Article
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Julita A. Krahel, Tomasz W. Kaminski, Magdalena Maciaszek, Iwona Flisiak
Summary: Psoriasis is associated with metabolic disorders, and this study found a correlation between psoriasis and cholesteryl ester transfer protein (CETP) and sortilin (SORT), which are involved in lipid metabolism. However, CETP and SORT cannot be used as individual biomarkers. CETP concentration may be investigated as a marker for liver side effects of acitretin treatment, while SORT could be considered as a new indicator of metabolically induced inflammation in psoriasis patients.
Review
Biochemistry & Molecular Biology
Adam J. Nelson, Allan D. Sniderman, Marc Ditmarsch, Mary R. Dicklin, Stephen J. Nicholls, Michael H. Davidson, John J. P. Kastelein
Summary: Cholesteryl ester transfer protein (CETP) facilitates the exchange of cholesteryl esters and triglycerides between HDL particles and TG-rich, apoB-containing particles. Initially, CETP inhibitors were developed to raise plasma HDL-C levels to lower the risk of ASCVD. However, recent evidence suggests that CETP inhibitors can reduce LDL-C and apoB concentrations, thereby reducing the risk of major coronary events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Anna E. Bortnick, Petra Buzkova, James Otvos, Majken Jensen, Michael Y. Tsai, Matthew Budoff, Rachel Mackey, Samar R. El Khoudary, Elda Favari, Ryung S. Kim, Carlos J. Rodriguez, George Thanassoulis, Jorge R. Kizer
Summary: This study found that high-density lipoprotein (HDL) cholesterol, HDL particle number and size, apoC3-defined HDL subtypes were inversely associated with the long-term incidence and progression of aortic valve calcification (AVC). Further investigation of HDL composition and mechanisms could be useful in understanding pathways that slow AVC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Reema Abu Khalaf, Areej NasrAllah, Wassan Jarrar, Dima A. Sabbah
Summary: The research describes the synthesis and design of seven compounds with cholesteryl ester transfer protein (CETP) inhibitory activity, with most of them showing appreciable CETP inhibitory activity. Some compounds demonstrate the highest inhibitory activity and match the features of known CETP inhibitors.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mark Trinder, Yanan Wang, Christian M. Madsen, Tatjana Ponomarev, Lubos Bohunek, Brendan A. Daisely, HyeJin Julia Kong, Lisanne L. Blauw, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Mark M. Wurfel, James A. Russell, Keith R. Walley, Patrick C. N. Rensen, John H. Boyd, Liam R. Brunham
Summary: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.
Article
Biochemistry & Molecular Biology
Jun Chen, Haihua Qi, Lijun Liu, Yandong Niu, Shuping Yu, Shucun Qin, Lei He
Summary: Elevated CETP and PLTP levels were found to worsen psoriasis symptoms in a mouse model, leading to increased expression of inflammatory cytokines.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Pharmacology & Pharmacy
Nehal Mehta, Katerina Dangas, Marc Ditmarsch, Patrick C. N. Rensen, Mary R. Dicklin, John J. P. Kastelein
Summary: The main role of cholesteryl ester transfer protein (CETP) is to transfer cholesteryl esters and triglycerides between different lipoprotein particles. Inhibition of CETP has been investigated as a target for reducing cardiovascular events, and it is now understood that CETP inhibitors primarily reduce LDL cholesterol and apolipoprotein B rather than increasing HDL cholesterol. Furthermore, HDL may have important roles in diseases beyond cardiovascular disease, such as Alzheimer's disease, diabetes, and sepsis.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Dayeon Shin, Sung Ryul Shim, Yueying Wu, Gayeon Hong, Hyunyu Jeon, Choong-Gon Kim, Kyung Ju Lee
Summary: This meta-analysis found that brown seaweed intake significantly decreased levels of total cholesterol and LDL cholesterol, but the association with HDL cholesterol and triglycerides was not significant. The results suggest that using brown seaweed may be an effective strategy to reduce the risk of dyslipidemia.
Article
Pharmacology & Pharmacy
Christie M. Ballantyne, Marc Ditmarsch, John J. P. Kastelein, Adam J. Nelson, Douglas Kling, Andrew Hsieh, Danielle L. Curcio, Kevin C. Maki, Michael H. Davidson, Stephen J. Nicholls
Summary: This study evaluated the efficacy and safety of obicetrapib plus ezetimibe combination therapy as an adjunct to high-intensity statin therapy. The results showed that the combination therapy significantly lowered atherogenic lipid and lipoprotein parameters and was safe and well tolerated.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Review
Clinical Neurology
Soheil Mohammadi, Fatemeh Moosaie, Amene Saghazadeh, Maryam Mahmoudi, Nima Rezaei
Summary: Narcolepsy patients show metabolic abnormalities, including higher prevalence of obesity, diabetes, hypertension, and dyslipidemia. Additionally, they have higher BMI, waist circumference, and plasma insulin levels compared to non-narcoleptic controls.
Review
Pharmacology & Pharmacy
Li Jiang, Shidong Wang, Jinxi Zhao, Chieh Chien, Yaofu Zhang, Guanxun Su, Xiaoyu Chen, Dechao Song, Yu Chen, Weijun Huang, Yonghua Xiao, Yandong Cao, Zixian Hu
Summary: This study conducted a network meta-analysis to compare the clinical efficacy and safety of six Traditional Chinese Patent Medicines (TCPM) in improving lipids for patients with prediabetes. The results showed that Jinqi and Shenqi combined with lifestyle modification were associated with a significant reduction in triglycerides (TG) and total cholesterol (TC). Among them, Shenqi + LM showed the most effective results, while Jinlida + LM showed the least effective results.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Surgery
Joachim N. Meuli, Martino Guiotto, Jolanda Elmers, Lucia Mazzolai, Pietro G. di Summa
Summary: Microsurgical treatments such as lymphovenous anastomosis and vascularized lymph node transfers have been found to be effective in reducing the severity of lymphedema. However, there is a lack of standardized evaluation methods and varying outcomes reported in different studies. Future research should focus on standardizing staging methods, outcome measurements, and reporting to ensure comparability and pooling of results.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Ingmar F. Rompen, Daniela C. Merz, Karam T. Alhalabi, Rosa Klotz, Eva Kalkum, Thomas M. Pausch, Hendrik Strothmann, Pascal Probst
Summary: This study aimed to provide an evidence-based overview on the best perioperative drug treatment in pancreatic surgery. The analysis showed that somatostatin analogues and glucocorticoids can reduce the incidence of postoperative pancreatic fistula, while there is limited evidence for other drug treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Mohamed M. G. Mohamed, Mohammed Osman, Babikir Kheiri, Maryam Saleem, Alexandre Lacasse, Mohamad Alkhouli
Summary: This meta-analysis demonstrates that the use of polypills is significantly associated with reductions in blood pressure and blood lipid levels compared to standard of care, leading to a significant decrease in cardiovascular events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Qianhang Xia, Yuquan Chen, Zijing Yu, Zhongyue Huang, Yujie Yang, Ayan Mao, Wuqi Qiu
Summary: Many epidemiological studies have been conducted on dyslipidemia in China, but a representative study on its epidemiological status is still lacking. This meta-analysis aims to explore the prevalence, rates of awareness, treatment, and control of dyslipidemia among adults in Chinese Mainland. The study found a severe epidemic situation of dyslipidemia among adults in China with extremely low rates of awareness, treatment, and control, indicating that dyslipidemia is a grave health issue.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)