Article
Multidisciplinary Sciences
Sara Daneshfar, Azar Dokht Khosravi, Mohammad Hashemzadeh
Summary: This study aimed to identify M. simiae isolates and assess their drug resistance. The results showed that M. simiae is highly resistant to antibiotics with high resistance rates. Therefore, species identification and antibiotic susceptibility testing are essential before treatment.
Article
Microbiology
Barbara A. Brown-Elliott, Richard J. Wallace
Summary: Nontuberculous mycobacteria (NTM) infections, especially caused by Mycobacterium avium complex (MAC) and M. abscessus species, are increasing worldwide. This study tested the in vitro activity of a new tetracycline derivative, eravacycline, against 110 clinical isolates of NTM. The results showed that eravacycline was active against rapidly growing Mycobacterium species, including M. abscessus. However, its activity against slowly growing Mycobacterium species was limited.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Barbara A. Brown-Elliott, Richard J. Wallace
Summary: This study evaluated the in vitro potency of the new tetracycline derivative omadacycline against NTM, showing high activity against most RGM species. MIC testing against RGM revealed over 90% resistance to tetracycline in the isolates tested.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kelley R. Hurst-Hess, Aavrati Saxena, Paulami Rudra, Yong Yang, Pallavi Ghosh
Summary: The frontline drug Rifampicin is ineffective against M. abscessus due to the presence of an ADP-ribosyltransferase (Arr) that inactivates Rifampicin. Exposure of M. abscessus to sublethal doses of Rifampicin and Rifabutin results in an upregulation of Mab_helR gene, and overexpression of Mab_helR confers Rifampicin tolerance in M. tuberculosis.
Article
Microbiology
Cara G. Tan, Nicole M. Oberlag, Acelyn E. Mcgowan, Stephanie N. Dawrs, Yvonne L. Chan, Michael Strong, Nabeeh A. Hasan, Jennifer R. Honda
Summary: Nontuberculous mycobacteria (NTM) are environmental opportunistic pathogens that cause severe and difficult to treat pulmonary disease. This study investigates iron acquisition via siderophores in NTM species and subspecies isolated from Hawai'i. The results show that respiratory isolates have more siderophore genes compared to environmental isolates. However, no significant differences are observed between different species when it comes to iron sequestration and siderophore activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Yizhak Hershko, Amos Adler
Summary: There is limited data on antimicrobial susceptibility testing of nontuberculous mycobacterial (NTM) in Israel and the Middle East. This study aimed to describe the antimicrobial susceptibility profiles of NTM in Israel, with Mycobacterium avium complex (MAC) being the most commonly isolated species. The most effective drugs against slowly growing mycobacteria (SGM) were amikacin and clarithromycin, while for rapidly growing mycobacteria (RGM), amikacin and linezolid were the most active agents. These findings provide valuable insights for guiding the treatment of NTM infections.
MICROBIAL DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Huiyun Zhang, Wenya Hua, Siran Lin, Yu Zhang, Xinchang Chen, Shiyong Wang, Jiazhen Chen, Wenhong Zhang
Summary: This study evaluated the susceptibility of clinical isolates of NTM to TZD, indicating that TZD has greater in vitro potency than LZD and shows synergistic effects with various antibiotics against NTM, suggesting it may be an important component of multi-drug treatment regimens.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Yiting Wang, Wencong He, Ping He, Huiwen Zheng, Yanlin Zhao
Summary: This study investigated differences in antimicrobial susceptibility of Mycobacterium abscessus complex (MABC) subsp. massiliense and subsp. abscessus, finding that multilocus variable number tandem repeat (VNTR) typing may provide valuable information for predicting resistance phenotype.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Respiratory System
Ho Namkoong, Yosuke Omae, Takanori Asakura, Makoto Ishii, Shoji Suzuki, Kozo Morimoto, Yosuke Kawai, Katsura Emoto, Andrew J. Oler, Eva P. Szymanski, Mitsunori Yoshida, Shuichi Matsuda, Kazuma Yagi, Isano Hase, Tomoyasu Nishimura, Yuka Sasaki, Takahiro Asami, Tetsuya Shiomi, Hiroaki Matsubara, Hisato Shimada, Junko Hamamoto, Byung Woo Jhun, Su-Young Kim, Hee Jae Huh, Hong-Hee Won, Manabu Ato, Kenjiro Kosaki, Tomoko Betsuyaku, Koichi Fukunaga, Atsuyuki Kurashima, Herve Tettelin, Hideki Yanai, Surakameth Mahasirimongkol, Kenneth N. Olivier, Yoshihiko Hoshino, Won-Jung Koh, Steven M. Holland, Katsushi Tokunaga, Naoki Hasegawa
Summary: This study identified rs109592 in the CHP2 locus as a susceptibility marker for pulmonary MAC disease.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Infectious Diseases
Yuwei Vivian Tsai, Caroline Derrick, Ismaeel Yunusa, Sharon Weissman, Majdi N. Al-Hasan, Julie Ann Justo, Paul Brandon Bookstaver
Summary: Nontuberculous mycobacterial (NTM) infections pose treatment challenges and limited data exists on treatment outcomes in U.S. adults. This retrospective study analyzed a cohort of NTM-infected adults and found Mycobacterium avium intracellulare complex and Mycobacterium abscessus to be the most prevalent isolates. Only 35% of patients received treatment, with a favorable outcome observed in 61.4% of cases. Multiple changes in antimicrobial therapy were associated with unfavorable outcomes, highlighting the importance of interdisciplinary collaboration to improve treatment outcomes in NTM infections.
Article
Microbiology
Stephen Adonai Leon-Icaza, Salimata Bagayoko, Romain Verge, Nino Iakobachvili, Chloe Ferrand, Talip Aydogan, Celia Bernard, Angelique Sanchez Dafun, Marlene Murris-Espin, Julien Mazieres, Pierre Jean Bordignon, Serge Mazeres, Pascale Bernes-Lasserre, Victoria Rame, Jean-Michel Lagarde, Julien Marcoux, Marie-Pierre Bousquet, Christian Chalut, Christophe Guilhot, Hans Clevers, Peter J. Peters, Virginie Molle, Geanncarlo Lugo-Villarino, Kaymeuang Cam, Laurence Berry, Etienne Meunier, Celine Cougoule
Summary: Although Mabs infection can induce oxidative stress, pharmacological activation of antioxidant pathways can better control Mabs growth and reduce its virulence. Genetic and pharmacological inhibition of CFTR is associated with improved Mabs growth and increased virulence. Pharmacological activation of antioxidant pathways can inhibit Mabs growth and improve efficacy when combined with cefoxitin.
Article
Infectious Diseases
Jian Lin, Yong Zhao, Shuzhen Wei, Zhisong Dai, Shufang Lin
Summary: This study evaluated a new commercial kit for Mycobacterium species identification and compared its results with the commonly used GenoType Mycobacterium CM assay. The MeltPro Myco assay showed high agreement with the GenoType assay in identifying different Mycobacterium species. The study also identified the predominant species of nontuberculous mycobacteria in Fujian, China.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Kalpana Thangavelu, Krishnapriya Krishnakumariamma, Gopichand Pallam, Dwivedi Dharm Prakash, Laxmisha Chandrashekar, Ellappan Kalaiarasan, Sindhusuta Das, Muthaiah Muthuraj, Noyal Mariya Joseph
Summary: A study conducted in a South Indian tertiary care hospital on 7633 TB suspects revealed a low frequency of NTM infection, with M. intracellulare being one of the most common NTM species isolated from both pulmonary and extrapulmonary specimens.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Microbiology
Ruoyan Ying, Jinghui Yang, Xiaocui Wu, Fangyou Yu, Wei Sha
Summary: Given the increasing prevalence of NTM diseases and their natural resistance to multiple antibiotics, it is necessary to test the susceptibility of different NTM species to drugs from the MYCO test system and new applied drugs. This study analyzed 241 NTM clinical isolates and found that most of the SGM strains were susceptible to certain antibiotics, while the RGM strains were susceptible to different antibiotics. In addition, epidemiological cutoff values were determined for CLO and BDQ. The study concluded that BDQ and CLO show effective activity against different NTM species in vitro, making them potential treatments for NTM diseases.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yoshitaka Tateishi, Yuriko Ozeki, Akihito Nishiyama, Mari Miki, Ryoji Maekura, Hiroshi Kida, Sohkichi Matsumoto
Summary: This study examined the virulence of nine M. intracellulare strains in mice and evaluated their therapeutic efficacy. The high virulence strains showed more severe neutrophilic infiltration in the lungs and led to a rapid progression of clinical disease. Chemotherapy containing clarithromycin was the most effective treatment for mice infected with a high virulence strain, while monotherapy with rifampicin exacerbated lung inflammation.
Article
Chemistry, Analytical
Xue Zhang, Qin Wei, Xin Meng, Lili Zhao, Zhaosheng Liu, Yanping Huang
Summary: A new strategy utilizing a dendrimer-like structure of boron materials based on octavinyl-polyhedral oligomeric silsesquioxanes (Ov-POSS) was suggested to improve boronate avidity with good accessibility of sites. The resulting Ov-POSS cross-linked boron monolith showed significantly stronger affinity for glycoproteins compared to the Ov-POSS-free monolith. The developed microfluidic platform, which integrated multiple functions, demonstrated high efficiency and high-throughput analysis for post-translational modification proteomics.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Qian Chen, Mingming Zhang, Fangxu Dai, Lili Zhao, Shuyang Liu, Huimin Zhao, Hong Zhou, Lihua Teng, Weigao Xu, Lei Wang, Jun Xing
Summary: In this study, a new lead-free hybrid Sn(IV) bromide hybrid with remarkable stability and excellent photoluminescence properties was synthesized. The hybrid showed impressive emission stability in the air and maintained high photoluminescence quantum yield under ultraviolet light irradiation for over 2000 hours. These findings demonstrate the promising prospect of environment-friendly organic-inorganic halide perovskites for optoelectronic applications.
ADVANCED OPTICAL MATERIALS
(2023)
Review
Genetics & Heredity
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Hong Fan, Qian Hao, Dingli Song, Jialiang Lu, Ziwei Lu, Yating Jian, Heying Wang, Xiaoya Wang, Yulun Wu, Guilian Zhang
Summary: This study found a significant association between the MTHFR rs1801133 (677C > T) gene mutation and an increased risk of ischemic stroke, particularly in the Asian, Hispanic, or Latin population and middle-aged and elderly individuals.
FRONTIERS IN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Ruifang Li, Jie Liu, Ping Han, Ruifang Shi, Lili Zhao, Jia Li
Summary: This study aims to explore the associations between various abdominal obesity indices and the pathological features of NAFLD. The results show that Chinese VAI (CVAI) is significantly associated with the pathological features of NAFLD, and it has the most superior efficacy in diagnosing fibrosis among these indices.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Lili Zhao, Yicheng Feng, Liping Wang, Lei Wang, Rui Fan, Tao Ma, Sicong Zhao
Summary: This study investigated the microstructure and mechanical properties of Mg-(7-x)Y-xNd-2Al (x = 0, 2, 4, 6) alloys with the substitution of Nd for Y. The results show that Nd promotes the formation of the Al-RE phase and Mg-RE eutectic phase in the as-cast alloy. After solution treatment, all eutectic phases dissolve into the alpha-Mg matrix, while the Al-RE phase (Al2RE phase) does not dissolve. Additionally, Nd promotes the precipitation of the lamellar Al2RE phase and the nanometer beta '' phase, which improve the mechanical properties of the alloy. The 4% Nd alloy exhibits the best peak-aging yield strength, tensile strength, and elongation of 182, 285 MPa, and 7.4%, respectively.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Engineering, Electrical & Electronic
Liwei Liu, Xiaoting Zhang, Yan Wang, Ruicong Chen, Lili Zhao, Bin Cui
Summary: In this study, Sr0.7Bi0.2TiO3-based ceramics with excellent dielectric temperature stability and energy storage efficiency were prepared by a two-step sintering process. The introduction of NNT and the design of a core-shell structure enhanced the relaxation behavior and temperature stability of the ceramics. The obtained ceramics showed promising energy storage performance and could be applied in dielectric ceramic capacitors.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Qing Xue, Yu Xie, Yukun He, Yan Yu, Guiju Fang, Wenyi Yu, Jianhui Wu, Jiwei Li, Lili Zhao, Xinyu Deng, Ran Li, Fang Wang, Yali Zheng, Zhancheng Gao
Summary: Increasing evidence suggests that respiratory tract microecological disorders may contribute to the development of chronic obstructive pulmonary disease (COPD). Understanding the respiratory microbiome in COPD patients and its connection with respiratory immunity can aid in the development of microbiome-based diagnostic and therapeutic strategies.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Xin Zhao, Ke-ke Chen, Lei-ting Wang, Li-Li Zhao, Pu-Chang Wang
Summary: A lack of soil phosphorus is a limiting factor for Lotus corniculatus growth in Guizhou Province, China. This study investigated the response mechanism of L.corniculatus to low-phosphorus stress using morphological, physiological, and transcriptome analysis. The results showed that a low-phosphorus tolerant line exhibited better performance and various morphological and biochemical changes were observed under low-phosphorus stress. Transcriptome analysis also identified differentially expressed genes and related pathways associated with low-phosphorus stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Yue-Ming Luo, Shu-Dong Yang, Miao-Yu Wen, Bing Wang, Jia-Hui Liu, Si-Ting Li, Yu-Yan Li, Hong Cheng, Li-Li Zhao, Shun-Min Li, Jian-Jun Jiang
Summary: Through network pharmacology and deep RNA-seq analysis, this study identified c-Jun as a potential target of Triptolide (TPL) and suggested that Per1 related circadian rhythm signaling is involved in TPL induced renal toxicity.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Wenhui Zhang, Yifei Huang, Huiling Xiang, LiYao Zhang, Lili Yuan, Xing Wang, Tong Dang, Guo Zhang, Shengjuan Hu, Chuan Liu, Xiuping Zhang, Lijun Peng, Min Gao, Dongli Xia, Jia Li, Ying Song, Xiqiao Zhou, Xingsi Qi, Jing Zeng, Xiaoyan Tan, Mingming Deng, Haiming Fang, Shenglin Qi, Song He, Yongfeng He, Bin Ye, Wei Wu, Jiangbo Shao, Wei Wei, Jianping Hu, Xin Yong, Chaohui He, Jinlun Bao, Yuening Zhang, Rui Ji, Yang Bo, Wei Yan, Hongjiang Li, Yong Wang, Yanling Wang, Mengmeng Li, Jia Lian, Chang'en Liu, Yunhai Wu, Ye Gu, Yan Wang, Ping Cao, Bin Wu, Limei Ren, Hongduo Pan, Yunxiao Liang, Shuni Tian, Lin Lu, Yanfei Fang, Pan Jiang, Zhenbei Liu, Aimin Liu, Lili Zhao, Shuang Li, Jinggui Qiao, Lihui Sun, Mengyu Li, Chengwen Fang, Hao Chen, Zibin Tian, Gaoyang Lin, Xuanhui Huang, Jitao Chen, Ying Deng, Muhan Lv, Jingyuan Liao, Lijiu Zhang, Junyu Lu, Suhua Wu, Xiaocui Yang, Wenwei Guo, Jianbo Wang, Chao Chen, Erjiong Huang, Yuehua Yu, Ming Yang, Shuangping Cheng, Yang Yang, Xiaoli Wu, Limaocai Rang, Ping Han, Yanmin Zhang, Xiaoguo Li, Fengmei Wang, Mark Edward McAlindon, Wai-Kay Seto, Chuanzhu Lv, Don C. Rockey, Xiaolong Qi
Summary: This study aimed to determine the optimal timing for endoscopy in patients with cirrhotic acute variceal bleeding (AVB). The results suggest that performing endoscopy within 6-12 or within 24 hours of presentation has similar treatment failure outcomes for patients with cirrhotic AVB.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Beirong Zhang, Zhou Gong, Lili Zhao, Yuxin An, Hang Gao, Jing Chen, Zhen Liang, Maili Liu, Yukui Zhang, Qun Zhao, Lihua Zhang
Summary: Protein dynamics are crucial for their diverse functions, and are significantly influenced by the intracellular environment. This study introduces a hierarchical decoding strategy that uses chemical cross-linking mass spectrometry to investigate protein dynamics in cells. Computational analysis based on distance restraints derived from cross-links is used to infer protein dynamics in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Hairong Wang, Yuan Liu, Jiawen Cui, Miaomiao Tong, Wenlong Guan, Zhi Cao, Xiaoli Gao, Xiaopeng Han, Xiaomeng Xian, Jiankun Li, Lili Zhao
Summary: The study aimed to investigate the effects of Scutellaria strigillosa Hemsl. (SSH) on the proliferation and apoptosis of human hepatoma cell HepG2 and identify the bioactive components. The results showed that SSH extract inhibited HepG2 proliferation and induced apoptosis. Specifically, SSH extract exhibited notable inhibitory activity against aspartate (3-hydroxylase), a key therapeutic target of hepatocellular carcinoma. The main bioactive constituents of SSH were elucidated through HPLC-Q-TOF/MS and molecular docking analysis. These findings suggest the potential value of SSH and its bioactive components for liver cancer prevention and treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Neurosciences
Chengcheng Dai, Changhong Tan, Lili Zhao, Yi Liang, Guohui Liu, Hang Liu, Yuke Zhong, Zhihui Liu, Lijuan Mo, Xi Liu, Lifen Chen
Summary: Impairments in systematic and regional glucose metabolism exist in patients with Parkinson's disease (PD) and are associated with various mechanisms that lead to energy supply insufficiency, neurotransmitter dysregulation, and dopaminergic neuron loss. This review discusses the glucose metabolism impairment in PD, its pathophysiological mechanisms, and available therapies targeting glucose metabolism impairment in PD.
BRAIN RESEARCH BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Yue Li, Tong Wu, Yujie Wang, Jiawei Li, Wanqiang Yu, Guixiang Zhang, Bin Chang, Lili Zhao, Hong Liu, Weijia Zhou
Summary: Laser-driven pyrolysis is a promising method to directly convert nitrogen-rich biomass into ammonia. This technique effectively utilizes the nitrogen resources in biomass and achieves a high ammonia production rate. The mild reaction environment with low temperature and normal pressure is ensured by the low-energy laser-induced local-transient thermal effect.
Article
Pharmacology & Pharmacy
Xihua Yang, Yongqin Liang, Lili Zhao, Lixia Chen, Yongming Yang, Jing Wang, Lei Yan, Shengwan Zhang, Xianping Liu, Huayi Zhang
Summary: This study aimed to investigate the effect of brazilin on breast cancer invasion and metastasis. The results showed that brazilin inhibited the proliferation and invasion of breast cancer cells, as well as significantly decreased the number of metastatic nodules in the lungs. In addition, brazilin also increased the average survival days and spleen index in the mice. These findings suggest that brazilin may have potential as a new therapeutic agent for breast cancer.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
