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Medicine, Research & Experimental
Kevin N. Su, Yina Ma, Marine Cacheux, Zeki Ilkan, Nour Raad, Grace K. Muller, Xiaohong Wu, Nicole Guerrera, Stephanie L. Thorn, Albert J. Sinusas, Marc Foretz, Benoit Viollet, Joseph G. Akar, Fadi G. Akar, Lawrence H. Young
Summary: AMPK plays an essential role in maintaining homeostasis in the atria by regulating key transcription factors that control the expression of atrial ion channels and gap junction proteins.
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Neurosciences
Chunyu Zhou, Cha-Gyun Jung, Mi-Jeong Kim, Atsushi Watanabe, Mona Abdelhamid, Ferdous Taslima, Makoto Michikawa
Summary: Insulin deficiency exacerbates Alzheimer's disease-like pathologies, with the involvement of Sirt2 protein.
MOLECULAR NEUROBIOLOGY
(2022)
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Developmental Biology
Momoe Ito, Masato Unou, Toshiya Higuchi, Shuhei So, Masahiko Ito, Keiichiro Yogo
Summary: SLC22A14 gene plays a critical role in male infertility in mice by regulating HCO3- transport and intracellular pH during sperm capacitation.
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Cell Biology
Emily Chang, Ryoki Kobayashi, Kohtaro Fujihashi, Masamichi Komiya, Tomoko Kurita-Ochiai
Summary: The study revealed significant differences in oral bacterial composition, metabolites, and periodontitis development between IgA-deficient mice and wild-type mice, highlighting the important role of SIgA in regulating oral microbiota to prevent periodontal diseases.
INFLAMMATION RESEARCH
(2021)
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Oncology
Yanxia Zhan, Jingjing Cao, Lili Ji, Miaomiao Zhang, Qi Shen, Pengcheng Xu, Xibing Zhuang, Shanshan Qin, Fanli Hua, Lihua Sun, Feng Li, Hao Chen, Yunfeng Cheng
Summary: The study found that 7 ITP patients tested positive for plasma pathogens. Among them, 71.4% of positive pathogen-ITP patients did not respond well to first-line treatment with corticosteroids. Regulatory T cells (Tregs) significantly increased in positive pathogen-ITP patients compared to negative pathogen-ITP patients and healthy controls. Mitochondrial membrane potential of Th17 and Tregs were decreased in both positive and negative pathogen-ITP patients compared to healthy controls.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
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Biochemistry & Molecular Biology
Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J. Lesnefsky, Kuniko Mitamura, Shigeo Ikegawa, Hajime Takei, Hiroshi Nittono, Michael Fuchs, William M. Pandak, Genta Kakiyama
Summary: CYP7B1 catalyzes the metabolism of cholesterol metabolites and its disrupted expression can lead to liver failure in newborns and nonalcoholic steatohepatitis. This study investigates the regulatory mechanism of mitochondrial cholesterol metabolites and their contribution to the onset of NASH.
JOURNAL OF LIPID RESEARCH
(2023)
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Medicine, Research & Experimental
Yang Zhou, Li Li, Xiaolei Chen, Qiubo Zhao, Ning Qu, Bing Zhang, Xin Jin, Chun Xia
Summary: This study revealed that PPARα deficiency aggravates cartilage damage in osteoarthritis and is associated with impaired autophagy and suppression of ERK and Akt. Activation of PPARα promotes autophagy and extracellular matrix synthesis in human OA chondrocytes. Therefore, triggering PPARα activation could be a potential therapeutic target for OA therapy.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Miruna Cristian, Radu Andrei Baz, Andreea Georgiana Stoica, Mariana Aschie, Maria Mihaela Ghinea, Mariana Deacu, Madalina Bosoteanu, Anca Florentina Mitroi, Nicolae Dobrin, Ionut Eduard Iordache, Gabriela Izabela Balatescu
Summary: In the era of antiretroviral therapy, lymphoma is the primary cause of cancer-related death among HIV-infected people. CD5-positive DLBCL is a relatively new entity and its early diagnosis is of utmost importance due to its poor prognosis. This study highlights the clinicopathological features of HIV-related lymphoma and emphasizes the criticality of early diagnosis of CD5-positive DLBCL.
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Thermodynamics
Amira I. Hussein, Deven Carroll, Mathew Bui, Alex Wolff, Heather Matheny, Brenna Hogue, Kyle Lybrand, Margaret Cooke, Beth Bragdon, Elise Morgan, Serkalem Demissie, Louis Gerstenfeld
Summary: Previous studies have shown that acute phosphate restriction delays chondrocyte differentiation and decreases bone morphogenetic protein signaling. This study found that a phosphate-deficient diet down-regulates genes associated with mitochondrial oxidative phosphorylation and other metabolic pathways. Additionally, it was discovered that dietary phosphate restriction indirectly controls endochondral growth through upregulation of oxidative activity and protein production through BMP signaling.
ENERGY CONVERSION AND MANAGEMENT
(2023)
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Rehabilitation
Arezoo Abbaszadeh, Guita Movallali, Masoume Pourmohamadreza-Tajrishi, Mohsen Vahedi
Summary: Interventions to promote parent-child relationship and maternal mental health are crucial for mothers of children with hearing impairment. The Baby Triple P positive parenting program showed no significant impact on maternal mental health but increased the overprotection component in the mother-child relationship. More research is needed to tailor interventions for the unique needs of children with hearing loss and their mothers.
ARCHIVES OF REHABILITATION
(2021)
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Medicine, Research & Experimental
Ryunosuke Muro, Takeshi Nitta, Kenta Nakano, Tadashi Okamura, Hiroshi Takayanagi, Harumi Suzuki
JOURNAL OF CLINICAL INVESTIGATION
(2018)
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Dermatology
Kunihiro Hayakawa, Keigo Ikeda, Maki Fujishiro, Yuko Yoshida, Takuya Hirai, Hiroshi Tsushima, Tomoko Miyashita, Shinji Morimoto, Yasushi Suga, Kenji Takamori, Hideoki Ogawa, Iwao Sekigawa
ANNALS OF DERMATOLOGY
(2018)
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Biochemistry & Molecular Biology
Ryunosuke Muro, Takeshi Nitta, Masayuki Kitajima, Toshiyuki Okada, Harumi Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
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Immunology
Akihiro Kimura, Masayuki Kitajima, Kyoko Nishida, Satoshi Serada, Minoru Fujimoto, Tetsuji Naka, Yoshiaki Fujii-Kuriyama, Satoshi Sakamato, Takumi Ito, Hiroshi Handa, Takashi Tanaka, Akihiko Yoshimura, Harumi Suzuki
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
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Immunology
Masayuki Kitajima, Akihiro Kimura, Harumi Suzuki
JOURNAL OF IMMUNOLOGY
(2018)
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Allergy
Norimasa Tamehiro, Kyoko Nishida, Yu Sugita, Kunihiro Hayakawa, Hiroyo Oda, Takeshi Nitta, Miwa Nakano, Akiko Nishioka, Reiko Yanobu-Takanashi, Motohito Goto, Tadashi Okamura, Reiko Adachi, Kazunari Kondo, Akimichi Morita, Harumi Suzuki
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
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Biochemistry & Molecular Biology
Kunihiro Hayakawa, Mikiko Kawasaki, Takuya Hirai, Yuko Yoshida, Hiroshi Tsushima, Maki Fujishiro, Keigo Ikeda, Shinji Morimoto, Kenji Takamori, Iwao Sekigawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
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Immunology
Masayuki Kitajima, Masato Kubo, Steven F. Ziegler, Harumi Suzuki
JOURNAL OF IMMUNOLOGY
(2020)
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Biochemistry & Molecular Biology
Yuko Yoshida, Kunihiro Hayakawa, Maki Fujishiro, Keigo Ikeda, Hiroshi Tsushima, Takuya Hirai, Mikiko Kawasaki, Mitsutoshi Tominaga, Yasushi Suga, Kenji Takamori, Yoshifumi Watanabe, Iwao Sekigawa, Shinji Morimoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
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Immunology
Kunihiro Hayakawa, Maki Fujishiro, Yuko Yoshida, Yuko Kataoka, Shota Sakuma, Takuya Nishi, Keigo Ikeda, Shinji Morimoto, Kenji Takamori, Iwao Sekigawa
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory and representative autoimmune disease. The activation of toll-like receptor (TLR) 7, which is related to genetic factors and environmental factors, is involved in the pathogenesis of SLE. This study suggests that TLR7 agonist exposure may aggravate lupus nephritis through the expression of IFN-gamma signaling-induced renal inflammation.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Wendy Dankers, Melissa Northcott, Taylah Bennett, Akshay D'Cruz, Rochelle Sherlock, Linden J. J. Gearing, Paul Hertzog, Brendan Russ, Iolanda Miceli, Sebastian Scheer, Maki Fujishiro, Kunihiro Hayakawa, Keigo Ikeda, Eric F. F. Morand, Sarah A. A. Jones
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are commonly used for SLE treatment, but their metabolic effects are detrimental. This study found that type 1 interferons (IFN) may reduce the effectiveness of GC in treating SLE by suppressing the expression of glucocorticoid-induced leucine zipper (GILZ). The findings have important implications for the development of alternative GC-sparing therapies for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
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Rheumatology
Y. Matsuoka, S. Morimoto, M. Fujishiro, K. Hayakawa, Y. Kataoka, S. Suzuki, K. Ikeda, K. Takamori, K. Yamaji, N. Tamura
Summary: The study found that metformin inhibits osteoclastogenesis and reduces osteoclast-specific gene expression. It also downregulates the expression of inflammatory cytokines and protease and growth factor genes in human RA cells, as well as disrupts tubular network formation in HUVECs. These results suggest the potential therapeutic effects of metformin in improving the pathogenesis of RA.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Meeting Abstract
Immunology
M. Kitajima, S. Ziegler, H. Suzuki
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Takuya Hirai, Keigo Ikeda, Hiroshi Tsushima, Maki Fujishiro, Kunihiro Hayakawa, Yuko Yoshida, Shinji Morimoto, Ken Yamaji, Yoshinari Takasaki, Kenji Takamori, Naoto Tamura, Iwao Sekigawa
INFLAMMATION AND REGENERATION
(2018)