Article
Oncology
Ragu Ratnakumaran, Victoria Hinder, Douglas Brand, John Staffurth, Emma Hall, Nicholas van As, Alison Tree
Summary: This study examines the association between short- and long-term bowel and urinary side-effects in prostate radiotherapy using modern techniques. Results show that patients with short-term side-effects are at higher risk of developing long-term side-effects, even after adjusting for various factors. Monitoring and early treatment for patients with significant short-term side-effects are recommended.
Article
Public, Environmental & Occupational Health
Liwei Cheng, Fan Zhang, Ying Wang, Jing Chen, Xiaoping Yuan
Summary: This meta-analysis study found an association between IFNGR1 gene polymorphisms and tuberculosis susceptibility. The rs2234711 polymorphism was associated with increased tuberculosis susceptibility in Africans and decreased susceptibility in Asians. Additionally, the rs7749390 polymorphism was associated with decreased tuberculosis susceptibility in Africans.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Xu Han, Lai Zheng, Yi-Yang Mu, Hong-Zhuo Li, Xiao-Feng He
Summary: The meta-analysis investigated the association between OPG gene polymorphisms and osteoporosis risk, finding a significant correlation in certain subgroups but overall pointing to false-positive results. This suggests that previous studies may not have accurately assessed the true association between OPG gene variants and osteoporosis risk.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Yunnan Jing, Siya Hu, Jing Song, Xu Dong, Ying Zhang, Xiaowei Sun, Dongyan Wang
Summary: This Meta-analysis found that four miRNA polymorphisms were associated with the risk of ischemic stroke, although the overall and subgroup analyses were not entirely consistent.
Article
Cell Biology
Xue-Feng Li, Guang-Bin Jiang, Shi-Yan Cheng, Ya-Feng Song, Cai Deng, Yu-Ming Niu, Jun-Wei Cai
Summary: The meta-analysis on the association between PPAR-gamma 2 gene polymorphisms and diabetic retinopathy risk did not find a significant relationship between the two factors. Subgroup analyses also failed to reveal any significant associations.
Review
Genetics & Heredity
Lin Zhao, Xiang-Xiongyi Yin, Jun Qin, Wei Wang, Xiao-Feng He
Summary: Based on a comprehensive analysis of a large number of studies, this meta-analysis found no significant association between TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms and breast cancer risk. The previous results suggesting an association may be false-positive results due to confounding factors.
FRONTIERS IN GENETICS
(2022)
Review
Orthopedics
Su Yang, Yue-peng Wang, Xi-yong Li, Peng-yong Han, Peng-fei Han
Summary: This study conducted a meta-analysis of multiple case-control studies and found that the polymorphism at the rs1871054 site of the ADAM12 gene is associated with genetic susceptibility to osteoarthritis, while the polymorphisms at the rs3740199, rs1044122, and rs1278279 sites are not significantly related to osteoarthritis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Obstetrics & Gynecology
Yuxi Li, Lanlan Fang, Yang Yan, Zhen Wang, Ze Wu, Qiongqiong Jia, Jung-Chien Cheng, Ying-Pu Sun
Summary: The presence of a polymorphism of eight or more SHBG (TAAAA)n may be a predictive factor for the risk of PCOS, as it is associated with PCOS risk and low serum SHBG concentrations in women with PCOS. Other SHBG gene polymorphisms were not significantly associated with either PCOS risk or serum SHBG concentrations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Multidisciplinary Sciences
Mohamad Ayub Khan Sharzehan, Hilary Sito, Noraidatulakma Abdullah, Athanasios Alexiou, Marios Papadakis, Rahman Jamal, Shing Cheng Tan
Summary: This meta-analysis found a significant association between CYP2E1 rs2031920 and CRC risk, while rs3813867 and rs6413432 were not associated.
SCIENTIFIC REPORTS
(2022)
Review
Genetics & Heredity
Hao Meng, Shaoyan Huang, Yali Yang, Xiaofeng He, Liping Fei, Yuping Xing
Summary: The study aimed to explore the risk correlation between two MTHFR polymorphisms and EH. Results showed that the C677T variant was associated with an increased risk of EH in various populations, but further statistical assessment using FPRP, BFDP, and Venice criteria suggested the associations may be false-positives. Conversely, no significant relationship was found between the A1298C polymorphism and EH.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Cuifen Li, Manli Xie, Weiwei Wang, Yanyan Liu, Dan Liao, Jingwen Yin, Hao Huang
Summary: This study is the first and most comprehensive investigation of the association between ERs and depression in women, and the findings support the concept that ERs participate in the etiology of sex heterogeneity in depression.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Emina Malisic, Nina Petrovic, Muriel Brengues, David Azria, Ivana Z. Matic, Ivana Srbljak Cuk, Katarina Kopcalic, Tatjana Stanojkovic, Marina Nikitovic
Summary: This study evaluated the impact of different genetic polymorphisms and radiation-induced CD8 T-lymphocyte apoptosis on adverse effects of radiotherapy for prostate cancer. The results showed that the CT genotype of TGFB1 C-509T could be a protective biomarker for acute genitourinary and gastrointestinal radiotoxicity, while the Thr variant of XRCC3 Thr241Met may predict the risk for acute genitourinary radiotoxicity.
SCIENTIFIC REPORTS
(2022)
Review
Health Care Sciences & Services
Sun-Young Shim, Ha-Young Yoon, Jeong Yee, Ji-Min Han, Hye-Sun Gwak
Summary: The meta-analysis demonstrated an association between ABCA1 gene polymorphisms and plasma lipid concentration. Carriers of the T allele and C allele had lower levels of high-density lipoprotein cholesterol. The findings suggest that ABCA1 genotyping could be valuable for managing lipid levels and potentially preventing related diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Genetics & Heredity
Li Liu, Zhenglong Zhai, Danyang Wang, Yun Ding, Xiaoqing Chen, Qiqi Wang, Zheyue Shu, Minglan Wu, Lei Chen, Xuelin He, Dazhi Fan, Faming Pan, Meiyuan Xing
Summary: This meta-analysis revealed significant associations between IL-1α rs3783553, IL-1 β + 31C/T, IL-1 β + 511C/T, and IL-1RN VNTR with colorectal cancer (CRC) susceptibility based on data from 18 independent studies.
Review
Biochemistry & Molecular Biology
Daniel Palinkas, Brigitta Teutsch, Endre Botond Gagyi, Marie Anne Engh, Patricia Kallo, Daniel S. Veres, Laszlo Foldvari-Nagy, Nora Hosszufalusi, Peter Hegyi, Balint Eross
Summary: This study found that restarting DOACs after GIB did not significantly increase the risk of rebleeding. However, the quality of the studies was limited and higher quality randomized clinical trials are needed.