Article
Immunology
Katherine E. Herman, Takeshi Yoshida, Angela Hughson, Alex Grier, Steven R. Gill, Lisa A. Beck, Deborah J. Fowell
Summary: Wiskott-Aldrich Syndrome is characterized by recurrent infections, thrombocytopenia, and eczema. WASp-deficient mice show dysregulated immune homeostasis and barrier dysfunction in the skin, with increased leukocyte accumulation and skin dysbiosis. IL-17 plays a critical role in skin immune infiltration and elevation of Type 2 and Type 17 cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
A. Oezcan, V Collado-Diaz, C. Egholm, M. Tomura, M. Gunzer, C. Halin, A. G. A. Kolios, O. Boyman
Summary: Neutrophil responses in inflamed or infected skin are regulated by CCR7-dependent migration and phagocytosis of neutrophils in draining lymph nodes.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
David Guerrero, Hoa Thi My Vo, Chanthap Lon, Jennifer A. Bohl, Sreynik Nhik, Sophana Chea, Somnang Man, Sokunthea Sreng, Andrea R. Pacheco, Sokna Ly, Rathanak Sath, Sokchea Lay, Dorothee Misse, Rekol Huy, Rithea Leang, Hok Kry, Jesus G. Valenzuela, Fabiano Oliveira, Tineke Cantaert, Jessica E. Manning
Summary: The study assesses the innate and adaptive immune responses to Aedes aegypti mosquito feedings in humans. The results show induction of neutrophil degranulation, recruitment of skin-resident dendritic cells and M2 macrophages, as well as activation of T cell priming and regulatory pathways.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Maryam Mahdavi, Reihaneh Aryan, Yalda Nahidi, Mehrdad Teimoorian, Vahid Mashayekhi
Summary: Clinicians should always consider the possibility of rare, atypical, and opportunistic infections in patients undergoing long-term systemic corticosteroid therapy, and diagnosis requires further evaluation and special consideration.
CLINICAL CASE REPORTS
(2021)
Article
Medicine, General & Internal
Antonio Carujo, Joel Reis, Andre Santos Silva, Miguel Araujo Abreu, Antonio Ludgero Vasconcelos
Summary: This article reports a rare case of complicated cutaneous leishmaniasis, emphasizing the treatment options and diagnostic challenges in immunosuppressed hosts.
ACTA MEDICA PORTUGUESA
(2023)
Article
Infectious Diseases
E. Yaneth Osorio, Ashanti Uscanga-Palomeque, Grace T. Patterson, Erika Cordova, Bruno L. Travi, Lynn Soong, Peter C. Melby
Summary: Malnutrition increases the risk of parasite dissemination from the skin to visceral organs, primarily driven by infected inflammatory monocytes. The production of PGE(2) promotes this process.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Urology & Nephrology
Soumaya Yaich, Hanen Abid, Salma Toumi, Beya Fendri, Hanen Chaker, Ikram Agrebi, Najla Dammak, Mondher Masmoudi, Abderrahmen Masmoudi, Hamida Turki, Khawla Kammoun, Mohamed Ben Hmida
Summary: Leishmaniasis is a zoonotic disease transmitted by sandflies, common in Mediterranean countries and Tunisia. It presents diagnostic and therapeutic difficulties in immunocompromised patients, with variable clinical manifestations.
NEPHROLOGIE & THERAPEUTIQUE
(2022)
Article
Infectious Diseases
Rosa Cristina Ribeiro da Silva, Leo Nava Piorsky Dominici Cruz, Joao Manoel da Silva Coutinho, Carlos Eduardo Fonseca-Alves, Jose Manuel Macario Rebelo, Silma Regina Ferreira Pereira
Summary: Lu. longipalpis has been shown to become infected and experimentally transmit L. (L.) amazonensis to immunosuppressed rodents, resulting in leishmaniotic lesions.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2021)
Article
Immunology
Xinying Li, Jocelyn Darby, A. Bruce Lyons, Gregory M. Woods, Heinrich Korner
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Article
Immunology
Adrian Y. S. Lee, Heinrich Korner
Review
Pharmacology & Pharmacy
Jiajie Tu, Yawei Guo, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Korner, Wei Wei
FRONTIERS IN PHARMACOLOGY
(2019)
Review
Oncology
Weijia Mao, Jie Zhang, Heinrich Korner, Yong Jiang, Songcheng Ying
FRONTIERS IN ONCOLOGY
(2019)
Article
Immunology
Miaomiao Li, Yang Dong, Zhangming Chen, Lei Meng, Xingyun Liu, Xinhui Zhang, Huimin Wang, Weijia Mao, Jie Zhang, Zhe Jiang, Ting Huang, Jie Hu, Panquan Luo, Heinrich Korner, Songcheng Ying, Jun Li
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Review
Immunology
Xinming Wang, Abishek Iyer, A. Bruce Lyons, Heinrich Korner, Wei Wei
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Immunology
Qi Liu, Heinrich Korner, Huaxun Wu, Wei Wei
Article
Immunology
Xiaoyun Chen, Pengying Zhang, Qi Liu, Qiaolin Zhang, Fang Gu, Shixia Xu, Heinrich Korner, Huaxun Wu, Wei Wei
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Review
Cell Biology
Adrian Y. S. Lee, Heinrich Korner
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Huaxun Wu, Xiaoyun Chen, Fang Gu, Pengying Zhang, Shixia Xu, Qi Liu, Qiaolin Zhang, Xinming Wang, Chun Wang, Heinrich Koerner, Wei Wei
Summary: The study demonstrated that CP-25 therapy inhibits the JAK1-STAT1/2-CXCL13 signaling pathway in HSGEC, preventing B cell migration into the salivary gland. CP-25 showed potential therapeutic effects in alleviating symptoms of Sjogren's syndrome and modulating immune responses in patients.
LABORATORY INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Ma Junaliah Tuazon Kels, Esther Ng, Zahrah Al Rumaih, Pratikshya Pandey, Sigrid R. Ruuls, Heinrich Korner, Timothy P. Newsome, Geeta Chaudhri, Gunasegaran Karupiah
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Microbiology
Xinying Li, Heinrich Koerner, Xiaoying Liu
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Xinying Li, Chen Chen, Lianjun Zhang, Xiaomin Cheng, Huiwu Geng, Qiang Ji, Chao Li, Huili Chen, Heinrich Korner, Xiaoying Liu
Summary: Research has shown that TNF plays a crucial role in immunity against Listeria monocytogenes, supporting the M1 phenotype and blocking M2 polarization in macrophages. TNF promotes the transition from M2 to M1 phenotype, with involvement of the NF-kappa B pathway and PPAR gamma receptor agonists. Competing signaling mechanisms are essential for macrophages to defeat Listeria monocytogenes infections, with TNF driving M1 polarization being a key factor.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Immunology
Xinming Wang, Jiajie Tu, Ji Jiang, Qiaolin Zhang, Qi Liu, Heinrich Korner, Jingjing Wu, Huaxun Wu, Wei Wei
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Ming Lu, Bennet J. McComish, Kathryn P. Burdon, Bruce Taylor, Heinrich Korner
FRONTIERS IN IMMUNOLOGY
(2019)