was also negatively correlated with in-hospital and in-ICU mortality.
BMC ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Zhen-Wei Wang, Min Li, Jing-Jie Li, Nai-Feng Liu
Summary: This study found a significant association between Lp(a) and the risk of all-cause and CVD-related mortality.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Yu-Jie Liu, Fu-Rong Li, Cai-Long Chen, Zhong-Xiao Wan, Jin-Si Chen, Jing Yang, Rong Liu, Jia-Ying Xu, Yan Zheng, Li-Qiang Qin, Guo-Chong Chen
Summary: This study aimed to investigate whether estimated glomerular filtration rates (eGFRs) by different biomarkers are differently associated with mortality, and whether the associations differ by diabetes status, especially in the Chinese population. The results showed that in individuals without diabetes, modestly declined eGFR was not associated with mortality, while CKD defined by eGFRcys and eGFRcr-cys was associated with a higher risk of mortality. In individuals with diabetes, both modestly declined eGFR and CKD were associated with a higher risk of mortality. Adding eGFRcys or eGFRcr-cys to traditional risk factors improved the prediction of all-cause mortality risk.
JOURNAL OF DIABETES
(2023)
Article
Urology & Nephrology
Hae Hyuk Jung
Summary: This study evaluated a prediction model for composite cardiovascular and kidney outcomes and found that adding albuminuria and estimated glomerular filtration rate (eGFR) to the model increased the prediction accuracy. In diabetic and hypertensive patients, a high incidence rate of ≥10 per 1,000 person-years was observed among those at high or very high risk according to the Kidney Disease: Improving Global Outcomes (KDIGO) risk categories, as well as those at moderate or low risk with a Pooled-Cohort-Equations (PCEs) 10-year risk of ≥10% or ≥20%.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Suxia Fang, Yuwen Chen, Qiyue Gao, Qucheng Wei
Summary: This study investigated the association between a novel kidney disease index (KDI) and mortality in individuals with hypertension. The results showed that elevated KDI levels were positively correlated with markers of glucose metabolism, insulin resistance, and inflammation. After adjustment for confounding factors, each standard deviation increment in KDI level was associated with a significantly increased risk of all-cause mortality and cardiovascular deaths. Furthermore, a J-shaped association was observed, with a substantial risk increase when KDI exceeded 0.27. These findings suggest the importance of routine testing of eGFR and uACR in hypertensive patients and the potential of KDI as a tool for identifying those who would benefit most from preventive therapies.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dong Hoon Lee, Leandro F. M. Rezende, Hee-Kyung Joh, NaNa Keum, Gerson Ferrari, Juan Pablo Rey-Lopez, Eric B. Rimm, Fred K. Tabung, Edward L. Giovannucci
Summary: Engaging in moderate or vigorous physical activities for an appropriate amount of time can reduce the risk of mortality.
Article
Transplantation
Graziella D'Arrigo, Francesca Mallamaci, Patrizia Pizzini, Daniela Leonardis, Giovanni Tripepi, Carmine Zoccali
Summary: This longitudinal study investigated the relationship between repeated measurements of CKD-MBD biomarkers and renal outcomes in CKD patients. The results suggested that serum PTH, calcium, phosphate, FGF23, and 1,25-dihydroxyvitamin D were independently associated with the progression to kidney failure.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Alda Huqi, Carmine Zoccali, Robert P. Giugliano, Raffaele De Caterina
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah B. Yildiz, Metehan Berkkan, Kathherine R. Tuttle, Carmine Zoccali
Summary: Metabolically healthy overweight and obese individuals have a higher risk of chronic kidney disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Transplantation
Carmine Zoccali, Giovanni Tripepi, Luca Neri, Matteo Savoia, Maria Eva Baro Salvador, Pedro Ponce, Jeffrey Hymes, Frank Maddux, Francesca Mallamaci, Stefano Stuard
Summary: A reduction in dialysate temperature was found to be associated with a decrease in the risk of IDH in HD patients, but had no impact on all-cause mortality.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Beatriz Martin-Carro, Juan F. Navarro-Gonzalez, Alberto Ortiz, Carmine Zoccali, Jurgen Floege, Manuel A. Ferreira, Jose L. Gorriz-Teruel, Natalia Carrillo-Lopez, Sara Panizo, Francesco Locatelli, Markus Ketteler, Gerard M. London, Manuel Naves-Diaz, Cristina Alonso-Montes, Jorge B. Cannata-Andia, Jose L. Fernandez-Martin
Summary: This study found that diabetic patients on haemodialysis have a higher risk of mortality, and high serum parathyroid hormone (PTH) levels are particularly associated with increased mortality risk in diabetic patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci, Raffaele De Caterina
Summary: In chronic kidney disease patients, hypofiltration can lead to drug accumulation, while hyperfiltration can cause increased renal excretion of drugs. This review focuses on whether hyperfiltration affects drug clearance and if dose adjustment is needed.
CLINICAL KIDNEY JOURNAL
(2023)
Editorial Material
Urology & Nephrology
Carmine Zoccali
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Patrick B. Mark, Pantelis Sarafidis, Rajiv Agarwal, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A. Massy, Peter Kotanko, Charles J. Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Francesca Mallamaci, Andrzej Wiecek
Summary: Patients with CKD are at high risk of CVD, so it's important to identify and monitor cardiovascular complications and hypertension. Biomarkers like troponins and ECG have limited use in diagnosing cardiac ischemia in these patients. However, techniques like stress echocardiography, myocardial perfusion scintigraphy, and stress testing can help detect coronary disease in patients with CKD.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Transplantation
Claudia Torino, Francesca Mallamaci, Pantelis Sarafidis, Aikaterini Papagianni, Robert Ekart, Radovan Hojs, Marian Klinger, Krzysztof Letachowicz, Danilo Fliser, Sarah Seiler-Mussler, Fabio Lizzi, Kostas Siamopoulos, Olga Balafa, Evangelia Ntounousi, Itzchak Slotki, Linda Shavit, Aristeidis Stavroulopoulos, Ziad A. Massy, Alexandre Seidowsky, Yuri Battaglia, Alberto Martinez-Castelao, Gustavo Villalobos, Enrico Fiaccadori, Giuseppe Regolisti, Thierry Hannedouche, Thomas Bachelet, Kitty J. Jager, Friedo W. Dekker, Rocco Tripepi, Giovanni Tripepi, Luna Gargani, Rosa Sicari, Eugenio Picano, Gerard Michel London, Carmine Zoccali
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Pedro Barrera-Baena, Minerva Rodriguez-Garcia, Enrique Rodriguez-Rubio, Lucia Gonzalez-Llorente, Alberto Ortiz, Carmine Zoccali, Francesco Locatelli, Juergen Floege, Martine Cohen-Solal, Manuel Anibal Ferreira, Markus Ketteler, Gerard Michel London, Jose Luis Gorriz-Teruel, Emilio Sanchez-Alvarez, Miguel Angel Hevia-Suarez, Jesus Maria Fernandez-Gomez, Beatriz Martin-Carro, Carlos Gomez-Alonso, Cristina Alonso-Montes, Jorge Benito Cannata-Andia, Jose Luis Fernandez-Martin
Summary: This study analyzed the association between biochemical parameters of CKD-MBD and bone fragility fractures in hemodialysis patients, and found that hyperphosphatemia is independently and consistently associated with an increased risk of bone fractures.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Carmine Zoccali, Fabio Manfredini, Mehmet Kanbay, Francesca Mallamaci
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci
Summary: The traditional peer review process in medicine is facing a crisis due to issues such as publication delays, potential bias, and a lack of transparency. In response, innovative models like Peer Community In Research Reports (PCI RR) provide a rapid, transparent, and collaborative evaluation process for scientific research. The success of the PCI RR model relies on the engagement and support of researchers, publishers, and other stakeholders.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci
Summary: The landscape of medical congresses is currently facing a crisis due to various factors such as the COVID-19 pandemic, declining attendance, concerns about content quality, and ethical issues related to the pharmaceutical industry. To address these challenges, potential solutions have been identified, including hybrid events, tiered registration fees, collaboration with sponsors, leveraging technology, and improving content quality and transparency.
JOURNAL OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Belinda Spoto, Ernesto Di Betta, Patrizia Pizzini, S. Lonardi, F. Mallamaci, G. Tripepi, Mehmet Kanbay, Giovanni Cancarini, Carmine Zoccali
Summary: This study compared individuals with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and found no significant differences in circulating levels of cytokines and adipokines, as well as the expression of inflammatory genes in adipose tissue. The results suggest that metabolically healthy obese individuals have similar inflammation profiles to metabolically unhealthy obese individuals.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Urology & Nephrology
Anna Pisano, Carmine Zoccali, Davide Bolignano, Graziella D'Arrigo, Francesca Mallamaci
Summary: The study aimed to define the clinical penetrance of sleep apnoea in patients with chronic kidney disease and end-stage kidney disease, revealing a high prevalence of sleep apnoea in both non-dialysis CKD and ESKD patients. This highlights the importance of using objective diagnostic tools to identify sleep apnoea in kidney disease patients.
CLINICAL KIDNEY JOURNAL
(2023)