Article
Microbiology
Mathilde Couteaudier, Thomas Montange, Richard Njouom, Chanceline Bilounga-Ndongo, Antoine Gessain, Florence Buseyne
Summary: This study found that SFV-specific antibodies from infected humans do not block cell-to-cell transmission, despite their capacity to bind to the surface of infected cells.
Review
Multidisciplinary Sciences
Jean-Laurent Casanova, Laurent Abel
Summary: Disease and inflammation are rare outcomes of viral infection in humans, often due to a failure in cell-intrinsic and leukocytic immunity to viruses. Inflammation indicates the efforts of newly recruited and activated leukocytes to resolve infection. Genetic studies can help clarify the underlying causes of inflammation and disease in viral infections.
Article
Virology
Widade Ziani, Anya Bauer, Hong Lu, Xiaolei Wang, Xueling Wu, Katharine J. Bar, Hui Li, Dongfang Liu, George M. Shaw, Ronald S. Veazey, Huanbin Xu
Summary: The newly developed SHIV.C.CH848 can establish sustained viremia and viral reservoirs in rhesus macaques with clinical immunodeficiency consequences, providing a valuable SHIV model for HIV research. The findings suggest that this CCR5-tropic, SHIVC strain is valuable for testing responses to HIV vaccines and therapeutics in nonhuman primate models.
JOURNAL OF VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Chao-Jung Chen, Mu-Lin Chiu, Chien-Hui Hung, Wen-Miin Liang, Mao-Wang Ho, Ting-Hsu Lin, Xiang Liu, Hsinyi Tsang, Chiu-Chu Liao, Shao-Mei Huang, Yi-Fang Wu, Yang-Chang Wu, Te-Mao Li, Fuu-Jen Tsai, Ying-Ju Lin
Summary: The study evaluated the effects of Xanthium strumarium and Pueraria montana on HIV-1 reactivation and found that X. strumarium could reactivate latently infected cells while inhibiting the nuclear regulatory protein XRCC6 associated with 5'-LTR, enhancing viral promoter activity. These findings contribute to the understanding of the 5'-LTR activity and host cell nuclear regulatory protein machinery for reactivating HIV-1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Shirley E. Braspenning, Georges M. G. M. Verjans, Tamana Mehraban, Ilhem Messaoudi, Daniel P. Depledge, Werner J. D. Ouwendijk
Summary: This study annotates the transcriptome of simian varicella virus (SVV) in African green monkey and rhesus macaque cells, revealing numerous RNA isoforms, splicing events, and non-coding RNAs unique to SVV. The expression of canonical and newly identified SVV transcripts was verified in vivo, and a detailed characterization of the SVV homolog of the VZV latency-associated transcript highlighted conservation between SVV and VZV core exons. The complexity of SVV gene expression and insights into lytic and latent SVV infection were further elucidated, underscoring the value of the SVV non-human primate model for developing strategies against herpes zoster.
Article
Virology
Laurent Hany, Marc-Olivier Turmel, Corinne Barat, Michel Ouellet, Michel J. Tremblay
Summary: Although LRAs can efficiently reactivate latent CD4(+) T cells, their impact on HIV-1 infection and production in macrophages remains unclear. This study found that certain LRAs exhibit antireplicative features in human macrophages and identified a new viral production inhibition mechanism by bryostatin-1 specific to myeloid cells. Further research is needed to fully assess the efficacy of HIV-1 eradicating strategies.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Keli Chai, Zhaohuan Wang, Yali Xu, Junshi Zhang, Juan Tan, Wentao Qiao
Summary: The study found that the envelope glycoprotein of bovine foamy virus is palmitoylated at amino acid positions C58 and C59, and mutations at these sites significantly inhibit viral replication.
Review
Biochemistry & Molecular Biology
Ewa Ostrycharz, Beata Hukowska-Szematowicz
Summary: This article presents key miRNAs involved in viral infections in humans and animals. The authors summarize existing literature data and reveal that 12 miRNAs are mainly involved in human viral infections, while 10 miRNAs are commonly found in animal viral infections. Investigating the roles of these miRNAs can contribute to understanding the pathogenesis of viral diseases and aid in the development of therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Peter G. E. Kennedy, Paul Montague
Summary: Varicella-Zoster virus (VZV), a human herpes virus, causes varicella and shingles. Understanding the gene expression of VZV during latency is crucial. Recent studies using RNA-Seq technology on human trigeminal ganglia at 6 hours post-mortem revealed a novel latency-associated VZV transcript, which can induce viral gene expression.
Article
Virology
Arpan Acharya, Omalla A. Olwenyi, Michellie Thurman, Kabita Pandey, Brenda M. Morsey, Benjamin Lamberty, Natasha Ferguson, Shannon Callen, Qiu Fang, Shilpa J. Buch, Howard S. Fox, Siddappa N. Byrareddy
Summary: This study established a morphine-dependent simian immunodeficiency virus SIVmac251-infected rhesus macaque model to investigate the impact of opioids on HIV reservoirs. The results suggested that opioids, specifically morphine, play a dual role by reducing CD4(+) T-cell reservoirs in lymphoid tissues while increasing the reservoir size in the central nervous system.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhe Cong, Yuting Sun, Cui Dang, Chenbo Yang, Jingjing Zhang, Jiahan Lu, Ting Chen, Qiang Wei, Wei Wang, Jing Xue
Summary: Antiretroviral therapy can inhibit HIV replication but not completely cure it due to HIV persistence. The shock and kill strategy is commonly used to cure HIV, in which latency-reversing agents are used to trigger viral reactivation and enhance cellular immunity. Finding the right drug combination is important for clinical trials.
Article
Virology
Eric Carlin, Braxton Greer, Kelsey Lowman, Alexander G. Dalecki, Alexandra Duverger, Frederic Wagner, Olaf Kutsch
Summary: Therapeutic attempts to eliminate the latent HIV-1 reservoir have been unsuccessful due to incomplete understanding of the biomolecular processes involved in latent HIV-1 infection. This study investigates the interaction between viral proteins, specifically HIV Nef, and host cells in the establishment of latency. It found that HIV-1 and HIV-2 Nef proteins have differential effects on latency establishment, suggesting that the HIV-1 lineage may have evolved mechanisms to counteract host cell suppression.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Henry Okonta, Xi Cheng, Ritu Chakravarti, Joan Duggan
Summary: The study revealed that antibiotic treatment and viral infection significantly impact the intestinal microbiota of mice, and viral infection leads to microbial dysbiosis.
Article
Immunology
Shenghua Chang, Haiying Guo, Jin Li, Yaoting Ji, Han Jiang, Lianguo Ruan, Minquan Du
Summary: The study compared the salivary mycobiome between HIV infections and healthy controls, finding higher diversity and richness in HIV-infected individuals compared to controls. After ART administration, diversity and richness significantly decreased. Certain fungal species, including Candida and Mortierella, were enriched in HIV patients but decreased post-ART, while others like Verticillium and Issatchenkia increased. Correlation analysis highlighted relationships between specific fungi and viral load or CD4(+) T-cell counts. The study demonstrates the impact of HIV infection and ART on the composition of salivary mycobiome communities, reflecting the complexity of changes in HIV infections after ART.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biology
Wei Wu, Ge Yi, Xinwei Lv, Qianzhuo Mao, Taiyun Wei
Summary: A calcium-binding protein (CBP) found in insect saliva allows for the transmission of the devastating rice gall dwarf virus into plant phloem. This interaction with CBP is compounded by stronger feeding barriers, more frequent probing behavior, and increased saliva secretion into plants by insect vectors, all increasing the likelihood of viral transmission.
COMMUNICATIONS BIOLOGY
(2022)
Correction
Immunology
Brandon Kwong, Rejane Rua, Yuanyuan Gao, John Flickinger, Yan Wang, Michael J. Kruhlak, Jinfang Zhu, Eric Vivier, Dorian B. McGavern, Vanja Lazarevic
Review
Biochemistry & Molecular Biology
Rejane Rua, Dorian B. McGavern
TRENDS IN MOLECULAR MEDICINE
(2018)
Article
Infectious Diseases
Sandrine Alais, Amandine Pasquier, Brice Jegado, Chloe Journo, Rejane Rua, Antoine Gessain, Joelle Tobaly-Tapiero, Romain Lacoste, Jocelyn Turpin, Renaud Mahieux
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Microbiology
Caroline Lambert, Mathilde Couteaudier, Julie Gouzil, Lea Richard, Thomas Montange, Edouard Betsem, Rejane Rua, Joelle Tobaly-Tapiero, Dirk Lindemann, Richard Njouom, Augustin Mouinga-Ondeme, Antoine Gessain, Florence Buseyne
Article
Immunology
Rejane Rua, Jane Lee, Alexander B. Silva, Isabella S. Swafford, Dragan Maric, Kory R. Johnson, Dorian B. McGavern
Article
Biochemical Research Methods
Monica Manglani, Rejane Rua, Amy Hendricksen, Daniel Braunschweig, Qian Gao, Woei Tan, Brett Houser, Dorian B. McGavern, Kenneth Oh
Editorial Material
Immunology
Rejane Rua, Nathalie Pujol
Article
Multidisciplinary Sciences
Nikita Mikhailov, Anais Virenque, Kseniia Koroleva, Elisa Eme-Scolan, Matei Teleman, Ali Abdollahzadeh, Raisa Giniatullina, Oleg Gafurov, Georgii Krivoshein, Tarja Malm, Riikka H. Hamalainen, Alejandra Sierra, Jussi Tohka, Rejane Rua, Francesco M. Noe, Rashid Giniatullin
Summary: Malfunctioning of the lymphatic system in the meninges affects the balance of pro- and anti-migraine mediators, but does not directly trigger meningeal nociceptive state.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Julie Rebejac, Elisa Eme-Scolan, Laurie Arnaud Paroutaud, Sarah Kharbouche, Matei Teleman, Lionel Spinelli, Emeline Gallo, Annie Roussel-Queval, Ana Zarubica, Amandine Sansoni, Quentin Bardin, Philippe Hoest, Marie-Cecile Michallet, Carine Brousse, Karine Crozat, Monica Manglani, Zhaoyuan Liu, Florent Ginhoux, Dorian B. McGavern, Marc Dalod, Bernard Malissen, Toby Lawrence, Rejane Rua
Summary: Meningeal macrophages (MMs) play a protective role in viral infection and may serve as potential targets for therapeutic intervention. High viral load correlates with low numbers of MHC-II+ MMs.
Editorial Material
Immunology
Rejane Rua, Nathalie Pujol
Summary: In this study, researchers discovered that a specific metabolite can be recognized by Caenorhabditis elegans, leading to the activation of detoxifying enzymes and immunity-related genes through binding with a nuclear hormone receptor, thus protecting the worm from pathogenic bacteria.
Article
Immunology
Michael Valente, Nils Collinet, Thien-Phong Vu Manh, Dimitri Popoff, Khalissa Rahmani, Karima Naciri, Gilles Bessou, Rejane Rua, Laurine Gil, Cyrille Mionnet, Pierre Milpied, Elena Tomasello, Marc Dalod
Article
Biochemical Research Methods
Annie Roussel-Queval, Julie Rebejac, Elisa Eme-Scolan, Laurie Arnaud Paroutaud, Rejane Rua
Summary: This article presents techniques for the immunological and virological assessment of mouse dural meninges. It includes steps for immunophenotyping and viral assessment upon lymphocytic choriomeningitis virus infection.
Review
Immunology
Elisa Eme-Scolan, Laurie Arnaud-Paroutaud, Narjess Haidar, Annie Roussel-Queval, Rejane Rua
Summary: Important discoveries have been made in the field of neuroimmunology, specifically regarding the role of meninges in brain infection and cognitive disorders. This review discusses the protective role of meningeal layers in the central nervous system against various infections and explores the neurological consequences of meningeal infections in both neonates and adults. The aim is to provide an integrated view of meningeal immune regulations and their impact on CNS infections and neurological outcomes.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Remy Char, Zhuangzhuang Liu, Cedric Jacqueline, Marion Davieau, Maria-Graciela Delgado, Clara Soufflet, Mathieu Fallet, Lionel Chasson, Raphael Chapuy, Voahirana Camosseto, Eva Strock, Rejane Rua, Catarina R. Almeida, Bing Su, Ana-Maria Lennon-Dumenil, Beatrice Nal, Antoine Roquilly, Yinming Liang, Stephane Meresse, Evelina Gatti, Philippe Pierre
Summary: This study shows that iRUFY3 plays a role in perinuclear positioning, phagocyte migration and antigen presentation during Salmonella infection. iRUFY3 controls macrophages migration, MHC II presentation and responses to Interferon-γ, while being important for intracellular Salmonella replication.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Immunology
Rejane Rua, Jane Lee, Alex Silva, Maric Dragan, Kory Johnson, Dorian B. McGavern
JOURNAL OF IMMUNOLOGY
(2018)