Article
Immunology
Yoshie Takahashi, Yo Okamura, Nanaki Harada, Mika Watanabe, Hiroshi Miyanishi, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: This study on Japanese medaka revealed that IL-22 is crucial for maintaining intestinal homeostasis and plays a significant role in promoting intestinal healing and preventing exacerbation of inflammatory pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Qiuchen Jin, Fangjun Teng, Zhigang Cheng
Summary: Functional polymorphisms of IL-1 alpha (C-889T), IL-1 beta (C+3954T, C-511T) and the composite genotype of IL-1 can serve as predictive markers for peri-implant disease, while the TNF alpha G-308A polymorphism is not associated with peri-implant disease.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Mohammad Hossein Antikchi, Fatemeh Asadian, Seyed Alireza Dastgheib, Yaser Ghelmani, Shadi Kargar, Jalal Sadeghizadeh-Yazdi, Hossein Neamatzadeh
Summary: The meta-analysis found no significant association between IL-8 -251T>A and IL-18 -607C>A polymorphisms and increased risk of CRC in the global population. Stratified analysis by ethnicity, source of controls, sample size, and Hardy-Weinberg equilibrium (HWE) also showed no significant association between IL-8 -251T>A polymorphism and CRC risk. Further studies with larger sample sizes and diverse ethnicities are recommended to confirm these findings.
JOURNAL OF GASTROINTESTINAL CANCER
(2021)
Article
Allergy
Zongqing Liu, Tong Sun, Linjian Song, Xiaoxing Xue, Shuang Liu, Huihui Kuang, Liyuan Tian, Zheng Xiao
Summary: This meta-analysis found that interleukin polymorphisms, particularly IL-1, IL-4, IL-6, and IL-10, may impact the predisposition of SLE. The results varied among different ethnicities, with positive findings observed in Asians for certain polymorphisms and in Caucasians for others.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Medical Laboratory Technology
Jing Ye, Haiyan Sun, Miao Chen, Qiqin Zhang, Zhen Lv, Yanna Zhao
Summary: The meta-analysis found a significant association between IL-18 promoter-607C>A polymorphism and breast cancer risk, particularly under allelic, homozygote, and recessive models. Sub-group analysis in the Asian population did not show a significant association between -607C>A gene polymorphism and breast cancer risk.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)
Article
Pediatrics
Jianrong Shi, Lin He, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Ran Tao
Summary: This study investigated the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of atopic dermatitis (AD) in Chinese children. The results showed that IL-4 rs2243283 G allele, CG genotype, and CG+GG genotype were significantly decreased in AD patients, while IL-18 rs7106524 A allele, AA genotype, and AG+AA genotype were significantly increased in severe AD patients.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Danyal Imani, Navid Dashti, Arash Parvari, Sajad Shafiekhani, Fatemeh Alebrahim, Bahman Razi, Masoud Hassanzadeh Makoui, Morteza Motallebnezhad, Saeed Aslani, Mansur Aliyu
Summary: The meta-analysis found that the IL-10 rs1800896 SNP is significantly associated with a decreased risk of asthma, especially in the African population. Additionally, the rs1800871 SNP has a protective role against asthma in Europeans.
BIOCHEMICAL GENETICS
(2021)
Article
Multidisciplinary Sciences
Hung-Yu Chiang, Hsueh-Han Lu, Janaki N. Sudhakar, Yu-Wen Chen, Nien-Shin Shih, Yi-Ting Weng, Jr-Wen Shui
Summary: IL-22 induces IL-18 expression by intestinal epithelial cells, and IL-18 plays an important role in host defense against intestinal infection and inflammation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This meta-analysis revealed that the circulating level of interleukin-18 is significantly higher in systemic lupus erythematosus (SLE) patients compared to healthy controls. Patients with higher SLEDAI scores, Asian, White, Arab, or mixed ethnicity tend to have elevated levels of IL-18, indicating the potential role of IL-18 in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Noha A. Hassuna, Mohamed El Feky, Aliae A. R. Mohamed Hussein, Manal A. Mahmoud, Naglaa K. Idriss, Sayed F. Abdelwahab, Maggie A. Ibrahim
Summary: This study evaluated the role of IL-18 and IFN-γ polymorphisms in susceptibility to tuberculosis infection among Egyptian patients. Results showed a protective effect against TB with IL-18 -137G/C CC genotype, a higher risk with GG and GC genotypes, and a significant risk with INF-γ+874 AA genotype.
Review
Cell Biology
Cennikon Pakpahan, Citrawati Dyah Kencono Wungu, Agustinus Agustinus, Darmadi Darmadi
Summary: This study found a correlation between the BsmI and FokI polymorphisms of the Vitamin D receptor gene and decreased bone density in men.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Dilek Karakaya, Gunes Cakmak Genc, Sevim Karakas Celik, Tugba Aktas, Taner Bayraktaroglu, Ahmet Dursun
Summary: The study found an association between IL-18 gene polymorphisms and Hashimoto's thyroiditis, with the CG genotype being a potential risk factor for HT and the AC genotype possibly playing a protective role. Further research will contribute to understanding the molecular and cellular mechanisms of HT.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Chiranjeevi Padala, Kaushik Puranam, Nivas Shyamala, Keerthi Kupsal, Ramanjaneyulu Kummari, Rajesh Kumar Galimudi, Kishore Kumar Gundapaneni, Mohini Aiyengar Tupurani, Aparna Suryadevera, Sanjeeva Kumari Chinta, Bramanandam Manavathi, Surekha Rani Hanumanth
Summary: This study evaluated the contribution of genetic polymorphisms of IL6 and IL18 genes to the risk and progression of breast cancer in a South Indian population. The results showed significant associations between specific genotypes and breast cancer stage, metastasis, and subtype. Haplotype combinations of IL6 and IL18 genes were also associated with breast cancer risk. These findings highlight the importance of genotypic and haplotype analysis in predicting and understanding the progression of breast cancer.
Article
Immunology
Preeti Shit, Nisha Sahu, Mohan Krishna Ghanta, Varsha Ahire, Ravindra Jagannath Jadhav, Neha Merchant, L. V. K. S. Bhaskar
Summary: This study found the association between IL-18 gene polymorphism and periodontitis through meta-analysis.
CRITICAL REVIEWS IN IMMUNOLOGY
(2022)