Article
Medicine, General & Internal
Wittaya Jomoui, Surada Satthakarn, Sitthichai Panyasai
Summary: This study aimed to characterize the beta- and alpha-globin genes and factors related to HbF expression in patients with a similar Hb phenotype to HbE heterozygotes. The results showed that rare beta and alpha-thalassemia mutations were identified in some patients, and an HbE level >= 35.0% may indicate the need for DNA analysis for HbE-beta(+)-thalassemia diagnosis.
ANNALS OF MEDICINE
(2023)
Article
Engineering, Chemical
Jilliano B. Silva, Josue S. Almeida, Rodrigo V. Barbosa, Glauber J. T. Fernandes, Ana C. F. Coriolano, Valter J. Fernandes, Antonio S. Araujo
Summary: The study revealed that the thermal and oxidative stability of diesel fuel mixtures decreases as the concentration of biodiesel decreases, emphasizing the need for rapid utilization to avoid degradation and performance issues in vehicles as well as corrosion and clogging in mechanical systems.
Article
Medicine, Research & Experimental
Li Du, Xiuqin Bao, Wei He, Danqing Qin, Jicheng Wang, Ying Xiong, Xiaomei Shi, Hongke Ding, Cuize Yao, Jing Wu
Summary: A case of fetal cardiomegaly and anemia was reported at 25 weeks of gestation, with severe complications leading to the termination of pregnancy. Molecular analysis revealed the maternal carrier of Hb QS, the paternal carrier of Hb ZA, and the fetus as a compound heterozygote for Hb ZA and Hb QA. This study provides a reference for genetic counseling and prenatal diagnosis in the Chinese population.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Biology
Stella Tamana, Maria Xenophontos, Anna Minaidou, Coralea Stephanou, Cornelis L. Harteveld, Celeste Bento, Joanne Traeger-Synodinos, Irene Fylaktou, Norafiza Mohd Yasin, Faidatul Syazlin Abdul Hamid, Ezalia Esa, Hashim Halim-Fikri, Bin Alwi Zilfalil, Andrea C. Kakouri, Marina Kleanthous, Petros Kountouris
Summary: This study evaluates the performance of 31 in silico predictors in globin gene clusters. The results show that CADD, Eigen-PC, and REVEL are the overall top performers, while SpliceAI is the best splicing predictor, and GERP++ and phyloP are the most accurate conservation tools. The study provides evidence about the optimal use of these computational tools under the ACMG/AMP framework.
Article
Pharmacology & Pharmacy
Bruna Rodrigues Belem, Gustavo Vaiano Carapeto, Michele Georges Issa, Humberto Gomes Ferraz
Summary: D-limonene, derived from citrus essential oils, has potential therapeutic benefits but is highly volatile, posing challenges in pharmaceutical formulations. This study explores microemulsions as a promising delivery system for volatile compounds, with a focus on thermal protection for D-limonene. The results show that microemulsions can be formulated at room temperature and provide enhanced oxidative stability for D-limonene, making them a viable strategy for protection against elevated temperatures.
Article
Materials Science, Composites
Marina Lobanova, Vladislav Aleshkevich, Alexander Babkin, Alexey Kepman, Viktor Avdeev, Oleg Morozov, Boris Bulgakov
Summary: This work focuses on the thermal-oxidative aging behavior of phthalonitrile thermosets and composites at high temperatures, and reveals the negative effect of high-temperature post-curing on the properties of the materials.
POLYMER COMPOSITES
(2023)
Article
Medical Laboratory Technology
Kasper Munch Lauridsen, Helle Pilgaard Kristiansen, Anne Winther-Larsen
Summary: This study aimed to establish pediatric reference intervals (RIs) of hemoglobin fractions using high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) in children and adolescents aged 1-18 years. The study found that HbA2 RI was 2.00-2.90% by HPLC and 2.2-3.0% by CE, and partitioning by age was suggested by CE but not by HPLC.
CLINICA CHIMICA ACTA
(2023)
Article
Food Science & Technology
Anton Venter, Hennie Fisher, Gary Stafford, Kwaku Gyebi Duodu
Summary: This study investigated the anthocyanin profiles of pigmented flower extracts from Geraniaceae and Lamiaceae plant species in South Africa, and assessed their thermal and oxidative stability. Lamiaceae pigments showed higher thermal and oxidative stability, potentially due to aromatic malonyl-acylated anthocyanin self-association and strong interactions with phenolic acids and derivatives.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sinem Kurt, Emel Ordu
Summary: The study showed that replacing methionine with leucine in NAD(+) dependent FDH can improve its catalytic efficiency and chemical stability. Under temperature and H2O2 conditions, the single mutant and triple mutant with methionine to leucine substitution demonstrated higher activity, while double and triple mutants significantly reduced k(in)(ef).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Maryam Khakbaz Heshmati, Maryam Jafarzadeh-Moghaddam, Akram Pezeshki, Rezvan Shaddel
Summary: The aim of this study was to improve the oxidative stability of grapeseed oil by combining it with sesame oil. The addition of sesame oil increased the phenolic compounds, antioxidant strength, and oxidative stability of the mixed oil samples. The best formulation was found to be a combination of 75% sesame oil and 25% grapeseed oil.
FOOD SCIENCE & NUTRITION
(2022)
Article
Thermodynamics
Jianying Ma, Chunlei Cao
Summary: Ionic liquids (ILs) have been widely used as solvents for organic synthesis, but their applications in polymer synthesis are still limited. This study investigates the use of ILs in copolymerization and shows that copolymerizing ILs can significantly improve the thermal stability of copolymers. The results indicate that copolymers with ILs have higher thermal stability and thermal oxidative stability compared to homopolymers.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Genetics & Heredity
Mathilde Filser, Betty Gardie, Mathieu Wemeau, Patricia Aguilar-Martinez, Muriel Giansily-Blaizot, Francois Girodon
Summary: High oxygen affinity hemoglobin (HOAH) is the main cause of constitutional erythrocytosis. The diagnosis of HOAH relies on specialized laboratory tests for mutations in HBA1, HBA2 or HBB genes. Phenotypic studies and electrophoretic analysis may not always be accurate. The measurement of venous P50, although important, is only available in a few specialized laboratories. A normal venous P50 value might not be sufficient to rule out a diagnosis of HOAH due to pre-analytical contingencies.
Article
Immunology
Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Xin Zhao, Yun Shao, Xiaohua Shi, Shigang Qiao, Jianzhong An, Xiaohong Du, F. Xiao-Feng Qin
Summary: The emerging variants N501Y.V1 and N501Y.V2 of SARS-CoV-2 may have higher infection efficiency and thermal stability, but show similar sensitivity to inhibitors of protease and endocytosis compared to the wildtype virus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Joanan Lopez-Morales, Rosario Vanella, Tamara Utzinger, Valentin Schittny, Julia Hirsiger, Michael Osthoff, Christoph T. Berger, Yakir Guri, Michael A. Nash
Summary: The emergence of the SARS-CoV-2 Omicron variant has changed patient risk profiles and the course of the COVID-19 pandemic. Therefore, there is a need for sensitive serological tests that can analyze patient IgG responses to multiple variants.
Article
Food Science & Technology
Yan Huo, Xiaoyu Hou, Youzhi Yu, Xiaobin Wen, Yi Ding, Yeguang Li, Zhongjie Wang
Summary: This study demonstrates that adding glucose, mannose, mannitol, and maltose can effectively improve the thermal and oxidative stability of C-PC, providing an economical and effective method for its preservation.
