Editorial Material
Biochemistry & Molecular Biology
Min Woo Kim, Jonathan Kipnis
Summary: This study demonstrates that opioid use affects the communication between the central nervous system and the peripheral immune system, leading to changes in T cell and cytokine modulation of brain function, and is associated with withdrawal-induced behavioral dysfunction.
Article
Microbiology
Tej Pratap Singh, Augusto M. Carvalho, Lais Amorim Sacramento, Elizabeth A. Grice, Phillip Scott
Summary: This study demonstrates the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. Skin microbiota promotes the generation of ROR gamma t(+) IL-17A-producing ILCs, which exacerbate skin inflammation in the disease.
Article
Multidisciplinary Sciences
Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Yuiko Goto, Yoko Sato, Hitoshi Ikeda, Chisato Onitsuka, Hiroki Sato, Kaho Akimoto, Takaya Ebato, Hiromitsu Suganuma, Tomoko Kawahara, Hatsuko Mikuni, Yoshitaka Uchida, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara
Summary: This study found that the expression of type III interferons (IFNs) is associated with disease severity in COVID-19 patients. The low expression of IL-28A/IFN-lambda 2 may predict the severity of COVID-19 and possibly through the mechanism of delayed viral elimination.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Andra Banete, Katrina Gee, Sameh Basta
Summary: Macrophages exhibit various functional phenotypes based on different stimuli, with IL-4 potentially playing a role in both proinflammatory and anti-inflammatory processes. The novel vaccine adjuvant R848 triggers a strong Th1 response, but the presence of IL-4 may affect its immune response. IL-4-induced M phi polarization may have an impact on the outcome of R848 stimulation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Leon Ullrich, Yvonne Lueder, Anna-Lena Juergens, Anneke Wilharm, Joana Barros-Martins, Anja Bubke, Abdi Demera, Koichi Ikuta, Gwendolyn Elena Patzer, Anika Janssen, Inga Sandrock, Immo Prinz, Francesca Rampoldi
Summary: The study found that gamma delta T cells play an important role in the GC reactions in the Peyer's patches of the small intestine, driving the proliferation of GC B cells and the switch towards IgA by producing IL-4, thus maintaining gut homeostasis and symbiosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Daijiro Yanagisawa, Hamizah Shahirah Hamezah, Aslina Pahrudin Arrozi, Ikuo Tooyama
Summary: This study investigated the effects of genetic background and sex on tau pathology accumulation in rTg4510 mice. The results showed significant effects of genetic background on differential accumulation of tau pathology, while sex had no apparent effect. Midline-1 (Mid1) was identified as a candidate gene associated with differences in tau pathology accumulation.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Chuntong Bao, Baijun Liu, Rining Zhu, Jiameng Xiao, Ziheng Li, Hexiang Jiang, Beinan Wang, P. R. Langford, Rui Fei, Na Li, Liancheng Lei
Summary: This study investigates the role of IFN-gamma in porcine pleuropneumonia through an IFN-gamma(-/-) mouse infection model. The findings suggest that IFN-gamma plays a key role in regulating the inflammatory response in the lung during A. pleuropneumoniae infection, and IL-18 administration may have therapeutic potential.
INFECTION AND IMMUNITY
(2021)
Article
Microbiology
Courtney R. Plumlee, Fergal J. Duffy, Benjamin H. Gern, Jared L. Delahaye, Sara B. Cohen, Caleb R. Stoltzfus, Tige R. Rustad, Scott G. Hansen, Michael K. Axthelm, Louis J. Picker, John D. Aitchison, David R. Sherman, Vitaly V. Ganusov, Michael Y. Gerner, Daniel E. Zak, Kevin B. Urdahl
Summary: The study successfully developed a tuberculosis model in mice that more closely resembles human disease by infecting them with an ultra-low dose of bacteria, resulting in highly heterogeneous bacterial burdens and granulomas similar to those in humans. By identifying blood RNA signatures, it was possible to predict infection outcomes in mice and infer the risk of progression to active tuberculosis in humans.
CELL HOST & MICROBE
(2021)
Review
Cell & Tissue Engineering
Ying Wang, Jiankai Fang, Benming Liu, Changshun Shao, Yufang Shi
Summary: This passage discusses the characteristics and functions of MSCs under different pathological conditions and emphasizes their interaction with the inflammatory microenvironment. The aim of the study is to provide new insights into the diverse immunoregulatory properties of MSCs during tissue regeneration and therapy.
Article
Immunology
Xiaochun Liu, Ronghui Zhu, Yang Luo, Shangshang Wang, Yi Zhao, Zhuoqiong Qiu, Yu Zhang, Xiao Liu, Xu Yao, Xiao Li, Wei Li
Summary: This study identified two steady-state (LC1 and LC2) and two activated LC subsets in human skin epidermis and LCs derived from CD34(+) hemopoietic stem cells. LC1 were characterized as classical LCs mainly related to innate immunity and antigen processing, while LC2 were similar to monocytes or myeloid dendritic cells, involving in immune responses and leukocyte activation. These distinct human LC subsets require different developmental regulation and orchestrate reciprocal functions.
Article
Dermatology
Beatriz Oliveira Fagundes, Thamires Rodrigues de-Sousa, Jefferson Russo Victor
Summary: Atopic dermatitis (AD) is a chronic disease that typically starts in childhood and can persist into adulthood. The major cytokines involved in inflammatory skin diseases, including AD, are IL-4, IL-17, IFN-gamma, and IL-10. The role of gamma delta T cells in AD is still largely unexplored.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng, Zhenkun Lou
Summary: The study reveals that RIG-I is recruited to double-stranded breaks, suppressing non-homologous end joining and compromising DNA repair, while XRCC4 plays a crucial role in RIG-I immune signaling. This reciprocal regulation uncovers a new function of RIG-I in suppressing virus integration and DNA repair, while endowing XRCC4 with a pivotal role in enhancing innate immune response.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Celine Posseme, Alba Llibre, Bruno Charbit, Vincent Bondet, Vincent Rouilly, Violaine Saint-Andre, Jeremy Boussier, Jacob Bergstedt, Nikaia Smith, Liam Townsend, Jamie A. Sugrue, Cliona Ni Cheallaigh, Niall Conlon, Maxime Rotival, Michael S. Kobor, Estelle Mottez, Stanislas Pol, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy
Summary: We found that interferon beta is a major determinant of IL-12p70 production induced by lipopolysaccharide and is associated with circulating monocytes. Reduced IFN beta-IL-12p70 responses were observed in patients with SARS-CoV-2 infection or chronic HCV infection, and these responses were resolved after viral clearance. This study provides important insights into the roles of IL-12p70 and IFN beta in healthy and infected individuals and how genetic and epigenetic variation may impact immune responses to bacterial infection.
Article
Immunology
Masaya Matsuda, Miki Inaba, Junpei Hamaguchi, Hiro Tomita, Miyu Omori, Hayato Shimora, Harumi Sakae, Kazuyuki Kitatani, Takeshi Nabe
Summary: IL-10 can suppress eosinophil and neutrophil infiltration by inhibiting the proliferation of ICAM-1+ and VCAM1+ pulmonary vascular endothelial cells, resulting in inhibition of airway hyperresponsiveness in steroid-insensitive asthmatic mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang, Jianxiong Liu
Summary: The study developed a new immunological method using IFN-gamma and IL-2 combinations to differentiate active TB from other pulmonary diseases, showing potential for accurate diagnosis. The sensitivity of series combination test was higher, while the specificity of parallel combination of IFN-gamma /IL-2 was increased. The diagnostic accuracy of series combination correlated with disease severity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)