Article
Materials Science, Multidisciplinary
Sandor I. Bernad, Izabell Craciunescu, Gurpreet S. Sandhu, Dan Dragomir-Daescu, Etelka Tombacz, Ladislau Vekas, Rodica Turcu
Summary: This study introduces a novel approach to facilitate rapid endothelialization of vascular stents through the use of magnetic clusters guided by magnetic forces around ferromagnetic stents. The experiment demonstrates excellent biocompatibility of the ferromagnetic stent and stable deposition of magnetic clusters, resulting in almost uniform coverage on stent struts within different segments.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Materials Science, Coatings & Films
G. Boomadevi Janaki, Joseph Raj Xavier
Summary: The study investigates embedding bi-functionalized alumina nanoparticles in epoxy resin and its impact on the electrochemical and mechanical properties. Addition of 3% bi-functionalized alumina nanoparticles significantly enhances the inhibitive and protective properties of the epoxy resin against corrosion. The nanocomposite consisting of epoxy-bi-functionalized/alumina nanoparticles with -NH2 and thiol (-SH) shows substantial improvement in barrier and mechanical properties.
SURFACE & COATINGS TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Isra Marei, Blerina Ahmetaj-Shala, Chris R. Triggle
Summary: Stent thrombosis is a common complication in patients with type 2 diabetes undergoing percutaneous coronary intervention, and it is caused by delayed and impaired endothelialization of the stent. Using specific molecules to induce endothelial cell adhesion, proliferation, and function can improve stent endothelialization and prevent thrombosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Coatings & Films
Wufang Yang, Weibin Feng, Zutai Liao, Yanping Yang, Guolong Miao, Bo Yu, Xiaowei Pei
Summary: A novel siloxane corrosion inhibitor precursor was successfully prepared and used to prepare molecular engineered nanofiller (NPInh) for epoxy composites, improving the dispersion and corrosion resistance of the coatings significantly.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Engineering, Environmental
Z. Fallahnejad, Gh Bakeri, A. F. Ismail
Summary: This study investigated the effects of different polymer coatings on the surface of halloysite nanotubes for the treatment of metal ion solutions, with the modified NF membranes showing higher water permeation flux and lower contact angle.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Multidisciplinary Sciences
Ivan S. Alferiev, Bahman Hooshdaran, Benjamin B. Pressly, Philip W. Zoltick, Stanley J. Stachelek, Michael Chorny, Robert J. Levy, Ilia Fishbein
Summary: Impaired endothelialization is a major cause of in-stent restenosis and late stent thrombosis. This study proposes a novel strategy of stent endothelialization by seeding biotin-modified endothelial cells onto avidin-functionalized stents. Results showed that this strategy significantly reduced in-stent restenosis in a rat model.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Changfen Bi, Baoxin Zheng, Ye Yuan, Hongxin Ning, Wenfeng Gou, Jianghong Guo, Langxing Chen, Wenbin Hou, Yiliang Li
Summary: Fe3O4@SiO2@UiO-66-TPP NPs exhibit fast adsorption rates, high adsorption capacities, and outstanding selectivity towards U(VI), outperforming most other magnetic adsorbents. Additionally, the adsorbent can be reused for U(VI) removal without significant loss of adsorption capacity after five consecutive cycles. This research provides a novel strategy for assembling phosphate group-functionalized MOFs.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jaya Chandrasekhar, Vera C. de Winter, Deborah N. Kalkman, Samantha Sartori, Rishi Chandiramani, Melissa B. Aquino, Puk de Wilde, Doreen Zeebregts, Pier Woudstra, Marcel A. Beijk, Petr Hajek, Borislav Atzev, Martin Hudec, Tiong Kiam Ong, Martin Mates, Borislav Borisov, Hazem M. Warda, Peter den Heijer, Jaroslaw Wojcik, Andres Iniguez, Zdenek Coufal, Michael Lee, Jan G. Tijssen, Karel T. Koch, Usman Baber, George D. Dangas, Antonio Colombo, Robbert J. de Winter, Roxana Mehran
Summary: Despite the novel EPC capture technology, COMBO stent PCI was associated with somewhat greater risk of 1-year TLF in ACS than in non-ACS patients, without significant differences in stent thrombosis. No differences were observed in 1-year TLF among ACS subtypes.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Biophysics
Anouck L. S. Burzava, Marek Jasieniak, Michaelia P. Cockshell, Nicolas H. Voelcker, Claudine S. Bonder, Hans J. Griesser, Eli Moore
Summary: Cardiovascular disease is a leading cause of death worldwide. This study investigated whether a surface with immobilized anti-CD34 antibodies attracts endothelial cells via specific CD34 binding or nonspecific binding. The results showed that the surface with immobilized anti-CD34 antibodies effectively attracted endothelial cells, but nonspecific binding was also observed, highlighting the importance of considering its consequences in future studies.
Article
Engineering, Biomedical
Yidi Wu, Saami K. Yazdani, Johanna Elin Marie Bolander, William D. Wagner
Summary: This study successfully enhanced the interaction between circulating endothelial colony forming cells (ECFCs) and a material by functionalizing the material with capture molecules, leading to the differentiation of ECFCs into endothelial cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Shima Tavakol, Alexander M. Seifalian
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Review
Cell & Tissue Engineering
Shima Tavakol, Hani Tavakol, Mo S. Alavijeh, Alexander Seifalian
Summary: Nanomachines, including viruses, have been around for thousands of years. In 2019, the world had to come together to fight against SARS-CoV-2, a life-threatening nanomachine causing COVID-19. This research focuses on finding biomaterials that can inhibit the signaling pathways and ligand sites of the virus.
CURRENT STEM CELL RESEARCH & THERAPY
(2022)
Review
Genetics & Heredity
Ivan Seah, Debbie Goh, Hwei Wuen Chan, Xinyi Su
Summary: Inherited retinal diseases (IRDs) are a group of diseases that can lead to blindness. Advances in sequencing technologies have improved molecular characterization and genotype-phenotype correlation of IRDs, fueling research into therapeutic development. Non-human primates (NHP) are ideal animal models due to their similarities to humans, but developing NHP disease models for specific IRDs can be challenging. This review discusses current NHP IRD models and their development methods, with a focus on gene-editing technologies.
Article
Biochemistry & Molecular Biology
Jakpar Jandosov, Mo Alavijeh, Shynggyskhan Sultakhan, Alzhan Baimenov, Maria Bernardo, Zuriyadda Sakipova, Seytkhan Azat, Svitlana Lyubchyk, Nurzhamal Zhylybayeva, Gulmira Naurzbayeva, Zulkhair Mansurov, Sergey Mikhalovsky, Dmitriy Berillo
Summary: A microgranulated binary biomedical preparation for oral use was developed in this study for the elimination of toxic substances from the gastrointestinal tract. The composite enterosorbent demonstrated high adsorption capacity for both lead and diclofenac, making it suitable for treating poisoning caused by substances of different chemical nature.
Review
Chemistry, Multidisciplinary
Yasamin Davatgaran Taghipour, Amir Zarebkohan, Roya Salehi, Fariborz Rahimi, Vladimir P. Torchilin, Michael R. Hamblin, Alexander Seifalian
Summary: The lack of efficient strategies for targeted delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) is a key issue in the treatment of solid tumors. This review focuses on dual targeting approaches, which combine biological strategies and physicochemical responsive smart delivery strategies, to increase the accumulation of nanoparticles within the TME and improve targeting efficiency towards cancer cells. The efficiency and rationale behind the choice of ligands for dual targeting strategies are critically reviewed. New approaches for smart drug delivery, including TME-specific responsive linkers and camouflaged nanoparticles, are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Ananya Pattnaik, A. Swaroop Sanket, Sanghamitra Pradhan, Rajashree Sahoo, Sudiptee Das, Swarnaprbha Pany, Timothy E. L. Douglas, Rambabu Dandela, Qiang Liu, Jaykumar Rajadas, Sanghamitra Pati, Stefaan C. Smedt, Kevin Braeckmans, Sangram Keshari Samal
Summary: Gradient scaffolds are three-dimensional structures that mimic the biological extracellular matrix with gradual transitions in various properties. They have shown advantages in nutrient and cell penetration, cellular adhesion, viability and differentiation, mechanical stability, and biocompatibility compared to conventional scaffolds. This review explains recent advancements in designing gradient scaffolds and their implications in tissue regeneration applications, as well as discussing the specific utility of gradients in different native tissues.
Article
Biochemistry & Molecular Biology
Mercedeh Babaluei, Fatemeh Mottaghitalab, Alexander Seifalian, Mehdi Farokhi
Summary: This study developed an injectable hydrogel for wound dressings, containing sodium carboxymethylcellulose/polyacrylamide/polydopamine with vitamin C (CMC/PAAm/PDA VitC) and silk fibroin/alginate nanoparticles loaded with curcumin (SF/SANPs CUR). The hydrogels demonstrated stable properties, biocompatibility, and antibacterial activity against MRSA. In preclinical rat models, the hydrogels showed significant support for full-thickness burn regeneration, wound closure, and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Elham Hasanzadeh, Alexander Seifalian, Amir Mellati, Jamileh Saremi, Shiva Asadpour, Seyed Ehsan Enderami, Houra Nekounam, Narges Mahmoodi
Summary: Repairing CNS is challenging due to the inability of neurons to recover. Injectable hydrogels have desirable attributes as biodegradable scaffolds for CNS tissue engineering and regeneration. They can imitate several aspects of CNS and are considered an effective therapeutic agent.
MATERIALS TODAY BIO
(2023)
Review
Biotechnology & Applied Microbiology
Mahsa Tashakori-Miyanroudi, Atousa Janzadeh, Alexander Seifalian, Nahid Aboutaleb, Yaser Azizi, Fatemeh Ramezani
Summary: Despite scientific advances, the number of cardiovascular patients is increasing worldwide. To protect damaged cardiomyocytes from further harm, novel and safer approaches are needed to help regeneration and prevent fibrosis. In this study, a systematic review of in vitro and preclinical studies of carbon nanotubes (CNTs) and carbon nanofibers (CNFs) for help to treat heart damage was conducted. The results showed that CNTs/CNFs in hydrogels increase conductivity, promote cardiac cell proliferation, and enhance expression of genes associated with stem cell differentiation into cardiac cells.
Article
Biochemistry & Molecular Biology
Farah Azhar, Humaira Naureen, Gul Shahnaz, Syed Damin Abbas Hamdani, Maria Hassan Kiani, Shahana Khattak, Manoj Kumar Manna, Mustafeez Mujtaba Babar, Jayakumar Rajadas, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Thiolated chitosan-lithocholic acid nanomicelles loaded with beta-carotene were designed to improve drug characteristics. The results showed that these nanomicelles could sustainably release the drug and delay skin cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Marjan Mirhaj, Jaleh Varshosaz, Sheyda Labbaf, Rahmatollah Emadi, Alexander Marcus Seifalian, Fariborz Sharifianjazi, Mohamadreza Tavakoli
Summary: A core-shell nanofibrous wound dressing based on F127 containing mupirocin core and pectin-keratin shell was fabricated, which showed controlled release of mupirocin and improved wound healing compared to blended nanofibers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Neda Keyhanvar, Nosratollah Zarghami, Alexander Seifalian, Peyman Keyhanvar, Rana Sarvari, Roya Salehi, Reza Rahbarghazi, Mohammadreza Ranjkesh, Molood Akbarzadeh, Mahdi Mahdipour, Mohamamd Nouri
Summary: This study aimed to direct mesenchymal stem cells (MSCs) towards keratinocyte-like cells (KLCs) using cell imprinting and sheet technology. Culturing AT-MSCs on a PDMS substrate with keratinocyte cell-imprinted topography induced differentiation towards keratinocyte-like cells. The data suggests that the keratinocyte cell-imprinted substrate can provide a specific niche and topographical cues to orient AT-MSCs towards KLCs.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
Article
Dentistry, Oral Surgery & Medicine
Farshid Bastami, Mohammad-Hadi Noori-Kooshki, Hassan Semyari, Reza Tabrizi, Alireza Abrishamchian, Fatemeh Mashhadi-Abbas, Shahriar Shahab, Alexander Seifalian
Summary: The study evaluated the effects of MWCNT/HA granules with or without L-PRF on bone regeneration in a sheep model. Results showed that there was no significant inflammation around the granules, and new lamellar bone was regenerated. The addition of L-PRF to MWCNT/HA significantly improved new bone formation, while the use of MWCNT/HA granules alone also significantly increased new bone formation compared to control.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)